GREMLIN Database
PROV - Glycine betaine/L-proline transport ATP-binding protein ProV
UniProt: P14175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10771
Length: 400 (314)
Sequences: 8119 (6706)
Seq/√Len: 378.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Q46_D4.9061.00
31_K34_I3.5701.00
32_E84_Q3.4481.00
42_L45_K3.3441.00
120_H163_D3.1111.00
55_E234_R2.9551.00
229_M250_D2.9171.00
36_E73_L2.8921.00
121_M129_F2.8281.00
347_P351_D2.8001.00
36_E81_T2.7471.00
71_V221_I2.5831.00
30_S50_A2.4501.00
34_I80_P2.4401.00
338_G342_A2.2461.00
31_K49_L2.2051.00
118_M121_M2.1991.00
35_L82_R2.1431.00
347_P350_V2.1341.00
340_D344_I2.1211.00
45_K242_E2.0961.00
58_V232_G2.0641.00
335_Q338_G2.0591.00
342_A346_A1.9171.00
37_K81_T1.8741.00
33_Q48_S1.8391.00
307_D313_V1.7931.00
328_S331_T1.7781.00
51_I57_F1.7761.00
297_R301_K1.7541.00
344_I348_L1.7361.00
297_R300_L1.7341.00
248_T251_E1.7341.00
57_F236_A1.7231.00
37_K42_L1.6961.00
309_E312_Y1.6901.00
58_V228_A1.6711.00
247_G251_E1.6651.00
73_L80_P1.6641.00
73_L85_V1.6551.00
295_G299_A1.6411.00
35_L46_D1.6371.00
336_Q340_D1.6361.00
75_N187_L1.6161.00
307_D314_I1.6131.00
207_L218_I1.6101.00
124_L128_A1.5961.00
310_Y314_I1.5831.00
292_P296_P1.5811.00
296_P300_L1.5731.00
348_L351_D1.5531.00
52_E55_E1.5511.00
71_V187_L1.5491.00
300_L304_Q1.5411.00
300_L307_D1.5401.00
287_L290_K1.5351.00
121_M125_D1.5211.00
327_D330_K1.5171.00
122_T125_D1.5171.00
160_S164_E1.5161.00
291_T294_F1.5081.00
126_N162_P1.5051.00
292_P295_G1.5031.00
30_S86_L1.4941.00
320_F323_A1.4941.00
302_L306_E1.4861.00
294_F297_R1.4801.00
307_D311_G1.4621.00
293_G297_R1.4491.00
349_A353_Q1.4391.00
318_N321_V1.4271.00
162_P173_V1.4251.00
109_A183_P1.4081.00
325_S328_S1.4051.00
126_N177_R1.3941.00
316_R319_K1.3891.00
307_D310_Y1.3741.00
49_L236_A1.3621.00
332_A335_Q1.3541.00
290_K293_G1.3471.00
337_Q341_A1.3361.00
32_E48_S1.3361.00
137_N140_E1.3311.00
334_T338_G1.3251.00
330_K333_L1.3251.00
345_D348_L1.3251.00
72_R78_I1.3101.00
298_S301_K1.2991.00
300_L303_L1.2941.00
123_V165_L1.2901.00
32_E86_L1.2781.00
305_D309_E1.2761.00
38_T43_G1.2701.00
124_L159_H1.2651.00
341_A345_D1.2631.00
289_R292_P1.2571.00
332_A350_V1.2501.00
44_V73_L1.2431.00
317_G321_V1.2421.00
34_I73_L1.2411.00
288_I292_P1.2351.00
301_K304_Q1.2311.00
286_G290_K1.2291.00
293_G296_P1.2281.00
27_Q86_L1.2261.00
144_K147_D1.2251.00
36_E78_I1.2251.00
157_Y160_S1.2241.00
289_R293_G1.2161.00
261_V265_F1.2151.00
299_A307_D1.2151.00
327_D331_T1.2121.00
312_Y316_R1.2101.00
313_V335_Q1.2071.00
328_S332_A1.2061.00
