GREMLIN Database
FDHE - Protein FdhE
UniProt: P13024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10284
Length: 309 (281)
Sequences: 524 (393)
Seq/√Len: 23.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_R62_H5.6321.00
108_M137_L3.8061.00
234_Q257_D3.6961.00
259_D294_Y3.3401.00
263_K282_S3.2561.00
263_K279_D3.1321.00
236_G257_D2.9961.00
251_K266_Y2.9691.00
99_R138_E2.8840.99
195_S216_N2.7640.99
241_W254_S2.6610.99
250_I282_S2.6570.99
63_A67_V2.5200.99
202_V266_Y2.4640.98
103_W141_A2.4430.98
46_E55_R2.4400.98
111_I126_I2.2470.97
279_D282_S2.0910.95
141_A164_L2.0630.95
225_V235_S2.0390.94
279_D296_R1.9870.94
34_Y165_S1.8890.92
51_G126_I1.8830.92
22_I27_F1.8700.91
133_S136_E1.8640.91
200_S213_L1.8630.91
200_S211_R1.8250.90
26_L29_R1.8240.90
64_Q279_D1.8110.90
202_V264_I1.8050.90
23_P33_L1.7880.89
252_A296_R1.7800.89
256_D294_Y1.7660.89
208_Q268_E1.7170.87
35_N39_E1.7060.87
209_G280_L1.7030.87
277_A281_A1.6850.86
108_M134_T1.6700.86
228_K240_Y1.6400.85
261_Y286_D1.6300.84
214_H221_E1.6010.83
225_V228_K1.5920.83
41_L110_L1.5620.82
203_Q221_E1.5580.82
64_Q162_A1.5300.80
263_K296_R1.5200.80
252_A289_M1.5180.80
29_R32_N1.5110.80
40_R44_L1.4810.78
88_G185_E1.4700.78
265_L273_I1.4200.75
192_V214_H1.4200.75
231_N297_S1.4170.75
227_V240_Y1.4040.74
299_I304_F1.3940.74
198_V276_V1.3670.72
280_L296_R1.3570.72
227_V266_Y1.3520.71
49_P63_A1.3450.71
213_L230_S1.3400.71
104_Q138_E1.3360.70
41_L61_A1.3250.70
212_Y253_E1.3240.70
51_G55_R1.3240.70
235_S251_K1.3230.70
100_D275_A1.3220.70
161_W165_S1.3220.70
99_R142_S1.3140.69
57_A282_S1.2800.67
24_P206_T1.2720.67
115_K130_E1.2670.66
147_S195_S1.2490.65
83_E86_A1.2490.65
190_C258_C1.2430.65
218_C255_C1.2430.65
193_C215_C1.2430.65
193_C258_C1.2430.65
193_C218_C1.2430.65
193_C229_C1.2430.65
193_C232_C1.2430.65
193_C255_C1.2430.65
190_C255_C1.2430.65
232_C258_C1.2430.65
232_C255_C1.2430.65
218_C229_C1.2430.65
218_C232_C1.2430.65
218_C258_C1.2430.65
215_C232_C1.2430.65
215_C229_C1.2430.65
190_C193_C1.2430.65
190_C215_C1.2430.65
215_C218_C1.2430.65
190_C218_C1.2430.65
190_C229_C1.2430.65
229_C232_C1.2430.65
190_C232_C1.2430.65
229_C255_C1.2430.65
229_C258_C1.2430.65
215_C258_C1.2430.65
215_C255_C1.2430.65
255_C258_C1.2430.65
100_D106_L1.2250.64
275_A282_S1.2230.63
233_E298_S1.2220.63
112_A130_E1.2160.63
199_S265_L1.2120.63
250_I263_K1.2100.63
56_F196_M1.2080.62
282_S296_R1.1840.61
192_V220_T1.1830.61
27_F31_K1.1680.60
80_R84_A1.1590.59
171_M197_P1.1490.59
237_K257_D1.1410.58
92_L145_F1.1410.58
57_A294_Y1.1370.58
235_S240_Y1.1300.57
