GREMLIN Database
MCRC - Protein McrC
UniProt: P15006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10575
Length: 348 (306)
Sequences: 1046 (861)
Seq/√Len: 49.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_Y278_N6.2981.00
72_I76_I6.2201.00
205_L258_A6.1601.00
102_D141_S4.5941.00
69_I94_S4.5141.00
66_T95_T4.3401.00
286_L299_G3.9131.00
221_S227_A3.8521.00
112_T169_C3.7901.00
68_I85_F3.4721.00
109_I165_V3.0401.00
114_A142_T3.0361.00
77_E80_K2.7121.00
165_V169_C2.5671.00
68_I93_V2.5461.00
81_T93_V2.5451.00
206_Y258_A2.4871.00
190_F260_Y2.4631.00
76_I92_T2.4301.00
281_Q285_Y2.4141.00
276_S280_Y2.4071.00
256_V302_I2.3531.00
51_L129_E2.3321.00
256_V300_L2.2721.00
245_I258_A2.2511.00
46_L169_C2.2351.00
155_G166_I2.1571.00
66_T77_E2.1541.00
59_E103_T2.0881.00
72_I92_T2.0741.00
113_L130_A2.0701.00
109_I169_C2.0691.00
298_G322_G2.0581.00
102_D107_R2.0461.00
8_V260_Y1.9800.99
81_T85_F1.9610.99
197_M260_Y1.9080.99
53_L162_Y1.7960.99
258_A302_I1.7680.99
77_E95_T1.7640.99
67_E96_F1.7400.99
77_E93_V1.7340.99
49_G165_V1.7310.99
204_F208_F1.7060.98
63_N100_N1.7030.98
69_I96_F1.6730.98
53_L165_V1.6640.98
85_F93_V1.6100.98
221_S226_D1.6050.98
114_A134_Y1.5820.97
81_T87_L1.5800.97
143_L149_H1.5720.97
156_G159_T1.5700.97
40_D126_I1.5610.97
134_Y137_L1.5290.97
47_N113_L1.5210.97
113_L133_L1.5170.97
68_I81_T1.4930.96
254_L298_G1.4860.96
241_M280_Y1.4790.96
254_L300_L1.4680.96
110_K114_A1.4650.96
57_G162_Y1.4480.96
46_L50_V1.4370.95
105_A162_Y1.4250.95
283_M287_W1.4210.95
252_K298_G1.4210.95
116_L130_A1.4030.95
206_Y245_I1.4020.95
111_S145_L1.3940.95
106_N201_Y1.3920.95
59_E106_N1.3850.94
223_L227_A1.3770.94
81_T92_T1.3560.94
117_I131_R1.3490.94
222_Y227_A1.3450.93
298_G320_D1.3390.93
300_L324_C1.3370.93
313_R320_D1.3250.93
160_R163_K1.3240.93
61_D103_T1.3160.93
47_N130_A1.3100.93
59_E162_Y1.3050.92
80_K93_V1.3040.92
126_I129_E1.2890.92
17_Y204_F1.2790.92
286_L319_F1.2780.92
79_A83_R1.2720.91
109_I162_Y1.2710.91
111_S173_V1.2580.91
145_L173_V1.2490.91
222_Y228_S1.2480.91
277_Q280_Y1.2250.90
255_I289_L1.2140.89
53_L161_Y1.2110.89
115_I173_V1.2060.89
195_K243_T1.1980.89
113_L116_L1.1900.88
241_M288_S1.1740.88
37_N40_D1.1720.88
261_Y281_Q1.1680.87
112_T291_P1.1590.87
201_Y286_L1.1530.87
239_P288_S1.1500.87
111_S142_T1.1270.85
105_A153_L1.1180.85
259_K281_Q1.1070.84
110_K134_Y1.0890.83
208_F326_V1.0850.83
53_L59_E1.0830.83
163_K167_S1.0820.83
244_D259_K1.0820.83
155_G159_T1.0800.83
