GREMLIN Database
MNGR - Mannosyl-D-glycerate transport/metabolism system repressor MngR
UniProt: P13669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11109
Length: 240 (195)
Sequences: 19896 (15359)
Seq/√Len: 1099.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K27_D4.0551.00
17_Q22_E3.8051.00
15_R56_Q3.3111.00
11_A52_Q3.0201.00
17_Q38_E3.0121.00
60_E70_K2.9591.00
121_D181_I2.6481.00
62_I65_S2.6251.00
10_I41_V2.5181.00
128_R174_D2.4161.00
13_R17_Q2.3851.00
32_E43_R2.3121.00
28_A68_Y2.2721.00
61_S67_T2.2251.00
184_M187_E2.1651.00
10_I39_F2.1551.00
65_S68_Y2.1061.00
16_E20_R2.0951.00
106_P189_M2.0741.00
13_R39_F2.0711.00
11_A56_Q2.0671.00
11_A15_R1.8621.00
54_V61_S1.8581.00
15_R19_A1.7961.00
48_Q51_R1.7811.00
187_E191_R1.7571.00
15_R58_I1.7561.00
125_H141_E1.6931.00
50_L59_L1.6771.00
116_Q153_T1.6541.00
186_T189_M1.6321.00
34_A38_E1.6161.00
112_Q117_I1.6151.00
111_L143_W1.6131.00
59_L67_T1.5661.00
127_K141_E1.5641.00
6_L9_Q1.5621.00
17_Q23_L1.5581.00
54_V59_L1.5221.00
13_R16_E1.5211.00
108_D111_L1.5021.00
9_Q13_R1.4981.00
96_H131_Y1.4921.00
25_P71_E1.4421.00
33_S37_T1.4351.00
35_L46_V1.4251.00
32_E47_R1.4241.00
133_K136_P1.4061.00
34_A37_T1.3871.00
41_V46_V1.3861.00
31_T34_A1.3781.00
51_R61_S1.3681.00
51_R55_E1.3421.00
17_Q21_G1.3331.00
110_F185_P1.3161.00
123_V140_E1.3131.00
189_M193_L1.2991.00
18_I69_V1.2761.00
117_I181_I1.2761.00
60_E68_Y1.2741.00
113_Q116_Q1.2681.00
163_H167_E1.2591.00
98_E131_Y1.2471.00
7_Y52_Q1.2431.00
128_R170_K1.2301.00
118_T121_D1.2271.00
5_P8_R1.2191.00
179_E187_E1.2141.00
99_V103_E1.2021.00
139_L189_M1.1931.00
23_L69_V1.1831.00
112_Q183_L1.1781.00
147_A150_P1.1761.00
127_K188_E1.1661.00
19_A58_I1.1661.00
196_S199_K1.1631.00
105_I125_H1.1571.00
28_A66_G1.1511.00
104_V122_R1.1311.00
126_V143_W1.1271.00
185_P195_I1.1191.00
51_R54_V1.0991.00
52_Q56_Q1.0951.00
104_V146_L1.0921.00
62_I68_Y1.0891.00
123_V143_W1.0831.00
62_I66_G1.0821.00
52_Q55_E1.0821.00
150_P158_E1.0701.00
92_H95_T1.0611.00
177_E181_I1.0481.00
48_Q52_Q1.0461.00
119_P147_A1.0421.00
130_R140_E1.0391.00
146_L150_P1.0351.00
107_A111_L1.0331.00
92_H155_Q1.0261.00
178_Q182_P1.0201.00
17_Q39_F1.0191.00
98_E102_F1.0111.00
121_D177_E1.0101.00
6_L45_T1.0011.00
12_D15_R0.9931.00
86_E90_D0.9851.00
182_P187_E0.9841.00
14_I35_L0.9811.00
92_H96_H0.9811.00
23_L27_D0.9801.00
117_I121_D0.9721.00
122_R126_V0.9521.00
8_R12_D0.9461.00
26_G60_E0.9431.00
50_L67_T0.9361.00
8_R52_Q0.9241.00
126_V140_E0.9211.00
174_D178_Q0.9211.00
101_I125_H0.9201.00
95_T111_L0.9171.00
145_P148_L0.9121.00
195_I199_K0.9021.00
10_I46_V0.8991.00
106_P185_P0.8871.00
106_P186_T0.8831.00
184_M199_K0.8751.00
165_I168_V0.8751.00
190_S194_N0.8671.00
117_I177_E0.8661.00
101_I127_K0.8521.00
121_D125_H0.8511.00
112_Q116_Q0.8461.00
64_G67_T0.8461.00
120_Q147_A0.8431.00
50_L54_V0.8311.00
117_I183_L0.8311.00
152_L158_E0.8291.00
7_Y11_A0.8271.00
187_E190_S0.8261.00
106_P122_R0.8251.00
93_V96_H0.8141.00
119_P150_P0.8061.00
13_R38_E0.8061.00
144_M177_E0.8051.00
126_V130_R0.8041.00
105_I111_L0.8031.00
143_W147_A0.8031.00
119_P123_V0.7981.00
164_F168_V0.7981.00
10_I13_R0.7931.00
136_P139_L0.7891.00
98_E193_L0.7871.00
124_W177_E0.7851.00
87_K91_R0.7801.00
36_Q46_V0.7761.00
