GREMLIN Database
FECD - Fe(3+) dicitrate transport system permease protein FecD
UniProt: P15029 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10289
Length: 318 (312)
Sequences: 13812 (9805)
Seq/√Len: 555.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_D264_R4.3681.00
63_A273_A3.7411.00
99_A114_L3.6091.00
16_C282_V3.5761.00
71_L197_S3.4221.00
17_A55_L3.3811.00
220_S223_H3.2641.00
64_A190_M3.1201.00
71_L228_A3.0471.00
59_L277_A2.9901.00
58_A175_L2.8431.00
257_M275_T2.7901.00
32_A43_H2.7301.00
57_L178_R2.5771.00
64_A235_M2.5111.00
67_V273_A2.4991.00
32_A35_T2.4671.00
17_A59_L2.4501.00
64_A239_G2.4491.00
211_D225_R2.3771.00
94_L152_L2.3731.00
13_L278_L2.3341.00
12_A278_L2.2941.00
61_V239_G2.2511.00
67_V194_L2.2281.00
70_V272_S2.2181.00
261_T271_V2.1931.00
22_H30_W2.1771.00
59_L281_V2.0801.00
61_V243_C2.0321.00
189_L238_T2.0161.00
203_D224_T2.0091.00
13_L59_L2.0071.00
40_G43_H1.9981.00
94_L149_W1.9821.00
29_P32_A1.9701.00
60_F187_I1.9551.00
98_G102_L1.9411.00
54_R284_D1.8931.00
20_S55_L1.8811.00
72_I232_A1.8621.00
74_G265_H1.8551.00
200_F203_D1.8241.00
206_L219_V1.8201.00
205_D265_H1.8181.00
16_C278_L1.8041.00
31_R35_T1.8041.00
196_L231_L1.7851.00
97_V153_T1.7651.00
193_F235_M1.7161.00
6_V271_V1.6961.00
44_Y48_M1.6861.00
178_R182_F1.6771.00
41_H44_Y1.6711.00
200_F227_W1.6331.00
56_L183_V1.5721.00
19_L22_H1.5631.00
223_H227_W1.5631.00
249_I280_L1.5531.00
286_L290_I1.5411.00
13_L274_L1.5401.00
184_K188_P1.5341.00
179_D182_F1.5061.00
36_D48_M1.5061.00
200_F224_T1.5061.00
96_S115_A1.4981.00
70_V268_L1.4981.00
193_F234_A1.4951.00
119_G237_S1.4631.00
9_I274_L1.4281.00
287_A298_V1.4241.00
19_L23_M1.4231.00
16_C281_V1.4221.00
175_L280_L1.4061.00
286_L301_L1.3981.00
123_L233_V1.3931.00
9_I271_V1.3661.00
20_S285_L1.3571.00
193_F231_L1.3531.00
95_A114_L1.3511.00
257_M271_V1.3511.00
68_A235_M1.3511.00
9_I275_T1.3301.00
188_P192_L1.3301.00
267_R270_P1.3291.00
196_L200_F1.3061.00
93_S153_T1.2811.00
184_K187_I1.2611.00
122_G149_W1.2591.00
57_L242_A1.2581.00
257_M268_L1.2531.00
200_F228_A1.2471.00
148_C307_A1.2391.00
253_V279_L1.2351.00
60_F183_V1.2321.00
215_T222_P1.2261.00
13_L277_A1.2221.00
27_P30_W1.2221.00
89_N236_T1.2191.00
45_Y49_E1.2141.00
253_V275_T1.2131.00
95_A118_G1.2091.00
213_R216_T1.1891.00
75_I228_A1.1881.00
66_A253_V1.1861.00
42_E45_Y1.1801.00
6_V267_R1.1751.00
224_T227_W1.1721.00
223_H226_F1.1671.00
206_L217_L1.1611.00
186_A242_A1.1611.00
93_S171_L1.1561.00
243_C246_I1.1541.00
