PROV - ECOLI - GREMLIN Contacts

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PROV - Glycine betaine/L-proline transport ATP-binding protein ProV

UniProt:	P14175	Sequences: MAIKLEIKNLYKIFGEHPQRAFKYIEQGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGINAEERREKALDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRTPNGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGAVSIDSLKTALTQQQGLDAALIDAPLAVDAQTPLSELLSHVGQAPCAVPVVDEDQQYVGIISKGMLLRALDREGVNNG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10771
Length:	400 (314)
Sequences:	8119 (6706)
Seq/√Len:	378.5

ECOLI - PROV POTG POTA MALK CYSA METN FBPC YCJV UGPC YDCT YHES RBSA MODC DPPF UUP OPPD MACB YEHX ARAG YADG DDPD DPPD OPPF SAPD GSIA DDPF MDLA MDLB CYDC FEPC MSBA CYDD MLAF YTFR SAPF YOJI HISP LSRA ETTA NIKE TAUB FHUC YECC FECE PHNC YHDZ SSUB GLNQ YPHE LPTB LIVG PSTB GLTL ARTP PHNK ZNUC XYLG SUFC LOLD LIVF MODF ALSA THIQ FTSE BTUD NIKD FETA YBBA MGLA PHNL YDDA YEJF CCMA YNJD YBHF YBIT
BACSU - OPUAA OPUCA OPUBA YVRA YURJ METN MSMX TAGH OPPD DPPD YFIL YKFD YDIF YHCH APPD YXLF YDBJ YHAQ YCBN APPF YFMR YVFR RBSA YHEH OPPF YFIC SUNT YFIB YTRB ECFA1 YGAD YKNV BMRA YKNU YFMM YUSV YHEI YKPA YWJA YFMF CYDC FHUC CYDD YCLP YLMA TCYN YKOD YXDL YVCR SKFE BCEA PSTB1 ECSA PSTB2 SUFC ECFA2 YTLC FTSE TCYC ARTM GLNQ YXEO YJKB NATA SSUB YVRO EXPZ ALBC YKNY YTHP MNTB YCLH ZNUC YHCG YYBJ YUFO YTRE YYDI
HALSA - Q9HMW0 Q9HMX3 BTUDA Q9HHQ5 Q9HNZ9 Q9HR06 Q9HMX2 Q9HMT3 Q9HRJ6 PSTB2 Q9HMU8 Q9HMG1 Q9HSQ7 Q9HRH8 Q9HMG6 Q9HHM2 PHNC Q9HNY3 PSTB1 Q9HRV7 Q9HRZ9 Y2317 Y1631 Q9HHR7 Q9HR96 Q9HS04 Q9HR21 Q9HQA8 Q9HT03 Q9HMC1 Q9HMW1
SULSO - Q97UF2 Q97UJ9 Q97YY4 Q7LX64 Q97UY8 Q97ZC0 Q97VF5 Q97UH3 Q97VC1 Q97VK9 Q97YP3 Q97VK8 Q97VH6 Q97YP7 Q97YP8 Q97X18 Q97VF4 Q97YK2 Q980W0 Q97UD4 Q97YQ7 Q97Z03 Q97U54 PSTB Q97UH4 Q97W42 Q97V01 Q7LXM4 Q97V00 Q7LY07 Y2030 Y1893 Q97VM2 Q97VY4 Q7LX80 Q97Z56 Q97UG5 Q97YP4 Q97Z96 Q97UC2 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_Q	46_D	4.906	1.00
31_K	34_I	3.570	1.00
32_E	84_Q	3.448	1.00
42_L	45_K	3.344	1.00
120_H	163_D	3.111	1.00
55_E	234_R	2.955	1.00
229_M	250_D	2.917	1.00
36_E	73_L	2.892	1.00
121_M	129_F	2.828	1.00
347_P	351_D	2.800	1.00
36_E	81_T	2.747	1.00
71_V	221_I	2.583	1.00
30_S	50_A	2.450	1.00
34_I	80_P	2.440	1.00
338_G	342_A	2.246	1.00
31_K	49_L	2.205	1.00
118_M	121_M	2.199	1.00
35_L	82_R	2.143	1.00
347_P	350_V	2.134	1.00
340_D	344_I	2.121	1.00
45_K	242_E	2.096	1.00
58_V	232_G	2.064	1.00
335_Q	338_G	2.059	1.00
342_A	346_A	1.917	1.00
37_K	81_T	1.874	1.00
33_Q	48_S	1.839	1.00
307_D	313_V	1.793	1.00
328_S	331_T	1.778	1.00
51_I	57_F	1.776	1.00
297_R	301_K	1.754	1.00
344_I	348_L	1.736	1.00
297_R	300_L	1.734	1.00
