GREMLIN Database
ZRAS - Sensor protein ZraS
UniProt: P14377 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10008
Length: 465 (410)
Sequences: 43946 (39833)
Seq/√Len: 1967.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_V352_A3.8181.00
394_T449_T3.8091.00
395_D399_G3.5611.00
439_Q451_T3.4621.00
428_H432_E3.3081.00
392_S449_T3.2711.00
388_G453_W3.2281.00
267_A287_M3.1181.00
352_A434_H2.9241.00
381_T392_S2.8811.00
340_R379_S2.8631.00
340_R377_V2.8291.00
314_A351_Q2.8151.00
390_K453_W2.8141.00
405_L442_S2.8041.00
392_S451_T2.8011.00
372_I396_S2.7981.00
271_A288_A2.7421.00
401_A404_Q2.7361.00
264_K292_D2.6621.00
383_S390_K2.6231.00
379_S394_T2.6101.00
390_K451_T2.6091.00
342_T381_T2.5771.00
271_A285_Q2.5151.00
443_Q446_K2.4471.00
377_V396_S2.4401.00
381_T394_T2.4301.00
440_V450_F2.4291.00
405_L440_V2.4241.00
383_S392_S2.3941.00
427_V438_I2.3911.00
264_K291_A2.3891.00
441_A449_T2.3411.00
360_V431_V2.3121.00
437_T453_W2.2981.00
225_Y228_S2.2871.00
342_T379_S2.2671.00
409_F438_I2.2591.00
323_H358_T2.2511.00
441_A451_T2.2481.00
316_D319_T2.2331.00
338_Q377_V2.1971.00
431_V436_G2.1901.00
328_V362_L2.1501.00
400_I408_I2.1381.00
313_Q354_P2.0531.00
431_V452_L2.0471.00
277_G280_A2.0261.00
402_A405_L2.0151.00
360_V427_V1.9901.00
442_S448_S1.9831.00
312_L351_Q1.9631.00
400_I404_Q1.9601.00
372_I376_G1.9421.00
332_A369_I1.9261.00
404_Q407_A1.9211.00
407_A410_T1.9091.00
376_G396_S1.9021.00
407_A413_F1.8861.00
352_A357_L1.8781.00
439_Q453_W1.8561.00
268_K288_A1.8561.00
264_K295_N1.8011.00
404_Q413_F1.8011.00
360_V430_I1.8001.00
276_A280_A1.7961.00
385_S390_K1.7911.00
314_A349_E1.7801.00
295_N299_S1.7601.00
230_Q233_Q1.7581.00
267_A288_A1.7561.00
366_L370_Q1.7211.00
225_Y229_R1.7171.00
404_Q415_T1.6871.00
247_H251_G1.6621.00
432_E437_T1.6321.00
361_L391_I1.6251.00
263_I291_A1.6181.00
384_E456_V1.6081.00
233_Q236_M1.6011.00
288_A292_D1.5981.00
353_D356_R1.5901.00
266_L283_L1.5751.00
233_Q237_K1.5691.00
271_A281_H1.5591.00
379_S396_S1.5521.00
430_I434_H1.5491.00
270_F284_A1.5401.00
363_N427_V1.5291.00
329_S333_N1.5281.00
245_L249_A1.5241.00
323_H354_P1.5201.00
391_I452_L1.5091.00
372_I378_I1.4961.00
400_I448_S1.4941.00
318_N382_A1.4901.00
236_M239_K1.4781.00
32_V36_R1.4751.00
354_P358_T1.4701.00
273_R280_A1.4561.00
232_L235_E1.4521.00
401_A444_E1.4361.00
222_Y225_Y1.4331.00
235_E238_R1.4301.00
235_E239_K1.4281.00
318_N322_N1.4201.00
262_S266_L1.4101.00
409_F440_V1.4071.00
325_L341_F1.4061.00
231_L235_E1.4041.00
264_K288_A1.4041.00
232_L236_M1.3961.00
410_T413_F1.3871.00
356_R433_Q1.3871.00
219_F222_Y1.3781.00
266_L286_V1.3591.00
276_A279_E1.3551.00
