MCRC - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MCRC - Protein McrC

UniProt:	P15006	Sequences: MEQPVIPVRNIYYMLTYAWGYLQEIKQANLEAIPGNNLLDILGYVLNKGVLQLSRRGLELDYNPNTEIIPGIKGRIEFAKTIRGFHLNHGKTVSTFDMLNEDTLANRIIKSTLAILIKHEKLNSTIRDEARSLYRKLPGISTLHLTPQHFSYLNGGKNTRYYKFVISVCKFIVNNSIPGQNKGHYRFYDFERNEKEMSLLYQKFLYEFCRRELTSANTTRSYLKWDASSISDQSLNLLPRMETDITIRSSEKILIVDAKYYKSIFSRRMGTEKFHSQNLYQLMNYLWSLKPENGENIGGLLIYPHVDTAVKHRYKINGFDIGLCTVNLGQEWPCIHQELLDIFDEYLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10575
Length:	348 (306)
Sequences:	1046 (861)
Seq/√Len:	49.2

ECOLI - MCRC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_Y	278_N	6.298	1.00
72_I	76_I	6.220	1.00
205_L	258_A	6.160	1.00
102_D	141_S	4.594	1.00
69_I	94_S	4.514	1.00
66_T	95_T	4.340	1.00
286_L	299_G	3.913	1.00
221_S	227_A	3.852	1.00
112_T	169_C	3.790	1.00
68_I	85_F	3.472	1.00
109_I	165_V	3.040	1.00
114_A	142_T	3.036	1.00
77_E	80_K	2.712	1.00
165_V	169_C	2.567	1.00
68_I	93_V	2.546	1.00
81_T	93_V	2.545	1.00
206_Y	258_A	2.487	1.00
190_F	260_Y	2.463	1.00
76_I	92_T	2.430	1.00
281_Q	285_Y	2.414	1.00
276_S	280_Y	2.407	1.00
256_V	302_I	2.353	1.00
51_L	129_E	2.332	1.00
256_V	300_L	2.272	1.00
245_I	258_A	2.251	1.00
46_L	169_C	2.235	1.00
155_G	166_I	2.157	1.00
66_T	77_E	2.154	1.00
59_E	103_T	2.088	1.00
72_I	92_T	2.074	1.00
113_L	130_A	2.070	1.00
109_I	169_C	2.069	1.00
298_G	322_G	2.058	1.00
102_D	107_R	2.046	1.00
8_V	260_Y	1.980	0.99
81_T	85_F	1.961	0.99
197_M	260_Y	1.908	0.99
53_L	162_Y	1.796	0.99
258_A	302_I	1.768	0.99
77_E	95_T	1.764	0.99
67_E	96_F	1.740	0.99
77_E	93_V	1.734	0.99
49_G	165_V	1.731	0.99
204_F	208_F	1.706	0.98
63_N	100_N	1.703	0.98
69_I	96_F	1.673	0.98
53_L	165_V	1.664	0.98
85_F	93_V	1.610	0.98
221_S	226_D	1.605	0.98
114_A	134_Y	1.582	0.97
81_T	87_L	1.580	0.97
143_L	149_H	1.572	0.97
156_G	159_T	1.570	0.97
40_D	126_I	1.561	0.97
134_Y	137_L	1.529	0.97
47_N	113_L	1.521	0.97
113_L	133_L	1.517	0.97
68_I	81_T	1.493	0.96
254_L	298_G	1.486	0.96
241_M	280_Y	1.479	0.96
254_L	300_L	1.468	0.96
110_K	114_A	1.465	0.96
57_G	162_Y	1.448	0.96
46_L	50_V	1.437	0.95
105_A	162_Y	1.425	0.95
283_M	287_W	1.421	0.95
252_K	298_G	1.421	0.95
116_L	130_A	1.403	0.95
206_Y	245_I	1.402	0.95
111_S	145_L	1.394	0.95
106_N	201_Y	1.392	0.95
59_E	106_N	1.385	0.94
223_L	227_A	1.377	0.94
81_T	92_T	1.356	0.94
