GREMLIN Database
FES - Enterochelin esterase
UniProt: P13039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10299
Length: 400 (354)
Sequences: 755 (553)
Seq/√Len: 29.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_V262_V4.7051.00
263_K268_F4.6601.00
269_S274_R4.3511.00
271_R274_R4.3311.00
232_I258_L4.1011.00
291_G301_V3.7861.00
152_Q382_G3.5741.00
184_F216_T3.2871.00
340_E383_G3.0581.00
306_G352_N3.0321.00
302_L387_G3.0311.00
126_D129_N2.9551.00
288_L308_Y2.8061.00
172_S257_E2.7881.00
205_W280_Q2.7401.00
183_I230_V2.6651.00
341_A348_I2.6081.00
305_S380_W2.5810.99
353_Q370_Q2.5440.99
288_L337_I2.4070.99
199_L384_L2.3600.99
183_I228_V2.3590.99
251_W290_A2.3550.99
281_S375_H2.2370.98
218_L385_M2.1740.98
184_F219_T2.1500.98
276_V392_W2.0570.97
288_L306_G2.0250.97
199_L278_A2.0200.97
85_A148_Q2.0090.97
285_L345_E2.0060.97
205_W278_A1.9630.96
303_S352_N1.9290.96
240_R244_L1.9290.96
232_I254_V1.9110.96
199_L211_V1.8830.96
163_I186_T1.8530.95
215_L229_Y1.8340.95
160_A220_H1.8190.95
27_M82_Q1.8060.94
261_L265_I1.8040.94
303_S339_L1.8000.94
199_L231_L1.7940.94
321_L324_K1.7920.94
245_P282_F1.7800.94
254_V290_A1.7750.94
358_Q362_I1.7740.94
163_I216_T1.7730.94
168_I181_V1.7460.93
186_T216_T1.7350.93
334_G364_E1.7290.93
68_M93_F1.7250.93
159_Q217_S1.7180.93
302_L391_L1.7160.93
301_V335_L1.7030.92
282_F286_S1.6750.92
170_W253_A1.6710.92
309_W345_E1.6690.92
83_L89_G1.6560.91
194_R228_V1.6400.91
68_M166_K1.6290.91
320_V324_K1.6270.90
369_R386_Q1.6250.90
356_Y368_W1.6210.90
72_A75_N1.6150.90
171_K178_S1.5960.90
88_R91_Y1.5730.89
303_S306_G1.5670.89
157_C217_S1.5610.89
360_H366_I1.5580.88
160_A217_S1.5530.88
280_Q380_W1.5460.88
356_Y360_H1.5390.88
357_A361_P1.5380.88
51_V68_M1.5360.88
319_G322_L1.5220.87
308_Y355_L1.5080.87
287_A301_V1.4960.86
36_D46_I1.4900.86
206_A231_L1.4830.86
197_A380_W1.4690.85
189_A194_R1.4660.85
168_I261_L1.4640.85
263_K275_T1.4500.84
91_Y96_T1.4400.84
373_G379_C1.4320.84
66_Q69_Q1.4240.83
201_D240_R1.4110.83
277_V291_G1.4010.82
335_L365_S1.3970.82
379_C383_G1.3950.82
86_N372_D1.3940.82
214_V217_S1.3760.81
243_E287_A1.3760.81
222_Q225_P1.3730.81
232_I345_E1.3660.81
219_T227_A1.3650.81
47_K68_M1.3630.81
339_L355_L1.3630.81
186_T219_T1.3600.80
126_D142_S1.3450.80
24_N27_M1.3410.79
180_R233_D1.3370.79
217_S220_H1.3320.79
172_S175_L1.3260.79
31_T80_T1.3130.78
244_L309_W1.3110.78
201_D387_G1.2990.77
258_L337_I1.2890.77
77_W91_Y1.2870.77
335_L364_E1.2860.77
192_E225_P1.2860.77
211_V384_L1.2840.76
356_Y366_I1.2770.76
195_P227_A1.2740.76
322_L325_L1.2740.76
252_L256_Q1.2700.76
177_K243_E1.2680.75
228_V262_V1.2680.75
91_Y95_P1.2640.75
209_M377_A1.2530.75
20_W76_V1.2510.74
165_A184_F1.2470.74
342_G375_H1.2470.74
322_L358_Q1.2380.74
223_Q389_I1.2270.73
343_I372_D1.2060.72
295_P348_I1.2060.72
30_V144_L1.2000.71
279_G375_H1.1980.71
