GREMLIN Database
ZRAR - Transcriptional regulatory protein ZraR
UniProt: P14375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10482
Length: 441 (427)
Sequences: 10008 (7009)
Seq/√Len: 339.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_E293_R3.9011.00
170_D313_R3.7131.00
214_E224_R3.6391.00
417_T427_Q3.4441.00
33_A50_F3.1591.00
228_R263_Q3.0441.00
130_E133_A3.0121.00
287_A291_A2.9641.00
199_A251_V2.9351.00
261_E270_I2.6501.00
155_I178_V2.6291.00
230_V264_R2.5651.00
262_V273_V2.5531.00
63_D66_A2.5191.00
283_R288_E2.4961.00
261_E272_S2.4891.00
38_G62_M2.4881.00
407_K411_L2.4631.00
203_E248_M2.4541.00
423_E426_R2.4491.00
18_C36_N2.4461.00
37_S40_Q2.4021.00
417_T424_A2.3641.00
229_F256_A2.3591.00
329_R362_E2.3591.00
101_L120_A2.2301.00
238_F280_A2.2121.00
157_L373_T2.1991.00
320_P346_M2.1991.00
18_C34_L2.1821.00
409_V413_A2.1641.00
69_K98_T2.1351.00
342_T378_S2.1311.00
284_D287_A2.1061.00
7_D31_N2.0851.00
263_Q270_I2.0751.00
36_N40_Q2.0651.00
323_A341_F2.0621.00
178_V309_V2.0461.00
341_F365_V2.0421.00
11_V41_A2.0171.00
354_W364_A2.0091.00
9_L35_A2.0031.00
288_E291_A1.9541.00
234_G274_D1.9301.00
214_E267_S1.8971.00
287_A290_N1.8811.00
416_K427_Q1.8801.00
244_D283_R1.8791.00
352_Y355_P1.8441.00
320_P350_I1.8381.00
258_Q362_E1.7811.00
229_F237_L1.7791.00
406_E438_K1.7311.00
144_K321_L1.7301.00
316_R320_P1.7241.00
39_R61_E1.7091.00
188_R274_D1.7051.00
168_H308_E1.6971.00
156_A185_S1.6911.00
257_I277_L1.6731.00
52_L117_L1.6711.00
324_G346_M1.6701.00
22_Q34_L1.6661.00
325_H329_R1.6571.00
323_A365_V1.6521.00
42_L70_E1.6431.00
316_R319_I1.6231.00
345_A349_L1.6191.00
173_T309_V1.6151.00
342_T345_A1.6021.00
413_A417_T1.5981.00
46_R74_L1.5961.00
45_V71_I1.5851.00
22_Q26_R1.5801.00
433_K437_A1.5741.00
33_A44_Q1.5591.00
7_D33_A1.5581.00
70_E73_A1.5541.00
214_E264_R1.5351.00
233_D273_V1.5191.00
207_E252_R1.5071.00
168_H306_A1.5061.00
316_R353_D1.5051.00
145_S317_E1.4991.00
143_G148_M1.4931.00
75_N78_I1.4831.00
267_S271_I1.4821.00
279_A302_L1.4811.00
345_A379_E1.4801.00
176_E255_R1.4661.00
256_A262_V1.4641.00
55_C67_T1.4551.00
53_V71_I1.4521.00
340_G376_Y1.4511.00
344_Q379_E1.4481.00
226_E230_V1.4401.00
35_A44_Q1.4351.00
213_H218_F1.4301.00
243_G281_T1.4251.00
153_S156_A1.3971.00
308_E314_Q1.3951.00
148_M152_L1.3871.00
333_R366_E1.3781.00
94_E98_T1.3781.00
28_W114_Q1.3741.00
348_L379_E1.3731.00
163_A366_E1.3721.00
322_L326_F1.3701.00
81_L116_T1.3601.00
158_V305_V1.3551.00
346_M350_I1.3521.00
225_R268_N1.3511.00
233_D274_D1.3481.00
59_M62_M1.3471.00
55_C82_I1.3421.00
130_E134_V1.3411.00
412_A416_K1.3391.00
327_L341_F1.3251.00
191_K234_G1.3241.00
377_I382_L1.3221.00
70_E74_L1.3221.00
285_L294_F1.3221.00