17_Y208_F1.0760.83
219_T222_Y1.0760.83
14_M204_F1.0720.82
122_L299_G1.0630.82
10_N13_Y1.0530.81
94_S197_M1.0520.81
69_I157_K1.0480.81
8_V204_F1.0450.81
202_Q259_K1.0450.81
239_P276_S1.0410.81
14_M57_G1.0410.81
112_T165_V1.0370.80
287_W319_F1.0350.80
206_Y220_R1.0310.80
244_D281_Q1.0240.79
257_D278_N1.0160.79
67_E110_K1.0130.79
112_T172_I1.0110.79
191_E195_K1.0080.78
190_F275_H0.9970.78
54_S133_L0.9930.77
222_Y226_D0.9910.77
222_Y246_T0.9840.77
274_F279_L0.9810.76
213_L247_I0.9790.76
154_N182_K0.9710.76
120_E126_I0.9670.75
239_P278_N0.9640.75
243_T289_L0.9630.75
257_D261_Y0.9620.75
67_E93_V0.9600.75
278_N303_Y0.9590.75
202_Q281_Q0.9580.75
280_Y301_L0.9520.74
202_Q261_Y0.9470.74
162_Y166_I0.9440.74
162_Y283_M0.9400.73
275_H278_N0.9360.73
140_I201_Y0.9350.73
170_K174_N0.9350.73
13_Y17_Y0.9340.73
259_K285_Y0.9340.73
53_L90_G0.9310.73
68_I88_N0.9220.72
113_L134_Y0.9210.72
115_I175_N0.9150.71
248_R252_K0.9130.71
267_R270_G0.9120.71
116_L172_I0.9070.71
65_N98_M0.9060.70
284_N303_Y0.9050.70
110_K142_T0.9030.70
66_T80_K0.8980.70
239_P280_Y0.8970.70
108_I150_F0.8910.69
209_C255_I0.8910.69
260_Y289_L0.8910.69
320_D323_L0.8910.69
88_N91_K0.8880.69
18_A21_Y0.8880.69
196_E278_N0.8850.69
119_H247_I0.8840.69
209_C328_L0.8830.68
53_L188_Y0.8790.68
245_I256_V0.8730.68
49_G164_F0.8720.68
107_R187_F0.8690.67
241_M285_Y0.8690.67
233_Q272_E0.8690.67
248_R251_E0.8680.67
81_T260_Y0.8670.67
195_K260_Y0.8660.67
18_A63_N0.8620.67
321_I326_V0.8610.67
195_K278_N0.8590.66
239_P261_Y0.8590.66
239_P273_K0.8540.66
50_V113_L0.8540.66
134_Y138_P0.8530.66
189_D261_Y0.8530.66
46_L113_L0.8510.66
280_Y284_N0.8470.65
244_D285_Y0.8460.65
278_N281_Q0.8420.65
42_L85_F0.8380.64
304_P326_V0.8370.64
244_D257_D0.8340.64
305_H327_N0.8340.64
17_Y207_E0.8320.64
172_I189_D0.8260.63
109_I146_T0.8260.63
45_V168_V0.8200.63
205_L323_L0.8160.62
249_S252_K0.8150.62
127_R130_A0.8100.62
85_F91_K0.8100.62
60_L101_E0.8080.62
249_S320_D0.8070.61
46_L247_I0.8060.61
116_L186_R0.8060.61
162_Y168_V0.8060.61
14_M137_L0.8060.61
155_G169_C0.8050.61
216_A219_T0.8050.61
280_Y303_Y0.8000.61
189_D243_T0.8000.61
243_T261_Y0.7980.61
204_F260_Y0.7960.60
110_K137_L0.7930.60
129_E290_K0.7900.60
221_S246_T0.7890.60
43_G286_L0.7870.60
257_D285_Y0.7870.60
196_E209_C0.7860.59
248_R253_I0.7830.59
138_P201_Y0.7810.59
191_E260_Y0.7790.59
42_L283_M0.7790.59
202_Q244_D0.7700.58
62_Y301_L0.7650.57
177_I260_Y0.7620.57
15_L190_F0.7580.57
13_Y204_F0.7570.57