265_H268_L1.1431.00
36_D44_Y1.1391.00
39_A44_Y1.1371.00
70_V269_L1.1271.00
124_I128_M1.1221.00
97_V167_A1.1211.00
222_P225_R1.1201.00
196_L227_W1.1151.00
63_A277_A1.1111.00
9_I278_L1.1081.00
91_A122_G1.1031.00
121_A125_L1.1011.00
195_P199_S1.0961.00
58_A280_L1.0941.00
58_A281_V1.0931.00
94_L98_G1.0901.00
26_I46_V1.0901.00
36_D39_A1.0761.00
197_S231_L1.0751.00
288_R295_E1.0701.00
101_L156_L1.0641.00
63_A66_A1.0641.00
57_L183_V1.0611.00
70_V265_H1.0601.00
210_G214_A1.0581.00
91_A118_G1.0521.00
270_P273_A1.0481.00
114_L118_G1.0391.00
107_P110_V1.0381.00
146_S150_A1.0311.00
192_L195_P1.0281.00
60_F186_A1.0281.00
222_P226_F1.0271.00
56_L180_W1.0261.00
116_F234_A1.0221.00
21_L55_L1.0211.00
186_A190_M1.0171.00
126_L145_L1.0141.00
113_L117_A1.0091.00
90_H149_W1.0081.00
131_K222_P1.0081.00
18_L22_H1.0011.00
98_G156_L0.9971.00
287_A301_L0.9941.00
193_F238_T0.9931.00
17_A281_V0.9921.00
22_H33_L0.9901.00
278_L282_V0.9891.00
48_M52_L0.9881.00
161_P165_N0.9831.00
204_L228_A0.9771.00
286_L289_I0.9771.00
36_D47_L0.9771.00
23_M289_I0.9741.00
284_D288_R0.9731.00
160_R163_D0.9711.00
261_T267_R0.9691.00
246_I280_L0.9681.00
11_L15_G0.9641.00
38_Q41_H0.9581.00
89_N245_P0.9501.00
224_T228_A0.9451.00
10_T14_A0.9431.00
55_L285_L0.9411.00
253_V257_M0.9401.00
16_C285_L0.9391.00
267_R271_V0.9341.00
60_F190_M0.9261.00
264_R267_R0.9201.00
185_I188_P0.9161.00
36_D43_H0.9121.00
33_L47_L0.9101.00
291_H294_L0.9101.00
303_A308_P0.9051.00
308_P312_W0.9021.00
219_V224_T0.9021.00
94_L153_T0.9011.00
188_P191_I0.8961.00
116_F120_M0.8961.00
180_W183_V0.8961.00
268_L272_S0.8961.00
39_A43_H0.8931.00
212_A215_T0.8931.00
260_I275_T0.8881.00
44_Y49_E0.8831.00
309_W312_W0.8821.00
205_D266_R0.8801.00
63_A194_L0.8681.00
239_G243_C0.8651.00
282_V286_L0.8631.00
211_D215_T0.8621.00
128_M131_K0.8561.00
126_L130_A0.8531.00
167_A171_L0.8521.00
24_G51_R0.8481.00
18_L30_W0.8461.00
106_L110_V0.8451.00
68_A232_A0.8451.00
100_L111_L0.8411.00
10_T274_L0.8401.00
94_L156_L0.8381.00
287_A297_P0.8311.00
69_G254_P0.8291.00
14_A18_L0.8261.00
211_D221_V0.8231.00
84_D89_N0.8191.00
196_L199_S0.8141.00
88_V119_G0.8141.00
64_A68_A0.8121.00
265_H270_P0.8061.00
96_S111_L0.8051.00
226_F230_L0.8041.00
290_I293_P0.8031.00
99_A111_L0.7981.00
258_R268_L0.7961.00
201_C266_R0.7961.00
200_F231_L0.7941.00
289_I292_P0.7941.00
52_L180_W0.7881.00
22_H27_P0.7851.00
221_V225_R0.7841.00
181_S184_K0.7821.00
55_L281_V0.7791.00
257_M261_T0.7791.00
127_K226_F0.7791.00
117_A121_A0.7791.00
