CSRD - ECOLI - GREMLIN Contacts

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CSRD - RNase E specificity factor CsrD

UniProt:	P13518	Sequences: MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSVLRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDNQLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDTEQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAVTREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENLAIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALGVRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10018
Length:	646 (503)
Sequences:	9470 (7516)
Seq/√Len:	335.1

ECOLI - CSRD YEGE YHJK DOSP YLIE YFGF YFEA GMR YLAB RTN YJCC YCGG ADRB BLUF YAHA
BACSU - YKOW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
429_R	636_N	4.813	1.00
222_S	226_Q	3.862	1.00
570_P	574_R	3.847	1.00
466_S	504_Q	3.828	1.00
628_A	631_Q	3.696	1.00
462_R	497_W	3.516	1.00
499_R	539_L	3.503	1.00
537_N	564_E	3.468	1.00
296_Y	299_A	3.391	1.00
461_D	488_S	3.385	1.00
413_R	436_F	3.257	1.00
395_G	446_E	3.232	1.00
605_V	622_G	3.033	1.00
594_S	620_T	2.935	1.00
416_Q	471_L	2.899	1.00
608_R	612_Q	2.776	1.00
473_R	477_E	2.702	1.00
437_D	440_E	2.597	1.00
402_L	437_D	2.574	1.00
238_F	310_A	2.540	1.00
359_D	362_Q	2.533	1.00
467_R	470_P	2.510	1.00
514_I	565_L	2.507	1.00
259_M	349_I	2.478	1.00
476_P	512_R	2.462	1.00
613_T	617_R	2.440	1.00
501_T	505_C	2.386	1.00
559_K	582_N	2.321	1.00
484_V	494_F	2.284	1.00
471_L	633_L	2.270	1.00
433_C	464_Q	2.206	1.00
213_H	217_D	2.184	1.00
544_A	565_L	2.169	1.00
415_Y	632_P	2.164	1.00
611_W	627_F	2.157	1.00
451_V	460_Y	2.144	1.00
420_V	627_F	2.124	1.00
280_E	283_F	2.028	1.00
533_I	543_V	2.015	1.00
472_L	508_S	2.013	1.00
611_W	622_G	1.986	1.00
471_L	475_W	1.981	1.00
463_L	467_R	1.979	1.00
632_P	635_T	1.969	1.00
187_T	191_W	1.955	1.00
436_F	441_E	1.944	1.00
259_M	325_A	1.937	1.00
587_Q	595_G	1.916	1.00
242_L	360_T	1.901	1.00
257_I	353_A	1.879	1.00
466_S	505_C	1.877	1.00
413_R	441_E	1.865	1.00
469_I	501_T	1.864	1.00
410_G	467_R	1.862	1.00
577_E	583_Q	1.852	1.00
467_R	471_L	1.824	1.00
405_Q	409_R	1.806	1.00
412_P	433_C	1.806	1.00
233_N	237_F	1.800	1.00
611_W	615_I	1.792	1.00
583_Q	613_T	1.782	1.00
414_L	464_Q	1.779	1.00
414_L	463_L	1.778	1.00
377_Q	383_A	1.763	1.00
587_Q	617_R	1.761	1.00
577_E	609_S	1.752	1.00
590_V	617_R	1.743	1.00
625_D	630_S	1.717	1.00