117_I	131_R	1.349	0.94
222_Y	227_A	1.345	0.93
298_G	320_D	1.339	0.93
300_L	324_C	1.337	0.93
313_R	320_D	1.325	0.93
160_R	163_K	1.324	0.93
61_D	103_T	1.316	0.93
47_N	130_A	1.310	0.93
59_E	162_Y	1.305	0.92
80_K	93_V	1.304	0.92
126_I	129_E	1.289	0.92
17_Y	204_F	1.279	0.92
286_L	319_F	1.278	0.92
79_A	83_R	1.272	0.91
109_I	162_Y	1.271	0.91
111_S	173_V	1.258	0.91
145_L	173_V	1.249	0.91
222_Y	228_S	1.248	0.91
277_Q	280_Y	1.225	0.90
255_I	289_L	1.214	0.89
53_L	161_Y	1.211	0.89
115_I	173_V	1.206	0.89
195_K	243_T	1.198	0.89
113_L	116_L	1.190	0.88
241_M	288_S	1.174	0.88
37_N	40_D	1.172	0.88
261_Y	281_Q	1.168	0.87
112_T	291_P	1.159	0.87
201_Y	286_L	1.153	0.87
239_P	288_S	1.150	0.87
111_S	142_T	1.127	0.85
105_A	153_L	1.118	0.85
259_K	281_Q	1.107	0.84
110_K	134_Y	1.089	0.83
208_F	326_V	1.085	0.83
53_L	59_E	1.083	0.83
163_K	167_S	1.082	0.83
244_D	259_K	1.082	0.83
155_G	159_T	1.080	0.83
17_Y	208_F	1.076	0.83
219_T	222_Y	1.076	0.83
14_M	204_F	1.072	0.82
122_L	299_G	1.063	0.82
10_N	13_Y	1.053	0.81
94_S	197_M	1.052	0.81
69_I	157_K	1.048	0.81
8_V	204_F	1.045	0.81
202_Q	259_K	1.045	0.81
239_P	276_S	1.041	0.81
14_M	57_G	1.041	0.81
112_T	165_V	1.037	0.80
287_W	319_F	1.035	0.80
206_Y	220_R	1.031	0.80
244_D	281_Q	1.024	0.79
257_D	278_N	1.016	0.79
67_E	110_K	1.013	0.79
112_T	172_I	1.011	0.79
191_E	195_K	1.008	0.78
190_F	275_H	0.997	0.78
54_S	133_L	0.993	0.77
222_Y	226_D	0.991	0.77
222_Y	246_T	0.984	0.77
274_F	279_L	0.981	0.76
213_L	247_I	0.979	0.76
154_N	182_K	0.971	0.76
120_E	126_I	0.967	0.75
239_P	278_N	0.964	0.75
243_T	289_L	0.963	0.75
257_D	261_Y	0.962	0.75
67_E	93_V	0.960	0.75
278_N	303_Y	0.959	0.75
202_Q	281_Q	0.958	0.75
280_Y	301_L	0.952	0.74
202_Q	261_Y	0.947	0.74
162_Y	166_I	0.944	0.74
162_Y	283_M	0.940	0.73
275_H	278_N	0.936	0.73
140_I	201_Y	0.935	0.73
170_K	174_N	0.935	0.73
13_Y	17_Y	0.934	0.73
259_K	285_Y	0.934	0.73
53_L	90_G	0.931	0.73
68_I	88_N	0.922	0.72
113_L	134_Y	0.921	0.72
115_I	175_N	0.915	0.71
248_R	252_K	0.913	0.71
267_R	270_G	0.912	0.71
116_L	172_I	0.907	0.71
65_N	98_M	0.906	0.70
284_N	303_Y	0.905	0.70
110_K	142_T	0.903	0.70
66_T	80_K	0.898	0.70
239_P	280_Y	0.897	0.70
108_I	150_F	0.891	0.69
209_C	255_I	0.891	0.69
260_Y	289_L	0.891	0.69
320_D	323_L	0.891	0.69
88_N	91_K	0.888	0.69
18_A	21_Y	0.888	0.69
196_E	278_N	0.885	0.69
119_H	247_I	0.884	0.69