316_D349_E1.3521.00
310_L353_D1.3521.00
356_R430_I1.3431.00
408_I440_V1.3231.00
97_D101_I1.3221.00
356_R359_Q1.3041.00
233_Q239_K1.2991.00
322_N341_F1.2951.00
243_V247_H1.2861.00
442_S446_K1.2661.00
267_A291_A1.2631.00
263_I287_M1.2581.00
327_L358_T1.2541.00
360_V452_L1.2531.00
431_V438_I1.2511.00
296_R355_D1.2501.00
414_T417_A1.2481.00
262_S290_E1.2461.00
149_L152_P1.2421.00
221_W225_Y1.2391.00
312_L434_H1.2361.00
343_A382_A1.2361.00
371_A414_T1.2351.00
331_D334_S1.2331.00
218_S221_W1.2311.00
251_G411_P1.2211.00
442_S445_G1.2201.00
429_N432_E1.2201.00
436_G454_L1.2081.00
321_I382_A1.1871.00
270_F280_A1.1871.00
255_E359_Q1.1811.00
211_V215_S1.1731.00
395_D447_G1.1711.00
265_G269_Y1.1611.00
267_A271_A1.1561.00
277_G281_H1.1561.00
388_G437_T1.1511.00
232_L239_K1.1401.00
337_I372_I1.1231.00
286_V290_E1.1161.00
400_I440_V1.1141.00
208_L211_V1.1131.00
281_H285_Q1.1121.00
411_P429_N1.1121.00
285_Q289_K1.1061.00
324_S358_T1.1061.00
318_N343_A1.1041.00
320_L324_S1.0961.00
267_A284_A1.0871.00
315_V320_L1.0861.00
357_L434_H1.0791.00
226_L229_R1.0771.00
395_D448_S1.0721.00
187_A190_L1.0641.00
36_R39_G1.0631.00
328_V365_Y1.0621.00
300_E356_R1.0551.00
409_F450_F1.0491.00
389_V456_V1.0481.00
324_S362_L1.0481.00
344_N383_S1.0401.00
405_L409_F1.0311.00
138_T142_P1.0281.00
310_L356_R1.0271.00
247_H411_P1.0171.00
440_V448_S1.0141.00
299_S303_E1.0111.00
220_F225_Y1.0081.00
373_G376_G0.9951.00
385_S388_G0.9841.00
325_L329_S0.9791.00
290_E293_R0.9781.00
429_N433_Q0.9751.00
436_G452_L0.9741.00
282_Q286_V0.9711.00
143_A147_Y0.9711.00
218_S225_Y0.9711.00
311_A353_D0.9671.00
53_G57_I0.9651.00
331_D366_L0.9601.00
320_L352_A0.9561.00
262_S265_G0.9531.00
221_W228_S0.9531.00
257_R299_S0.9511.00
240_E243_V0.9501.00
363_N366_L0.9501.00
212_L215_S0.9491.00
394_T443_Q0.9491.00
42_S46_R0.9461.00
358_T362_L0.9441.00
371_A398_K0.9341.00
122_Q126_P0.9311.00
364_L450_F0.9311.00
264_K268_K0.9261.00
324_S328_V0.9241.00
327_L362_L0.9241.00
257_R295_N0.9231.00
291_A295_N0.9201.00
183_I186_D0.9201.00
365_Y380_V0.9191.00
368_A378_I0.9171.00
312_L435_G0.9141.00
304_L425_A0.9141.00
399_G448_S0.9121.00
147_Y150_F0.9121.00
148_R152_P0.9101.00
64_S68_M0.9081.00
210_T214_A0.9061.00
300_E359_Q0.9061.00
310_L433_Q0.9051.00
409_F428_H0.9021.00
278_G281_H0.9011.00
258_N262_S0.9001.00
248_L252_V0.8981.00
400_I405_L0.8971.00
317_L391_I0.8961.00
256_I294_L0.8941.00
355_D358_T0.8921.00
361_L365_Y0.8911.00
190_L193_T0.8901.00
216_V220_F0.8901.00
385_S453_W0.8861.00
289_K323_H0.8861.00
431_V454_L0.8841.00
319_T323_H0.8841.00
312_L352_A0.8811.00
150_F154_S0.8781.00
287_M291_A0.8771.00