214_S	217_D	1.713	1.00
374_A	383_A	1.711	1.00
542_R	564_E	1.694	1.00
466_S	501_T	1.680	1.00
433_C	460_Y	1.679	1.00
607_S	610_E	1.678	1.00
325_A	351_I	1.673	1.00
611_W	626_F	1.665	1.00
419_A	565_L	1.665	1.00
419_A	621_G	1.660	1.00
415_Y	441_E	1.652	1.00
284_T	336_P	1.646	1.00
317_T	320_E	1.635	1.00
509_Q	512_R	1.623	1.00
280_E	339_K	1.611	1.00
357_G	366_H	1.603	1.00
559_K	575_N	1.602	1.00
293_M	301_L	1.600	1.00
284_T	287_N	1.598	1.00
608_R	626_F	1.597	1.00
396_N	453_Q	1.589	1.00
241_Q	300_L	1.580	1.00
222_S	231_G	1.566	1.00
205_E	209_A	1.565	1.00
565_L	601_Y	1.561	1.00
237_F	241_Q	1.559	1.00
313_L	324_I	1.559	1.00
411_G	437_D	1.554	1.00
265_D	379_G	1.554	1.00
475_W	633_L	1.544	1.00
184_V	192_P	1.541	1.00
599_Q	620_T	1.539	1.00
337_N	342_D	1.538	1.00
476_P	509_Q	1.535	1.00
261_I	347_I	1.520	1.00
257_I	321_A	1.500	1.00
172_A	175_I	1.500	1.00
577_E	613_T	1.496	1.00
168_L	171_R	1.493	1.00
419_A	428_H	1.485	1.00
426_V	639_K	1.478	1.00
287_N	290_S	1.458	1.00
419_A	514_I	1.452	1.00
502_L	541_V	1.441	1.00
219_L	223_Y	1.428	1.00
599_Q	621_G	1.423	1.00
182_S	202_L	1.417	1.00
281_Q	345_D	1.406	1.00
433_C	463_L	1.396	1.00
405_Q	411_G	1.395	1.00
472_L	480_L	1.378	1.00
285_L	332_V	1.377	1.00
484_V	515_I	1.374	1.00
199_L	203_L	1.373	1.00
478_E	637_V	1.369	1.00
264_P	348_H	1.368	1.00
545_V	563_V	1.367	1.00
498_L	536_V	1.365	1.00
486_V	520_A	1.363	1.00
631_Q	639_K	1.362	1.00
241_Q	244_T	1.361	1.00
427_H	621_G	1.355	1.00
322_E	384_I	1.350	1.00
563_V	598_T	1.340	1.00
576_I	613_T	1.337	1.00
635_T	638_K	1.325	1.00
514_I	544_A	1.324	1.00
332_V	347_I	1.323	1.00
399_W	450_M	1.322	1.00
414_L	468_L	1.309	1.00
590_V	619_V	1.307	1.00
499_R	535_L	1.306	1.00
337_N	340_M	1.305	1.00
270_S	278_V	1.304	1.00
168_L	172_A	1.301	1.00
237_F	300_L	1.296	1.00
468_L	480_L	1.292	1.00
321_A	325_A	1.284	1.00
612_Q	616_Q	1.282	1.00
211_E	214_S	1.280	1.00
158_L	162_L	1.277	1.00
263_L	285_L	1.277	1.00
566_L	593_C	1.275	1.00
612_Q	615_I	1.268	1.00
212_Q	215_R	1.267	1.00
565_L	599_Q	1.266	1.00
608_R	611_W	1.258	1.00
169_E	173_T	1.247	1.00
445_A	570_P	1.247	1.00
631_Q	635_T	1.245	1.00
326_G	330_K	1.244	1.00
225_A	236_L	1.242	1.00
497_W	501_T	1.240	1.00
351_I	384_I	1.238	1.00
354_W	363_V	1.236	1.00
322_E	326_G	1.235	1.00
530_Q	534_R	1.232	1.00
474_Y	478_E	1.230	1.00
472_L	476_P	1.226	1.00
374_A	381_S	1.226	1.00
221_R	225_A	1.225	1.00