209_C	328_L	0.883	0.68
53_L	188_Y	0.879	0.68
245_I	256_V	0.873	0.68
49_G	164_F	0.872	0.68
107_R	187_F	0.869	0.67
241_M	285_Y	0.869	0.67
233_Q	272_E	0.869	0.67
248_R	251_E	0.868	0.67
81_T	260_Y	0.867	0.67
195_K	260_Y	0.866	0.67
18_A	63_N	0.862	0.67
321_I	326_V	0.861	0.67
195_K	278_N	0.859	0.66
239_P	261_Y	0.859	0.66
239_P	273_K	0.854	0.66
50_V	113_L	0.854	0.66
134_Y	138_P	0.853	0.66
189_D	261_Y	0.853	0.66
46_L	113_L	0.851	0.66
280_Y	284_N	0.847	0.65
244_D	285_Y	0.846	0.65
278_N	281_Q	0.842	0.65
42_L	85_F	0.838	0.64
304_P	326_V	0.837	0.64
244_D	257_D	0.834	0.64
305_H	327_N	0.834	0.64
17_Y	207_E	0.832	0.64
172_I	189_D	0.826	0.63
109_I	146_T	0.826	0.63
45_V	168_V	0.820	0.63
205_L	323_L	0.816	0.62
249_S	252_K	0.815	0.62
127_R	130_A	0.810	0.62
85_F	91_K	0.810	0.62
60_L	101_E	0.808	0.62
249_S	320_D	0.807	0.61
46_L	247_I	0.806	0.61
116_L	186_R	0.806	0.61
162_Y	168_V	0.806	0.61
14_M	137_L	0.806	0.61
155_G	169_C	0.805	0.61
216_A	219_T	0.805	0.61
280_Y	303_Y	0.800	0.61
189_D	243_T	0.800	0.61
243_T	261_Y	0.798	0.61
204_F	260_Y	0.796	0.60
110_K	137_L	0.793	0.60
129_E	290_K	0.790	0.60
221_S	246_T	0.789	0.60
43_G	286_L	0.787	0.60
257_D	285_Y	0.787	0.60
196_E	209_C	0.786	0.59
248_R	253_I	0.783	0.59
138_P	201_Y	0.781	0.59
191_E	260_Y	0.779	0.59
42_L	283_M	0.779	0.59
202_Q	244_D	0.770	0.58
62_Y	301_L	0.765	0.57
177_I	260_Y	0.762	0.57
15_L	190_F	0.758	0.57
13_Y	204_F	0.757	0.57
74_G	244_D	0.756	0.56
77_E	81_T	0.754	0.56
311_K	325_T	0.753	0.56
269_M	274_F	0.743	0.55
103_T	159_T	0.742	0.55
191_E	261_Y	0.738	0.55
57_G	204_F	0.736	0.54
108_I	159_T	0.735	0.54
15_L	62_Y	0.732	0.54
196_E	261_Y	0.730	0.54
43_G	120_E	0.730	0.54
279_L	323_L	0.728	0.54
256_V	288_S	0.726	0.53
12_Y	200_L	0.725	0.53
256_V	324_C	0.723	0.53
151_S	170_K	0.723	0.53
95_T	219_T	0.721	0.53
50_V	169_C	0.721	0.53
50_V	254_L	0.718	0.53
284_N	289_L	0.715	0.52
228_S	243_T	0.714	0.52
112_T	115_I	0.714	0.52
75_R	95_T	0.713	0.52
283_M	288_S	0.712	0.52
12_Y	41_I	0.710	0.52
218_T	222_Y	0.706	0.51
97_D	157_K	0.704	0.51
204_F	302_I	0.704	0.51
277_Q	310_V	0.704	0.51
223_L	228_S	0.703	0.51
92_T	260_Y	0.701	0.51
69_I	98_M	0.699	0.51
32_A	150_F	0.698	0.51
34_P	179_G	0.698	0.51
280_Y	324_C	0.698	0.51
72_I	157_K	0.698	0.51
104_L	143_L	0.694	0.50
64_P	80_K	0.693	0.50
252_K	277_Q	0.690	0.50
83_R	217_N	0.689	0.50