293_R358_T0.8731.00
414_T419_G0.8711.00
325_L339_L0.8711.00
296_R300_E0.8691.00
81_L84_M0.8681.00
208_L212_L0.8661.00
219_F225_Y0.8641.00
336_E375_H0.8611.00
286_V289_K0.8601.00
92_W105_H0.8571.00
427_V431_V0.8531.00
63_G67_G0.8511.00
201_T205_L0.8501.00
78_Q82_E0.8461.00
230_Q234_D0.8441.00
219_F223_R0.8431.00
218_S222_Y0.8431.00
337_I369_I0.8421.00
359_Q430_I0.8421.00
194_Q197_E0.8381.00
428_H437_T0.8331.00
328_V366_L0.8321.00
337_I341_F0.8321.00
315_V354_P0.8301.00
400_I406_D0.8301.00
330_Q333_N0.8291.00
408_I425_A0.8271.00
282_Q285_Q0.8271.00
114_A118_P0.8261.00
402_A442_S0.8251.00
246_G308_T0.8231.00
33_T37_D0.8231.00
364_L452_L0.8231.00
130_S134_L0.8211.00
370_Q417_A0.8211.00
364_L438_I0.8211.00
285_Q288_A0.8211.00
118_P122_Q0.8191.00
362_L366_L0.8181.00
252_V301_L0.8161.00
43_E46_R0.8121.00
234_D238_R0.8091.00
229_R233_Q0.8081.00
215_S219_F0.8071.00
361_L393_V0.8031.00
344_N347_L0.8011.00
332_A378_I0.8001.00
223_R226_L0.7971.00
275_P280_A0.7961.00
318_N345_D0.7951.00
356_R434_H0.7941.00
408_I450_F0.7931.00
48_A52_K0.7931.00
398_K417_A0.7921.00
422_L426_V0.7911.00
179_Q183_I0.7901.00
244_A247_H0.7861.00
292_D295_N0.7831.00
283_L286_V0.7811.00
338_Q341_F0.7811.00
215_S218_S0.7781.00
254_H363_N0.7781.00
324_S365_Y0.7771.00
321_I380_V0.7771.00
271_A284_A0.7751.00
222_Y226_L0.7721.00
50_L54_N0.7691.00
260_L298_V0.7681.00
330_Q334_S0.7671.00
220_F228_S0.7651.00
380_V393_V0.7651.00
214_A225_Y0.7641.00
395_D398_K0.7601.00
364_L427_V0.7601.00
42_S45_D0.7551.00
41_A44_A0.7541.00
387_A456_V0.7521.00
370_Q419_G0.7491.00
273_R276_A0.7491.00
303_E359_Q0.7481.00
269_Y273_R0.7471.00
236_M240_E0.7431.00
201_T204_I0.7421.00
280_A283_L0.7411.00
223_R228_S0.7411.00
65_R68_M0.7401.00
436_G455_P0.7401.00
44_A48_A0.7401.00
290_E327_L0.7371.00
402_A443_Q0.7361.00
365_Y378_I0.7321.00
53_G56_L0.7311.00
91_L94_A0.7281.00
212_L216_V0.7281.00
217_L221_W0.7251.00
255_E363_N0.7251.00
181_I190_L0.7191.00
190_L194_Q0.7181.00
333_N336_E0.7181.00
321_I361_L0.7141.00
303_E356_R0.7131.00
215_S225_Y0.7101.00
317_L389_V0.7101.00
322_N343_A0.7091.00
146_V150_F0.7091.00
63_G66_V0.7091.00
234_D237_K0.7051.00
269_Y283_L0.7011.00
132_W224_R0.7011.00
143_A146_V0.7001.00
400_I442_S0.6991.00
214_A217_L0.6981.00
57_I61_E0.6981.00
322_N326_Q0.6971.00
45_D48_A0.6971.00
150_F153_M0.6971.00
144_L147_Y0.6961.00
335_R374_Q0.6951.00
370_Q416_K0.6951.00
39_G42_S0.6941.00
364_L431_V0.6931.00
54_N58_R0.6931.00
77_Q81_L0.6921.00
372_I375_H0.6901.00
49_L53_G0.6871.00
35_I38_Y0.6871.00
326_Q329_S0.6861.00
119_D123_K0.6861.00
94_A102_I0.6841.00
133_R137_K0.6831.00
214_A218_S0.6811.00
