FECD - ECOLI - GREMLIN Contacts

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FECD - Fe(3+) dicitrate transport system permease protein FecD

UniProt:	P15029	Sequences: MKIALVIFITLALAGCALLSLHMGVIPVPWRALLTDWQAGHEHYYVLMEYRLPRLLLALFVGAALAVAGVLIQGIVRNPLASPDILGVNHAASLASVGALLLMPSLPVMVLPLLAFAGGMAGLILLKMLAKTHQPMKLALTGVALSACWASLTDYLMLSRPQDVNNALLWLTGSLWGRDWSFVKIAIPLMILFLPLSLSFCRDLDLLALGDARATTLGVSVPHTRFWALLLAVAMTSTGVAACGPISFIGLVVPHMMRSITGGRHRRLLPVSALTGALLLVVADLLARIIHPPLELPVGVLTAIIGAPWFVWLLVRMR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10289
Length:	318 (312)
Sequences:	13812 (9805)
Seq/√Len:	555.1

ECOLI - FECD FEPG FEPD FECC BTUC FHUB
BACSU - FHUB FHUG YVRB YFME YFIZ YFHA FEUC YCLN FEUB YFMD YCLO
HALSA - Q9HMG7 Q9HMG0 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
205_D	264_R	4.368	1.00
63_A	273_A	3.741	1.00
99_A	114_L	3.609	1.00
16_C	282_V	3.576	1.00
71_L	197_S	3.422	1.00
17_A	55_L	3.381	1.00
220_S	223_H	3.264	1.00
64_A	190_M	3.120	1.00
71_L	228_A	3.047	1.00
59_L	277_A	2.990	1.00
58_A	175_L	2.843	1.00
257_M	275_T	2.790	1.00
32_A	43_H	2.730	1.00
57_L	178_R	2.577	1.00
64_A	235_M	2.511	1.00
67_V	273_A	2.499	1.00
32_A	35_T	2.467	1.00
17_A	59_L	2.450	1.00
64_A	239_G	2.449	1.00
211_D	225_R	2.377	1.00
94_L	152_L	2.373	1.00
13_L	278_L	2.334	1.00
12_A	278_L	2.294	1.00
61_V	239_G	2.251	1.00
67_V	194_L	2.228	1.00
70_V	272_S	2.218	1.00
261_T	271_V	2.193	1.00
22_H	30_W	2.177	1.00
59_L	281_V	2.080	1.00
61_V	243_C	2.032	1.00
189_L	238_T	2.016	1.00
203_D	224_T	2.009	1.00
13_L	59_L	2.007	1.00
40_G	43_H	1.998	1.00
94_L	149_W	1.982	1.00
29_P	32_A	1.970	1.00
60_F	187_I	1.955	1.00
98_G	102_L	1.941	1.00
54_R	284_D	1.893	1.00
20_S	55_L	1.881	1.00
72_I	232_A	1.862	1.00
74_G	265_H	1.855	1.00
200_F	203_D	1.824	1.00
206_L	219_V	1.820	1.00
205_D	265_H	1.818	1.00
16_C	278_L	1.804	1.00
31_R	35_T	1.804	1.00
196_L	231_L	1.785	1.00
97_V	153_T	1.765	1.00
193_F	235_M	1.716	1.00
6_V	271_V	1.696	1.00
44_Y	48_M	1.686	1.00
178_R	182_F	1.677	1.00
41_H	44_Y	1.671	1.00
200_F	227_W	1.633	1.00
56_L	183_V	1.572	1.00
19_L	22_H	1.563	1.00
223_H	227_W	1.563	1.00
249_I	280_L	1.553	1.00
286_L	290_I	1.541	1.00
13_L	274_L	1.540	1.00
184_K	188_P	1.534	1.00
179_D	182_F	1.506	1.00
36_D	48_M	1.506	1.00
200_F	224_T	1.506	1.00
96_S	115_A	1.498	1.00
70_V	268_L	1.498	1.00
193_F	234_A	1.495	1.00
119_G	237_S	1.463	1.00
9_I	274_L	1.428	1.00