257_D	281_Q	0.689	0.50
42_L	314_Y	0.683	0.49
145_L	148_Q	0.682	0.49
54_S	117_I	0.681	0.49
57_G	97_D	0.681	0.49
195_K	261_Y	0.679	0.49
202_Q	257_D	0.679	0.49
105_A	159_T	0.676	0.48
225_W	228_S	0.675	0.48
101_E	109_I	0.667	0.47
107_R	141_S	0.666	0.47
221_S	228_S	0.662	0.47
10_N	17_Y	0.660	0.47
40_D	128_D	0.660	0.47
44_Y	48_K	0.659	0.47
92_T	109_I	0.658	0.47
12_Y	177_I	0.656	0.46
208_F	212_E	0.656	0.46
191_E	278_N	0.655	0.46
160_R	255_I	0.653	0.46
33_I	302_I	0.653	0.46
102_D	131_R	0.652	0.46
202_Q	285_Y	0.650	0.46
243_T	278_N	0.646	0.45
197_M	285_Y	0.646	0.45
217_N	255_I	0.646	0.45
276_S	283_M	0.645	0.45
253_I	256_V	0.645	0.45
10_N	260_Y	0.645	0.45
14_M	157_K	0.644	0.45
11_I	23_Q	0.643	0.45
8_V	17_Y	0.641	0.45
75_R	87_L	0.638	0.45
99_L	108_I	0.636	0.44
210_R	247_I	0.633	0.44
162_Y	204_F	0.632	0.44
209_C	243_T	0.631	0.44
162_Y	165_V	0.631	0.44
104_L	108_I	0.631	0.44
15_L	39_L	0.629	0.44
63_N	144_H	0.628	0.44
284_N	287_W	0.627	0.43
34_P	248_R	0.626	0.43
45_V	155_G	0.625	0.43
75_R	110_K	0.625	0.43
18_A	203_K	0.623	0.43
81_T	195_K	0.622	0.43
222_Y	242_E	0.619	0.43
94_S	157_K	0.619	0.43
50_V	200_L	0.618	0.43
53_L	166_I	0.618	0.43
148_Q	152_Y	0.616	0.42
64_P	251_E	0.613	0.42
75_R	82_I	0.612	0.42
62_Y	99_L	0.610	0.42
75_R	328_L	0.609	0.42
173_V	246_T	0.604	0.41
102_D	140_I	0.599	0.41
255_I	291_P	0.597	0.40
164_F	235_L	0.596	0.40
67_E	201_Y	0.595	0.40
274_F	316_I	0.595	0.40
182_K	251_E	0.594	0.40
155_G	170_K	0.591	0.40
199_L	242_E	0.591	0.40
127_R	131_R	0.591	0.40
228_S	289_L	0.590	0.40
40_D	71_G	0.589	0.40
73_K	91_K	0.589	0.40
64_P	95_T	0.589	0.40
212_E	218_T	0.588	0.40
282_L	321_I	0.585	0.39
221_S	225_W	0.585	0.39
11_I	164_F	0.584	0.39
97_D	284_N	0.583	0.39
91_K	118_K	0.582	0.39
74_G	259_K	0.581	0.39
42_L	102_D	0.579	0.39
204_F	261_Y	0.578	0.39
50_V	109_I	0.577	0.38
9_R	277_Q	0.576	0.38
200_L	203_K	0.575	0.38
108_I	198_S	0.575	0.38
46_L	108_I	0.574	0.38
99_L	169_C	0.570	0.38
106_N	140_I	0.569	0.38
196_E	243_T	0.568	0.38
81_T	278_N	0.568	0.38
65_N	182_K	0.567	0.38
199_L	203_K	0.566	0.37
189_D	279_L	0.566	0.37
82_I	206_Y	0.565	0.37
80_K	182_K	0.564	0.37
115_I	172_I	0.563	0.37
118_K	157_K	0.563	0.37
46_L	106_N	0.563	0.37
61_D	168_V	0.563	0.37
68_I	84_G	0.563	0.37
241_M	261_Y	0.562	0.37
103_T	107_R	0.562	0.37
14_M	17_Y	0.562	0.37
