GREMLIN Database
GLPB - Anaerobic glycerol-3-phosphate dehydrogenase subunit B
UniProt: P13033 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10392
Length: 419 (408)
Sequences: 320 (241)
Seq/√Len: 11.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
363_D367_R11.0791.00
7_I18_G5.4081.00
18_G266_F4.7201.00
18_G30_I4.4701.00
219_L244_M4.0880.99
17_C308_V3.7180.99
104_G353_Q3.6660.99
60_I109_A3.1330.97
404_A408_A3.1260.97
266_F271_G3.0160.96
23_K97_E2.9390.95
197_N200_N2.9350.95
282_V289_V2.9260.95
63_G363_D2.7760.93
23_K265_Q2.5930.90
210_P239_L2.5790.90
129_V254_L2.5710.90
202_P206_D2.5640.90
21_L408_A2.5310.89
68_R72_P2.4940.89
88_A353_Q2.4170.87
388_F399_V2.3870.86
142_V171_I2.3810.86
5_T26_L2.3600.86
46_D122_T2.3590.86
222_A247_P2.3540.85
68_R77_S2.2890.84
141_V219_L2.1330.79
333_L368_P2.0870.78
304_P307_A2.0040.75
142_V208_L1.9570.73
91_A245_L1.9510.72
73_A142_V1.9510.72
10_G187_R1.9480.72
18_G271_G1.9400.72
104_G380_A1.9030.70
341_R344_W1.8740.69
21_L411_I1.8710.69
57_V316_S1.8610.69
346_K351_A1.8590.69
270_G318_G1.8570.69
34_G149_D1.8330.67
265_Q269_Q1.8310.67
225_G257_R1.8300.67
102_L126_S1.8190.67
66_S308_V1.7720.65
239_L243_L1.7690.65
50_H121_S1.7690.65
36_S350_F1.7250.63
283_T293_W1.7190.62
9_G14_G1.7090.62
11_G14_G1.7090.62
362_T385_L1.7090.62
218_I241_C1.7060.62
245_L400_C1.7000.61
263_Q267_V1.6940.61
84_V155_A1.6910.61
80_E83_R1.6710.60
306_F411_I1.6610.60
149_D377_N1.6600.59
37_A399_V1.6530.59
72_P77_S1.6310.58
258_L366_L1.6230.58
318_G344_W1.6190.57
49_S109_A1.6170.57
186_F223_C1.6110.57
311_S318_G1.5920.56
369_S374_T1.5830.56
13_A204_L1.5510.54
91_A95_I1.5370.53
34_G124_L1.5230.53
286_N302_L1.5090.52
316_S408_A1.5050.52
87_L245_L1.5040.52
331_L378_L1.4890.51
148_M353_Q1.4760.50
154_L362_T1.4570.49
82_Q122_T1.4560.49
276_G349_F1.4540.49
10_G329_P1.4370.48
218_I243_L1.4340.48
21_L190_N1.4330.48
279_V330_I1.4310.48
194_F197_N1.4210.48
18_G28_C1.4170.47
222_A248_T1.4150.47
233_R237_E1.4140.47
289_V378_L1.4040.47
47_L88_A1.4010.47
235_L321_A1.3840.46
144_I223_C1.3690.45
144_I231_L1.3690.45
45_L166_V1.3630.45
40_F248_T1.3600.45
120_R162_L1.3560.44
143_G387_G1.3540.44
350_F362_T1.3510.44
205_L239_L1.3400.44
355_W400_C1.3370.43
234_W238_K1.3340.43
217_M274_M1.3340.43
18_G224_F1.3320.43
34_G377_N1.3180.43
141_V407_A1.3100.42
224_F335_V1.3000.42
32_T350_F1.2980.42
253_V404_A1.2960.41
361_T387_G1.2940.41
6_V31_V1.2940.41
84_V195_L1.2930.41
158_S245_L1.2930.41
91_A402_V1.2810.41
110_H125_S1.2740.40
350_F389_D1.2700.40
283_T288_V1.2660.40
44_S112_R1.2650.40
149_D313_S1.2610.40