74_G244_D0.7560.56
77_E81_T0.7540.56
311_K325_T0.7530.56
269_M274_F0.7430.55
103_T159_T0.7420.55
191_E261_Y0.7380.55
57_G204_F0.7360.54
108_I159_T0.7350.54
15_L62_Y0.7320.54
196_E261_Y0.7300.54
43_G120_E0.7300.54
279_L323_L0.7280.54
256_V288_S0.7260.53
12_Y200_L0.7250.53
256_V324_C0.7230.53
151_S170_K0.7230.53
95_T219_T0.7210.53
50_V169_C0.7210.53
50_V254_L0.7180.53
284_N289_L0.7150.52
228_S243_T0.7140.52
112_T115_I0.7140.52
75_R95_T0.7130.52
283_M288_S0.7120.52
12_Y41_I0.7100.52
218_T222_Y0.7060.51
97_D157_K0.7040.51
204_F302_I0.7040.51
277_Q310_V0.7040.51
223_L228_S0.7030.51
92_T260_Y0.7010.51
69_I98_M0.6990.51
32_A150_F0.6980.51
34_P179_G0.6980.51
280_Y324_C0.6980.51
72_I157_K0.6980.51
104_L143_L0.6940.50
64_P80_K0.6930.50
252_K277_Q0.6900.50
83_R217_N0.6890.50
257_D281_Q0.6890.50
42_L314_Y0.6830.49
145_L148_Q0.6820.49
54_S117_I0.6810.49
57_G97_D0.6810.49
195_K261_Y0.6790.49
202_Q257_D0.6790.49
105_A159_T0.6760.48
225_W228_S0.6750.48
101_E109_I0.6670.47
107_R141_S0.6660.47
221_S228_S0.6620.47
10_N17_Y0.6600.47
40_D128_D0.6600.47
44_Y48_K0.6590.47
92_T109_I0.6580.47
12_Y177_I0.6560.46
208_F212_E0.6560.46
191_E278_N0.6550.46
160_R255_I0.6530.46
33_I302_I0.6530.46
102_D131_R0.6520.46
202_Q285_Y0.6500.46
243_T278_N0.6460.45
197_M285_Y0.6460.45
217_N255_I0.6460.45
276_S283_M0.6450.45
253_I256_V0.6450.45
10_N260_Y0.6450.45
14_M157_K0.6440.45
11_I23_Q0.6430.45
8_V17_Y0.6410.45
75_R87_L0.6380.45
99_L108_I0.6360.44
210_R247_I0.6330.44
162_Y204_F0.6320.44
209_C243_T0.6310.44
162_Y165_V0.6310.44
104_L108_I0.6310.44
15_L39_L0.6290.44
63_N144_H0.6280.44
284_N287_W0.6270.43
34_P248_R0.6260.43
45_V155_G0.6250.43
75_R110_K0.6250.43
18_A203_K0.6230.43
81_T195_K0.6220.43
222_Y242_E0.6190.43
94_S157_K0.6190.43
50_V200_L0.6180.43
53_L166_I0.6180.43
148_Q152_Y0.6160.42
64_P251_E0.6130.42
75_R82_I0.6120.42
62_Y99_L0.6100.42
75_R328_L0.6090.42
173_V246_T0.6040.41
102_D140_I0.5990.41
255_I291_P0.5970.40
164_F235_L0.5960.40
67_E201_Y0.5950.40
274_F316_I0.5950.40
182_K251_E0.5940.40
155_G170_K0.5910.40
199_L242_E0.5910.40
127_R131_R0.5910.40
228_S289_L0.5900.40
40_D71_G0.5890.40
73_K91_K0.5890.40
64_P95_T0.5890.40
212_E218_T0.5880.40
282_L321_I0.5850.39
221_S225_W0.5850.39
11_I164_F0.5840.39
97_D284_N0.5830.39
91_K118_K0.5820.39
74_G259_K0.5810.39
42_L102_D0.5790.39
204_F261_Y0.5780.39
50_V109_I0.5770.38
9_R277_Q0.5760.38
200_L203_K0.5750.38
108_I198_S0.5750.38
46_L108_I0.5740.38
99_L169_C0.5700.38
