GREMLIN Database
TOP3 - DNA topoisomerase 3
UniProt: P14294 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11014
Length: 653 (543)
Sequences: 6244 (3741)
Seq/√Len: 160.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_R263_E5.2431.00
311_N398_N4.2521.00
214_E555_K3.8891.00
211_E559_H3.7351.00
292_F300_E3.6641.00
278_S469_K3.6131.00
97_E130_Q3.3311.00
404_N408_R3.2891.00
326_I406_I3.2411.00
258_H261_L3.1701.00
277_T428_D3.0861.00
220_D482_E3.0661.00
580_Q585_Q3.0661.00
283_R419_V3.0321.00
281_D421_R2.9591.00
419_V443_E2.9161.00
285_S419_V2.8851.00
86_N90_R2.8071.00
397_E401_K2.7901.00
203_L535_L2.6251.00
130_Q151_S2.6001.00
139_P143_E2.5401.00
425_I467_V2.5401.00
220_D484_Q2.5141.00
144_R148_R2.4881.00
428_D431_K2.4881.00
533_E537_K2.4861.00
263_E267_N2.4621.00
318_K399_E2.4621.00
210_D490_H2.4441.00
421_R442_A2.3761.00
287_S417_D2.3681.00
307_L401_K2.3471.00
468_A471_D2.3151.00
283_R442_A2.3101.00
225_K237_T2.2781.00
206_V541_L2.2761.00
423_C440_F2.2711.00
273_P472_E2.2601.00
301_A402_V2.2531.00
267_N270_S2.2461.00
310_Q314_D2.2191.00
278_S426_E2.2171.00
39_T88_I2.1851.00
316_C326_I2.1811.00
41_C115_V2.1791.00
2_R97_E2.1741.00
587_R590_D2.1691.00
77_P85_L2.1111.00
310_Q533_E2.0981.00
272_Q430_A2.0971.00
444_A448_T2.0941.00
207_V550_S2.0931.00
62_N65_D2.0441.00
230_T471_D2.0411.00
100_H112_V2.0071.00
221_F483_R1.9831.00
306_G546_R1.9791.00
275_I472_E1.9731.00
204_G208_R1.9671.00
420_F441_L1.9511.00
39_T87_V1.9501.00
418_A441_L1.9351.00
140_Q144_R1.9081.00
37_V95_A1.8881.00
284_E422_K1.8861.00
438_A465_P1.8861.00
219_K257_L1.8801.00
152_N159_C1.8741.00
283_R421_R1.8591.00
238_A427_L1.8561.00
157_P584_K1.8481.00
577_V594_P1.8421.00
102_G112_V1.8391.00
349_N356_P1.8301.00
400_A404_N1.8261.00
218_A484_Q1.8121.00
82_T86_N1.8061.00
224_V262_A1.8041.00
66_L593_Q1.8011.00
268_R432_G1.7921.00
307_L315_I1.7911.00
228_I238_A1.7801.00
274_A427_L1.7701.00
208_R212_E1.7561.00
3_L92_L1.7521.00
581_I591_F1.7501.00
392_A400_A1.7491.00
285_S417_D1.7451.00
211_E215_N1.7271.00
343_G388_A1.7071.00
259_R482_E1.6811.00
227_H477_K1.6591.00
2_R99_V1.6571.00
421_R440_F1.6461.00
257_L261_L1.6401.00
426_E435_V1.6391.00
573_H577_V1.6361.00
90_R94_E1.6281.00
223_E483_R1.6151.00
307_L398_N1.6151.00
210_D550_S1.6081.00
256_L265_V1.6021.00
156_V160_V1.5811.00
79_P82_T1.5771.00
419_V442_A1.5761.00
39_T91_F1.5711.00
536_F543_K1.5701.00
534_L538_R1.5671.00
157_P160_V1.5651.00
