FECB - ECOLI - GREMLIN Contacts

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FECB - Fe(3+) dicitrate-binding periplasmic protein

UniProt:	P15028	Sequences: MLAFIRFLFAGLLLVISHAFAATVQDEHGTFTLEKTPQRIVVLELSFADALAAVDVIPIGIADDNDAKRILPEVRAHLKPWQSVGTRAQPSLEAIAALKPDLIIADSSRHAGVYIALQQIAPVLLLKSRNETYAENLQSAAIIGEMVGKKREMQARLEQHKERMAQWASQLPKGTRVAFGTSREQQFNLHTQETWTGSVLASLGLNVPAAMAGASMPSIGLEQLLAVNPAWLLVAHYREESIVKRWQQDPLWQMLTAAQKQQVASVDSNTWARMRGIFAAERIAADTVKIFHHQPLTVVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10287
Length:	300 (270)
Sequences:	14728 (11429)
Seq/√Len:	695.6

ECOLI - FECB FEPB FHUD BTUF
BACSU - YHFQ YFIY YFMC YXEB FEUA YVRC FHUD YCLQ BTR
HALSA - BTUFA Q9HMG8 Q9HMF9 Q9HPB0 Q9HSB2
SULSO - Q980Z0 Q97ZU2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_A	154_Q	3.887	1.00
144_G	153_M	3.814	1.00
228_N	256_T	3.716	1.00
163_R	285_A	3.457	1.00
149_K	152_E	3.311	1.00
137_L	161_K	3.164	1.00
145_E	150_K	3.052	1.00
25_Q	30_T	2.899	1.00
256_T	260_K	2.853	1.00
42_V	48_A	2.851	1.00
141_A	157_L	2.713	1.00
152_E	155_A	2.571	1.00
165_A	169_S	2.488	1.00
200_L	205_L	2.425	1.00
23_T	30_T	2.425	1.00
158_E	162_E	2.406	1.00
154_Q	158_E	2.395	1.00
94_A	97_A	2.362	1.00
223_Q	226_A	2.197	1.00
41_V	95_I	2.114	1.00
163_R	281_E	2.058	1.00
197_G	201_A	2.041	1.00
51_L	147_V	2.016	1.00
40_I	147_V	2.013	1.00
26_D	31_F	2.004	1.00
39_R	59_I	1.992	1.00
176_R	206_N	1.988	1.00
161_K	165_A	1.972	1.00
166_Q	170_Q	1.944	1.00
56_V	149_K	1.936	1.00
56_V	147_V	1.933	1.00
247_Q	261_Q	1.930	1.00
116_A	119_Q	1.905	1.00
244_K	248_Q	1.882	1.00
162_E	166_Q	1.857	1.00
230_A	256_T	1.820	1.00
114_Y	118_Q	1.790	1.00
155_A	159_Q	1.752	1.00
231_W	264_A	1.731	1.00
60_G	98_L	1.727	1.00
23_T	32_T	1.725	1.00
50_A	140_A	1.721	1.00
104_I	143_I	1.712	1.00
255_L	258_A	1.658	1.00
243_V	247_Q	1.638	1.00
231_W	262_Q	1.624	1.00
151_R	155_A	1.616	1.00
165_A	168_A	1.563	1.00
256_T	259_Q	1.539	1.00
132_T	135_E	1.531	1.00
82_Q	94_A	1.521	1.00
135_E	138_Q	1.506	1.00
264_A	290_I	1.501	1.00
152_E	156_R	1.481	1.00
159_Q	163_R	1.477	1.00
90_P	95_I	1.465	1.00
167_W	288_V	1.463	1.00
254_M	259_Q	1.462	1.00
115_I	119_Q	1.458	1.00
22_A	145_E	1.437	1.00
244_K	247_Q	1.428	1.00
91_S	94_A	1.411	1.00
96_A	120_I	1.405	1.00
111_A	115_I	1.398	1.00
138_Q	142_I	1.392	1.00
115_I	118_Q	1.388	1.00
175_T	231_W	1.387	1.00
240_E	244_K	1.383	1.00
177_V	205_L	1.372	1.00
252_W	258_A	1.369	1.00
59_I	98_L	1.357	1.00
41_V	98_L	1.350	1.00
223_Q	227_V	1.340	1.00
169_S	172_P	1.334	1.00
167_W	284_A	1.333	1.00
42_V	51_L	1.329	1.00
26_D	29_G	1.325	1.00
221_L	249_D	1.324	1.00
54_V	149_K	1.318	1.00
286_D	289_K	1.310	1.00
150_K	154_Q	1.309	1.00