162_E333_R1.3171.00
352_Y360_E1.3141.00
206_L249_M1.3081.00
54_L117_L1.3041.00
44_Q50_F1.2971.00
151_L307_I1.2911.00
264_R267_S1.2861.00
163_A334_N1.2861.00
345_A377_I1.2791.00
341_F346_M1.2671.00
89_V93_V1.2641.00
327_L369_V1.2601.00
330_F369_V1.2601.00
378_S381_E1.2601.00
143_G152_L1.2561.00
203_E246_S1.2531.00
150_H153_S1.2401.00
38_G67_T1.2371.00
262_V272_S1.2371.00
433_K436_L1.2361.00
413_A428_L1.2341.00
431_T434_T1.2321.00
8_I30_Y1.2271.00
413_A427_Q1.2251.00
37_S61_E1.2191.00
91_T103_Y1.2131.00
152_L155_I1.2131.00
402_L405_V1.2111.00
347_D351_H1.2051.00
154_E371_L1.1991.00
326_F362_E1.1981.00
24_L110_F1.1971.00
230_V271_I1.1961.00
162_E188_R1.1951.00
331_A339_K1.1891.00
411_L415_E1.1881.00
421_K436_L1.1861.00
422_T426_R1.1821.00
244_D282_H1.1771.00
30_Y118_E1.1711.00
53_V78_I1.1711.00
420_N423_E1.1701.00
129_A134_V1.1691.00
68_L82_I1.1651.00
372_L381_E1.1641.00
155_I181_A1.1601.00
423_E427_Q1.1591.00
142_V325_H1.1551.00
401_P405_V1.1531.00
342_T376_Y1.1521.00
339_K375_E1.1491.00
38_G59_M1.1471.00
12_D18_C1.1401.00
431_T437_A1.1391.00
193_L235_G1.1391.00
286_A290_N1.1381.00
68_L80_V1.1371.00
141_M152_L1.1361.00
383_P386_I1.1361.00
320_P323_A1.1331.00
151_L309_V1.1331.00
409_V428_L1.1321.00
180_R195_T1.1321.00
420_N432_R1.1321.00
170_D311_S1.1311.00
57_V91_T1.1301.00
213_H217_A1.1271.00
324_G328_Q1.1201.00
151_L178_V1.1201.00
317_E350_I1.1181.00
209_E225_R1.1171.00
199_A244_D1.1101.00
326_F330_F1.1061.00
42_L62_M1.1051.00
434_T438_K1.1051.00
197_N244_D1.1031.00
260_R272_S1.1021.00
243_G285_L1.1001.00
140_G184_A1.1001.00
33_A48_Q1.0961.00
208_S213_H1.0931.00
422_T432_R1.0911.00
65_I95_A1.0911.00
167_I278_I1.0901.00
58_R86_Y1.0851.00
330_F365_V1.0841.00
166_L279_A1.0821.00
290_N296_Q1.0791.00
331_A337_A1.0761.00
176_E195_T1.0741.00
160_P187_A1.0731.00
155_I182_I1.0691.00
230_V262_V1.0681.00
215_K223_K1.0621.00
206_L210_L1.0571.00
344_Q378_S1.0421.00
38_G42_L1.0421.00
414_L439_L1.0411.00
35_A41_A1.0351.00
7_D50_F1.0351.00
328_Q332_E1.0341.00
167_I178_V1.0331.00
148_M151_L1.0331.00
410_I435_L1.0331.00
55_C80_V1.0321.00
66_A69_K1.0291.00
7_D48_Q1.0281.00
316_R350_I1.0281.00
413_A424_A1.0261.00
12_D59_M1.0251.00
94_E97_K1.0241.00
155_I307_I1.0221.00
303_N306_A1.0221.00
141_M177_L1.0131.00
28_W118_E1.0101.00
54_L113_L1.0091.00
286_A385_A1.0051.00
233_D275_V1.0051.00
405_V409_V0.9971.00
164_T260_R0.9971.00
368_A372_L0.9871.00
236_T278_I0.9871.00
181_A185_S0.9801.00
163_A304_V0.9791.00
319_I349_L0.9771.00
55_C59_M0.9711.00
218_F221_A0.9711.00
141_M178_V0.9641.00
217_A265_V0.9601.00
146_P150_H0.9551.00
326_F365_V0.9531.00
51_D124_T0.9501.00
52_L121_L0.9471.00
170_D173_T0.9451.00
10_V32_V0.9441.00