161_P187_G1.1950.71
25_D28_F1.1860.70
319_G325_L1.1800.70
307_S310_W1.1790.70
123_A250_F1.1790.70
203_E207_Q1.1710.69
163_I184_F1.1700.69
55_G58_D1.1660.69
163_I217_S1.1610.69
258_L309_W1.1510.68
84_N372_D1.1420.67
209_M214_V1.1380.67
318_E325_L1.1290.67
198_V262_V1.1280.66
215_L219_T1.1260.66
22_R220_H1.1260.66
251_W294_W1.1240.66
371_V379_C1.1210.66
198_V268_F1.1210.66
367_F390_D1.1100.65
161_P220_H1.1070.65
219_T224_L1.1070.65
285_L308_Y1.1010.65
14_S173_E1.1010.65
318_E326_K1.0990.64
18_P35_R1.0950.64
229_Y388_L1.0840.63
75_N78_Q1.0830.63
285_L309_W1.0820.63
331_S334_G1.0760.63
330_V334_G1.0680.62
285_L307_S1.0590.61
201_D282_F1.0590.61
252_L293_H1.0550.61
216_T220_H1.0460.60
240_R309_W1.0340.60
243_E345_E1.0260.59
205_W384_L1.0240.59
224_L227_A1.0220.59
21_Q24_N1.0220.59
317_Q320_V1.0180.58
318_E324_K1.0120.58
163_I197_A1.0110.58
198_V263_K1.0040.57
340_E379_C1.0030.57
74_T128_L1.0010.57
295_P374_G1.0000.57
23_L33_W0.9950.57
115_G118_K0.9950.57
77_W93_F0.9870.56
216_T219_T0.9830.56
341_A351_A0.9810.56
197_A227_A0.9790.55
28_F85_A0.9760.55
83_L86_N0.9700.55
175_L253_A0.9680.55
54_T58_D0.9620.54
236_D258_L0.9610.54
205_W209_M0.9570.54
358_Q361_P0.9560.54
184_F229_Y0.9550.53
279_G342_G0.9500.53
259_L263_K0.9450.53
219_T226_P0.9440.53
51_V241_A0.9440.53
159_Q331_S0.9390.52
179_R243_E0.9320.52
85_A91_Y0.9320.52
91_Y94_I0.9310.52
270_D296_E0.9280.51
319_G323_E0.9270.51
246_C289_Y0.9250.51
190_T287_A0.9250.51
275_T298_F0.9230.51
240_R307_S0.9210.51
113_R117_R0.9190.51
51_V60_H0.9160.50
241_A282_F0.9110.50
251_W282_F0.9100.50
113_R219_T0.9060.50
156_D213_P0.9030.49
201_D345_E0.9030.49
310_W345_E0.9020.49
195_P392_W0.9010.49
157_C160_A0.8980.49
197_A392_W0.8980.49
365_S386_Q0.8860.48
184_F377_A0.8850.48
201_D304_Q0.8820.48
15_K327_A0.8760.47
281_S284_G0.8760.47
283_G375_H0.8730.47
320_V323_E0.8710.47
198_V230_V0.8640.46
77_W95_P0.8630.46
59_H144_L0.8620.46
111_E115_G0.8590.46
240_R243_E0.8580.46
249_D252_L0.8540.46
161_P218_L0.8450.45
284_G375_H0.8430.45
318_E322_L0.8420.45
91_Y388_L0.8410.45
15_K20_W0.8410.45
304_Q387_G0.8400.44
248_A251_W0.8390.44
110_L115_G0.8390.44
204_F208_S0.8370.44
49_V95_P0.8370.44
241_A245_P0.8320.44
51_V79_W0.8310.44
277_V374_G0.8280.44
115_G119_L0.8240.43
113_R116_W0.8240.43
184_F298_F0.8210.43
158_P187_G0.8140.42
181_V258_L0.8130.42
165_A226_P0.8100.42
272_A352_N0.8100.42
285_L289_Y0.8080.42
115_G120_L0.8060.42
307_S345_E0.8050.42
189_A266_A0.8040.42
174_R257_E0.8030.42
321_L326_K0.8020.42
202_G233_D0.7980.41
289_Y310_W0.7970.41
117_R120_L0.7970.41
139_H144_L0.7960.41
356_Y370_Q0.7930.41
236_D239_H0.7920.41
240_R345_E0.7920.41
183_I266_A0.7890.41
337_I364_E0.7860.40
50_W54_T0.7860.40
325_L355_L0.7840.40
199_L205_W0.7820.40
181_V261_L0.7820.40
200_L286_S0.7810.40
191_A265_I0.7750.40
280_Q304_Q0.7740.39