62_A	65_N	1.303	1.00
141_A	161_K	1.292	1.00
186_Q	218_S	1.291	1.00
158_E	161_K	1.290	1.00
174_G	206_N	1.281	1.00
232_L	257_A	1.274	1.00
93_E	222_E	1.268	1.00
156_R	159_Q	1.263	1.00
163_R	166_Q	1.253	1.00
110_H	113_V	1.251	1.00
137_L	157_L	1.246	1.00
205_L	291_F	1.244	1.00
41_V	60_G	1.243	1.00
170_Q	288_V	1.239	1.00
142_I	145_E	1.227	1.00
164_M	284_A	1.224	1.00
51_L	56_V	1.215	1.00
208_P	227_V	1.210	1.00
151_R	154_Q	1.208	1.00
209_A	227_V	1.205	1.00
162_E	165_A	1.204	1.00
76_A	79_K	1.179	1.00
33_L	36_T	1.157	1.00
166_Q	169_S	1.155	1.00
157_L	161_K	1.154	1.00
38_Q	101_D	1.146	1.00
192_Q	201_A	1.143	1.00
138_Q	141_A	1.140	1.00
21_A	32_T	1.136	1.00
176_R	230_A	1.132	1.00
52_A	78_L	1.127	1.00
38_Q	57_I	1.115	1.00
37_P	101_D	1.114	1.00
92_L	116_A	1.110	1.00
168_A	202_S	1.100	1.00
134_A	137_L	1.096	1.00
122_P	125_L	1.089	1.00
124_L	142_I	1.087	1.00
159_Q	162_E	1.084	1.00
105_A	125_L	1.082	1.00
285_A	289_K	1.078	1.00
178_A	181_T	1.071	1.00
231_W	291_F	1.067	1.00
241_S	244_K	1.064	1.00
124_L	146_M	1.059	1.00
39_R	99_K	1.057	1.00
134_A	161_K	1.049	1.00
123_V	127_K	1.046	1.00
178_A	229_P	1.042	1.00
40_I	102_L	1.031	1.00
21_A	35_K	1.031	1.00
233_L	287_T	1.031	1.00
53_A	156_R	1.030	1.00
206_N	210_A	1.011	1.00
245_R	248_Q	1.003	1.00
160_H	202_S	1.003	1.00
252_W	255_L	1.002	1.00
72_P	75_R	0.999	1.00
168_A	172_P	0.997	1.00
241_S	245_R	0.993	1.00
51_L	58_P	0.979	1.00
26_D	114_Y	0.978	1.00
140_A	153_M	0.972	1.00
63_D	83_S	0.967	1.00
242_I	245_R	0.965	1.00
175_T	262_Q	0.964	1.00
234_V	265_S	0.960	1.00
57_I	149_K	0.955	1.00
163_R	167_W	0.953	1.00
113_V	116_A	0.951	1.00
258_A	263_V	0.946	1.00
61_I	83_S	0.940	1.00
49_D	276_G	0.938	1.00
28_H	118_Q	0.938	1.00
144_G	157_L	0.937	1.00
20_F	148_G	0.935	1.00
71_L	74_V	0.935	1.00
142_I	146_M	0.934	1.00
51_L	104_I	0.934	1.00
133_Y	136_N	0.933	1.00
179_F	200_L	0.933	1.00
54_V	156_R	0.932	1.00
36_T	149_K	0.927	1.00
58_P	81_W	0.926	1.00
267_D	286_D	0.922	1.00
198_S	202_S	0.922	1.00
75_R	78_L	0.918	1.00
143_I	147_V	0.916	1.00
164_M	168_A	0.916	1.00
177_V	180_G	0.912	1.00
171_L	288_V	0.911	1.00
166_Q	285_A	0.910	1.00
49_D	278_F	0.910	1.00
211_M	227_V	0.909	1.00
198_S	201_A	0.901	1.00
50_A	143_I	0.895	1.00
153_M	157_L	0.893	1.00
61_I	81_W	0.893	1.00
250_P	253_Q	0.892	1.00
178_A	189_L	0.886	1.00
141_A	145_E	0.876	1.00
102_L	124_L	0.876	1.00
52_A	58_P	0.868	1.00
131_E	134_A	0.859	1.00
42_V	58_P	0.856	1.00
122_P	127_K	0.852	1.00
179_F	235_A	0.851	1.00
26_D	30_T	0.851	1.00
103_I	121_A	0.849	1.00
278_F	281_E	0.849	1.00
163_R	288_V	0.847	1.00
209_A	223_Q	0.844	1.00
177_V	200_L	0.842	1.00
180_G	183_R	0.838	1.00
256_T	262_Q	0.835	1.00