213_H265_V0.9421.00
231_E268_N0.9411.00
165_V182_I0.9391.00
40_Q43_E0.9381.00
414_L424_A0.9361.00
71_I80_V0.9301.00
67_T71_I0.9231.00
126_S129_A0.9221.00
162_E187_A0.9211.00
69_K94_E0.9181.00
25_L117_L0.9181.00
414_L421_K0.9151.00
319_I323_A0.9151.00
408_E412_A0.9141.00
43_E47_E0.9131.00
421_K433_K0.9131.00
147_A150_H0.9111.00
54_L81_L0.9091.00
195_T255_R0.9071.00
410_I438_K0.9041.00
194_V232_A0.9001.00
412_A415_E0.8991.00
264_R271_I0.8961.00
57_V82_I0.8931.00
17_H108_L0.8921.00
424_A427_Q0.8901.00
347_D350_I0.8841.00
421_K428_L0.8801.00
180_R184_A0.8711.00
44_Q47_E0.8711.00
168_H286_A0.8711.00
434_T437_A0.8701.00
331_A338_V0.8701.00
126_S130_E0.8701.00
237_L277_L0.8681.00
229_F275_V0.8681.00
408_E411_L0.8671.00
213_H225_R0.8661.00
43_E46_R0.8631.00
362_E366_E0.8631.00
151_L155_I0.8621.00
421_K439_L0.8591.00
44_Q48_Q0.8591.00
368_A377_I0.8561.00
419_G439_L0.8541.00
122_A125_H0.8531.00
143_G178_V0.8531.00
208_S218_F0.8521.00
410_I428_L0.8511.00
341_F345_A0.8481.00
143_G155_I0.8471.00
143_G321_L0.8451.00
39_R43_E0.8441.00
367_R371_L0.8421.00
277_L302_L0.8411.00
324_G340_G0.8391.00
40_Q44_Q0.8381.00
402_L409_V0.8361.00
435_L438_K0.8311.00
124_T128_D0.8301.00
432_R436_L0.8291.00
231_E267_S0.8281.00
15_I18_C0.8261.00
194_V231_E0.8251.00
213_H221_A0.8211.00
341_F377_I0.8211.00
167_I309_V0.8211.00
55_C71_I0.8191.00
13_D56_D0.8151.00
206_L245_I0.8151.00
62_M66_A0.8141.00
401_P404_E0.8101.00
149_Q153_S0.8101.00
66_A70_E0.8081.00
69_K73_A0.8071.00
304_V363_N0.8041.00
428_L438_K0.8031.00
343_P346_M0.8011.00
430_I434_T0.7981.00
122_A127_I0.7981.00
37_S59_M0.7951.00
12_D17_H0.7951.00
245_I249_M0.7931.00
164_T279_A0.7931.00
115_A119_K0.7911.00
42_L67_T0.7911.00
146_P149_Q0.7901.00
8_I25_L0.7901.00
237_L256_A0.7871.00
262_V271_I0.7851.00
224_R269_Q0.7841.00
97_K102_D0.7831.00
336_K369_V0.7831.00
202_N265_V0.7831.00
62_M70_E0.7821.00
11_V67_T0.7761.00
286_A299_Y0.7761.00
52_L79_P0.7731.00
35_A38_G0.7731.00
38_G61_E0.7721.00
93_V97_K0.7711.00
383_P387_A0.7691.00
320_P324_G0.7681.00
54_L83_M0.7671.00
167_I179_A0.7671.00
10_V21_L0.7651.00
163_A305_V0.7611.00
229_F273_V0.7601.00
286_A296_Q0.7601.00
144_K149_Q0.7601.00
289_V299_Y0.7591.00
45_V53_V0.7571.00
109_D112_N0.7561.00
431_T436_L0.7541.00
13_D106_K0.7511.00
319_I350_I0.7501.00
13_D84_T0.7501.00
364_A368_A0.7471.00
35_A40_Q0.7461.00
72_K79_P0.7461.00
152_L178_V0.7451.00
197_N245_I0.7451.00
417_T423_E0.7420.99
224_R264_R0.7410.99
21_L113_L0.7400.99
428_L434_T0.7390.99
213_H222_D0.7390.99
11_V53_V0.7380.99
226_E231_E0.7340.99
141_M148_M0.7330.99
229_F262_V0.7330.99
255_R259_E0.7310.99
152_L181_A0.7310.99
163_A370_V0.7310.99
55_C68_L0.7300.99
158_V165_V0.7300.99
129_A133_A0.7280.99