329_I	349_I	1.225	1.00
411_G	435_I	1.222	1.00
622_G	627_F	1.221	1.00
500_D	504_Q	1.216	1.00
471_L	474_Y	1.214	1.00
593_C	600_V	1.214	1.00
198_A	201_T	1.199	1.00
245_L	256_G	1.194	1.00
238_F	302_A	1.193	1.00
414_L	433_C	1.185	1.00
176_L	179_E	1.180	1.00
587_Q	591_E	1.180	1.00
304_Y	310_A	1.173	1.00
260_M	371_T	1.173	1.00
356_S	384_I	1.172	1.00
260_M	310_A	1.172	1.00
421_T	425_Q	1.168	1.00
159_Q	162_L	1.165	1.00
470_P	505_C	1.161	1.00
373_N	376_L	1.159	1.00
206_I	209_A	1.159	1.00
284_T	288_L	1.158	1.00
213_H	216_L	1.155	1.00
268_M	400_R	1.154	1.00
373_N	383_A	1.149	1.00
289_L	301_L	1.143	1.00
265_D	268_M	1.143	1.00
437_D	442_V	1.142	1.00
628_A	639_K	1.142	1.00
468_L	482_I	1.132	1.00
331_A	334_T	1.131	1.00
494_F	498_L	1.124	1.00
403_I	412_P	1.122	1.00
419_A	601_Y	1.122	1.00
570_P	604_G	1.120	1.00
281_Q	336_P	1.115	1.00
502_L	510_R	1.113	1.00
419_A	481_A	1.110	1.00
215_R	219_L	1.105	1.00
248_D	314_P	1.104	1.00
219_L	222_S	1.104	1.00
476_P	479_N	1.095	1.00
469_I	513_I	1.090	1.00
602_A	619_V	1.087	1.00
333_D	380_N	1.083	1.00
473_R	505_C	1.081	1.00
495_Q	532_V	1.081	1.00
280_E	284_T	1.072	1.00
186_G	192_P	1.071	1.00
411_G	438_G	1.070	1.00
195_T	199_L	1.065	1.00
238_F	312_L	1.061	1.00
154_A	157_W	1.056	1.00
448_M	457_S	1.056	1.00
499_R	503_M	1.055	1.00
565_L	621_G	1.055	1.00
182_S	196_S	1.051	1.00
277_Q	341_L	1.050	1.00
498_L	515_I	1.048	1.00
490_I	524_Q	1.046	1.00
470_P	474_Y	1.043	1.00
176_L	194_R	1.042	1.00
275_H	368_E	1.040	1.00
466_S	470_P	1.039	1.00
197_S	201_T	1.035	1.00
243_A	360_T	1.033	1.00
454_F	458_E	1.032	1.00
465_I	501_T	1.030	1.00
172_A	176_L	1.026	1.00
270_S	306_R	1.025	1.00
325_A	382_W	1.023	1.00
481_A	514_I	1.017	1.00
346_M	380_N	1.016	1.00
226_Q	237_F	1.012	1.00
263_L	347_I	1.012	1.00
306_R	372_R	1.010	1.00
362_Q	366_H	1.005	1.00
288_L	336_P	1.004	1.00
164_G	168_L	1.004	1.00
402_L	439_N	1.002	1.00
276_S	361_E	1.002	1.00
412_P	463_L	1.002	1.00
332_V	336_P	1.001	1.00
265_D	400_R	0.999	1.00
329_I	382_W	0.999	1.00
456_L	459_E	0.998	1.00
273_W	341_L	0.998	1.00
530_Q	560_E	0.997	1.00
184_V	199_L	0.994	1.00
338_N	343_R	0.993	1.00
459_E	462_R	0.992	1.00
190_E	193_P	0.991	1.00
594_S	600_V	0.989	1.00
227_D	303_R	0.989	1.00
413_R	632_P	0.985	1.00
373_N	377_Q	0.978	1.00
602_A	614_L	0.977	1.00
525_H	528_R	0.975	1.00
195_T	200_D	0.974	1.00
259_M	311_A	0.973	1.00
534_R	538_A	0.972	1.00