248_T	251_E	1.734	1.00
57_F	236_A	1.723	1.00
37_K	42_L	1.696	1.00
309_E	312_Y	1.690	1.00
58_V	228_A	1.671	1.00
247_G	251_E	1.665	1.00
73_L	80_P	1.664	1.00
73_L	85_V	1.655	1.00
295_G	299_A	1.641	1.00
35_L	46_D	1.637	1.00
336_Q	340_D	1.636	1.00
75_N	187_L	1.616	1.00
307_D	314_I	1.613	1.00
207_L	218_I	1.610	1.00
124_L	128_A	1.596	1.00
310_Y	314_I	1.583	1.00
292_P	296_P	1.581	1.00
296_P	300_L	1.573	1.00
348_L	351_D	1.553	1.00
52_E	55_E	1.551	1.00
71_V	187_L	1.549	1.00
300_L	304_Q	1.541	1.00
300_L	307_D	1.540	1.00
287_L	290_K	1.535	1.00
121_M	125_D	1.521	1.00
327_D	330_K	1.517	1.00
122_T	125_D	1.517	1.00
160_S	164_E	1.516	1.00
291_T	294_F	1.508	1.00
126_N	162_P	1.505	1.00
292_P	295_G	1.503	1.00
30_S	86_L	1.494	1.00
320_F	323_A	1.494	1.00
302_L	306_E	1.486	1.00
294_F	297_R	1.480	1.00
307_D	311_G	1.462	1.00
293_G	297_R	1.449	1.00
349_A	353_Q	1.439	1.00
318_N	321_V	1.427	1.00
162_P	173_V	1.425	1.00
109_A	183_P	1.408	1.00
325_S	328_S	1.405	1.00
126_N	177_R	1.394	1.00
316_R	319_K	1.389	1.00
307_D	310_Y	1.374	1.00
49_L	236_A	1.362	1.00
332_A	335_Q	1.354	1.00
290_K	293_G	1.347	1.00
337_Q	341_A	1.336	1.00
32_E	48_S	1.336	1.00
137_N	140_E	1.331	1.00
334_T	338_G	1.325	1.00
330_K	333_L	1.325	1.00
345_D	348_L	1.325	1.00
72_R	78_I	1.310	1.00
298_S	301_K	1.299	1.00
300_L	303_L	1.294	1.00
123_V	165_L	1.290	1.00
32_E	86_L	1.278	1.00
305_D	309_E	1.276	1.00
38_T	43_G	1.270	1.00
124_L	159_H	1.265	1.00
341_A	345_D	1.263	1.00
289_R	292_P	1.257	1.00
332_A	350_V	1.250	1.00
44_V	73_L	1.243	1.00
317_G	321_V	1.242	1.00
34_I	73_L	1.241	1.00
288_I	292_P	1.235	1.00
301_K	304_Q	1.231	1.00
286_G	290_K	1.229	1.00
293_G	296_P	1.228	1.00
27_Q	86_L	1.226	1.00
144_K	147_D	1.225	1.00
36_E	78_I	1.225	1.00
157_Y	160_S	1.224	1.00
289_R	293_G	1.216	1.00
261_V	265_F	1.215	1.00
299_A	307_D	1.215	1.00
327_D	331_T	1.212	1.00
312_Y	316_R	1.210	1.00
313_V	335_Q	1.207	1.00
328_S	332_A	1.206	1.00
309_E	313_V	1.205	1.00
314_I	318_N	1.201	1.00
345_D	349_A	1.201	1.00
311_G	314_I	1.198	1.00
303_L	307_D	1.197	1.00
331_T	335_Q	1.184	1.00
334_T	337_Q	1.165	1.00
72_R	77_L	1.159	1.00
294_F	300_L	1.156	1.00
31_K	74_L	1.151	1.00
187_L	219_V	1.150	1.00
121_M	126_N	1.146	1.00
299_A	303_L	1.144	1.00
35_L	42_L	1.144	1.00
317_G	320_F	1.138	1.00
281_R	284_P	1.136	1.00
228_A	232_G	1.135	1.00
62_L	65_S	1.132	1.00
330_K	334_T	1.126	1.00
208_V	230_R	1.123	1.00
344_I	350_V	1.123	1.00
343_L	347_P	1.114	1.00
308_R	311_G	1.114	1.00
307_D	321_V	1.111	1.00
234_R	245_Q	1.110	1.00
344_I	347_P	1.106	1.00
306_E	310_Y	1.087	1.00
282_R	285_N	1.087	1.00
338_G	341_A	1.086	1.00
259_D	262_R	1.084	1.00
349_A	352_A	1.077	1.00
300_L	306_E	1.076	1.00