309_E313_V1.2051.00
314_I318_N1.2011.00
345_D349_A1.2011.00
311_G314_I1.1981.00
303_L307_D1.1971.00
331_T335_Q1.1841.00
334_T337_Q1.1651.00
72_R77_L1.1591.00
294_F300_L1.1561.00
31_K74_L1.1511.00
187_L219_V1.1501.00
121_M126_N1.1461.00
299_A303_L1.1441.00
35_L42_L1.1441.00
317_G320_F1.1381.00
281_R284_P1.1361.00
228_A232_G1.1351.00
62_L65_S1.1321.00
330_K334_T1.1261.00
208_V230_R1.1231.00
344_I350_V1.1231.00
343_L347_P1.1141.00
308_R311_G1.1141.00
307_D321_V1.1111.00
234_R245_Q1.1101.00
344_I347_P1.1061.00
306_E310_Y1.0871.00
282_R285_N1.0871.00
338_G341_A1.0861.00
259_D262_R1.0841.00
349_A352_A1.0771.00
300_L306_E1.0761.00
284_P287_L1.0691.00
279_I283_T1.0661.00
298_S302_L1.0651.00
220_F231_I1.0651.00
304_Q307_D1.0641.00
321_V324_V1.0631.00
319_K323_A1.0621.00
299_A302_L1.0581.00
304_Q308_R1.0511.00
285_N288_I1.0501.00
340_D347_P1.0471.00
341_A344_I1.0461.00
333_L337_Q1.0451.00
55_E233_D1.0451.00
305_D308_R1.0441.00
323_A326_I1.0421.00
342_A345_D1.0411.00
130_G177_R1.0401.00
337_Q340_D1.0381.00
314_I317_G1.0371.00
292_P297_R1.0361.00
320_F324_V1.0331.00
125_D128_A1.0211.00
161_Y164_E1.0201.00
262_R266_R1.0201.00
143_E147_D1.0201.00
333_L336_Q1.0161.00
148_A151_Q1.0151.00
34_I85_V1.0141.00
119_P163_D1.0061.00
296_P299_A1.0041.00
44_V47_A1.0031.00
73_L81_T1.0031.00
346_A349_A0.9981.00
311_G315_E0.9971.00
117_L126_N0.9941.00
313_V316_R0.9931.00
74_L219_V0.9821.00
36_E69_T0.9811.00
290_K294_F0.9791.00
306_E314_I0.9781.00
253_L257_A0.9761.00
222_S228_A0.9731.00
262_R265_F0.9731.00
314_I320_F0.9731.00
150_R155_E0.9721.00
293_G300_L0.9601.00
343_L350_V0.9601.00
329_L336_Q0.9571.00
329_L333_L0.9561.00
283_T286_G0.9531.00
138_A141_R0.9511.00
122_T126_N0.9461.00
33_Q82_R0.9421.00
65_S238_M0.9411.00
118_M126_N0.9411.00
253_L256_P0.9411.00
29_L87_I0.9341.00
330_K336_Q0.9301.00
291_T295_G0.9281.00
239_Q242_E0.9261.00
124_L158_A0.9241.00
306_E313_V0.9211.00
300_L314_I0.9201.00
237_I252_I0.9181.00
339_L342_A0.9171.00
107_K181_I0.9131.00
294_F301_K0.9131.00
31_K85_V0.9121.00
57_F219_V0.9101.00
250_D254_N0.9081.00
261_V264_F0.9031.00
350_V353_Q0.9021.00
220_F228_A0.8991.00
148_A176_A0.8911.00
220_F232_G0.8911.00
260_Y264_F0.8861.00
292_P300_L0.8851.00
280_A284_P0.8831.00
278_D281_R0.8801.00
335_Q339_L0.8761.00
295_G302_L0.8741.00
287_L293_G0.8731.00
287_L294_F0.8671.00
315_E318_N0.8661.00
109_A178_A0.8651.00
314_I321_V0.8581.00
295_G300_L0.8551.00
137_N142_R0.8541.00
39_G42_L0.8521.00
290_K295_G0.8471.00
60_M237_I0.8431.00
306_E309_E0.8421.00
331_T334_T0.8401.00
197_P201_T0.8391.00