167_L	171_R	0.972	1.00
475_W	637_V	0.971	1.00
452_L	457_S	0.969	1.00
482_I	513_I	0.968	1.00
495_Q	535_L	0.966	1.00
262_R	375_G	0.966	1.00
576_I	586_V	0.963	1.00
422_R	615_I	0.959	1.00
261_I	311_A	0.955	1.00
513_I	541_V	0.950	1.00
200_D	206_I	0.948	1.00
505_C	508_S	0.944	1.00
217_D	221_R	0.943	1.00
465_I	498_L	0.943	1.00
342_D	405_Q	0.939	1.00
633_L	637_V	0.935	1.00
225_A	240_N	0.934	1.00
308_D	368_E	0.932	1.00
495_Q	499_R	0.932	1.00
264_P	379_G	0.930	1.00
496_R	535_L	0.930	1.00
406_M	412_P	0.929	1.00
514_I	542_R	0.927	1.00
179_E	183_N	0.919	1.00
420_V	639_K	0.919	1.00
194_R	207_Q	0.918	1.00
196_S	199_L	0.918	1.00
184_V	196_S	0.916	1.00
526_I	561_L	0.915	1.00
292_F	331_A	0.915	1.00
458_E	491_R	0.915	1.00
366_H	390_P	0.915	1.00
245_L	314_P	0.913	1.00
322_E	382_W	0.913	1.00
400_R	404_E	0.913	1.00
183_N	196_S	0.912	1.00
140_L	143_A	0.911	1.00
469_I	505_C	0.909	1.00
577_E	607_S	0.908	1.00
293_M	311_A	0.906	1.00
203_L	210_R	0.901	1.00
590_V	594_S	0.900	1.00
523_G	557_W	0.899	1.00
352_C	366_H	0.898	1.00
431_L	480_L	0.898	1.00
471_L	637_V	0.895	1.00
185_L	196_S	0.893	1.00
368_E	372_R	0.892	1.00
241_Q	302_A	0.892	1.00
424_G	615_I	0.892	1.00
277_Q	280_E	0.890	1.00
154_A	158_L	0.888	1.00
489_L	533_I	0.887	1.00
183_N	187_T	0.884	1.00
262_R	307_S	0.884	1.00
526_I	529_L	0.880	1.00
502_L	508_S	0.879	1.00
283_F	287_N	0.876	1.00
216_L	220_I	0.876	1.00
369_S	389_L	0.876	1.00
601_Y	621_G	0.874	1.00
251_K	296_Y	0.874	1.00
410_G	466_S	0.873	1.00
515_I	541_V	0.873	1.00
193_P	196_S	0.872	1.00
462_R	466_S	0.870	1.00
588_S	595_G	0.869	1.00
162_L	166_E	0.869	1.00
296_Y	327_Q	0.868	1.00
579_R	582_N	0.866	1.00
348_H	379_G	0.866	1.00
421_T	620_T	0.866	1.00
220_I	223_Y	0.865	1.00
403_I	451_V	0.865	1.00
386_D	389_L	0.865	1.00
254_T	315_H	0.860	1.00
403_I	406_M	0.860	1.00
140_L	144_I	0.860	1.00
246_L	354_W	0.859	1.00
286_T	301_L	0.859	1.00
239_D	361_E	0.857	1.00
256_G	354_W	0.856	1.00
404_E	456_L	0.854	1.00
237_F	240_N	0.854	1.00
442_V	449_P	0.853	1.00
250_E	358_Q	0.853	1.00
296_Y	324_I	0.852	1.00
262_R	372_R	0.851	1.00
416_Q	431_L	0.851	1.00
533_I	562_N	0.850	1.00
310_A	364_M	0.849	1.00
436_F	440_E	0.849	1.00
240_N	244_T	0.848	1.00
195_T	203_L	0.848	1.00
465_I	482_I	0.846	1.00
405_Q	408_S	0.846	1.00
176_L	180_R	0.846	1.00
199_L	202_L	0.845	1.00
430_E	483_Q	0.844	1.00
165_Q	168_L	0.843	1.00
267_N	271_D	0.841	1.00
