GREMLIN Database
FECB - Fe(3+) dicitrate-binding periplasmic protein
UniProt: P15028 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10287
Length: 300 (270)
Sequences: 14728 (11429)
Seq/√Len: 695.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_A154_Q3.8871.00
144_G153_M3.8141.00
228_N256_T3.7161.00
163_R285_A3.4571.00
149_K152_E3.3111.00
137_L161_K3.1641.00
145_E150_K3.0521.00
25_Q30_T2.8991.00
256_T260_K2.8531.00
42_V48_A2.8511.00
141_A157_L2.7131.00
152_E155_A2.5711.00
165_A169_S2.4881.00
200_L205_L2.4251.00
23_T30_T2.4251.00
158_E162_E2.4061.00
154_Q158_E2.3951.00
94_A97_A2.3621.00
223_Q226_A2.1971.00
41_V95_I2.1141.00
163_R281_E2.0581.00
197_G201_A2.0411.00
51_L147_V2.0161.00
40_I147_V2.0131.00
26_D31_F2.0041.00
39_R59_I1.9921.00
176_R206_N1.9881.00
161_K165_A1.9721.00
166_Q170_Q1.9441.00
56_V149_K1.9361.00
56_V147_V1.9331.00
247_Q261_Q1.9301.00
116_A119_Q1.9051.00
244_K248_Q1.8821.00
162_E166_Q1.8571.00
230_A256_T1.8201.00
114_Y118_Q1.7901.00
155_A159_Q1.7521.00
231_W264_A1.7311.00
60_G98_L1.7271.00
23_T32_T1.7251.00
50_A140_A1.7211.00
104_I143_I1.7121.00
255_L258_A1.6581.00
243_V247_Q1.6381.00
231_W262_Q1.6241.00
151_R155_A1.6161.00
165_A168_A1.5631.00
256_T259_Q1.5391.00
132_T135_E1.5311.00
82_Q94_A1.5211.00
135_E138_Q1.5061.00
264_A290_I1.5011.00
152_E156_R1.4811.00
159_Q163_R1.4771.00
90_P95_I1.4651.00
167_W288_V1.4631.00
254_M259_Q1.4621.00
115_I119_Q1.4581.00
22_A145_E1.4371.00
244_K247_Q1.4281.00
91_S94_A1.4111.00
96_A120_I1.4051.00
111_A115_I1.3981.00
138_Q142_I1.3921.00
115_I118_Q1.3881.00
175_T231_W1.3871.00
240_E244_K1.3831.00
177_V205_L1.3721.00
252_W258_A1.3691.00
59_I98_L1.3571.00
41_V98_L1.3501.00
223_Q227_V1.3401.00
169_S172_P1.3341.00
167_W284_A1.3331.00
42_V51_L1.3291.00
26_D29_G1.3251.00
221_L249_D1.3241.00
54_V149_K1.3181.00
286_D289_K1.3101.00
150_K154_Q1.3091.00
62_A65_N1.3031.00
141_A161_K1.2921.00
186_Q218_S1.2911.00
158_E161_K1.2901.00
174_G206_N1.2811.00
232_L257_A1.2741.00
93_E222_E1.2681.00
156_R159_Q1.2631.00
163_R166_Q1.2531.00
110_H113_V1.2511.00
137_L157_L1.2461.00
205_L291_F1.2441.00
41_V60_G1.2431.00
170_Q288_V1.2391.00
142_I145_E1.2271.00
164_M284_A1.2241.00
51_L56_V1.2151.00
208_P227_V1.2101.00
151_R154_Q1.2081.00
209_A227_V1.2051.00
162_E165_A1.2041.00
76_A79_K1.1791.00
33_L36_T1.1571.00
166_Q169_S1.1551.00
157_L161_K1.1541.00
38_Q101_D1.1461.00
192_Q201_A1.1431.00
138_Q141_A1.1401.00
21_A32_T1.1361.00
176_R230_A1.1321.00
52_A78_L1.1271.00
38_Q57_I1.1151.00
37_P101_D1.1141.00
92_L116_A1.1101.00
168_A202_S1.1001.00
134_A137_L1.0961.00
122_P125_L1.0891.00
124_L142_I1.0871.00
159_Q162_E1.0841.00
105_A125_L1.0821.00
285_A289_K1.0781.00
178_A181_T1.0711.00
231_W291_F1.0671.00
241_S244_K1.0641.00
124_L146_M1.0591.00
39_R99_K1.0571.00
134_A161_K1.0491.00
123_V127_K1.0461.00
178_A229_P1.0421.00
40_I102_L1.0311.00
21_A35_K1.0311.00
233_L287_T1.0311.00
53_A156_R1.0301.00