14_I23_L0.7741.00
12_D16_E0.7701.00
127_K139_L0.7681.00
103_E106_P0.7681.00
105_I109_D0.7641.00
112_Q120_Q0.7621.00
121_D147_A0.7591.00
147_A151_D0.7591.00
192_L195_I0.7521.00
7_Y48_Q0.7511.00
29_L59_L0.7511.00
124_W174_D0.7501.00
107_A123_V0.7471.00
125_H143_W0.7451.00
30_P38_E0.7381.00
162_Y166_E0.7371.00
160_S164_F0.7351.00
25_P70_K0.7331.00
141_E145_P0.7321.00
26_G71_E0.7311.00
185_P189_M0.7311.00
84_F88_L0.7271.00
88_L132_R0.7271.00
42_S45_T0.7261.00
17_Q20_R0.7251.00
125_H128_R0.7251.00
86_E89_S0.7221.00
102_F193_L0.7221.00
183_L189_M0.7211.00
126_V129_V0.7211.00
188_E192_L0.7161.00
50_L61_S0.7121.00
139_L143_W0.7111.00
100_L129_V0.7091.00
123_V147_A0.7091.00
119_P122_R0.7041.00
32_E61_S0.7021.00
97_S130_R0.7011.00
186_T190_S0.6971.00
99_V157_M0.6961.00
170_K174_D0.6951.00
112_Q151_D0.6921.00
121_D174_D0.6871.00
129_V136_P0.6861.00
111_L115_L0.6861.00
156_V159_N0.6861.00
109_D119_P0.6831.00
163_H166_E0.6811.00
171_M175_R0.6801.00
28_A31_T0.6751.00
28_A65_S0.6691.00
162_Y165_I0.6681.00
39_F46_V0.6651.00
37_T40_G0.6601.00
89_S92_H0.6551.00
16_E19_A0.6551.00
103_E107_A0.6521.00
89_S95_T0.6421.00
102_F189_M0.6401.00
164_F169_K0.6351.00
120_Q123_V0.6351.00
35_L39_F0.6341.00
85_D89_S0.6321.00
36_Q39_F0.6251.00
97_S101_I0.6221.00
93_V133_K0.6181.00
145_P173_I0.6181.00
125_H129_V0.6181.00
77_D80_Q0.6151.00
103_E189_M0.6111.00
115_L120_Q0.6091.00
176_S191_R0.6061.00
122_R146_L0.6051.00
96_H134_Q0.6051.00
102_F106_P0.6021.00
23_L29_L0.6021.00
114_Q183_L0.6001.00
33_S36_Q0.5991.00
153_T156_V0.5981.00
105_I108_D0.5971.00
35_L50_L0.5961.00
160_S165_I0.5921.00
126_V136_P0.5911.00
89_S94_D0.5911.00
104_V149_F0.5861.00
104_V124_W0.5851.00
44_V48_Q0.5801.00
103_E125_H0.5801.00
36_Q43_R0.5781.00
136_P140_E0.5761.00
139_L192_L0.5761.00
192_L196_S0.5761.00
45_T48_Q0.5721.00
102_F105_I0.5711.00
101_I105_I0.5671.00
105_I143_W0.5641.00
107_A112_Q0.5621.00
102_F153_T0.5611.00
109_D112_Q0.5541.00
22_E38_E0.5531.00
23_L30_P0.5531.00
123_V126_V0.5521.00
164_F167_E0.5511.00
54_V67_T0.5511.00
31_T46_V0.5501.00
124_W128_R0.5491.00
107_A117_I0.5481.00
178_Q181_I0.5481.00
175_R187_E0.5471.00
46_V49_A0.5471.00
76_Y80_Q0.5471.00
149_F165_I0.5461.00
85_D88_L0.5441.00
108_D143_W0.5431.00
148_L180_I0.5411.00
144_M161_K0.5341.00
112_Q119_P0.5301.00
46_V59_L0.5291.00
141_E189_M0.5261.00
190_S197_Q0.5251.00
8_R11_A0.5231.00
33_S43_R0.5211.00
166_E172_V0.5181.00
118_T122_R0.5161.00
98_E197_Q0.5161.00
57_Q70_K0.5151.00
11_A49_A0.5131.00
115_L119_P0.5111.00
99_V102_F0.5111.00
98_E129_V0.5091.00
116_Q151_D0.5091.00
109_D113_Q0.5091.00
115_L123_V0.5081.00
36_Q44_V0.5071.00
83_S87_K0.5051.00
160_S163_H0.5031.00
120_Q151_D0.5021.00
10_I14_I0.5021.00
116_Q119_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9875 100 0.132 Contact Map
3f8mA 2 0.9542 100 0.157 Contact Map
3edpA 2 0.9125 100 0.165 Contact Map
2ra5A 2 0.6167 100 0.167 Contact Map
3eetA 2 0.9583 100 0.169 Contact Map
3bwgA 2 0.95 100 0.192 Contact Map
3f8lA 2 0.6792 100 0.434 Contact Map
1hw1A 2 0.8083 99.9 0.506 Contact Map
4p96A 2 0.8917 99.9 0.526 Contact Map
2di3A 2 0.8292 99.9 0.527 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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