27_Q30_S0.8391.00
318_N322_G0.8311.00
35_L45_K0.8291.00
300_L320_F0.8281.00
326_I330_K0.8261.00
77_L116_A0.8261.00
37_K40_L0.8201.00
298_S307_D0.8201.00
316_R320_F0.8201.00
140_E143_E0.8201.00
315_E319_K0.8171.00
295_G298_S0.8121.00
264_F268_V0.8111.00
295_G301_K0.8111.00
147_D151_Q0.8041.00
59_I70_M0.8031.00
313_V317_G0.7991.00
111_V171_Q0.7961.00
139_E143_E0.7961.00
254_N257_A0.7941.00
220_F227_E0.7891.00
75_N110_M0.7881.00
319_K322_G0.7881.00
146_L158_A0.7881.00
123_V173_V0.7851.00
280_A283_T0.7851.00
348_L352_A0.7841.00
286_G289_R0.7761.00
138_A142_R0.7761.00
300_L310_Y0.7761.00
226_D230_R0.7751.00
38_T78_I0.7731.00
266_R269_D0.7731.00
260_Y263_T0.7711.00
332_A336_Q0.7661.00
339_L343_L0.7661.00
119_P170_R0.7661.00
263_T267_G0.7631.00
136_I139_E0.7621.00
141_R144_K0.7621.00
76_R79_E0.7591.00
74_L187_L0.7591.00
275_S278_D0.7591.00
288_I291_T0.7581.00
302_L305_D0.7571.00
237_I256_P0.7531.00
303_L306_E0.7531.00
26_E52_E0.7451.00
251_E255_N0.7421.00
200_R224_D0.7411.00
300_L324_V0.7391.00
128_A145_A0.7381.00
139_E142_R0.7331.00
300_L313_V0.7311.00
294_F307_D0.7231.00
235_I249_P0.7221.00
259_D263_T0.7171.00
195_L203_M0.7171.00
340_D350_V0.7111.00
183_P214_H0.7101.00
296_P301_K0.7101.00
137_N141_R0.7071.00
126_N129_F0.7061.00
263_T266_R0.7051.00
249_P252_I0.7040.99
207_L231_I0.7040.99
290_K300_L0.7020.99
301_K305_D0.7000.99
326_I333_L0.6980.99
346_A350_V0.6960.99
336_Q343_L0.6950.99
292_P299_A0.6930.99
327_D332_A0.6920.99
290_K297_R0.6910.99
128_A132_E0.6900.99
148_A180_A0.6880.99
293_G299_A0.6880.99
293_G314_I0.6860.99
185_I219_V0.6860.99
267_G270_I0.6850.99
24_Y106_K0.6820.99
296_P307_D0.6790.99
28_G53_E0.6770.99
239_Q243_V0.6770.99
308_R312_Y0.6730.99
261_V268_V0.6730.99
290_K302_L0.6720.99
307_D320_F0.6700.99
343_L346_A0.6690.99
47_A236_A0.6680.99
282_R287_L0.6650.99
288_I293_G0.6650.99
317_G322_G0.6640.99
297_R307_D0.6620.99
291_T300_L0.6590.99
302_L307_D0.6560.99
264_F267_G0.6560.99
288_I294_F0.6550.99
54_G217_T0.6540.99
107_K184_D0.6500.99
288_I295_G0.6490.99
142_R146_L0.6480.99
280_A285_N0.6470.99
147_D150_R0.6470.99
260_Y265_F0.6470.99
279_I282_R0.6460.99
146_L150_R0.6450.99
123_V162_P0.6440.99
290_K296_P0.6410.99
287_L292_P0.6350.99
59_I236_A0.6350.99
287_L291_T0.6330.99
285_N289_R0.6310.99
120_H161_Y0.6290.99
304_Q324_V0.6290.99
53_E184_D0.6280.99
131_M180_A0.6270.99
299_A304_Q0.6260.99
313_V320_F0.6260.99
332_A347_P0.6240.99
57_F234_R0.6240.99
329_L332_A0.6230.99
249_P253_L0.6220.99
222_S227_E0.6210.99
290_K298_S0.6170.99
293_G303_L0.6160.99
289_R300_L0.6160.99