33_L36_D0.7741.00
127_K131_K0.7741.00
189_L193_F0.7701.00
92_A119_G0.7651.00
274_L278_L0.7601.00
127_K222_P0.7591.00
28_V47_L0.7591.00
249_I302_T0.7571.00
197_S228_A0.7571.00
165_N168_L0.7551.00
82_S85_I0.7551.00
229_L233_V0.7531.00
54_R288_R0.7521.00
162_Q166_N0.7501.00
41_H45_Y0.7501.00
214_A221_V0.7491.00
304_I308_P0.7481.00
186_A238_T0.7471.00
63_A190_M0.7471.00
72_I86_L0.7451.00
182_F242_A0.7451.00
91_A149_W0.7441.00
280_L302_T0.7431.00
120_M233_V0.7381.00
257_M260_I0.7361.00
123_L127_K0.7351.00
190_M239_G0.7341.00
66_A70_V0.7331.00
98_G103_M0.7321.00
191_I195_P0.7301.00
203_D219_V0.7281.00
88_V123_L0.7261.00
28_V43_H0.7241.00
198_L201_C0.7231.00
20_S288_R0.7221.00
199_S203_D0.7211.00
13_L17_A0.7211.00
56_L60_F0.7201.00
26_I30_W0.7201.00
125_L128_M0.7191.00
40_G44_Y0.7191.00
90_H93_S0.7191.00
14_A17_A0.7171.00
15_G18_L0.7171.00
67_V197_S0.7141.00
9_I13_L0.7141.00
57_L186_A0.7121.00
120_M237_S0.7101.00
291_H296_L0.7051.00
23_M27_P0.7021.00
97_V157_M0.7011.00
98_G152_L0.7011.00
119_G123_L0.7001.00
238_T241_A0.6991.00
65_L249_I0.6991.00
45_Y48_M0.6981.00
13_L281_V0.6981.00
54_R295_E0.6981.00
133_H137_K0.6921.00
38_Q44_Y0.6921.00
238_T242_A0.6921.00
110_V113_L0.6901.00
66_A273_A0.6881.00
21_L52_L0.6851.00
118_G122_G0.6841.00
35_T39_A0.6771.00
205_D270_P0.6751.00
256_M275_T0.6731.00
259_S313_L0.6721.00
26_I29_P0.6711.00
123_L229_L0.6691.00
246_I298_V0.6691.00
215_T221_V0.6671.00
116_F119_G0.6671.00
68_A236_T0.6641.00
187_I191_I0.6641.00
76_V139_A0.6641.00
194_L198_L0.6631.00
28_V36_D0.6621.00
186_A189_L0.6611.00
280_L298_V0.6611.00
256_M259_S0.6581.00
32_A39_A0.6571.00
33_L37_W0.6541.00
122_G126_L0.6531.00
74_G208_A0.6521.00
30_W34_L0.6521.00
21_L47_L0.6491.00
277_A281_V0.6481.00
100_L166_N0.6471.00
93_S245_P0.6471.00
207_L221_V0.6451.00
67_V269_L0.6441.00
154_D170_W0.6431.00
52_L56_L0.6371.00
109_M113_L0.6371.00
134_Q137_K0.6361.00
17_A21_L0.6361.00
279_L283_A0.6341.00
157_M168_L0.6341.00
45_Y50_Y0.6331.00
130_A141_T0.6291.00
254_P272_S0.6291.00
150_A171_L0.6271.00
312_W316_R0.6261.00
203_D206_L0.6251.00
249_I279_L0.6251.00
117_A120_M0.6241.00
15_G19_L0.6231.00
163_D166_N0.6221.00
63_A67_V0.6211.00
82_S250_G0.6211.00
101_L159_S0.6201.00
180_W184_K0.6201.00
168_L171_L0.6191.00
100_L167_A0.6191.00
189_L234_A0.6181.00
175_L298_V0.6181.00
61_V175_L0.6161.00
283_A301_L0.6151.00
252_V310_F0.6141.00
150_A154_D0.6141.00
99_A110_V0.6141.00
282_V285_L0.6131.00
8_F12_A0.6121.00
31_R34_L0.6061.00