508_S	513_I	0.839	1.00
591_E	595_G	0.839	1.00
293_M	299_A	0.839	1.00
200_D	207_Q	0.838	1.00
173_T	177_N	0.838	1.00
218_T	221_R	0.836	1.00
321_A	353_A	0.831	1.00
292_F	327_Q	0.831	1.00
577_E	610_E	0.830	1.00
422_R	620_T	0.829	1.00
421_T	427_H	0.829	1.00
547_Q	603_T	0.829	1.00
242_L	312_L	0.828	1.00
473_R	476_P	0.827	1.00
243_A	247_E	0.826	1.00
292_F	328_L	0.825	1.00
265_D	453_Q	0.823	1.00
232_L	286_T	0.822	1.00
270_S	279_E	0.820	1.00
351_I	382_W	0.820	1.00
528_R	532_V	0.817	1.00
285_L	336_P	0.817	1.00
238_F	242_L	0.815	1.00
233_N	300_L	0.813	1.00
473_R	506_E	0.813	1.00
584_L	595_G	0.810	1.00
275_H	372_R	0.805	1.00
288_L	335_L	0.803	1.00
267_N	372_R	0.802	1.00
269_L	281_Q	0.802	1.00
532_V	535_L	0.799	1.00
269_L	278_V	0.798	1.00
195_T	210_R	0.798	1.00
493_R	497_W	0.794	1.00
325_A	329_I	0.791	1.00
344_D	404_E	0.790	1.00
216_L	219_L	0.790	1.00
613_T	616_Q	0.790	1.00
271_D	372_R	0.789	1.00
454_F	457_S	0.789	1.00
489_L	521_D	0.789	1.00
147_I	154_A	0.787	1.00
550_L	571_G	0.787	1.00
362_Q	365_E	0.781	1.00
515_I	543_V	0.780	1.00
491_R	497_W	0.780	1.00
313_L	321_A	0.779	1.00
200_D	203_L	0.776	1.00
415_Y	436_F	0.775	1.00
316_R	321_A	0.774	1.00
451_V	457_S	0.774	1.00
159_Q	163_A	0.773	1.00
501_T	504_Q	0.769	1.00
324_I	327_Q	0.767	1.00
378_G	381_S	0.766	1.00
316_R	320_E	0.765	1.00
291_T	331_A	0.765	1.00
259_M	313_L	0.764	1.00
398_R	402_L	0.764	1.00
191_W	196_S	0.764	1.00
444_S	447_Y	0.763	1.00
171_R	175_I	0.759	1.00
574_R	610_E	0.759	1.00
585_L	592_A	0.758	1.00
605_V	614_L	0.757	1.00
269_L	343_R	0.754	1.00
262_R	270_S	0.754	1.00
420_V	424_G	0.753	1.00
192_P	199_L	0.752	1.00
410_G	463_L	0.748	0.99
170_T	174_R	0.747	0.99
241_Q	245_L	0.746	0.99
502_L	505_C	0.741	0.99
174_R	179_E	0.740	0.99
330_K	333_D	0.740	0.99
583_Q	587_Q	0.738	0.99
196_S	200_D	0.738	0.99
244_T	314_P	0.737	0.99
431_L	468_L	0.736	0.99
404_E	459_E	0.734	0.99
387_D	391_E	0.733	0.99
287_N	291_T	0.732	0.99
307_S	375_G	0.732	0.99
394_R	398_R	0.731	0.99
143_A	154_A	0.730	0.99
260_M	367_A	0.730	0.99
408_S	459_E	0.729	0.99
181_G	184_V	0.727	0.99
194_R	197_S	0.727	0.99
161_Q	164_G	0.725	0.99
228_V	236_L	0.724	0.99
559_K	579_R	0.724	0.99
155_V	159_Q	0.724	0.99
190_E	196_S	0.724	0.99
531_P	535_L	0.723	0.99
249_Q	256_G	0.723	0.99
451_V	455_G	0.722	0.99
497_W	500_D	0.721	0.99
271_D	368_E	0.720	0.99
166_E	169_E	0.717	0.99
475_W	636_N	0.716	0.99