85_L118_Y1.5631.00
264_H268_R1.5601.00
274_A429_I1.5501.00
412_M450_L1.5501.00
275_I428_D1.5411.00
536_F548_I1.5401.00
407_A411_L1.5381.00
593_Q597_G1.5301.00
300_E303_K1.5241.00
261_L264_H1.5171.00
279_Y425_I1.5101.00
276_V427_L1.5091.00
600_Y604_D1.4981.00
227_H479_E1.4961.00
426_E433_K1.4951.00
424_V437_K1.4931.00
256_L262_A1.4841.00
227_H237_T1.4831.00
499_A520_D1.4761.00
305_F401_K1.4721.00
266_V270_S1.4641.00
577_V586_C1.4621.00
345_H349_N1.4591.00
229_V476_E1.4571.00
418_A447_R1.4541.00
266_V480_V1.4501.00
194_S538_R1.4441.00
438_A464_L1.4401.00
260_P264_H1.4331.00
132_C146_I1.4331.00
605_Q609_T1.4321.00
391_S394_N1.4311.00
4_F146_I1.4171.00
133_L150_R1.4101.00
204_G562_P1.4051.00
338_E375_D1.4041.00
542_T551_T1.4041.00
240_W432_G1.4011.00
167_R592_M1.3941.00
99_V149_L1.3831.00
301_A405_L1.3711.00
211_E214_E1.3541.00
236_F427_L1.3341.00
109_Q113_D1.3331.00
70_P73_W1.3321.00
37_V91_F1.3301.00
262_A480_V1.3301.00
52_D74_Q1.3291.00
318_K322_T1.3231.00
16_A37_V1.3181.00
281_D423_C1.3171.00
580_Q586_C1.3151.00
4_F36_Q1.3151.00
42_I81_V1.3141.00
336_L413_Q1.3111.00
590_D593_Q1.3101.00
396_T399_E1.2991.00
314_D318_K1.2971.00
358_L444_A1.2961.00
499_A519_T1.2941.00
86_N89_K1.2881.00
228_I427_L1.2861.00
428_D433_K1.2851.00
47_E78_R1.2781.00
268_R430_A1.2771.00
272_Q429_I1.2741.00
98_I121_L1.2681.00
577_V580_Q1.2671.00
277_T433_K1.2661.00
83_K87_V1.2651.00
110_L162_A1.2621.00
420_F439_R1.2621.00
46_L118_Y1.2601.00
427_L473_L1.2551.00
263_E266_V1.2531.00
311_N314_D1.2491.00
15_I38_V1.2421.00
116_L129_V1.2391.00
210_D214_E1.2371.00
486_Q489_R1.2371.00
194_S199_Q1.2341.00
416_P443_E1.2291.00
207_V558_F1.2261.00
490_H550_S1.2261.00
307_L402_V1.2231.00
576_S580_Q1.2141.00
315_I398_N1.2131.00
47_E166_A1.2051.00
83_K86_N1.2011.00
238_A436_A1.1931.00
14_A17_D1.1911.00
325_L395_L1.1881.00
286_E447_R1.1771.00
105_D380_A1.1771.00
228_I274_A1.1771.00
225_K239_I1.1751.00
544_K549_H1.1741.00
143_E147_D1.1681.00
140_Q339_E1.1651.00
241_Q435_V1.1641.00
326_I329_P1.1601.00
144_R147_D1.1531.00
397_E400_A1.1521.00
541_L548_I1.1461.00
307_L311_N1.1461.00
225_K481_V1.1431.00
269_I429_I1.1431.00
346_A350_A1.1411.00
348_M411_L1.1411.00
579_T582_S1.1351.00
42_I84_Q1.1301.00
389_R411_L1.1241.00
92_L98_I1.1201.00
161_S582_S1.1121.00
211_E555_K1.1091.00
315_I402_V1.1061.00
224_V478_G1.0981.00
160_V588_Y1.0971.00
535_L541_L1.0971.00
2_R35_G1.0971.00
299_I498_S1.0870.99