284_P	287_L	1.069	1.00
279_I	283_T	1.066	1.00
298_S	302_L	1.065	1.00
220_F	231_I	1.065	1.00
304_Q	307_D	1.064	1.00
321_V	324_V	1.063	1.00
319_K	323_A	1.062	1.00
299_A	302_L	1.058	1.00
304_Q	308_R	1.051	1.00
285_N	288_I	1.050	1.00
340_D	347_P	1.047	1.00
341_A	344_I	1.046	1.00
333_L	337_Q	1.045	1.00
55_E	233_D	1.045	1.00
305_D	308_R	1.044	1.00
323_A	326_I	1.042	1.00
342_A	345_D	1.041	1.00
130_G	177_R	1.040	1.00
337_Q	340_D	1.038	1.00
314_I	317_G	1.037	1.00
292_P	297_R	1.036	1.00
320_F	324_V	1.033	1.00
125_D	128_A	1.021	1.00
161_Y	164_E	1.020	1.00
262_R	266_R	1.020	1.00
143_E	147_D	1.020	1.00
333_L	336_Q	1.016	1.00
148_A	151_Q	1.015	1.00
34_I	85_V	1.014	1.00
119_P	163_D	1.006	1.00
296_P	299_A	1.004	1.00
44_V	47_A	1.003	1.00
73_L	81_T	1.003	1.00
346_A	349_A	0.998	1.00
311_G	315_E	0.997	1.00
117_L	126_N	0.994	1.00
313_V	316_R	0.993	1.00
74_L	219_V	0.982	1.00
36_E	69_T	0.981	1.00
290_K	294_F	0.979	1.00
306_E	314_I	0.978	1.00
253_L	257_A	0.976	1.00
222_S	228_A	0.973	1.00
262_R	265_F	0.973	1.00
314_I	320_F	0.973	1.00
150_R	155_E	0.972	1.00
293_G	300_L	0.960	1.00
343_L	350_V	0.960	1.00
329_L	336_Q	0.957	1.00
329_L	333_L	0.956	1.00
283_T	286_G	0.953	1.00
138_A	141_R	0.951	1.00
122_T	126_N	0.946	1.00
33_Q	82_R	0.942	1.00
65_S	238_M	0.941	1.00
118_M	126_N	0.941	1.00
253_L	256_P	0.941	1.00
29_L	87_I	0.934	1.00
330_K	336_Q	0.930	1.00
291_T	295_G	0.928	1.00
239_Q	242_E	0.926	1.00
124_L	158_A	0.924	1.00
306_E	313_V	0.921	1.00
300_L	314_I	0.920	1.00
237_I	252_I	0.918	1.00
339_L	342_A	0.917	1.00
107_K	181_I	0.913	1.00
294_F	301_K	0.913	1.00
31_K	85_V	0.912	1.00
57_F	219_V	0.910	1.00
250_D	254_N	0.908	1.00
261_V	264_F	0.903	1.00
350_V	353_Q	0.902	1.00
220_F	228_A	0.899	1.00
148_A	176_A	0.891	1.00
220_F	232_G	0.891	1.00
260_Y	264_F	0.886	1.00
292_P	300_L	0.885	1.00
280_A	284_P	0.883	1.00
278_D	281_R	0.880	1.00
335_Q	339_L	0.876	1.00
295_G	302_L	0.874	1.00
287_L	293_G	0.873	1.00
287_L	294_F	0.867	1.00
315_E	318_N	0.866	1.00
109_A	178_A	0.865	1.00
314_I	321_V	0.858	1.00
295_G	300_L	0.855	1.00
137_N	142_R	0.854	1.00
39_G	42_L	0.852	1.00
290_K	295_G	0.847	1.00
60_M	237_I	0.843	1.00
306_E	309_E	0.842	1.00
331_T	334_T	0.840	1.00
197_P	201_T	0.839	1.00
27_Q	30_S	0.839	1.00
318_N	322_G	0.831	1.00
35_L	45_K	0.829	1.00
300_L	320_F	0.828	1.00
326_I	330_K	0.826	1.00
77_L	116_A	0.826	1.00
37_K	40_L	0.820	1.00
298_S	307_D	0.820	1.00
316_R	320_F	0.820	1.00
140_E	143_E	0.820	1.00
315_E	319_K	0.817	1.00
295_G	298_S	0.812	1.00
264_F	268_V	0.811	1.00
295_G	301_K	0.811	1.00
147_D	151_Q	0.804	1.00
59_I	70_M	0.803	1.00
313_V	317_G	0.799	1.00
111_V	171_Q	0.796	1.00
139_E	143_E	0.796	1.00
254_N	257_A	0.794	1.00
220_F	227_E	0.789	1.00