385_Y	389_L	0.715	0.99
305_H	308_D	0.715	0.99
429_R	480_L	0.715	0.99
321_A	351_I	0.714	0.99
350_G	367_A	0.714	0.99
185_L	195_T	0.714	0.99
142_G	154_A	0.713	0.99
489_L	494_F	0.709	0.99
462_R	501_T	0.709	0.99
200_D	210_R	0.708	0.99
424_G	611_W	0.707	0.99
399_W	402_L	0.705	0.99
192_P	196_S	0.703	0.99
186_G	203_L	0.700	0.99
176_L	196_S	0.700	0.99
239_D	243_A	0.698	0.99
575_N	578_K	0.697	0.99
329_I	347_I	0.697	0.99
460_Y	464_Q	0.697	0.99
418_P	426_V	0.697	0.99
568_L	589_L	0.697	0.99
377_Q	381_S	0.694	0.99
311_A	328_L	0.692	0.99
443_S	449_P	0.691	0.99
465_I	513_I	0.688	0.99
625_D	629_S	0.686	0.99
164_G	167_L	0.685	0.99
185_L	192_P	0.683	0.99
495_Q	539_L	0.682	0.99
492_P	528_R	0.682	0.99
249_Q	354_W	0.681	0.99
318_L	322_E	0.680	0.99
390_P	394_R	0.679	0.99
144_I	154_A	0.678	0.99
153_L	156_R	0.678	0.99
590_V	600_V	0.676	0.99
531_P	534_R	0.675	0.99
301_L	311_A	0.675	0.99
240_N	300_L	0.674	0.99
319_K	322_E	0.674	0.99
276_S	365_E	0.674	0.99
154_A	162_L	0.674	0.99
393_G	397_V	0.674	0.99
518_A	547_Q	0.673	0.99
414_L	431_L	0.673	0.99
266_F	282_F	0.672	0.99
225_A	237_F	0.672	0.99
277_Q	343_R	0.672	0.99
413_R	634_D	0.671	0.99
326_G	329_I	0.669	0.99
385_Y	390_P	0.668	0.99
186_G	199_L	0.666	0.99
469_I	508_S	0.666	0.99
256_G	312_L	0.665	0.99
169_E	172_A	0.665	0.99
290_S	301_L	0.664	0.99
196_S	204_R	0.664	0.99
156_R	159_Q	0.664	0.99
530_Q	562_N	0.661	0.99
220_I	225_A	0.661	0.99
400_R	454_F	0.661	0.99
406_M	411_G	0.660	0.99
573_V	602_A	0.658	0.99
186_G	190_E	0.657	0.99
534_R	562_N	0.657	0.99
277_Q	338_N	0.657	0.99
325_A	349_I	0.655	0.99
585_L	589_L	0.653	0.99
526_I	530_Q	0.652	0.99
465_I	515_I	0.650	0.99
388_S	392_K	0.649	0.99
330_K	334_T	0.649	0.99
420_V	426_V	0.649	0.99
306_R	368_E	0.647	0.99
559_K	585_L	0.647	0.99
407_L	460_Y	0.645	0.99
273_W	343_R	0.644	0.98
557_W	561_L	0.643	0.98
183_N	194_R	0.641	0.98
175_I	180_R	0.640	0.98
566_L	598_T	0.640	0.98
472_L	512_R	0.639	0.98
264_P	375_G	0.639	0.98
326_G	382_W	0.639	0.98
214_S	218_T	0.635	0.98
154_A	159_Q	0.634	0.98
498_L	541_V	0.632	0.98
353_A	384_I	0.631	0.98
182_S	186_G	0.630	0.98
329_I	380_N	0.630	0.98
474_Y	477_E	0.630	0.98
489_L	532_V	0.630	0.98
496_R	499_R	0.630	0.98
181_G	198_A	0.629	0.98
580_T	583_Q	0.629	0.98
175_I	179_E	0.629	0.98
264_P	346_M	0.629	0.98
199_L	210_R	0.629	0.98
637_V	640_Y	0.627	0.98
211_E	215_R	0.627	0.98
631_Q	636_N	0.627	0.98