229_V474_L1.0850.99
224_V265_V1.0820.99
422_K437_K1.0800.99
292_F409_Q1.0760.99
259_R480_V1.0680.99
213_I490_H1.0660.99
230_T234_E1.0660.99
274_A473_L1.0650.99
269_I478_G1.0640.99
424_V435_V1.0580.99
358_L443_E1.0570.99
164_A588_Y1.0560.99
281_D466_V1.0550.99
134_I145_A1.0530.99
300_E409_Q1.0500.99
164_A592_M1.0480.99
211_E562_P1.0450.99
227_H235_R1.0440.99
226_A274_A1.0390.99
132_C149_L1.0380.99
475_C478_G1.0370.99
371_R374_D1.0360.99
492_T547_Y1.0300.99
300_E304_R1.0290.99
497_L532_I1.0290.99
222_F482_E1.0260.99
550_S555_K1.0260.99
194_S534_L1.0230.99
300_E405_L1.0220.99
301_A312_V1.0210.99
491_F499_A1.0170.99
230_T473_L1.0170.99
121_L127_Q1.0150.99
322_T399_E1.0140.99
84_Q87_V1.0130.99
490_H549_H1.0040.99
274_A475_C1.0020.99
295_S525_E1.0010.99
212_E491_F1.0010.99
223_E481_V1.0000.99
345_H359_L1.0000.99
307_L312_V0.9990.99
335_Y379_D0.9990.99
601_Q605_Q0.9940.99
346_A349_N0.9900.99
297_L316_C0.9890.99
222_F259_R0.9870.99
264_H267_N0.9860.99
18_V139_P0.9860.99
344_R410_Y0.9860.99
109_Q152_N0.9830.99
236_F467_V0.9800.99
203_L554_G0.9790.99
63_L68_I0.9780.99
235_R476_E0.9760.99
223_E239_I0.9690.99
427_L436_A0.9680.99
297_L312_V0.9620.99
309_A529_A0.9610.99
45_L118_Y0.9540.99
263_E480_V0.9530.99
78_R81_V0.9530.99
205_L499_A0.9510.99
202_V500_M0.9490.99
398_N401_K0.9490.99
49_A74_Q0.9480.99
160_V587_R0.9480.99
444_A451_G0.9450.99
68_I593_Q0.9440.99
145_A149_L0.9430.99
176_M195_V0.9420.99
543_K548_I0.9410.99
467_V471_D0.9390.98
68_I174_I0.9390.98
370_N373_W0.9380.98
209_R212_E0.9370.98
536_F541_L0.9370.98
604_D608_R0.9350.98
185_R607_K0.9310.98
586_C590_D0.9300.98
136_D141_A0.9300.98
362_P448_T0.9250.98
269_I434_F0.9250.98
311_N315_I0.9240.98
359_L363_V0.9240.98
451_G454_E0.9230.98
117_D120_Q0.9190.98
113_D152_N0.9190.98
224_V266_V0.9170.98
199_Q534_L0.9150.98
266_V478_G0.9150.98
226_A478_G0.9130.98
256_L261_L0.9120.98
500_M531_I0.9120.98
207_V555_K0.9110.98
308_S311_N0.9090.98
286_E446_W0.9090.98
10_S14_A0.9090.98
273_P474_L0.9080.98
236_F436_A0.9080.98
604_D607_K0.9050.98
226_A429_I0.9050.98
492_T495_T0.9040.98
49_A76_Q0.9040.98
77_P118_Y0.9030.98
97_E128_Q0.9000.98
320_Y329_P0.8980.98
590_D594_P0.8970.98
89_K93_H0.8950.98
3_L95_A0.8890.98
416_P419_V0.8890.98
276_V425_I0.8880.98
61_W167_R0.8870.98
104_P142_V0.8850.98
9_P42_I0.8830.98
128_Q151_S0.8820.98
136_D337_P0.8810.98
573_H576_S0.8770.98
317_Q321_E0.8750.98
281_D440_F0.8730.98
561_L566_T0.8710.98