287_A	298_V	1.424	1.00
19_L	23_M	1.423	1.00
16_C	281_V	1.422	1.00
175_L	280_L	1.406	1.00
286_L	301_L	1.398	1.00
123_L	233_V	1.393	1.00
9_I	271_V	1.366	1.00
20_S	285_L	1.357	1.00
193_F	231_L	1.353	1.00
95_A	114_L	1.351	1.00
257_M	271_V	1.351	1.00
68_A	235_M	1.351	1.00
9_I	275_T	1.330	1.00
188_P	192_L	1.330	1.00
267_R	270_P	1.329	1.00
196_L	200_F	1.306	1.00
93_S	153_T	1.281	1.00
184_K	187_I	1.261	1.00
122_G	149_W	1.259	1.00
57_L	242_A	1.258	1.00
257_M	268_L	1.253	1.00
200_F	228_A	1.247	1.00
148_C	307_A	1.239	1.00
253_V	279_L	1.235	1.00
60_F	183_V	1.232	1.00
215_T	222_P	1.226	1.00
13_L	277_A	1.222	1.00
27_P	30_W	1.222	1.00
89_N	236_T	1.219	1.00
45_Y	49_E	1.214	1.00
253_V	275_T	1.213	1.00
95_A	118_G	1.209	1.00
213_R	216_T	1.189	1.00
75_I	228_A	1.188	1.00
66_A	253_V	1.186	1.00
42_E	45_Y	1.180	1.00
6_V	267_R	1.175	1.00
224_T	227_W	1.172	1.00
223_H	226_F	1.167	1.00
206_L	217_L	1.161	1.00
186_A	242_A	1.161	1.00
93_S	171_L	1.156	1.00
243_C	246_I	1.154	1.00
265_H	268_L	1.143	1.00
36_D	44_Y	1.139	1.00
39_A	44_Y	1.137	1.00
70_V	269_L	1.127	1.00
124_I	128_M	1.122	1.00
97_V	167_A	1.121	1.00
222_P	225_R	1.120	1.00
196_L	227_W	1.115	1.00
63_A	277_A	1.111	1.00
9_I	278_L	1.108	1.00
91_A	122_G	1.103	1.00
121_A	125_L	1.101	1.00
195_P	199_S	1.096	1.00
58_A	280_L	1.094	1.00
58_A	281_V	1.093	1.00
94_L	98_G	1.090	1.00
26_I	46_V	1.090	1.00
36_D	39_A	1.076	1.00
197_S	231_L	1.075	1.00
288_R	295_E	1.070	1.00
101_L	156_L	1.064	1.00
63_A	66_A	1.064	1.00
57_L	183_V	1.061	1.00
70_V	265_H	1.060	1.00
210_G	214_A	1.058	1.00
91_A	118_G	1.052	1.00
270_P	273_A	1.048	1.00
114_L	118_G	1.039	1.00
107_P	110_V	1.038	1.00
146_S	150_A	1.031	1.00
192_L	195_P	1.028	1.00
60_F	186_A	1.028	1.00
222_P	226_F	1.027	1.00
56_L	180_W	1.026	1.00
116_F	234_A	1.022	1.00
21_L	55_L	1.021	1.00
186_A	190_M	1.017	1.00
126_L	145_L	1.014	1.00
113_L	117_A	1.009	1.00
90_H	149_W	1.008	1.00
131_K	222_P	1.008	1.00
18_L	22_H	1.001	1.00
98_G	156_L	0.997	1.00
287_A	301_L	0.994	1.00
193_F	238_T	0.993	1.00
17_A	281_V	0.992	1.00
22_H	33_L	0.990	1.00
278_L	282_V	0.989	1.00
48_M	52_L	0.988	1.00
161_P	165_N	0.983	1.00
204_L	228_A	0.977	1.00
286_L	289_I	0.977	1.00
36_D	47_L	0.977	1.00
23_M	289_I	0.974	1.00
284_D	288_R	0.973	1.00
160_R	163_D	0.971	1.00
261_T	267_R	0.969	1.00
246_I	280_L	0.968	1.00
11_L	15_G	0.964	1.00
38_Q	41_H	0.958	1.00
89_N	245_P	0.950	1.00
224_T	228_A	0.945	1.00
10_T	14_A	0.943	1.00