182_S	199_L	0.626	0.98
496_R	500_D	0.626	0.98
445_A	449_P	0.626	0.98
614_L	619_V	0.625	0.98
356_S	366_H	0.624	0.98
575_N	579_R	0.624	0.98
636_N	639_K	0.623	0.98
373_N	392_K	0.623	0.98
172_A	180_R	0.622	0.98
264_P	380_N	0.622	0.98
320_E	323_S	0.621	0.98
264_P	378_G	0.620	0.98
576_I	583_Q	0.620	0.98
259_M	351_I	0.618	0.98
448_M	518_A	0.618	0.98
458_E	488_S	0.618	0.98
202_L	206_I	0.616	0.98
235_R	368_E	0.615	0.98
182_S	185_L	0.614	0.98
195_T	198_A	0.613	0.98
483_Q	546_N	0.610	0.98
592_A	596_T	0.610	0.98
270_S	307_S	0.609	0.98
235_R	279_E	0.608	0.98
240_N	243_A	0.608	0.98
391_E	395_G	0.606	0.98
147_I	150_M	0.606	0.98
260_M	304_Y	0.605	0.98
535_L	538_A	0.605	0.98
606_R	625_D	0.605	0.98
179_E	182_S	0.605	0.98
536_V	541_V	0.604	0.98
560_E	581_E	0.604	0.98
164_G	169_E	0.603	0.98
305_H	368_E	0.602	0.98
206_I	210_R	0.599	0.98
600_V	620_T	0.599	0.98
407_L	463_L	0.598	0.98
196_S	206_I	0.598	0.98
182_S	187_T	0.598	0.98
484_V	488_S	0.597	0.98
474_Y	633_L	0.597	0.98
305_H	372_R	0.597	0.98
472_L	505_C	0.595	0.97
216_L	223_Y	0.595	0.97
289_L	328_L	0.594	0.97
281_Q	338_N	0.594	0.97
195_T	205_E	0.592	0.97
605_V	611_W	0.590	0.97
197_S	200_D	0.590	0.97
527_S	560_E	0.588	0.97
435_I	440_E	0.586	0.97
336_P	345_D	0.586	0.97
175_I	182_S	0.586	0.97
433_C	447_Y	0.585	0.97
400_R	450_M	0.585	0.97
416_Q	468_L	0.584	0.97
462_R	500_D	0.581	0.97
465_I	497_W	0.581	0.97
225_A	233_N	0.580	0.97
508_S	512_R	0.580	0.97
591_E	594_S	0.579	0.97
278_V	306_R	0.579	0.97
222_S	225_A	0.579	0.97
402_L	438_G	0.578	0.97
204_R	209_A	0.578	0.97
185_L	200_D	0.574	0.97
276_S	339_K	0.574	0.97
609_S	612_Q	0.574	0.97
300_L	312_L	0.573	0.97
587_Q	613_T	0.573	0.97
480_L	508_S	0.573	0.97
452_L	485_T	0.573	0.97
464_Q	468_L	0.572	0.97
203_L	206_I	0.571	0.97
457_S	487_E	0.571	0.97
299_A	327_Q	0.571	0.97
245_L	248_D	0.571	0.97
590_V	620_T	0.570	0.97
590_V	614_L	0.569	0.97
215_R	218_T	0.568	0.97
150_M	154_A	0.566	0.97
176_L	182_S	0.565	0.97
465_I	469_I	0.565	0.97
403_I	456_L	0.565	0.97
289_L	293_M	0.564	0.97
575_N	582_N	0.564	0.97
229_K	279_E	0.564	0.97
275_H	306_R	0.564	0.97
246_L	256_G	0.562	0.96
498_L	501_T	0.561	0.96
250_E	354_W	0.561	0.96
472_L	513_I	0.560	0.96
245_L	300_L	0.560	0.96
228_V	231_G	0.559	0.96
175_I	178_G	0.558	0.96
308_D	372_R	0.558	0.96
266_F	375_G	0.558	0.96
142_G	147_I	0.557	0.96
506_E	509_Q	0.556	0.96
267_N	270_S	0.555	0.96
388_S	391_E	0.555	0.96