133_Y	137_L	0.830	1.00
253_Q	258_A	0.827	1.00
21_A	36_T	0.825	1.00
267_D	270_T	0.817	1.00
224_L	255_L	0.814	1.00
100_P	103_I	0.814	1.00
28_H	125_L	0.813	1.00
82_Q	85_G	0.811	1.00
60_G	85_G	0.808	1.00
40_I	51_L	0.804	1.00
134_A	138_Q	0.801	1.00
22_A	33_L	0.798	1.00
37_P	102_L	0.797	1.00
175_T	205_L	0.797	1.00
44_E	106_D	0.792	1.00
54_V	144_G	0.790	1.00
33_L	37_P	0.786	1.00
104_I	146_M	0.785	1.00
54_V	147_V	0.783	1.00
234_V	263_V	0.778	1.00
178_A	182_S	0.777	1.00
77_H	80_P	0.776	1.00
155_A	158_E	0.776	1.00
247_Q	263_V	0.776	1.00
178_A	224_L	0.773	1.00
160_H	164_M	0.770	1.00
36_T	148_G	0.768	1.00
154_Q	157_L	0.766	1.00
122_P	126_L	0.766	1.00
47_F	104_I	0.764	1.00
43_L	103_I	0.763	1.00
199_V	284_A	0.755	1.00
141_A	144_G	0.755	1.00
164_M	202_S	0.749	1.00
139_S	142_I	0.746	1.00
60_G	84_V	0.745	1.00
233_L	264_A	0.745	1.00
143_I	146_M	0.743	1.00
286_D	290_I	0.740	1.00
177_V	181_T	0.738	1.00
249_D	253_Q	0.737	1.00
53_A	278_F	0.736	1.00
102_L	146_M	0.735	1.00
167_W	171_L	0.735	1.00
189_L	209_A	0.732	1.00
103_I	120_I	0.727	1.00
54_V	152_E	0.723	1.00
287_T	291_F	0.719	1.00
35_K	38_Q	0.719	1.00
147_V	150_K	0.714	1.00
126_L	142_I	0.712	1.00
33_L	122_P	0.709	1.00
203_L	284_A	0.709	1.00
225_L	255_L	0.703	1.00
225_L	229_P	0.702	1.00
180_G	249_D	0.700	1.00
140_A	156_R	0.698	1.00
107_S	127_K	0.698	1.00
190_H	194_T	0.697	1.00
268_S	272_A	0.696	1.00
112_G	115_I	0.694	1.00
243_V	265_S	0.694	1.00
86_T	89_Q	0.692	1.00
207_V	211_M	0.686	1.00
208_P	211_M	0.684	1.00
82_Q	98_L	0.683	1.00
190_H	216_M	0.683	1.00
278_F	282_R	0.682	1.00
55_D	149_K	0.678	1.00
84_V	98_L	0.678	1.00
281_E	285_A	0.678	1.00
219_I	227_V	0.674	1.00
156_R	160_H	0.671	1.00
20_F	35_K	0.668	1.00
180_G	232_L	0.667	1.00
160_H	280_A	0.666	1.00
41_V	100_P	0.663	1.00
225_L	254_M	0.663	1.00
18_H	21_A	0.657	1.00
118_Q	123_V	0.657	1.00
39_R	101_D	0.656	1.00
193_E	197_G	0.656	1.00
55_D	152_E	0.653	1.00
20_F	36_T	0.643	1.00
78_L	81_W	0.641	1.00
72_P	76_A	0.640	1.00
52_A	77_H	0.639	1.00
93_E	96_A	0.639	1.00
24_V	124_L	0.638	1.00
240_E	243_V	0.637	1.00
209_A	219_I	0.635	1.00
270_T	286_D	0.634	1.00
220_G	223_Q	0.633	1.00
180_G	185_Q	0.628	1.00
75_R	79_K	0.628	1.00
141_A	150_K	0.628	1.00
95_I	117_L	0.627	1.00
24_V	33_L	0.627	1.00
193_E	214_A	0.626	1.00
285_A	288_V	0.625	1.00
31_F	124_L	0.623	1.00
274_M	279_A	0.621	1.00
48_A	61_I	0.620	1.00
233_L	290_I	0.617	1.00
21_A	34_E	0.614	1.00
92_L	95_I	0.614	1.00
194_T	197_G	0.613	1.00
192_Q	210_A	0.613	1.00
54_V	153_M	0.613	1.00
170_Q	173_K	0.610	1.00
168_A	203_L	0.606	1.00
205_L	231_W	0.600	1.00
41_V	103_I	0.598	1.00
235_A	266_V	0.597	1.00
51_L	143_I	0.595	1.00