106_N140_I0.5690.38
196_E243_T0.5680.38
81_T278_N0.5680.38
65_N182_K0.5670.38
199_L203_K0.5660.37
189_D279_L0.5660.37
82_I206_Y0.5650.37
80_K182_K0.5640.37
115_I172_I0.5630.37
118_K157_K0.5630.37
46_L106_N0.5630.37
61_D168_V0.5630.37
68_I84_G0.5630.37
241_M261_Y0.5620.37
103_T107_R0.5620.37
14_M17_Y0.5620.37
198_S299_G0.5620.37
176_S300_L0.5610.37
251_E331_E0.5610.37
108_I162_Y0.5600.37
106_N158_N0.5590.37
20_G282_L0.5590.37
209_C278_N0.5590.37
81_T261_Y0.5590.37
67_E139_G0.5580.37
153_L156_G0.5580.37
106_N110_K0.5570.37
227_A288_S0.5560.36
93_V103_T0.5550.36
8_V46_L0.5550.36
57_G195_K0.5530.36
118_K245_I0.5520.36
115_I119_H0.5510.36
155_G163_K0.5490.36
184_H267_R0.5450.35
46_L171_F0.5450.35
223_L243_T0.5450.35
239_P274_F0.5450.35
59_E161_Y0.5450.35
44_Y129_E0.5450.35
241_M303_Y0.5430.35
227_A233_Q0.5430.35
56_R70_P0.5430.35
47_N53_L0.5420.35
10_N328_L0.5410.35
46_L99_L0.5410.35
112_T116_L0.5400.35
64_P315_K0.5380.35
322_G325_T0.5360.35
250_S320_D0.5360.35
22_L94_S0.5360.35
308_T317_N0.5360.35
211_R218_T0.5340.34
80_K84_G0.5340.34
241_M279_L0.5330.34
11_I62_Y0.5330.34
152_Y184_H0.5320.34
145_L149_H0.5310.34
99_L274_F0.5310.34
33_I39_L0.5310.34
59_E137_L0.5300.34
17_Y211_R0.5290.34
59_E87_L0.5290.34
274_F277_Q0.5290.34
315_K320_D0.5280.34
198_S239_P0.5280.34
170_K199_L0.5260.34
177_I241_M0.5240.34
18_A36_N0.5240.34
146_T149_H0.5230.33
144_H234_S0.5230.33
173_V261_Y0.5230.33
78_F128_D0.5220.33
35_G171_F0.5200.33
120_E147_P0.5200.33
106_N137_L0.5190.33
27_Q190_F0.5190.33
114_A224_K0.5170.33
103_T106_N0.5170.33
31_E275_H0.5160.33
239_P299_G0.5150.33
227_A235_L0.5150.33
97_D280_Y0.5140.33
42_L83_R0.5110.32
125_T250_S0.5110.32
203_K206_Y0.5100.32
111_S211_R0.5100.32
43_G85_F0.5090.32
167_S170_K0.5090.32
50_V133_L0.5090.32
128_D154_N0.5070.32
82_I204_F0.5060.32
12_Y19_W0.5060.32
36_N78_F0.5060.32
319_F325_T0.5050.32
41_I239_P0.5050.32
46_L62_Y0.5000.31
99_L283_M0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ic1A 5 0.5172 84.4 0.938 Contact Map
1xmxA 2 0.8506 56 0.95 Contact Map
4r5qA 1 0.5546 54.7 0.95 Contact Map
3s1sA 1 0.4052 46.2 0.953 Contact Map
1y88A 5 0.3563 43.4 0.953 Contact Map
1hh1A 2 0.3391 34.7 0.956 Contact Map
2p14A 1 0.4454 30.1 0.957 Contact Map
2eo0A 2 0.3592 29.2 0.958 Contact Map
2vldA 2 0.5948 19.2 0.961 Contact Map
1ob8A 1 0.3362 15.6 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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