9_L50_F0.7280.99
14_D17_H0.7270.99
245_I253_L0.7240.99
149_Q152_L0.7230.99
225_R228_R0.7220.99
159_A186_S0.7220.99
323_A368_A0.7210.99
436_L440_S0.7210.99
436_L439_L0.7190.99
421_K432_R0.7160.99
243_G282_H0.7150.99
400_Q404_E0.7150.99
368_A382_L0.7130.99
330_F362_E0.7110.99
39_R62_M0.7110.99
142_V321_L0.7100.99
228_R231_E0.7100.99
24_L114_Q0.7090.99
64_G106_K0.7090.99
286_A306_A0.7070.99
10_V22_Q0.7050.99
303_N367_R0.7020.99
83_M108_L0.6990.99
330_F334_N0.6960.99
68_L100_A0.6950.99
336_K339_K0.6950.99
348_L352_Y0.6940.99
119_K126_S0.6940.99
13_D85_A0.6940.99
153_S373_T0.6920.99
118_E122_A0.6900.99
311_S314_Q0.6870.99
56_D106_K0.6870.99
89_V92_A0.6870.99
339_K369_V0.6860.99
401_P409_V0.6840.99
323_A346_M0.6830.99
226_E268_N0.6800.99
435_L439_L0.6800.99
92_A100_A0.6800.99
147_A314_Q0.6790.99
157_L371_L0.6780.99
21_L83_M0.6750.99
403_V407_K0.6750.99
299_Y303_N0.6740.99
87_S105_I0.6670.99
45_V78_I0.6670.99
219_T280_A0.6670.99
116_T120_A0.6660.99
330_F366_E0.6650.99
90_E94_E0.6650.99
15_I19_T0.6640.99
7_D51_D0.6620.99
57_V63_D0.6600.99
414_L419_G0.6590.99
402_L438_K0.6590.99
215_K222_D0.6590.99
45_V75_N0.6570.99
13_D64_G0.6560.99
217_A221_A0.6550.99
415_E419_G0.6550.99
115_A126_S0.6520.99
430_I435_L0.6510.99
400_Q408_E0.6500.99
53_V67_T0.6500.99
243_G283_R0.6480.99
420_N436_L0.6460.99
410_I439_L0.6450.99
404_E408_E0.6450.99
65_I94_E0.6440.99
30_Y114_Q0.6430.99
202_N205_L0.6430.99
348_L382_L0.6410.99
11_V59_M0.6410.99
316_R321_L0.6410.99
122_A126_S0.6400.98
432_R437_A0.6400.98
151_L154_E0.6370.98
343_P347_D0.6350.98
157_L336_K0.6330.98
215_K224_R0.6330.98
171_S244_D0.6320.98
224_R267_S0.6320.98
138_Q152_L0.6310.98
140_G181_A0.6310.98
201_L210_L0.6300.98
219_T282_H0.6290.98
298_L302_L0.6280.98
331_A336_K0.6260.98
243_G294_F0.6230.98
79_P127_I0.6220.98
327_L365_V0.6190.98
323_A327_L0.6180.98
87_S92_A0.6170.98
154_E157_L0.6150.98
331_A369_V0.6150.98
46_R70_E0.6150.98
102_D116_T0.6130.98
196_L228_R0.6120.98
196_L237_L0.6100.98
157_L381_E0.6090.98
437_A440_S0.6050.98
215_K221_A0.6050.98
432_R435_L0.6050.98
101_L116_T0.6020.98
421_K438_K0.6020.98
108_L113_L0.6010.98
162_E334_N0.6010.98
229_F277_L0.6000.98
177_L181_A0.5990.98
188_R191_K0.5960.98
23_A27_G0.5960.98
126_S133_A0.5940.98
159_A185_S0.5940.98
144_K317_E0.5940.98
87_S103_Y0.5920.98
364_A386_I0.5920.98
205_L219_T0.5920.98
84_T106_K0.5920.98
9_L41_A0.5910.97
45_V50_F0.5910.97
260_R275_V0.5900.97
433_K440_S0.5890.97
321_L324_G0.5860.97
334_N369_V0.5860.97
121_L124_T0.5860.97
20_I24_L0.5850.97
242_I302_L0.5850.97
404_E407_K0.5800.97
112_N115_A0.5780.97
225_R231_E0.5760.97
155_I185_S0.5740.97
79_P124_T0.5740.97
286_A289_V0.5730.97
50_F78_I0.5710.97