136_N	160_H	0.593	1.00
92_L	120_I	0.587	1.00
134_A	202_S	0.586	1.00
167_W	170_Q	0.581	1.00
157_L	160_H	0.579	1.00
229_P	232_L	0.578	1.00
156_R	277_I	0.577	1.00
114_Y	117_L	0.576	1.00
47_F	126_L	0.575	1.00
188_N	218_S	0.575	1.00
177_V	233_L	0.575	1.00
232_L	252_W	0.573	1.00
237_Y	268_S	0.573	1.00
276_G	282_R	0.571	1.00
66_D	274_M	0.570	1.00
160_H	163_R	0.570	1.00
236_H	265_S	0.570	1.00
58_P	61_I	0.567	1.00
167_W	280_A	0.567	1.00
43_L	84_V	0.567	1.00
249_D	252_W	0.565	1.00
190_H	196_T	0.565	1.00
242_I	247_Q	0.562	1.00
103_I	117_L	0.562	1.00
126_L	143_I	0.561	1.00
137_L	160_H	0.559	1.00
279_A	282_R	0.558	1.00
176_R	208_P	0.558	1.00
197_G	210_A	0.555	1.00
50_A	53_A	0.555	1.00
111_A	114_Y	0.554	1.00
192_Q	197_G	0.554	1.00
182_S	185_Q	0.552	1.00
271_W	286_D	0.551	1.00
96_A	222_E	0.548	1.00
33_L	146_M	0.548	1.00
92_L	113_V	0.546	1.00
137_L	141_A	0.545	1.00
16_I	20_F	0.543	1.00
231_W	235_A	0.542	1.00
159_Q	281_E	0.542	1.00
42_V	47_F	0.542	1.00
27_E	142_I	0.540	1.00
213_G	217_P	0.538	1.00
199_V	287_T	0.538	1.00
47_F	143_I	0.537	1.00
53_A	140_A	0.536	1.00
93_E	220_G	0.535	1.00
246_W	249_D	0.535	1.00
168_A	171_L	0.534	1.00
73_E	76_A	0.533	1.00
94_A	98_L	0.533	1.00
178_A	232_L	0.532	1.00
188_N	216_M	0.532	1.00
197_G	207_V	0.530	1.00
28_H	111_A	0.530	1.00
169_S	173_K	0.530	1.00
79_K	82_Q	0.529	1.00
203_L	288_V	0.527	1.00
137_L	164_M	0.526	1.00
54_V	143_I	0.526	1.00
203_L	291_F	0.526	1.00
47_F	50_A	0.525	1.00
33_L	102_L	0.525	1.00
41_V	84_V	0.524	1.00
131_E	135_E	0.523	1.00
183_R	186_Q	0.520	1.00
194_T	216_M	0.520	1.00
52_A	81_W	0.518	1.00
16_I	19_A	0.518	1.00
167_W	203_L	0.517	1.00
207_V	210_A	0.516	0.99
140_A	157_L	0.514	0.99
161_K	164_M	0.513	0.99
36_T	101_D	0.512	0.99
41_V	59_I	0.512	0.99
284_A	288_V	0.512	0.99
22_A	35_K	0.512	0.99
212_A	217_P	0.512	0.99
74_V	78_L	0.510	0.99
221_L	252_W	0.510	0.99
179_F	196_T	0.510	0.99
136_N	279_A	0.509	0.99
97_A	226_A	0.509	0.99
275_R	278_F	0.507	0.99
109_R	113_V	0.507	0.99
199_V	279_A	0.506	0.99
141_A	153_M	0.506	0.99
17_S	20_F	0.506	0.99
275_R	282_R	0.504	0.99
48_A	52_A	0.503	0.99
42_V	61_I	0.503	0.99
63_D	86_T	0.502	0.99
195_W	272_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mlzA	1	0.9167	100	0.219	Contact Map
4n01A	1	0.9033	100	0.221	Contact Map
3lhsA	1	0.9233	100	0.224	Contact Map
4hn9A	1	0.9233	100	0.228	Contact Map
4ovkA	1	0.9167	100	0.246	Contact Map
4pagA	2	0.91	100	0.248	Contact Map
3r5tA	1	0.92	100	0.251	Contact Map
3mwfA	1	0.9	100	0.251	Contact Map
4mo9A	1	0.92	100	0.252	Contact Map
3tnyA	1	0.8967	100	0.255	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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