4_D305_R1.2560.40
243_L401_A1.2550.39
147_L184_T1.2500.39
19_L269_Q1.2420.39
335_V358_F1.2380.39
15_L34_G1.2380.39
42_S318_G1.2340.38
201_W205_L1.2300.38
408_A411_I1.2270.38
291_E307_A1.2230.38
185_E313_S1.2180.38
326_I358_F1.2090.37
55_Q375_I1.2060.37
19_L265_Q1.2020.37
12_L31_V1.2010.37
4_D27_R1.1980.37
208_L237_E1.1920.37
189_V226_L1.1900.36
140_C215_C1.1800.36
20_Q276_G1.1780.36
78_L364_E1.1780.36
124_L408_A1.1760.36
207_A210_P1.1750.36
58_T365_T1.1710.36
96_A403_S1.1570.35
13_A332_G1.1560.35
248_T341_R1.1470.34
354_P389_D1.1460.34
45_L404_A1.1420.34
120_R186_F1.1390.34
141_V387_G1.1340.34
42_S399_V1.1320.34
143_G366_L1.1310.34
383_S399_V1.1250.33
118_T157_A1.1230.33
41_S321_A1.1230.33
30_I266_F1.1220.33
208_L214_T1.1160.33
138_K216_E1.1150.33
212_A241_C1.1050.33
208_L220_M1.1040.33
49_S121_S1.1030.32
36_S296_N1.0990.32
148_M245_L1.0960.32
319_L372_G1.0900.32
15_L271_G1.0860.32
318_G389_D1.0860.32
201_W231_L1.0850.32
218_I239_L1.0790.31
308_V411_I1.0790.31
87_L402_V1.0770.31
212_A347_G1.0750.31
98_S143_G1.0730.31
128_E245_L1.0730.31
245_L402_V1.0720.31
335_V339_A1.0720.31
25_G250_P1.0670.31
15_L262_L1.0650.31
36_S187_R1.0650.31
79_L365_T1.0580.31
51_L57_V1.0490.30
185_E277_D1.0450.30
115_P249_L1.0440.30
65_E199_E1.0400.30
49_S85_L1.0350.30
141_V264_R1.0280.29
100_A360_V1.0270.29
314_F319_L1.0200.29
13_A209_I1.0200.29
385_L396_G1.0190.29
142_V237_E1.0150.29
31_V167_E1.0120.29
201_W234_W1.0080.28
227_A253_V1.0020.28
67_L304_P1.0000.28
154_L378_L0.9990.28
37_A188_A0.9980.28
353_Q402_V0.9960.28
35_Q191_I0.9930.28
62_S376_E0.9910.28
212_A216_E0.9890.28
49_S394_G0.9870.28
94_L404_A0.9860.28
270_G321_A0.9820.27
110_H235_L0.9780.27
311_S330_I0.9760.27
102_L368_P0.9760.27
319_L326_I0.9750.27
129_V151_Q0.9720.27
44_S316_S0.9710.27
171_I207_A0.9690.27
382_G398_G0.9660.27
359_G382_G0.9650.27
269_Q285_K0.9600.27
96_A209_I0.9580.26
319_L335_V0.9570.26
84_V246_L0.9550.26
87_L405_L0.9540.26
357_Q389_D0.9530.26
37_A315_F0.9520.26
283_T291_E0.9510.26
172_E220_M0.9490.26
13_A48_L0.9480.26
74_H255_G0.9460.26
219_L246_L0.9460.26
155_A273_W0.9430.26
266_F390_P0.9430.26
68_R240_P0.9410.26
17_C28_C0.9370.26
11_G43_G0.9360.26
9_G43_G0.9360.26
321_A394_G0.9360.26
63_G367_R0.9350.26
66_S213_N0.9350.26
148_M334_D0.9340.26
120_R350_F0.9330.26
150_F276_G0.9330.26
283_T286_N0.9330.26
200_N319_L0.9310.25
57_V319_L0.9290.25
193_R196_D0.9280.25
6_V302_L0.9280.25
282_V331_L0.9270.25
66_S167_E0.9270.25
294_T334_D0.9260.25
177_D223_C0.9240.25
111_Q238_K0.9230.25
91_A253_V0.9200.25
31_V302_L0.9190.25
24_H407_A0.9180.25