430_I438_K0.5710.97
153_S157_L0.5710.97
369_V372_L0.5700.97
352_Y386_I0.5680.97
146_P317_E0.5670.97
53_V80_V0.5670.97
216_G221_A0.5650.97
243_G280_A0.5640.97
348_L386_I0.5630.97
228_R270_I0.5610.97
421_K435_L0.5560.96
233_D272_S0.5550.96
160_P186_S0.5550.96
161_S370_V0.5540.96
218_F225_R0.5510.96
214_E271_I0.5500.96
283_R293_R0.5490.96
233_D260_R0.5490.96
79_P123_H0.5470.96
103_Y112_N0.5470.96
234_G275_V0.5460.96
41_A67_T0.5460.96
238_F278_I0.5460.96
179_A193_L0.5450.96
154_E305_V0.5430.96
37_S60_A0.5420.96
305_V370_V0.5400.96
22_Q32_V0.5400.96
16_S20_I0.5400.96
59_M64_G0.5390.96
176_E259_E0.5390.96
420_N424_A0.5380.96
304_V366_E0.5370.96
26_R32_V0.5370.96
15_I36_N0.5370.96
348_L351_H0.5360.96
240_D359_R0.5350.96
101_L123_H0.5330.95
197_N200_A0.5330.95
327_L331_A0.5320.95
196_L210_L0.5320.95
148_M178_V0.5320.95
64_G85_A0.5310.95
226_E262_V0.5300.95
405_V428_L0.5300.95
201_L206_L0.5270.95
328_Q338_V0.5270.95
173_T177_L0.5270.95
83_M86_Y0.5260.95
333_R362_E0.5260.95
233_D271_I0.5250.95
325_H328_Q0.5250.95
205_L265_V0.5250.95
406_E410_I0.5250.95
208_S216_G0.5240.95
150_H154_E0.5240.95
327_L338_V0.5240.95
164_T304_V0.5240.95
143_G318_D0.5220.95
18_C38_G0.5220.95
256_A273_V0.5210.95
138_Q181_A0.5210.95
104_L108_L0.5210.95
288_E294_F0.5200.95
338_V369_V0.5190.95
223_K268_N0.5180.95
421_K437_A0.5180.95
65_I91_T0.5170.95
192_P231_E0.5170.95
178_V181_A0.5170.95
224_R271_I0.5150.94
191_K233_D0.5150.94
138_Q185_S0.5120.94
147_A317_E0.5120.94
317_E320_P0.5120.94
11_V38_G0.5120.94
256_A259_E0.5120.94
373_T381_E0.5120.94
433_K438_K0.5110.94
214_E217_A0.5110.94
141_M181_A0.5110.94
152_L156_A0.5110.94
37_S62_M0.5100.94
400_Q405_V0.5090.94
421_K431_T0.5090.94
105_I112_N0.5080.94
10_V25_L0.5080.94
19_T22_Q0.5070.94
58_R88_S0.5070.94
83_M104_L0.5070.94
330_F333_R0.5060.94
192_P235_G0.5060.94
421_K424_A0.5050.94
71_I78_I0.5050.94
8_I121_L0.5040.94
431_T438_K0.5040.94
123_H127_I0.5040.94
13_D59_M0.5030.94
233_D262_V0.5030.94
243_G288_E0.5030.94
112_N116_T0.5020.94
90_E112_N0.5020.94
25_L32_V0.5020.94
64_G84_T0.5020.94
209_E228_R0.5010.94
422_T425_A0.5010.94
177_L358_I0.5010.94
409_V436_L0.5000.94
260_R273_V0.5000.94
421_K430_I0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.8662 100 0.097 Contact Map
3dzdA 2 0.8345 100 0.257 Contact Map
1ojlA 3 0.6825 100 0.438 Contact Map
4fwgA 3 0.6122 100 0.619 Contact Map
1r6bX 1 0.8798 100 0.635 Contact Map
3pxiA 3 0.8277 100 0.642 Contact Map
1qvrA 3 0.8594 100 0.642 Contact Map
4qhsA 3 0.5533 100 0.656 Contact Map
4d2uA 3 0.873 100 0.657 Contact Map
4ciuA 1 0.8526 100 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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