111_V178_A0.6150.99
51_I217_T0.6110.99
336_Q350_V0.6110.99
152_V176_A0.6080.99
252_I256_P0.6080.99
205_D209_K0.6080.99
326_I329_L0.6050.98
221_I224_D0.6040.98
122_T159_H0.6030.98
325_S330_K0.6030.98
108_I185_I0.6020.98
125_D159_H0.6020.98
259_D264_F0.5990.98
190_E223_H0.5980.98
314_I324_V0.5980.98
312_Y315_E0.5970.98
242_E246_V0.5920.98
325_S332_A0.5890.98
76_R87_I0.5890.98
124_L142_R0.5880.98
70_M238_M0.5860.98
238_M243_V0.5850.98
290_K303_L0.5840.98
309_E316_R0.5810.98
329_L347_P0.5800.98
246_V255_N0.5770.98
303_L310_Y0.5770.98
146_L154_L0.5760.98
291_T297_R0.5760.98
294_F298_S0.5750.98
251_E254_N0.5730.98
296_P304_Q0.5720.98
276_A280_A0.5710.98
25_I28_G0.5710.98
283_T287_L0.5700.98
157_Y169_M0.5700.98
328_S335_Q0.5690.98
36_E44_V0.5680.98
261_V267_G0.5670.98
80_P85_V0.5660.98
297_R314_I0.5660.98
124_L145_A0.5660.98
123_V129_F0.5640.98
295_G307_D0.5640.98
277_K281_R0.5630.98
128_A142_R0.5590.97
344_I351_D0.5590.97
28_G217_T0.5590.97
307_D324_V0.5580.97
241_G246_V0.5560.97
289_R294_F0.5540.97
287_L295_G0.5530.97
299_A313_V0.5520.97
186_L216_R0.5460.97
340_D343_L0.5460.97
279_I284_P0.5450.97
152_V169_M0.5440.97
285_N290_K0.5430.97
122_T161_Y0.5410.97
299_A317_G0.5400.97
301_K314_I0.5390.97
303_L324_V0.5380.97
326_I332_A0.5340.97
278_D284_P0.5330.97
112_F115_F0.5330.97
129_F132_E0.5330.97
297_R302_L0.5290.97
46_D82_R0.5290.97
243_V246_V0.5290.97
306_E346_A0.5290.97
29_L185_I0.5270.96
324_V327_D0.5260.96
172_R195_L0.5250.96
127_T131_M0.5250.96
34_I44_V0.5230.96
28_G88_D0.5220.96
127_T134_A0.5210.96
310_Y313_V0.5210.96
274_F277_K0.5200.96
75_N108_I0.5180.96
73_L79_E0.5180.96
295_G310_Y0.5170.96
127_T130_G0.5160.96
192_F203_M0.5130.96
325_S350_V0.5120.96
291_T307_D0.5120.96
340_D348_L0.5120.96
134_A137_N0.5110.96
56_I208_V0.5110.96
265_F274_F0.5100.96
281_R285_N0.5100.96
307_D317_G0.5100.96
265_F269_D0.5080.96
346_A351_D0.5080.96
266_R271_S0.5080.96
306_E318_N0.5060.96
300_L317_G0.5050.95
126_N130_G0.5050.95
300_L321_V0.5040.95
132_E138_A0.5040.95
149_L158_A0.5030.95
280_A286_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.8425 100 0.305 Contact Map
4ry2A 2 0.635 100 0.309 Contact Map
4f4cA 1 0.62 100 0.311 Contact Map
4yerA 2 0.715 100 0.317 Contact Map
4u00A 1 0.5975 100 0.327 Contact Map
1vplA 2 0.595 100 0.328 Contact Map
4q9hA 1 0.6525 100 0.329 Contact Map
4ymuJ 2 0.5925 100 0.329 Contact Map
4mkiB 2 0.69 100 0.331 Contact Map
1oxxK 1 0.865 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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