55_L	285_L	0.941	1.00
253_V	257_M	0.940	1.00
16_C	285_L	0.939	1.00
267_R	271_V	0.934	1.00
60_F	190_M	0.926	1.00
264_R	267_R	0.920	1.00
185_I	188_P	0.916	1.00
36_D	43_H	0.912	1.00
33_L	47_L	0.910	1.00
291_H	294_L	0.910	1.00
303_A	308_P	0.905	1.00
308_P	312_W	0.902	1.00
219_V	224_T	0.902	1.00
94_L	153_T	0.901	1.00
188_P	191_I	0.896	1.00
116_F	120_M	0.896	1.00
180_W	183_V	0.896	1.00
268_L	272_S	0.896	1.00
39_A	43_H	0.893	1.00
212_A	215_T	0.893	1.00
260_I	275_T	0.888	1.00
44_Y	49_E	0.883	1.00
309_W	312_W	0.882	1.00
205_D	266_R	0.880	1.00
63_A	194_L	0.868	1.00
239_G	243_C	0.865	1.00
282_V	286_L	0.863	1.00
211_D	215_T	0.862	1.00
128_M	131_K	0.856	1.00
126_L	130_A	0.853	1.00
167_A	171_L	0.852	1.00
24_G	51_R	0.848	1.00
18_L	30_W	0.846	1.00
106_L	110_V	0.845	1.00
68_A	232_A	0.845	1.00
100_L	111_L	0.841	1.00
10_T	274_L	0.840	1.00
94_L	156_L	0.838	1.00
287_A	297_P	0.831	1.00
69_G	254_P	0.829	1.00
14_A	18_L	0.826	1.00
211_D	221_V	0.823	1.00
84_D	89_N	0.819	1.00
196_L	199_S	0.814	1.00
88_V	119_G	0.814	1.00
64_A	68_A	0.812	1.00
265_H	270_P	0.806	1.00
96_S	111_L	0.805	1.00
226_F	230_L	0.804	1.00
290_I	293_P	0.803	1.00
99_A	111_L	0.798	1.00
258_R	268_L	0.796	1.00
201_C	266_R	0.796	1.00
200_F	231_L	0.794	1.00
289_I	292_P	0.794	1.00
52_L	180_W	0.788	1.00
22_H	27_P	0.785	1.00
221_V	225_R	0.784	1.00
181_S	184_K	0.782	1.00
55_L	281_V	0.779	1.00
257_M	261_T	0.779	1.00
127_K	226_F	0.779	1.00
117_A	121_A	0.779	1.00
33_L	36_D	0.774	1.00
127_K	131_K	0.774	1.00
189_L	193_F	0.770	1.00
92_A	119_G	0.765	1.00
274_L	278_L	0.760	1.00
127_K	222_P	0.759	1.00
28_V	47_L	0.759	1.00
249_I	302_T	0.757	1.00
197_S	228_A	0.757	1.00
165_N	168_L	0.755	1.00
82_S	85_I	0.755	1.00
229_L	233_V	0.753	1.00
54_R	288_R	0.752	1.00
162_Q	166_N	0.750	1.00
41_H	45_Y	0.750	1.00
214_A	221_V	0.749	1.00
304_I	308_P	0.748	1.00
186_A	238_T	0.747	1.00
63_A	190_M	0.747	1.00
72_I	86_L	0.745	1.00
182_F	242_A	0.745	1.00
91_A	149_W	0.744	1.00
280_L	302_T	0.743	1.00
120_M	233_V	0.738	1.00
257_M	260_I	0.736	1.00
123_L	127_K	0.735	1.00
190_M	239_G	0.734	1.00
66_A	70_V	0.733	1.00
98_G	103_M	0.732	1.00
191_I	195_P	0.730	1.00
203_D	219_V	0.728	1.00
88_V	123_L	0.726	1.00
28_V	43_H	0.724	1.00
198_L	201_C	0.723	1.00
20_S	288_R	0.722	1.00
199_S	203_D	0.721	1.00
13_L	17_A	0.721	1.00
56_L	60_F	0.720	1.00
26_I	30_W	0.720	1.00
125_L	128_M	0.719	1.00
40_G	44_Y	0.719	1.00