164_A581_I0.8710.98
282_K422_K0.8680.97
199_Q538_R0.8670.97
39_T84_Q0.8660.97
270_S477_K0.8630.97
552_D556_A0.8630.97
205_L520_D0.8590.97
423_C438_A0.8580.97
98_I127_Q0.8570.97
63_L66_L0.8550.97
597_G600_Y0.8510.97
309_A548_I0.8480.97
420_F447_R0.8460.97
265_V432_G0.8450.97
236_F240_W0.8450.97
65_D68_I0.8450.97
104_P133_L0.8410.97
241_Q426_E0.8390.97
281_D469_K0.8380.97
309_A497_L0.8360.97
207_V211_E0.8350.97
175_N600_Y0.8350.97
360_P363_V0.8330.97
395_L399_E0.8330.97
301_A305_F0.8330.97
4_F101_A0.8310.97
318_K396_T0.8280.97
77_P80_S0.8210.96
277_T426_E0.8210.96
297_L402_V0.8190.96
92_L119_L0.8160.96
309_A493_D0.8140.96
594_P597_G0.8110.96
46_L117_D0.8110.96
276_V473_L0.8110.96
597_G601_Q0.8100.96
228_I429_I0.8090.96
290_L334_R0.8070.96
46_L85_L0.8050.96
104_P135_N0.8030.96
210_D555_K0.8020.96
530_G534_L0.7980.96
229_V235_R0.7970.96
113_D159_C0.7970.96
73_W167_R0.7970.96
216_F485_T0.7960.96
221_F485_T0.7950.96
113_D156_V0.7920.96
37_V94_E0.7910.96
66_L589_Q0.7890.96
227_H476_E0.7880.96
65_D69_V0.7840.95
284_E420_F0.7820.95
415_C449_L0.7790.95
228_I434_F0.7780.95
45_L85_L0.7770.95
280_N424_V0.7770.95
309_A533_E0.7740.95
586_C594_P0.7740.95
418_A444_A0.7730.95
36_Q99_V0.7720.95
275_I470_G0.7700.95
228_I475_C0.7690.95
493_D543_K0.7680.95
305_F402_V0.7680.95
39_T42_I0.7680.95
91_F94_E0.7670.95
574_W591_F0.7650.95
88_I119_L0.7640.95
3_L91_F0.7630.95
59_A171_L0.7630.95
2_R36_Q0.7620.95
10_S320_Y0.7620.95
341_F345_H0.7610.95
229_V233_D0.7600.95
425_I466_V0.7590.95
408_R451_G0.7580.95
136_D339_E0.7570.94
59_A175_N0.7560.94
501_T525_E0.7540.94
200_T561_L0.7530.94
494_A497_L0.7510.94
187_A560_S0.7510.94
356_P360_P0.7500.94
495_T499_A0.7500.94
534_L537_K0.7500.94
441_L444_A0.7490.94
391_S400_A0.7480.94
92_L116_L0.7470.94
284_E418_A0.7450.94
250_Q431_K0.7450.94
279_Y467_V0.7450.94
127_Q151_S0.7430.94
441_L447_R0.7430.94
228_I473_L0.7400.94
61_W68_I0.7400.94
293_S334_R0.7390.94
339_E343_G0.7390.94
315_I399_E0.7370.94
357_D419_V0.7370.94
374_D377_K0.7340.94
129_V151_S0.7320.93
197_R571_T0.7320.93
116_L121_L0.7320.93
293_S296_A0.7310.93
61_W66_L0.7310.93
345_H360_P0.7310.93
181_T192_V0.7310.93
343_G346_A0.7310.93
589_Q593_Q0.7280.93
341_F344_R0.7280.93
75_L163_L0.7270.93
300_E450_L0.7270.93
569_D573_H0.7250.93
357_D361_Q0.7230.93
17_D139_P0.7220.93
166_A170_W0.7220.93
210_D213_I0.7220.93
219_K255_R0.7220.93
204_G558_F0.7180.93
175_N603_I0.7170.93
268_R431_K0.7150.93