188_A239_L0.9160.25
230_K322_E0.9160.25
59_D108_L0.9110.25
191_I350_F0.9090.25
140_C211_V0.9030.24
44_S110_H0.9010.24
345_Y355_W0.9000.24
62_S93_A0.9000.24
79_L403_S0.8970.24
192_A253_V0.8970.24
140_C153_H0.8960.24
286_N364_E0.8950.24
17_C21_L0.8920.24
290_N307_A0.8910.24
146_G318_G0.8910.24
171_I204_L0.8900.24
22_Q87_L0.8870.24
109_A205_L0.8820.24
261_Q308_V0.8810.24
78_L332_G0.8760.23
55_Q238_K0.8750.23
315_F395_C0.8720.23
112_R125_S0.8710.23
296_N300_I0.8680.23
219_L412_A0.8670.23
40_F185_E0.8650.23
247_P378_L0.8550.23
40_F123_W0.8510.23
367_R376_E0.8510.23
342_G363_D0.8450.22
60_I121_S0.8450.22
335_V392_A0.8440.22
6_V379_F0.8410.22
56_P208_L0.8410.22
36_S334_D0.8400.22
226_L289_V0.8350.22
91_A102_L0.8340.22
309_L319_L0.8320.22
187_R313_S0.8300.22
344_W358_F0.8290.22
406_H410_Q0.8290.22
31_V172_E0.8260.22
113_V387_G0.8260.22
243_L286_N0.8240.22
233_R305_R0.8220.22
26_L411_I0.8220.22
95_I184_T0.8210.21
149_D154_L0.8210.21
41_S44_S0.8200.21
123_W334_D0.8200.21
88_A354_P0.8200.21
208_L219_L0.8190.21
156_A240_P0.8190.21
59_D137_K0.8170.21
61_H403_S0.8150.21
123_W294_T0.8140.21
187_R341_R0.8100.21
344_W389_D0.8080.21
21_L180_R0.8040.21
317_G362_T0.8040.21
305_R327_R0.8020.21
64_L77_S0.7990.21
91_A401_A0.7990.21
17_C368_P0.7960.21
137_K288_V0.7960.21
143_G195_L0.7950.21
35_Q187_R0.7940.21
283_T401_A0.7940.21
144_I338_T0.7940.21
36_S358_F0.7890.20
149_D262_L0.7880.20
94_L354_P0.7850.20
45_L64_L0.7810.20
33_R397_G0.7800.20
258_L389_D0.7800.20
371_A381_I0.7770.20
7_I14_G0.7770.20
42_S344_W0.7750.20
277_D313_S0.7710.20
83_R363_D0.7710.20
336_L403_S0.7700.20
120_R171_I0.7700.20
224_F345_Y0.7670.20
142_V279_V0.7650.20
300_I400_C0.7640.20
162_L171_I0.7630.20
5_T335_V0.7630.20
367_R374_T0.7610.20
190_N380_A0.7580.19
39_H271_G0.7570.19
359_G398_G0.7530.19
315_F349_F0.7520.19
63_G366_L0.7510.19
4_D9_G0.7510.19
4_D11_G0.7510.19
31_V100_A0.7510.19
14_G396_G0.7500.19
51_L395_C0.7500.19
44_S187_R0.7490.19
52_P57_V0.7490.19
79_L405_L0.7470.19
63_G379_F0.7460.19
6_V157_A0.7450.19
381_I404_A0.7450.19
222_A380_A0.7440.19
120_R395_C0.7420.19
82_Q347_G0.7410.19
59_D268_R0.7380.19
163_G276_G0.7370.19
353_Q401_A0.7360.19
206_D238_K0.7360.19
36_S39_H0.7360.19
344_W350_F0.7350.19
346_K403_S0.7350.19
380_A383_S0.7340.19
123_W185_E0.7340.19
242_S349_F0.7340.19
84_V291_E0.7340.19
110_H187_R0.7330.19
232_W243_L0.7310.19
288_V370_Q0.7300.19
389_D392_A0.7280.19
81_P212_A0.7260.18
313_S356_Q0.7180.18
91_A184_T0.7180.18
277_D294_T0.7180.18
123_W277_D0.7180.18
187_R277_D0.7180.18
314_F408_A0.7170.18
180_R190_N0.7160.18
93_A330_I0.7150.18