206_N210_A1.0111.00
245_R248_Q1.0031.00
160_H202_S1.0031.00
252_W255_L1.0021.00
72_P75_R0.9991.00
168_A172_P0.9971.00
241_S245_R0.9931.00
51_L58_P0.9791.00
26_D114_Y0.9781.00
140_A153_M0.9721.00
63_D83_S0.9671.00
242_I245_R0.9651.00
175_T262_Q0.9641.00
234_V265_S0.9601.00
57_I149_K0.9551.00
163_R167_W0.9531.00
113_V116_A0.9511.00
258_A263_V0.9461.00
61_I83_S0.9401.00
49_D276_G0.9381.00
28_H118_Q0.9381.00
144_G157_L0.9371.00
20_F148_G0.9351.00
71_L74_V0.9351.00
142_I146_M0.9341.00
51_L104_I0.9341.00
133_Y136_N0.9331.00
179_F200_L0.9331.00
54_V156_R0.9321.00
36_T149_K0.9271.00
58_P81_W0.9261.00
267_D286_D0.9221.00
198_S202_S0.9221.00
75_R78_L0.9181.00
143_I147_V0.9161.00
164_M168_A0.9161.00
177_V180_G0.9121.00
171_L288_V0.9111.00
166_Q285_A0.9101.00
49_D278_F0.9101.00
211_M227_V0.9091.00
198_S201_A0.9011.00
50_A143_I0.8951.00
153_M157_L0.8931.00
61_I81_W0.8931.00
250_P253_Q0.8921.00
178_A189_L0.8861.00
141_A145_E0.8761.00
102_L124_L0.8761.00
52_A58_P0.8681.00
131_E134_A0.8591.00
42_V58_P0.8561.00
122_P127_K0.8521.00
179_F235_A0.8511.00
26_D30_T0.8511.00
103_I121_A0.8491.00
278_F281_E0.8491.00
163_R288_V0.8471.00
209_A223_Q0.8441.00
177_V200_L0.8421.00
180_G183_R0.8381.00
256_T262_Q0.8351.00
133_Y137_L0.8301.00
253_Q258_A0.8271.00
21_A36_T0.8251.00
267_D270_T0.8171.00
224_L255_L0.8141.00
100_P103_I0.8141.00
28_H125_L0.8131.00
82_Q85_G0.8111.00
60_G85_G0.8081.00
40_I51_L0.8041.00
134_A138_Q0.8011.00
22_A33_L0.7981.00
37_P102_L0.7971.00
175_T205_L0.7971.00
44_E106_D0.7921.00
54_V144_G0.7901.00
33_L37_P0.7861.00
104_I146_M0.7851.00
54_V147_V0.7831.00
234_V263_V0.7781.00
178_A182_S0.7771.00
77_H80_P0.7761.00
155_A158_E0.7761.00
247_Q263_V0.7761.00
178_A224_L0.7731.00
160_H164_M0.7701.00
36_T148_G0.7681.00
154_Q157_L0.7661.00
122_P126_L0.7661.00
47_F104_I0.7641.00
43_L103_I0.7631.00
199_V284_A0.7551.00
141_A144_G0.7551.00
164_M202_S0.7491.00
139_S142_I0.7461.00
60_G84_V0.7451.00
233_L264_A0.7451.00
143_I146_M0.7431.00
286_D290_I0.7401.00
177_V181_T0.7381.00
249_D253_Q0.7371.00
53_A278_F0.7361.00
102_L146_M0.7351.00
167_W171_L0.7351.00
189_L209_A0.7321.00
103_I120_I0.7271.00
54_V152_E0.7231.00
287_T291_F0.7191.00
35_K38_Q0.7191.00
147_V150_K0.7141.00
126_L142_I0.7121.00
33_L122_P0.7091.00
203_L284_A0.7091.00
225_L255_L0.7031.00
225_L229_P0.7021.00
180_G249_D0.7001.00
140_A156_R0.6981.00
107_S127_K0.6981.00
190_H194_T0.6971.00
268_S272_A0.6961.00
112_G115_I0.6941.00
243_V265_S0.6941.00
86_T89_Q0.6921.00
207_V211_M0.6861.00
208_P211_M0.6841.00
82_Q98_L0.6831.00
190_H216_M0.6831.00
278_F282_R0.6821.00
55_D149_K0.6781.00
84_V98_L0.6781.00
281_E285_A0.6781.00
219_I227_V0.6741.00
156_R160_H0.6711.00
20_F35_K0.6681.00
180_G232_L0.6671.00
160_H280_A0.6661.00
41_V100_P0.6631.00
225_L254_M0.6631.00
18_H21_A0.6571.00
118_Q123_V0.6571.00
39_R101_D0.6561.00
193_E197_G0.6561.00
55_D152_E0.6531.00
20_F36_T0.6431.00
78_L81_W0.6411.00
72_P76_A0.6401.00