25_D223_Q0.7670.39
77_W86_N0.7650.39
272_A289_Y0.7650.39
230_V290_A0.7600.38
258_L387_G0.7580.38
198_V275_T0.7570.38
200_L205_W0.7540.38
93_F110_L0.7530.38
95_P99_D0.7520.38
180_R207_Q0.7510.38
282_F307_S0.7490.38
50_W59_H0.7480.38
149_A152_Q0.7460.37
92_C141_V0.7440.37
162_E216_T0.7430.37
185_T189_A0.7420.37
90_S280_Q0.7410.37
176_K256_Q0.7390.37
68_M72_A0.7380.37
84_N87_W0.7370.37
195_P381_R0.7360.37
153_P382_G0.7350.37
193_E263_K0.7330.36
376_D380_W0.7320.36
189_A267_P0.7310.36
35_R128_L0.7310.36
186_T229_Y0.7310.36
70_R75_N0.7310.36
23_L27_M0.7300.36
344_R372_D0.7300.36
21_Q29_E0.7280.36
321_L364_E0.7270.36
200_L280_Q0.7250.36
93_F116_W0.7230.36
201_D307_S0.7220.36
197_A384_L0.7200.35
218_L338_V0.7130.35
193_E267_P0.7100.35
196_L230_V0.7090.35
148_Q160_A0.7080.35
262_V268_F0.7050.34
185_T194_R0.7030.34
214_V349_M0.7030.34
83_L91_Y0.7010.34
244_L258_L0.7010.34
35_R75_N0.6990.34
73_G273_D0.6950.34
330_V333_E0.6940.34
54_T282_F0.6940.34
201_D232_I0.6940.34
355_L358_Q0.6940.34
167_E180_R0.6910.33
29_E144_L0.6890.33
144_L153_P0.6890.33
116_W311_P0.6880.33
204_F209_M0.6880.33
20_W128_L0.6860.33
233_D258_L0.6860.33
170_W219_T0.6840.33
348_I370_Q0.6800.33
284_G307_S0.6790.33
354_A357_A0.6780.33
276_V302_L0.6760.32
285_L371_V0.6760.32
282_F345_E0.6760.32
159_Q230_V0.6760.32
348_I351_A0.6730.32
339_L366_I0.6720.32
56_V60_H0.6720.32
171_K176_K0.6720.32
205_W380_W0.6700.32
180_R391_L0.6690.32
211_V214_V0.6660.32
166_K185_T0.6650.32
173_E325_L0.6650.32
186_T194_R0.6640.32
194_R266_A0.6630.31
201_D380_W0.6590.31
327_A361_P0.6580.31
253_A258_L0.6570.31
21_Q33_W0.6570.31
272_A299_G0.6550.31
307_S388_L0.6550.31
199_L376_D0.6550.31
148_Q288_L0.6530.31
173_E267_P0.6510.31
84_N221_R0.6510.31
205_W376_D0.6500.31
81_T85_A0.6490.31
301_V351_A0.6490.31
299_G387_G0.6420.30
213_P217_S0.6370.30
374_G379_C0.6370.30
183_I196_L0.6360.30
172_S243_E0.6360.30
235_I259_L0.6350.30
309_W312_H0.6340.30
260_P298_F0.6340.30
288_L301_V0.6320.29
281_S342_G0.6320.29
350_R354_A0.6320.29
57_T60_H0.6300.29
317_Q323_E0.6290.29
198_V259_L0.6290.29
200_L246_C0.6230.29
181_V306_G0.6220.29
251_W254_V0.6200.29
266_A298_F0.6200.29
30_V334_G0.6190.29
116_W119_L0.6180.29
320_V325_L0.6170.28
94_I97_E0.6170.28
66_Q70_R0.6130.28
325_L331_S0.6120.28
168_I265_I0.6110.28
201_D388_L0.6100.28
309_W355_L0.6100.28
349_M353_Q0.6090.28
250_F253_A0.6090.28
170_W257_E0.6090.28
53_I56_V0.6070.28
244_L310_W0.6070.28
157_C221_R0.6050.28
46_I97_E0.6050.28
144_L208_S0.6050.28
307_S359_L0.6000.27
215_L388_L0.6000.27
127_P213_P0.6000.27
198_V228_V0.5990.27
308_Y352_N0.5970.27
253_A257_E0.5970.27
165_A307_S0.5960.27
159_Q322_L0.5960.27
187_G306_G0.5930.27
182_W233_D0.5920.27
209_M280_Q0.5920.27
201_D285_L0.5910.27
15_K198_V0.5890.27
240_R285_L0.5890.27
47_K361_P0.5870.27
84_N91_Y0.5870.27
286_S307_S0.5840.26