75_N	110_M	0.788	1.00
319_K	322_G	0.788	1.00
146_L	158_A	0.788	1.00
123_V	173_V	0.785	1.00
280_A	283_T	0.785	1.00
348_L	352_A	0.784	1.00
286_G	289_R	0.776	1.00
138_A	142_R	0.776	1.00
300_L	310_Y	0.776	1.00
226_D	230_R	0.775	1.00
38_T	78_I	0.773	1.00
266_R	269_D	0.773	1.00
260_Y	263_T	0.771	1.00
332_A	336_Q	0.766	1.00
339_L	343_L	0.766	1.00
119_P	170_R	0.766	1.00
263_T	267_G	0.763	1.00
136_I	139_E	0.762	1.00
141_R	144_K	0.762	1.00
76_R	79_E	0.759	1.00
74_L	187_L	0.759	1.00
275_S	278_D	0.759	1.00
288_I	291_T	0.758	1.00
302_L	305_D	0.757	1.00
237_I	256_P	0.753	1.00
303_L	306_E	0.753	1.00
26_E	52_E	0.745	1.00
251_E	255_N	0.742	1.00
200_R	224_D	0.741	1.00
300_L	324_V	0.739	1.00
128_A	145_A	0.738	1.00
139_E	142_R	0.733	1.00
300_L	313_V	0.731	1.00
294_F	307_D	0.723	1.00
235_I	249_P	0.722	1.00
259_D	263_T	0.717	1.00
195_L	203_M	0.717	1.00
340_D	350_V	0.711	1.00
183_P	214_H	0.710	1.00
296_P	301_K	0.710	1.00
137_N	141_R	0.707	1.00
126_N	129_F	0.706	1.00
263_T	266_R	0.705	1.00
249_P	252_I	0.704	0.99
207_L	231_I	0.704	0.99
290_K	300_L	0.702	0.99
301_K	305_D	0.700	0.99
326_I	333_L	0.698	0.99
346_A	350_V	0.696	0.99
336_Q	343_L	0.695	0.99
292_P	299_A	0.693	0.99
327_D	332_A	0.692	0.99
290_K	297_R	0.691	0.99
128_A	132_E	0.690	0.99
148_A	180_A	0.688	0.99
293_G	299_A	0.688	0.99
293_G	314_I	0.686	0.99
185_I	219_V	0.686	0.99
267_G	270_I	0.685	0.99
24_Y	106_K	0.682	0.99
296_P	307_D	0.679	0.99
28_G	53_E	0.677	0.99
239_Q	243_V	0.677	0.99
308_R	312_Y	0.673	0.99
261_V	268_V	0.673	0.99
290_K	302_L	0.672	0.99
307_D	320_F	0.670	0.99
343_L	346_A	0.669	0.99
47_A	236_A	0.668	0.99
282_R	287_L	0.665	0.99
288_I	293_G	0.665	0.99
317_G	322_G	0.664	0.99
297_R	307_D	0.662	0.99
291_T	300_L	0.659	0.99
302_L	307_D	0.656	0.99
264_F	267_G	0.656	0.99
288_I	294_F	0.655	0.99
54_G	217_T	0.654	0.99
107_K	184_D	0.650	0.99
288_I	295_G	0.649	0.99
142_R	146_L	0.648	0.99
280_A	285_N	0.647	0.99
147_D	150_R	0.647	0.99
260_Y	265_F	0.647	0.99
279_I	282_R	0.646	0.99
146_L	150_R	0.645	0.99
123_V	162_P	0.644	0.99
290_K	296_P	0.641	0.99
287_L	292_P	0.635	0.99
59_I	236_A	0.635	0.99
287_L	291_T	0.633	0.99
285_N	289_R	0.631	0.99
120_H	161_Y	0.629	0.99
304_Q	324_V	0.629	0.99
53_E	184_D	0.628	0.99
131_M	180_A	0.627	0.99
299_A	304_Q	0.626	0.99
313_V	320_F	0.626	0.99
332_A	347_P	0.624	0.99
57_F	234_R	0.624	0.99
329_L	332_A	0.623	0.99
249_P	253_L	0.622	0.99
222_S	227_E	0.621	0.99
290_K	298_S	0.617	0.99
293_G	303_L	0.616	0.99
289_R	300_L	0.616	0.99
111_V	178_A	0.615	0.99
51_I	217_T	0.611	0.99
336_Q	350_V	0.611	0.99
152_V	176_A	0.608	0.99
252_I	256_P	0.608	0.99
205_D	209_K	0.608	0.99
326_I	329_L	0.605	0.98
221_I	224_D	0.604	0.98
122_T	159_H	0.603	0.98