52_A77_H0.6391.00
93_E96_A0.6391.00
24_V124_L0.6381.00
240_E243_V0.6371.00
209_A219_I0.6351.00
270_T286_D0.6341.00
220_G223_Q0.6331.00
180_G185_Q0.6281.00
75_R79_K0.6281.00
141_A150_K0.6281.00
95_I117_L0.6271.00
24_V33_L0.6271.00
193_E214_A0.6261.00
285_A288_V0.6251.00
31_F124_L0.6231.00
274_M279_A0.6211.00
48_A61_I0.6201.00
233_L290_I0.6171.00
21_A34_E0.6141.00
92_L95_I0.6141.00
194_T197_G0.6131.00
192_Q210_A0.6131.00
54_V153_M0.6131.00
170_Q173_K0.6101.00
168_A203_L0.6061.00
205_L231_W0.6001.00
41_V103_I0.5981.00
235_A266_V0.5971.00
51_L143_I0.5951.00
136_N160_H0.5931.00
92_L120_I0.5871.00
134_A202_S0.5861.00
167_W170_Q0.5811.00
157_L160_H0.5791.00
229_P232_L0.5781.00
156_R277_I0.5771.00
114_Y117_L0.5761.00
47_F126_L0.5751.00
188_N218_S0.5751.00
177_V233_L0.5751.00
232_L252_W0.5731.00
237_Y268_S0.5731.00
276_G282_R0.5711.00
66_D274_M0.5701.00
160_H163_R0.5701.00
236_H265_S0.5701.00
58_P61_I0.5671.00
167_W280_A0.5671.00
43_L84_V0.5671.00
249_D252_W0.5651.00
190_H196_T0.5651.00
242_I247_Q0.5621.00
103_I117_L0.5621.00
126_L143_I0.5611.00
137_L160_H0.5591.00
279_A282_R0.5581.00
176_R208_P0.5581.00
197_G210_A0.5551.00
50_A53_A0.5551.00
111_A114_Y0.5541.00
192_Q197_G0.5541.00
182_S185_Q0.5521.00
271_W286_D0.5511.00
96_A222_E0.5481.00
33_L146_M0.5481.00
92_L113_V0.5461.00
137_L141_A0.5451.00
16_I20_F0.5431.00
231_W235_A0.5421.00
159_Q281_E0.5421.00
42_V47_F0.5421.00
27_E142_I0.5401.00
213_G217_P0.5381.00
199_V287_T0.5381.00
47_F143_I0.5371.00
53_A140_A0.5361.00
93_E220_G0.5351.00
246_W249_D0.5351.00
168_A171_L0.5341.00
73_E76_A0.5331.00
94_A98_L0.5331.00
178_A232_L0.5321.00
188_N216_M0.5321.00
197_G207_V0.5301.00
28_H111_A0.5301.00
169_S173_K0.5301.00
79_K82_Q0.5291.00
203_L288_V0.5271.00
137_L164_M0.5261.00
54_V143_I0.5261.00
203_L291_F0.5261.00
47_F50_A0.5251.00
33_L102_L0.5251.00
41_V84_V0.5241.00
131_E135_E0.5231.00
183_R186_Q0.5201.00
194_T216_M0.5201.00
52_A81_W0.5181.00
16_I19_A0.5181.00
167_W203_L0.5171.00
207_V210_A0.5160.99
140_A157_L0.5140.99
161_K164_M0.5130.99
36_T101_D0.5120.99
41_V59_I0.5120.99
284_A288_V0.5120.99
22_A35_K0.5120.99
212_A217_P0.5120.99
74_V78_L0.5100.99
221_L252_W0.5100.99
179_F196_T0.5100.99
136_N279_A0.5090.99
97_A226_A0.5090.99
275_R278_F0.5070.99
109_R113_V0.5070.99
199_V279_A0.5060.99
141_A153_M0.5060.99
17_S20_F0.5060.99
275_R282_R0.5040.99
48_A52_A0.5030.99
42_V61_I0.5030.99
63_D86_T0.5020.99
195_W272_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mlzA 1 0.9167 100 0.219 Contact Map
4n01A 1 0.9033 100 0.221 Contact Map
3lhsA 1 0.9233 100 0.224 Contact Map
4hn9A 1 0.9233 100 0.228 Contact Map
4ovkA 1 0.9167 100 0.246 Contact Map
4pagA 2 0.91 100 0.248 Contact Map
3r5tA 1 0.92 100 0.251 Contact Map
3mwfA 1 0.9 100 0.251 Contact Map
4mo9A 1 0.92 100 0.252 Contact Map
3tnyA 1 0.8967 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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