198_S	299_G	0.562	0.37
176_S	300_L	0.561	0.37
251_E	331_E	0.561	0.37
108_I	162_Y	0.560	0.37
106_N	158_N	0.559	0.37
20_G	282_L	0.559	0.37
209_C	278_N	0.559	0.37
81_T	261_Y	0.559	0.37
67_E	139_G	0.558	0.37
153_L	156_G	0.558	0.37
106_N	110_K	0.557	0.37
227_A	288_S	0.556	0.36
93_V	103_T	0.555	0.36
8_V	46_L	0.555	0.36
57_G	195_K	0.553	0.36
118_K	245_I	0.552	0.36
115_I	119_H	0.551	0.36
155_G	163_K	0.549	0.36
184_H	267_R	0.545	0.35
46_L	171_F	0.545	0.35
223_L	243_T	0.545	0.35
239_P	274_F	0.545	0.35
59_E	161_Y	0.545	0.35
44_Y	129_E	0.545	0.35
241_M	303_Y	0.543	0.35
227_A	233_Q	0.543	0.35
56_R	70_P	0.543	0.35
47_N	53_L	0.542	0.35
10_N	328_L	0.541	0.35
46_L	99_L	0.541	0.35
112_T	116_L	0.540	0.35
64_P	315_K	0.538	0.35
322_G	325_T	0.536	0.35
250_S	320_D	0.536	0.35
22_L	94_S	0.536	0.35
308_T	317_N	0.536	0.35
211_R	218_T	0.534	0.34
80_K	84_G	0.534	0.34
241_M	279_L	0.533	0.34
11_I	62_Y	0.533	0.34
152_Y	184_H	0.532	0.34
145_L	149_H	0.531	0.34
99_L	274_F	0.531	0.34
33_I	39_L	0.531	0.34
59_E	137_L	0.530	0.34
17_Y	211_R	0.529	0.34
59_E	87_L	0.529	0.34
274_F	277_Q	0.529	0.34
315_K	320_D	0.528	0.34
198_S	239_P	0.528	0.34
170_K	199_L	0.526	0.34
177_I	241_M	0.524	0.34
18_A	36_N	0.524	0.34
146_T	149_H	0.523	0.33
144_H	234_S	0.523	0.33
173_V	261_Y	0.523	0.33
78_F	128_D	0.522	0.33
35_G	171_F	0.520	0.33
120_E	147_P	0.520	0.33
106_N	137_L	0.519	0.33
27_Q	190_F	0.519	0.33
114_A	224_K	0.517	0.33
103_T	106_N	0.517	0.33
31_E	275_H	0.516	0.33
239_P	299_G	0.515	0.33
227_A	235_L	0.515	0.33
97_D	280_Y	0.514	0.33
42_L	83_R	0.511	0.32
125_T	250_S	0.511	0.32
203_K	206_Y	0.510	0.32
111_S	211_R	0.510	0.32
43_G	85_F	0.509	0.32
167_S	170_K	0.509	0.32
50_V	133_L	0.509	0.32
128_D	154_N	0.507	0.32
82_I	204_F	0.506	0.32
12_Y	19_W	0.506	0.32
36_N	78_F	0.506	0.32
319_F	325_T	0.505	0.32
41_I	239_P	0.505	0.32
46_L	62_Y	0.500	0.31
99_L	283_M	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ic1A	5	0.5172	84.4	0.938	Contact Map
1xmxA	2	0.8506	56	0.95	Contact Map
4r5qA	1	0.5546	54.7	0.95	Contact Map
3s1sA	1	0.4052	46.2	0.953	Contact Map
1y88A	5	0.3563	43.4	0.953	Contact Map
1hh1A	2	0.3391	34.7	0.956	Contact Map
2p14A	1	0.4454	30.1	0.957	Contact Map
2eo0A	2	0.3592	29.2	0.958	Contact Map
2vldA	2	0.5948	19.2	0.961	Contact Map
1ob8A	1	0.3362	15.6	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.