30_W33_L0.6041.00
252_V256_M0.6041.00
193_F197_S0.6041.00
129_L141_T0.6031.00
47_L52_L0.6011.00
279_L305_I0.6001.00
190_M194_L0.6001.00
127_K130_A0.5991.00
89_N92_A0.5971.00
273_A277_A0.5961.00
57_L61_V0.5941.00
236_T240_V0.5931.00
71_L231_L0.5931.00
161_P164_V0.5921.00
251_L313_L0.5911.00
136_M139_A0.5911.00
256_M279_L0.5901.00
90_H146_S0.5891.00
199_S202_R0.5891.00
29_P43_H0.5871.00
141_T144_A0.5851.00
252_V309_W0.5851.00
119_G233_V0.5831.00
58_A298_V0.5831.00
192_L196_L0.5811.00
227_W231_L0.5801.00
23_M285_L0.5801.00
18_L34_L0.5780.99
270_P274_L0.5770.99
95_A99_A0.5770.99
233_V237_S0.5770.99
8_F11_L0.5760.99
128_M132_T0.5750.99
72_I81_A0.5740.99
111_L114_L0.5730.99
99_A103_M0.5710.99
90_H150_A0.5710.99
76_V79_P0.5690.99
37_W47_L0.5680.99
237_S241_A0.5680.99
20_S281_V0.5680.99
181_S185_I0.5660.99
202_R205_D0.5660.99
284_D295_E0.5630.99
228_A232_A0.5620.99
108_V112_P0.5600.99
256_M309_W0.5590.99
175_L243_C0.5580.99
207_L224_T0.5570.99
72_I88_V0.5560.99
19_L285_L0.5560.99
6_V274_L0.5530.99
262_G270_P0.5510.99
6_V10_T0.5490.99
312_W315_V0.5490.99
287_A295_E0.5440.99
257_M272_S0.5440.99
157_M171_L0.5430.99
127_K133_H0.5410.99
205_D208_A0.5410.99
96_S114_L0.5400.99
122_G145_L0.5390.99
275_T278_L0.5380.99
70_V257_M0.5370.99
220_S227_W0.5370.99
285_L289_I0.5360.99
227_W230_L0.5320.99
115_A119_G0.5310.99
157_M164_V0.5290.99
16_C19_L0.5290.99
121_A124_I0.5270.99
91_A145_L0.5260.99
190_M195_P0.5250.99
57_L243_C0.5250.99
13_L55_L0.5230.99
197_S269_L0.5220.99
220_S226_F0.5220.99
102_L105_S0.5210.99
26_I43_H0.5210.99
185_I189_L0.5200.99
185_I238_T0.5200.99
197_S201_C0.5190.99
281_V285_L0.5180.99
77_R211_D0.5170.99
287_A290_I0.5160.99
66_A276_G0.5150.99
183_V187_I0.5150.99
183_V186_A0.5140.99
164_V167_A0.5130.99
157_M167_A0.5100.99
166_N169_L0.5100.99
266_R270_P0.5100.99
132_T137_K0.5100.99
130_A138_L0.5100.99
17_A56_L0.5100.99
165_N171_L0.5080.99
119_G126_L0.5060.99
27_P31_R0.5050.99
141_T145_L0.5040.99
247_S252_V0.5030.99
22_H34_L0.5010.99
155_Y300_V0.5000.99
92_A115_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.9748 100 0.176 Contact Map
4g1uA 2 0.9151 100 0.178 Contact Map
2nq2A 2 0.9654 100 0.181 Contact Map
3dh4A 3 0.6132 6.3 0.969 Contact Map
2l9uA 2 0.0818 4.9 0.971 Contact Map
2xq2A 2 0.6069 3.7 0.972 Contact Map
2m20A 2 0.0723 3.5 0.973 Contact Map
3tuiA 2 0.3931 2.7 0.974 Contact Map
3rlfF 1 0.3868 2.6 0.974 Contact Map
4tquM 1 0.4057 2.6 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.