90_H	93_S	0.719	1.00
14_A	17_A	0.717	1.00
15_G	18_L	0.717	1.00
67_V	197_S	0.714	1.00
9_I	13_L	0.714	1.00
57_L	186_A	0.712	1.00
120_M	237_S	0.710	1.00
291_H	296_L	0.705	1.00
23_M	27_P	0.702	1.00
97_V	157_M	0.701	1.00
98_G	152_L	0.701	1.00
119_G	123_L	0.700	1.00
238_T	241_A	0.699	1.00
65_L	249_I	0.699	1.00
45_Y	48_M	0.698	1.00
13_L	281_V	0.698	1.00
54_R	295_E	0.698	1.00
133_H	137_K	0.692	1.00
38_Q	44_Y	0.692	1.00
238_T	242_A	0.692	1.00
110_V	113_L	0.690	1.00
66_A	273_A	0.688	1.00
21_L	52_L	0.685	1.00
118_G	122_G	0.684	1.00
35_T	39_A	0.677	1.00
205_D	270_P	0.675	1.00
256_M	275_T	0.673	1.00
259_S	313_L	0.672	1.00
26_I	29_P	0.671	1.00
123_L	229_L	0.669	1.00
246_I	298_V	0.669	1.00
215_T	221_V	0.667	1.00
116_F	119_G	0.667	1.00
68_A	236_T	0.664	1.00
187_I	191_I	0.664	1.00
76_V	139_A	0.664	1.00
194_L	198_L	0.663	1.00
28_V	36_D	0.662	1.00
186_A	189_L	0.661	1.00
280_L	298_V	0.661	1.00
256_M	259_S	0.658	1.00
32_A	39_A	0.657	1.00
33_L	37_W	0.654	1.00
122_G	126_L	0.653	1.00
74_G	208_A	0.652	1.00
30_W	34_L	0.652	1.00
21_L	47_L	0.649	1.00
277_A	281_V	0.648	1.00
100_L	166_N	0.647	1.00
93_S	245_P	0.647	1.00
207_L	221_V	0.645	1.00
67_V	269_L	0.644	1.00
154_D	170_W	0.643	1.00
52_L	56_L	0.637	1.00
109_M	113_L	0.637	1.00
134_Q	137_K	0.636	1.00
17_A	21_L	0.636	1.00
279_L	283_A	0.634	1.00
157_M	168_L	0.634	1.00
45_Y	50_Y	0.633	1.00
130_A	141_T	0.629	1.00
254_P	272_S	0.629	1.00
150_A	171_L	0.627	1.00
312_W	316_R	0.626	1.00
203_D	206_L	0.625	1.00
249_I	279_L	0.625	1.00
117_A	120_M	0.624	1.00
15_G	19_L	0.623	1.00
163_D	166_N	0.622	1.00
63_A	67_V	0.621	1.00
82_S	250_G	0.621	1.00
101_L	159_S	0.620	1.00
180_W	184_K	0.620	1.00
168_L	171_L	0.619	1.00
100_L	167_A	0.619	1.00
189_L	234_A	0.618	1.00
175_L	298_V	0.618	1.00
61_V	175_L	0.616	1.00
283_A	301_L	0.615	1.00
252_V	310_F	0.614	1.00
150_A	154_D	0.614	1.00
99_A	110_V	0.614	1.00
282_V	285_L	0.613	1.00
8_F	12_A	0.612	1.00
31_R	34_L	0.606	1.00
30_W	33_L	0.604	1.00
252_V	256_M	0.604	1.00
193_F	197_S	0.604	1.00
129_L	141_T	0.603	1.00
47_L	52_L	0.601	1.00
279_L	305_I	0.600	1.00
190_M	194_L	0.600	1.00
127_K	130_A	0.599	1.00
89_N	92_A	0.597	1.00
273_A	277_A	0.596	1.00
57_L	61_V	0.594	1.00
236_T	240_V	0.593	1.00
71_L	231_L	0.593	1.00
161_P	164_V	0.592	1.00
251_L	313_L	0.591	1.00
136_M	139_A	0.591	1.00
256_M	279_L	0.590	1.00
90_H	146_S	0.589	1.00
199_S	202_R	0.589	1.00
29_P	43_H	0.587	1.00
141_T	144_A	0.585	1.00