37_A394_G0.7150.18
356_Q388_F0.7140.18
367_R375_I0.7140.18
45_L207_A0.7140.18
104_G124_L0.7140.18
196_D362_T0.7130.18
48_L52_P0.7120.18
199_E401_A0.7110.18
151_Q384_V0.7060.18
116_L349_F0.7050.18
86_D231_L0.7030.18
65_E319_L0.7010.18
318_G399_V0.7010.18
215_C240_P0.7010.18
40_F146_G0.7000.18
185_E315_F0.7000.18
45_L84_V0.6980.18
196_D350_F0.6960.18
61_H353_Q0.6950.18
104_G148_M0.6950.18
187_R334_D0.6920.17
50_H394_G0.6910.17
366_L389_D0.6900.17
213_N236_N0.6900.17
244_M247_P0.6890.17
19_L101_Q0.6890.17
23_K157_A0.6880.17
327_R358_F0.6860.17
63_G285_K0.6840.17
182_N185_E0.6840.17
224_F380_A0.6840.17
385_L403_S0.6830.17
56_P62_S0.6830.17
309_L384_V0.6820.17
196_D226_L0.6800.17
176_L249_L0.6790.17
167_E291_E0.6770.17
380_A384_V0.6770.17
193_R208_L0.6770.17
80_E360_V0.6770.17
102_L127_P0.6760.17
198_E275_P0.6740.17
368_P380_A0.6730.17
5_T224_F0.6730.17
160_R369_S0.6730.17
28_C179_L0.6720.17
87_L400_C0.6700.17
274_M396_G0.6680.17
117_G312_G0.6680.17
364_E384_V0.6680.17
152_A383_S0.6660.17
267_V279_V0.6660.17
148_M400_C0.6650.17
281_K293_W0.6610.17
101_Q209_I0.6610.17
21_L88_A0.6600.17
118_T405_L0.6600.17
48_L57_V0.6580.16
64_L211_V0.6580.16
205_L209_I0.6580.16
190_N388_F0.6560.16
112_R123_W0.6530.16
344_W399_V0.6510.16
296_N329_P0.6500.16
22_Q175_E0.6500.16
143_G152_A0.6500.16
108_L230_K0.6490.16
208_L212_A0.6470.16
214_T240_P0.6450.16
175_E263_Q0.6450.16
62_S65_E0.6400.16
218_I236_N0.6390.16
95_I404_A0.6380.16
200_N289_V0.6380.16
125_S186_F0.6370.16
292_I346_K0.6340.16
3_F40_F0.6340.16
194_F388_F0.6330.16
264_R291_E0.6320.16
19_L72_P0.6320.16
7_I122_T0.6310.16
36_S362_T0.6300.16
78_L362_T0.6280.16
243_L311_S0.6270.16
185_E334_D0.6240.16
32_T147_L0.6230.16
128_E148_M0.6230.16
35_Q271_G0.6220.16
286_N326_I0.6210.15
45_L279_V0.6200.15
306_F400_C0.6180.15
247_P328_E0.6170.15
62_S108_L0.6160.15
314_F317_G0.6150.15
309_L380_A0.6140.15
228_D302_L0.6130.15
107_E305_R0.6120.15
91_A205_L0.6120.15
45_L88_A0.6120.15
304_P360_V0.6100.15
348_D360_V0.6090.15
89_C285_K0.6080.15
88_A104_G0.6070.15
48_L80_E0.6070.15
102_L147_L0.6060.15
367_R412_A0.6040.15
356_Q394_G0.6040.15
90_Q148_M0.6030.15
114_T348_D0.6030.15
222_A404_A0.6030.15
79_L366_L0.6020.15
40_F277_D0.6010.15
103_Q214_T0.6010.15
383_S397_G0.6000.15
155_A168_T0.5990.15
10_G270_G0.5980.15
193_R296_N0.5980.15
239_L348_D0.5980.15
181_N227_A0.5970.15
326_I351_A0.5960.15
309_L331_L0.5930.15
36_S317_G0.5900.15
9_G13_A0.5890.15
6_V404_A0.5870.15
195_L225_G0.5850.15
65_E286_N0.5850.15
60_I335_V0.5840.15
148_M380_A0.5840.15
390_P394_G0.5840.15
209_I239_L0.5810.14