325_S	330_K	0.603	0.98
108_I	185_I	0.602	0.98
125_D	159_H	0.602	0.98
259_D	264_F	0.599	0.98
190_E	223_H	0.598	0.98
314_I	324_V	0.598	0.98
312_Y	315_E	0.597	0.98
242_E	246_V	0.592	0.98
325_S	332_A	0.589	0.98
76_R	87_I	0.589	0.98
124_L	142_R	0.588	0.98
70_M	238_M	0.586	0.98
238_M	243_V	0.585	0.98
290_K	303_L	0.584	0.98
309_E	316_R	0.581	0.98
329_L	347_P	0.580	0.98
246_V	255_N	0.577	0.98
303_L	310_Y	0.577	0.98
146_L	154_L	0.576	0.98
291_T	297_R	0.576	0.98
294_F	298_S	0.575	0.98
251_E	254_N	0.573	0.98
296_P	304_Q	0.572	0.98
276_A	280_A	0.571	0.98
25_I	28_G	0.571	0.98
283_T	287_L	0.570	0.98
157_Y	169_M	0.570	0.98
328_S	335_Q	0.569	0.98
36_E	44_V	0.568	0.98
261_V	267_G	0.567	0.98
80_P	85_V	0.566	0.98
297_R	314_I	0.566	0.98
124_L	145_A	0.566	0.98
123_V	129_F	0.564	0.98
295_G	307_D	0.564	0.98
277_K	281_R	0.563	0.98
128_A	142_R	0.559	0.97
344_I	351_D	0.559	0.97
28_G	217_T	0.559	0.97
307_D	324_V	0.558	0.97
241_G	246_V	0.556	0.97
289_R	294_F	0.554	0.97
287_L	295_G	0.553	0.97
299_A	313_V	0.552	0.97
186_L	216_R	0.546	0.97
340_D	343_L	0.546	0.97
279_I	284_P	0.545	0.97
152_V	169_M	0.544	0.97
285_N	290_K	0.543	0.97
122_T	161_Y	0.541	0.97
299_A	317_G	0.540	0.97
301_K	314_I	0.539	0.97
303_L	324_V	0.538	0.97
326_I	332_A	0.534	0.97
278_D	284_P	0.533	0.97
112_F	115_F	0.533	0.97
129_F	132_E	0.533	0.97
297_R	302_L	0.529	0.97
46_D	82_R	0.529	0.97
243_V	246_V	0.529	0.97
306_E	346_A	0.529	0.97
29_L	185_I	0.527	0.96
324_V	327_D	0.526	0.96
172_R	195_L	0.525	0.96
127_T	131_M	0.525	0.96
34_I	44_V	0.523	0.96
28_G	88_D	0.522	0.96
127_T	134_A	0.521	0.96
310_Y	313_V	0.521	0.96
274_F	277_K	0.520	0.96
75_N	108_I	0.518	0.96
73_L	79_E	0.518	0.96
295_G	310_Y	0.517	0.96
127_T	130_G	0.516	0.96
192_F	203_M	0.513	0.96
325_S	350_V	0.512	0.96
291_T	307_D	0.512	0.96
340_D	348_L	0.512	0.96
134_A	137_N	0.511	0.96
56_I	208_V	0.511	0.96
265_F	274_F	0.510	0.96
281_R	285_N	0.510	0.96
307_D	317_G	0.510	0.96
265_F	269_D	0.508	0.96
346_A	351_D	0.508	0.96
266_R	271_S	0.508	0.96
306_E	318_N	0.506	0.96
300_L	317_G	0.505	0.95
126_N	130_G	0.505	0.95
300_L	321_V	0.504	0.95
132_E	138_A	0.504	0.95
149_L	158_A	0.503	0.95
280_A	286_G	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tuiC	2	0.8425	100	0.305	Contact Map
4ry2A	2	0.635	100	0.309	Contact Map
4f4cA	1	0.62	100	0.311	Contact Map
4yerA	2	0.715	100	0.317	Contact Map
4u00A	1	0.5975	100	0.327	Contact Map
1vplA	2	0.595	100	0.328	Contact Map
4q9hA	1	0.6525	100	0.329	Contact Map
4ymuJ	2	0.5925	100	0.329	Contact Map
4mkiB	2	0.69	100	0.331	Contact Map
1oxxK	1	0.865	100	0.332	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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