280_N469_K0.7150.93
14_A324_K0.7120.93
98_I116_L0.7110.92
21_K35_G0.7070.92
59_A62_N0.7060.92
99_V146_I0.7050.92
156_V159_C0.7040.92
308_S314_D0.7030.92
100_H109_Q0.7030.92
402_V406_I0.7020.92
539_G542_T0.7020.92
153_S157_P0.7010.92
409_Q450_L0.6980.92
344_R411_L0.6970.92
13_R17_D0.6970.92
296_A299_I0.6960.92
580_Q583_E0.6960.92
313_L529_A0.6960.92
138_N141_A0.6950.92
292_F405_L0.6940.92
336_L410_Y0.6930.91
289_P303_K0.6910.91
295_S497_L0.6910.91
291_P372_C0.6910.91
49_A174_I0.6900.91
543_K547_Y0.6890.91
356_P404_N0.6890.91
102_G109_Q0.6890.91
343_G390_S0.6880.91
298_Q529_A0.6830.91
226_A475_C0.6820.91
602_L605_Q0.6820.91
5_I112_V0.6810.91
8_K11_L0.6810.91
575_E578_L0.6810.91
355_A358_L0.6810.91
269_I274_A0.6790.91
85_L119_L0.6790.91
47_E76_Q0.6780.91
6_A11_L0.6770.91
338_E341_F0.6760.90
489_R547_Y0.6760.90
262_A266_V0.6750.90
193_L553_A0.6750.90
59_A66_L0.6750.90
368_I417_D0.6740.90
309_A543_K0.6740.90
15_I142_V0.6740.90
595_L599_L0.6730.90
358_L448_T0.6720.90
535_L539_G0.6700.90
4_F19_L0.6690.90
226_A434_F0.6680.90
279_Y469_K0.6650.90
543_K546_R0.6650.90
396_T400_A0.6650.90
236_F473_L0.6650.90
322_T325_L0.6640.90
106_R578_L0.6630.90
225_K479_E0.6630.90
542_T549_H0.6620.90
520_D568_P0.6620.90
106_R575_E0.6590.89
6_A15_I0.6580.89
109_Q112_V0.6530.89
382_H385_I0.6530.89
85_L89_K0.6520.89
333_C378_V0.6510.89
562_P566_T0.6510.89
51_P174_I0.6500.89
347_V389_R0.6500.89
304_R450_L0.6470.88
87_V91_F0.6460.88
443_E448_T0.6450.88
254_G432_G0.6450.88
66_L69_V0.6440.88
5_I98_I0.6430.88
348_M360_P0.6420.88
313_L329_P0.6420.88
425_I464_L0.6420.88
265_V268_R0.6410.88
116_L126_R0.6400.88
160_V163_L0.6400.88
205_L568_P0.6380.88
286_E439_R0.6380.88
20_P143_E0.6380.88
167_R588_Y0.6360.88
216_F488_P0.6350.88
59_A63_L0.6330.87
496_L532_I0.6310.87
69_V589_Q0.6300.87
401_K404_N0.6300.87
153_S156_V0.6300.87
59_A68_I0.6290.87
63_L70_P0.6280.87
176_M565_A0.6250.87
579_T583_E0.6220.86
493_D536_F0.6210.86
230_T236_F0.6200.86
593_Q596_V0.6200.86
334_R372_C0.6190.86
332_D525_E0.6180.86
279_Y423_C0.6180.86
425_I471_D0.6170.86
389_R410_Y0.6160.86
408_R450_L0.6160.86
350_A390_S0.6150.86
214_E550_S0.6150.86
5_I88_I0.6140.86
335_Y377_K0.6140.86
168_A574_W0.6130.86
133_L142_V0.6130.86
208_R562_P0.6130.86
288_A417_D0.6110.85
12_A16_A0.6110.85
177_T192_V0.6110.85
6_A162_A0.6110.85
286_E420_F0.6100.85
283_R423_C0.6100.85
218_A487_P0.6100.85
224_V480_V0.6090.85
116_L120_Q0.6070.85