62_S141_V0.5810.14
146_G248_T0.5810.14
307_A377_N0.5780.14
56_P375_I0.5780.14
126_S245_L0.5770.14
108_L376_E0.5750.14
192_A387_G0.5750.14
129_V386_G0.5750.14
118_T396_G0.5740.14
307_A321_A0.5730.14
22_Q205_L0.5730.14
114_T378_L0.5720.14
273_W364_E0.5710.14
53_D160_R0.5700.14
112_R271_G0.5700.14
19_L271_G0.5690.14
296_N362_T0.5680.14
93_A122_T0.5660.14
48_L67_L0.5620.14
330_I375_I0.5620.14
62_S96_A0.5620.14
218_I287_G0.5610.14
260_N307_A0.5600.14
77_S206_D0.5600.14
77_S292_I0.5590.14
213_N281_K0.5590.14
94_L380_A0.5590.14
19_L94_L0.5580.14
53_D233_R0.5580.14
17_C224_F0.5560.14
35_Q185_E0.5550.14
125_S252_S0.5550.14
73_A357_Q0.5520.14
22_Q269_Q0.5520.14
142_V392_A0.5500.14
309_L318_G0.5490.14
76_Y80_E0.5490.14
221_P312_G0.5490.14
117_G221_P0.5490.14
67_L281_K0.5480.14
100_A308_V0.5480.14
194_F271_G0.5470.14
20_Q167_E0.5460.14
49_S119_L0.5450.14
167_E233_R0.5430.14
184_T313_S0.5420.14
141_V152_A0.5420.14
149_D251_P0.5410.14
144_I155_A0.5390.13
225_G404_A0.5390.13
274_M353_Q0.5360.13
6_V243_L0.5340.13
330_I384_V0.5340.13
219_L338_T0.5320.13
62_S82_Q0.5310.13
104_G163_G0.5310.13
61_H85_L0.5300.13
5_T21_L0.5290.13
34_G262_L0.5280.13
294_T404_A0.5280.13
115_P248_T0.5270.13
52_P247_P0.5260.13
145_S208_L0.5250.13
353_Q380_A0.5250.13
34_G313_S0.5240.13
175_E268_R0.5210.13
137_K211_V0.5210.13
10_G146_G0.5200.13
318_G321_A0.5200.13
78_L335_V0.5190.13
302_L393_Q0.5190.13
40_F334_D0.5180.13
96_A364_E0.5170.13
6_V66_S0.5170.13
12_L150_F0.5170.13
57_V63_G0.5160.13
20_Q173_L0.5140.13
109_A397_G0.5130.13
208_L286_N0.5120.13
352_P357_Q0.5120.13
141_V155_A0.5120.13
141_V218_I0.5110.13
168_T287_G0.5100.13
137_K332_G0.5100.13
90_Q134_L0.5090.13
169_A403_S0.5090.13
84_V257_R0.5080.13
51_L67_L0.5080.13
28_C397_G0.5070.13
47_L243_L0.5070.13
351_A381_I0.5060.13
16_L233_R0.5060.13
197_N349_F0.5050.13
119_L232_W0.5040.13
269_Q281_K0.5040.13
45_L289_V0.5030.13
110_H123_W0.5030.13
95_I313_S0.5030.13
159_L354_P0.5020.13
213_N240_P0.5020.13
21_L353_Q0.5010.13
64_L301_P0.5010.13
230_K361_T0.5010.13
83_R376_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c3xA 4 0.7637 99.8 0.862 Contact Map
4at0A 2 0.7136 99.8 0.862 Contact Map
2h88A 2 0.6802 99.8 0.865 Contact Map
3o0hA 2 0.7327 99.8 0.866 Contact Map
2a8xA 2 0.7518 99.8 0.866 Contact Map
1qo8A 2 0.6874 99.8 0.867 Contact Map
2i0zA 1 0.6229 99.8 0.867 Contact Map
2wdqA 1 0.7041 99.8 0.868 Contact Map
3ctyA 2 0.6993 99.8 0.869 Contact Map
3ladA 2 0.7637 99.8 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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