416_Q	429_R	0.553	0.96
516_E	567_K	0.553	0.96
186_G	195_T	0.553	0.96
286_T	290_S	0.551	0.96
171_R	176_L	0.549	0.96
230_T	282_F	0.548	0.96
398_R	401_T	0.547	0.96
358_Q	362_Q	0.547	0.96
299_A	313_L	0.547	0.96
273_W	277_Q	0.546	0.96
418_P	628_A	0.545	0.96
466_S	497_W	0.544	0.96
573_V	576_I	0.544	0.96
481_A	565_L	0.542	0.96
137_T	140_L	0.542	0.96
192_P	195_T	0.542	0.96
181_G	186_G	0.542	0.96
318_L	384_I	0.542	0.96
275_H	278_V	0.542	0.96
462_R	488_S	0.541	0.96
354_W	357_G	0.540	0.96
448_M	451_V	0.540	0.96
268_M	396_N	0.539	0.96
184_V	203_L	0.538	0.95
184_V	195_T	0.538	0.95
443_S	446_E	0.536	0.95
181_G	194_R	0.535	0.95
573_V	586_V	0.534	0.95
346_M	378_G	0.533	0.95
432_M	483_Q	0.533	0.95
181_G	185_L	0.532	0.95
266_F	270_S	0.531	0.95
192_P	210_R	0.531	0.95
217_D	220_I	0.529	0.95
323_S	327_Q	0.528	0.95
155_V	158_L	0.527	0.95
324_I	328_L	0.527	0.95
168_L	176_L	0.526	0.95
266_F	307_S	0.525	0.95
402_L	435_I	0.524	0.95
176_L	183_N	0.523	0.95
203_L	209_A	0.521	0.95
261_I	349_I	0.521	0.95
185_L	199_L	0.521	0.95
212_Q	216_L	0.520	0.95
568_L	619_V	0.520	0.95
329_I	346_M	0.519	0.95
518_A	603_T	0.518	0.94
522_V	545_V	0.518	0.94
448_M	452_L	0.517	0.94
350_G	370_A	0.516	0.94
458_E	461_D	0.516	0.94
174_R	178_G	0.515	0.94
237_F	302_A	0.515	0.94
528_R	531_P	0.515	0.94
187_T	193_P	0.515	0.94
229_K	270_S	0.514	0.94
442_V	448_M	0.514	0.94
424_G	608_R	0.513	0.94
557_W	560_E	0.513	0.94
474_Y	637_V	0.512	0.94
182_S	200_D	0.510	0.94
615_I	622_G	0.508	0.94
584_L	588_S	0.508	0.94
527_S	531_P	0.508	0.94
175_I	181_G	0.507	0.94
398_R	439_N	0.505	0.94
256_G	363_V	0.504	0.94
554_S	572_L	0.504	0.94
242_L	256_G	0.504	0.94
200_D	205_E	0.504	0.94
395_G	399_W	0.504	0.94
229_K	283_F	0.503	0.94
582_N	610_E	0.503	0.94
352_C	367_A	0.503	0.94
545_V	557_W	0.502	0.94
483_Q	623_Q	0.501	0.93
158_L	161_Q	0.501	0.93
584_L	587_Q	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rnhA	2	0.6347	100	0.303	Contact Map
4j40A	2	0.3793	100	0.314	Contact Map
3pjxA	1	0.644	100	0.32	Contact Map
3gfzA	2	0.582	100	0.42	Contact Map
4hjfA	1	0.3916	100	0.47	Contact Map
4hu4A	1	0.37	100	0.541	Contact Map
4kieA	1	0.3932	100	0.544	Contact Map
2r6oA	2	0.387	100	0.545	Contact Map
4rniA	2	0.3824	100	0.547	Contact Map
3sy8A	6	0.5898	100	0.566	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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