14_S111_E0.5830.26
68_M77_W0.5830.26
205_W373_G0.5830.26
326_K355_L0.5820.26
304_Q383_G0.5820.26
384_L388_L0.5820.26
235_I239_H0.5800.26
161_P215_L0.5790.26
215_L354_A0.5780.26
163_I283_G0.5780.26
51_V161_P0.5770.26
210_P306_G0.5760.26
27_M223_Q0.5740.26
258_L313_R0.5730.26
37_P47_K0.5720.26
52_Y55_G0.5710.26
325_L358_Q0.5710.26
327_A357_A0.5710.26
156_D221_R0.5690.25
257_E306_G0.5680.25
198_V209_M0.5670.25
161_P188_D0.5650.25
174_R334_G0.5650.25
163_I220_H0.5650.25
56_V344_R0.5650.25
313_R323_E0.5640.25
304_Q379_C0.5640.25
285_L375_H0.5630.25
128_L307_S0.5610.25
72_A132_S0.5610.25
141_V277_V0.5610.25
199_L226_P0.5600.25
299_G364_E0.5590.25
338_V343_I0.5580.25
141_V187_G0.5580.25
201_D280_Q0.5580.25
50_W61_Q0.5550.25
17_G298_F0.5530.25
38_Q171_K0.5530.25
20_W94_I0.5520.24
179_R278_A0.5520.24
87_W225_P0.5510.24
57_T61_Q0.5490.24
50_W218_L0.5490.24
167_E207_Q0.5480.24
339_L368_W0.5460.24
236_D387_G0.5460.24
96_T172_S0.5450.24
34_W277_V0.5430.24
57_T253_A0.5430.24
288_L373_G0.5420.24
176_K238_T0.5420.24
173_E176_K0.5420.24
280_Q381_R0.5410.24
347_M392_W0.5410.24
206_A212_W0.5410.24
198_V302_L0.5400.24
198_V298_F0.5400.24
147_P299_G0.5390.24
87_W311_P0.5390.24
84_N144_L0.5390.24
58_D141_V0.5380.24
299_G352_N0.5370.24
68_M372_D0.5370.24
37_P195_P0.5350.24
250_F260_P0.5340.23
77_W359_L0.5330.23
177_K341_A0.5330.23
91_Y126_D0.5320.23
345_E375_H0.5300.23
164_P169_I0.5300.23
158_P166_K0.5280.23
338_V390_D0.5270.23
155_W385_M0.5270.23
228_V268_F0.5270.23
303_S374_G0.5250.23
115_G121_P0.5250.23
72_A77_W0.5230.23
263_K366_I0.5230.23
30_V202_G0.5220.23
18_P128_L0.5220.23
265_I365_S0.5210.23
263_K317_Q0.5200.23
54_T57_T0.5200.23
291_G335_L0.5200.23
29_E80_T0.5180.23
178_S331_S0.5180.23
240_R359_L0.5180.23
76_V180_R0.5170.23
217_S221_R0.5160.22
86_N361_P0.5160.22
53_I58_D0.5160.22
349_M355_L0.5160.22
95_P98_R0.5140.22
287_A302_L0.5130.22
136_G143_A0.5130.22
211_V262_V0.5130.22
50_W67_S0.5130.22
223_Q332_A0.5120.22
227_A381_R0.5120.22
389_I393_Q0.5090.22
21_Q78_Q0.5090.22
176_K249_D0.5080.22
77_W88_R0.5070.22
175_L236_D0.5060.22
164_P167_E0.5060.22
189_A214_V0.5060.22
304_Q308_Y0.5050.22
77_W89_G0.5040.22
146_M201_D0.5040.22
250_F258_L0.5030.22
85_A90_S0.5030.22
59_H95_P0.5020.22
58_D74_T0.5020.22
342_G380_W0.5020.22
74_T77_W0.5020.22
91_Y110_L0.5010.22
214_V218_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8dA 2 0.9625 100 0.365 Contact Map
4w9rA 2 0.56 100 0.668 Contact Map
1jjfA 1 0.615 100 0.678 Contact Map
1gklA 1 0.6325 100 0.706 Contact Map
3gffA 2 0.56 100 0.707 Contact Map
2gzsA 1 0.565 100 0.717 Contact Map
3ls2A 2 0.5825 100 0.726 Contact Map
2uz0A 4 0.56 100 0.728 Contact Map
4rotA 4 0.5825 100 0.731 Contact Map
2qm0A 3 0.585 100 0.734 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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