252_V	309_W	0.585	1.00
119_G	233_V	0.583	1.00
58_A	298_V	0.583	1.00
192_L	196_L	0.581	1.00
227_W	231_L	0.580	1.00
23_M	285_L	0.580	1.00
18_L	34_L	0.578	0.99
270_P	274_L	0.577	0.99
95_A	99_A	0.577	0.99
233_V	237_S	0.577	0.99
8_F	11_L	0.576	0.99
128_M	132_T	0.575	0.99
72_I	81_A	0.574	0.99
111_L	114_L	0.573	0.99
99_A	103_M	0.571	0.99
90_H	150_A	0.571	0.99
76_V	79_P	0.569	0.99
37_W	47_L	0.568	0.99
237_S	241_A	0.568	0.99
20_S	281_V	0.568	0.99
181_S	185_I	0.566	0.99
202_R	205_D	0.566	0.99
284_D	295_E	0.563	0.99
228_A	232_A	0.562	0.99
108_V	112_P	0.560	0.99
256_M	309_W	0.559	0.99
175_L	243_C	0.558	0.99
207_L	224_T	0.557	0.99
72_I	88_V	0.556	0.99
19_L	285_L	0.556	0.99
6_V	274_L	0.553	0.99
262_G	270_P	0.551	0.99
6_V	10_T	0.549	0.99
312_W	315_V	0.549	0.99
287_A	295_E	0.544	0.99
257_M	272_S	0.544	0.99
157_M	171_L	0.543	0.99
127_K	133_H	0.541	0.99
205_D	208_A	0.541	0.99
96_S	114_L	0.540	0.99
122_G	145_L	0.539	0.99
275_T	278_L	0.538	0.99
70_V	257_M	0.537	0.99
220_S	227_W	0.537	0.99
285_L	289_I	0.536	0.99
227_W	230_L	0.532	0.99
115_A	119_G	0.531	0.99
157_M	164_V	0.529	0.99
16_C	19_L	0.529	0.99
121_A	124_I	0.527	0.99
91_A	145_L	0.526	0.99
190_M	195_P	0.525	0.99
57_L	243_C	0.525	0.99
13_L	55_L	0.523	0.99
197_S	269_L	0.522	0.99
220_S	226_F	0.522	0.99
102_L	105_S	0.521	0.99
26_I	43_H	0.521	0.99
185_I	189_L	0.520	0.99
185_I	238_T	0.520	0.99
197_S	201_C	0.519	0.99
281_V	285_L	0.518	0.99
77_R	211_D	0.517	0.99
287_A	290_I	0.516	0.99
66_A	276_G	0.515	0.99
183_V	187_I	0.515	0.99
183_V	186_A	0.514	0.99
164_V	167_A	0.513	0.99
157_M	167_A	0.510	0.99
166_N	169_L	0.510	0.99
266_R	270_P	0.510	0.99
132_T	137_K	0.510	0.99
130_A	138_L	0.510	0.99
17_A	56_L	0.510	0.99
165_N	171_L	0.508	0.99
119_G	126_L	0.506	0.99
27_P	31_R	0.505	0.99
141_T	145_L	0.504	0.99
247_S	252_V	0.503	0.99
22_H	34_L	0.501	0.99
155_Y	300_V	0.500	0.99
92_A	115_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qi9A	2	0.9748	100	0.176	Contact Map
4g1uA	2	0.9151	100	0.178	Contact Map
2nq2A	2	0.9654	100	0.181	Contact Map
3dh4A	3	0.6132	6.3	0.969	Contact Map
2l9uA	2	0.0818	4.9	0.971	Contact Map
2xq2A	2	0.6069	3.7	0.972	Contact Map
2m20A	2	0.0723	3.5	0.973	Contact Map
3tuiA	2	0.3931	2.7	0.974	Contact Map
3rlfF	1	0.3868	2.6	0.974	Contact Map
4tquM	1	0.4057	2.6	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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