392_S441_A0.6811.00
401_A415_T0.6801.00
223_R227_R0.6801.00
211_V214_A0.6781.00
266_L290_E0.6751.00
332_A339_L0.6741.00
320_L357_L0.6731.00
328_V369_I0.6711.00
210_T216_V0.6711.00
52_K55_V0.6681.00
96_T102_I0.6681.00
217_L220_F0.6681.00
292_D296_R0.6671.00
221_W224_R0.6651.00
331_D335_R0.6651.00
405_L441_A0.6651.00
117_S120_E0.6651.00
317_L350_I0.6651.00
344_N382_A0.6641.00
337_I378_I0.6621.00
315_V351_Q0.6591.00
97_D103_I0.6581.00
121_M125_K0.6581.00
28_G32_V0.6571.00
283_L287_M0.6541.00
148_R151_Q0.6521.00
139_E143_A0.6491.00
257_R302_L0.6491.00
258_N265_G0.6471.00
294_L298_V0.6471.00
102_I106_S0.6461.00
210_T213_L0.6451.00
270_F283_L0.6441.00
47_Q50_L0.6441.00
183_I197_E0.6441.00
370_Q418_E0.6421.00
32_V35_I0.6411.00
113_R117_S0.6401.00
181_I186_D0.6391.00
232_L237_K0.6381.00
347_L382_A0.6381.00
336_E374_Q0.6361.00
181_I184_A0.6351.00
249_A253_A0.6341.00
206_F209_A0.6331.00
220_F223_R0.6321.00
414_T418_E0.6311.00
203_I207_A0.6311.00
439_Q452_L0.6311.00
217_L228_S0.6271.00
254_H258_N0.6261.00
46_R50_L0.6241.00
121_M124_L0.6221.00
335_R369_I0.6211.00
213_L218_S0.6201.00
33_T36_R0.6201.00
344_N381_T0.6191.00
279_E283_L0.6171.00
100_G104_L0.6171.00
230_Q236_M0.6161.00
368_A393_V0.6161.00
203_I208_L0.6161.00
186_D197_E0.6151.00
319_T322_N0.6151.00
145_E148_R0.6141.00
268_K272_E0.6121.00
237_K240_E0.6121.00
56_L60_L0.6121.00
146_V151_Q0.6121.00
323_H327_L0.6091.00
300_E355_D0.6091.00
193_T197_E0.6081.00
64_S67_G0.6081.00
308_T411_P0.6071.00
268_K271_A0.6061.00
224_R228_S0.6061.00
261_S265_G0.6051.00
59_A63_G0.6021.00
405_L450_F0.6021.00
79_A82_E0.6021.00
266_L287_M0.6011.00
404_Q416_K0.6011.00
80_L84_M0.6011.00
209_A213_L0.6001.00
262_S286_V0.5991.00
243_V246_G0.5971.00
325_L380_V0.5961.00
402_A406_D0.5961.00
360_V434_H0.5951.00
213_L217_L0.5941.00
114_A117_S0.5941.00
344_N348_P0.5941.00
130_S133_R0.5941.00
75_V78_Q0.5931.00
61_E65_R0.5931.00
137_K140_T0.5921.00
205_L210_T0.5911.00
58_R62_S0.5901.00
58_R61_E0.5891.00
132_W136_G0.5891.00
31_A35_I0.5871.00
97_D100_G0.5861.00
284_A288_A0.5861.00
275_P281_H0.5851.00
357_L361_L0.5851.00
237_K241_K0.5841.00
197_E200_N0.5831.00
92_W106_S0.5831.00
77_Q80_L0.5791.00
22_V26_L0.5781.00
115_L118_P0.5781.00
48_A51_E0.5771.00
401_A405_L0.5771.00
35_I39_G0.5771.00
19_L22_V0.5761.00
400_I450_F0.5751.00
332_A335_R0.5741.00
146_V149_L0.5731.00
255_E258_N0.5731.00
320_L354_P0.5731.00
184_A187_A0.5721.00
310_L434_H0.5711.00
59_A62_S0.5711.00
135_L221_W0.5701.00
102_I105_H0.5701.00
111_V114_A0.5701.00
231_L234_D0.5691.00
211_V218_S0.5691.00
425_A429_N0.5681.00
45_D49_L0.5671.00
51_E54_N0.5671.00
390_K439_Q0.5661.00