126_R151_S0.6070.85
347_V350_A0.6060.85
230_T233_D0.6060.85
182_I185_R0.6050.85
171_L175_N0.6050.85
337_P378_V0.6050.85
564_M602_L0.6040.85
599_L603_I0.6040.85
336_L385_I0.6030.85
370_N374_D0.6030.85
336_L383_A0.6030.85
287_S371_R0.6020.85
451_G455_R0.6010.85
236_F465_P0.5990.84
310_Q537_K0.5990.84
295_S299_I0.5980.84
601_Q604_D0.5970.84
251_D255_R0.5960.84
603_I607_K0.5960.84
41_C45_L0.5950.84
291_P383_A0.5950.84
240_W256_L0.5950.84
78_R82_T0.5950.84
48_Q73_W0.5930.84
483_R486_Q0.5930.84
208_R211_E0.5910.84
2_R96_S0.5910.84
6_A38_V0.5910.84
592_M596_V0.5900.83
325_L554_G0.5900.83
532_I536_F0.5900.83
434_F478_G0.5880.83
467_V473_L0.5880.83
203_L558_F0.5870.83
277_T469_K0.5870.83
112_V116_L0.5860.83
92_L127_Q0.5860.83
316_C402_V0.5860.83
126_R129_V0.5850.83
170_W174_I0.5840.83
116_L152_N0.5840.83
284_E439_R0.5840.83
168_A595_L0.5830.83
327_T382_H0.5810.82
251_D254_G0.5810.82
423_C465_P0.5810.82
447_R451_G0.5810.82
174_I177_T0.5800.82
265_V269_I0.5800.82
102_G113_D0.5800.82
92_L121_L0.5790.82
52_D59_A0.5790.82
429_I478_G0.5780.82
163_L588_Y0.5770.82
112_V152_N0.5770.82
439_R461_G0.5770.82
110_L114_E0.5750.82
275_I469_K0.5740.82
316_C406_I0.5740.82
181_T184_G0.5730.82
159_C163_L0.5710.81
262_A478_G0.5710.81
201_P535_L0.5710.81
132_C145_A0.5710.81
134_I316_C0.5710.81
299_I494_A0.5700.81
303_K451_G0.5690.81
81_V84_Q0.5690.81
337_P340_H0.5690.81
91_F95_A0.5680.81
440_F466_V0.5670.81
452_S455_R0.5650.81
228_I467_V0.5640.81
16_A21_K0.5640.81
206_V550_S0.5640.81
598_T601_Q0.5630.81
104_P132_C0.5620.80
76_Q79_P0.5600.80
574_W578_L0.5590.80
84_Q91_F0.5580.80
40_W84_Q0.5580.80
138_N340_H0.5570.80
208_R568_P0.5560.80
98_I129_V0.5560.80
338_E342_A0.5550.80
146_I149_L0.5530.79
308_S543_K0.5520.79
206_V309_A0.5510.79
423_C464_L0.5510.79
558_F562_P0.5510.79
130_Q149_L0.5510.79
102_G152_N0.5500.79
586_C591_F0.5490.79
237_T479_E0.5490.79
336_L373_W0.5480.79
85_L88_I0.5480.79
15_I18_V0.5470.79
99_V130_Q0.5470.79
46_L113_D0.5460.78
293_S501_T0.5460.78
184_G187_A0.5450.78
342_A346_A0.5440.78
120_Q126_R0.5430.78
224_V269_I0.5430.78
138_N387_T0.5430.78
294_L313_L0.5430.78
60_R65_D0.5420.78
60_R64_A0.5420.78
350_A353_V0.5410.78
141_A145_A0.5410.78
349_N359_L0.5400.78
106_R161_S0.5400.78
332_D379_D0.5390.78
552_D555_K0.5390.78
8_K524_T0.5390.78
18_V135_N0.5390.78
394_N400_A0.5390.78
77_P82_T0.5380.77
309_A532_I0.5370.77
150_R158_L0.5360.77
177_T181_T0.5360.77
112_V115_V0.5360.77
490_H547_Y0.5360.77
100_H113_D0.5350.77
185_R191_G0.5350.77
556_A559_H0.5350.77
3_L39_T0.5340.77
141_A339_E0.5330.77
116_L151_S0.5330.77
10_S135_N0.5330.77
203_L539_G0.5330.77
46_L114_E0.5320.77
338_E370_N0.5310.77
290_L335_Y0.5300.76
427_L467_V0.5300.76
436_A464_L0.5300.76
597_G604_D0.5290.76
564_M598_T0.5280.76
491_F495_T0.5280.76
152_N156_V0.5280.76
9_P317_Q0.5280.76
463_P466_V0.5280.76
183_L186_N0.5270.76
498_S519_T0.5270.76
64_A68_I0.5250.76
587_R593_Q0.5240.76
132_C327_T0.5240.76
436_A465_P0.5240.76
259_R266_V0.5230.75
153_S158_L0.5230.75
206_V548_I0.5210.75
163_L167_R0.5210.75
237_T462_T0.5200.75
369_R372_C0.5200.75
15_I101_A0.5200.75
276_V467_V0.5200.75
274_A478_G0.5200.75
336_L341_F0.5200.75
605_Q608_R0.5190.75
11_L525_E0.5190.75
265_V478_G0.5190.75
69_V73_W0.5180.75
5_I102_G0.5170.75
542_T552_D0.5170.75
226_A473_L0.5160.75
348_M359_L0.5160.75
500_M522_L0.5160.75
115_V119_L0.5150.74
539_G553_A0.5150.74
209_R491_F0.5140.74
42_I530_G0.5140.74
411_L415_C0.5140.74
544_K547_Y0.5140.74
302_A546_R0.5140.74
170_W175_N0.5130.74
51_P61_W0.5120.74
335_Y374_D0.5120.74
2_R130_Q0.5120.74
304_R309_A0.5120.74
195_V200_T0.5120.74
392_A395_L0.5120.74
61_W177_T0.5110.74
9_P40_W0.5110.74
41_C88_I0.5110.74
402_V405_L0.5110.74
121_L129_V0.5110.74
42_I83_K0.5110.74
308_S493_D0.5100.74
164_A591_F0.5100.74
302_A312_V0.5100.74
524_T528_R0.5090.74
302_A308_S0.5090.74
219_K253_E0.5090.74
69_V596_V0.5090.74
282_K424_V0.5080.73
110_L166_A0.5080.73
356_P359_L0.5080.73
609_T612_R0.5060.73
270_S430_A0.5060.73
237_T481_V0.5060.73
16_A38_V0.5060.73
127_Q130_Q0.5060.73
232_A235_R0.5050.73
100_H152_N0.5050.73
322_T394_N0.5050.73
149_L152_N0.5040.73
62_N68_I0.5040.73
230_T467_V0.5040.73
530_G533_E0.5040.73
45_L84_Q0.5030.73
135_N382_H0.5030.73
137_L446_W0.5020.73
110_L163_L0.5010.72
521_G575_E0.5010.72
555_K559_H0.5000.72
11_L15_I0.5000.72
9_P13_R0.5000.72
295_S501_T0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i7dA 1 0.9372 100 0.077 Contact Map
4cgyA 1 0.8714 100 0.192 Contact Map
1mw9X 1 0.8346 100 0.202 Contact Map
2gaiA 1 0.8407 100 0.227 Contact Map
4dduA 1 0.7948 100 0.254 Contact Map
1gkuB 1 0.755 100 0.265 Contact Map
1vddA 7 0.1715 99.5 0.918 Contact Map
2fcjA 2 0.173 98.4 0.949 Contact Map
3vdpA 2 0.17 98.1 0.952 Contact Map
1r7jA 2 0.1378 87 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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