261_S266_L0.5661.00
348_P389_V0.5651.00
206_F213_L0.5621.00
248_L255_E0.5621.00
322_N325_L0.5611.00
246_G250_A0.5611.00
410_T428_H0.5611.00
120_E124_L0.5601.00
312_L315_V0.5591.00
378_I393_V0.5591.00
179_Q182_F0.5591.00
60_L64_S0.5581.00
219_F226_L0.5571.00
319_T354_P0.5561.00
241_K244_A0.5521.00
313_Q355_D0.5521.00
123_K126_P0.5521.00
326_Q330_Q0.5521.00
219_F228_S0.5511.00
207_A216_V0.5501.00
112_G115_L0.5501.00
105_H108_P0.5491.00
316_D347_L0.5481.00
249_A252_V0.5481.00
120_E123_K0.5471.00
370_Q414_T0.5421.00
342_T383_S0.5421.00
356_R360_V0.5421.00
247_H429_N0.5411.00
253_A259_P0.5411.00
222_Y228_S0.5411.00
208_L215_S0.5401.00
137_K143_A0.5401.00
47_Q51_E0.5401.00
110_K113_R0.5401.00
332_A337_I0.5381.00
147_Y152_P0.5381.00
203_I206_F0.5381.00
359_Q362_L0.5371.00
304_L308_T0.5351.00
337_I376_G0.5351.00
256_I259_P0.5341.00
438_I450_F0.5331.00
218_S223_R0.5331.00
184_A188_S0.5331.00
61_E64_S0.5331.00
288_A291_A0.5331.00
321_I341_F0.5321.00
258_N261_S0.5311.00
350_I454_L0.5291.00
23_I26_L0.5271.00
149_L153_M0.5271.00
211_V219_F0.5261.00
209_A212_L0.5251.00
209_A217_L0.5241.00
384_E388_G0.5241.00
388_G456_V0.5231.00
273_R279_E0.5211.00
302_L306_K0.5211.00
209_A216_V0.5211.00
381_T449_T0.5201.00
141_T144_L0.5201.00
253_A257_R0.5191.00
194_Q198_K0.5191.00
20_P23_I0.5181.00
321_I325_L0.5181.00
179_Q186_D0.5171.00
388_G455_P0.5161.00
196_G200_N0.5151.00
255_E259_P0.5151.00
270_F287_M0.5151.00
431_V437_T0.5141.00
295_N298_V0.5131.00
34_V38_Y0.5131.00
357_L454_L0.5121.00
264_K267_A0.5121.00
302_L305_V0.5111.00
280_A284_A0.5111.00
184_A193_T0.5111.00
394_T446_K0.5101.00
411_P425_A0.5101.00
320_L358_T0.5091.00
24_V28_G0.5091.00
207_A210_T0.5091.00
145_E149_L0.5091.00
444_E447_G0.5061.00
186_D191_V0.5061.00
82_E86_G0.5061.00
426_V430_I0.5061.00
256_I297_V0.5051.00
144_L149_L0.5041.00
50_L53_G0.5041.00
54_N57_I0.5041.00
216_V219_F0.5041.00
304_L411_P0.5031.00
203_I211_V0.5031.00
52_K56_L0.5031.00
332_A336_E0.5031.00
205_L209_A0.5021.00
147_Y154_S0.5021.00
205_L212_L0.5011.00
318_N346_T0.5011.00
282_Q326_Q0.5011.00
123_K127_E0.5001.00
404_Q408_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8258 100 0.339 Contact Map
3a0rA 2 0.7118 100 0.34 Contact Map
4gczA 2 0.7677 100 0.354 Contact Map
4q20A 2 0.4882 100 0.433 Contact Map
3d36A 2 0.4731 100 0.438 Contact Map
3jz3A 2 0.3398 100 0.445 Contact Map
4mpcA 2 0.6581 100 0.455 Contact Map
2c2aA 2 0.4946 100 0.457 Contact Map
2q8gA 2 0.6516 100 0.458 Contact Map
4bixA 2 0.486 100 0.46 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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