134_T183_Y1.1230.57
56_F279_D1.1170.56
104_Q137_L1.1060.56
39_E42_R1.1020.55
278_D282_S1.0990.55
87_Q158_P1.0990.55
92_L164_L1.0870.54
119_S169_A1.0810.54
25_L220_T1.0810.54
40_R278_D1.0780.54
58_A283_L1.0730.53
227_V233_E1.0670.53
213_L262_L1.0620.52
202_V261_Y1.0620.52
65_E69_Y1.0550.52
267_Q289_M1.0550.52
209_G228_K1.0510.52
24_P204_I1.0510.52
241_W292_E1.0470.51
33_L169_A1.0460.51
279_D286_D1.0340.51
67_V110_L1.0320.50
97_L109_A1.0290.50
35_N139_D1.0260.50
198_V277_A1.0260.50
189_Y196_M1.0250.50
211_R278_D1.0230.50
200_S238_L1.0210.50
143_A148_D1.0130.49
162_A165_S1.0060.49
22_I204_I0.9950.48
153_S156_K0.9930.48
104_Q288_R0.9930.48
57_A296_R0.9930.48
263_K286_D0.9910.48
66_V128_N0.9900.47
25_L31_K0.9900.47
25_L77_L0.9870.47
110_L295_A0.9850.47
56_F140_M0.9850.47
41_L57_A0.9850.47
191_P229_C0.9810.47
191_P232_C0.9810.47
191_P255_C0.9810.47
191_P218_C0.9810.47
191_P215_C0.9810.47
191_P258_C0.9810.47
164_L217_L0.9810.47
56_F263_K0.9780.47
127_E145_F0.9720.46
289_M292_E0.9710.46
74_E79_A0.9680.46
248_A254_S0.9600.45
32_N35_N0.9590.45
24_P227_V0.9560.45
211_R263_K0.9510.45
289_M293_G0.9500.45
224_V230_S0.9450.44
64_Q275_A0.9450.44
165_S288_R0.9420.44
51_G146_A0.9340.44
112_A174_L0.9340.44
27_F33_L0.9310.43
231_N260_T0.9280.43
50_L194_G0.9240.43
126_I131_K0.9210.43
200_S264_I0.9210.43
161_W304_F0.9190.43
136_E140_M0.9180.42
160_I195_S0.9160.42
67_V70_D0.9130.42
98_P138_E0.9120.42
240_Y243_L0.9090.42
224_V270_D0.9040.41
46_E79_A0.9030.41
106_L167_Y0.9000.41
222_W274_E0.9000.41
34_Y219_E0.8990.41
202_V209_G0.8980.41
29_R36_R0.8960.41
214_H219_E0.8930.41
250_I265_L0.8800.40
212_Y223_H0.8780.40
64_Q278_D0.8760.40
71_H116_P0.8730.39
63_A114_L0.8720.39
89_K189_Y0.8720.39
149_F152_V0.8680.39
45_A55_R0.8640.39
118_M210_L0.8600.39
23_P221_E0.8490.38
84_A233_E0.8490.38
145_F260_T0.8460.38
105_K137_L0.8460.38
120_G123_L0.8440.37
76_D111_I0.8390.37
245_D288_R0.8370.37
263_K278_D0.8350.37
32_N36_R0.8350.37
90_P194_G0.8350.37
245_D248_A0.8310.37
25_L110_L0.8290.36
49_P222_W0.8210.36
44_L301_P0.8210.36
166_L289_M0.8190.36
146_A150_S0.8170.36
24_P304_F0.8140.36
34_Y241_W0.8120.35
244_D282_S0.8100.35
66_V113_E0.8070.35
145_F270_D0.8010.35
260_T297_S0.7980.34
152_V161_W0.7960.34
139_D143_A0.7940.34
28_P39_E0.7920.34
60_I276_V0.7910.34
40_R45_A0.7900.34
56_F280_L0.7860.34
220_T284_V0.7840.34
48_N289_M0.7810.33
238_L241_W0.7760.33
168_W208_Q0.7750.33
52_D146_A0.7750.33
266_Y289_M0.7740.33
128_N139_D0.7740.33
26_L287_A0.7710.33
124_A127_E0.7690.33
152_V160_I0.7680.33
140_M236_G0.7660.32
25_L35_N0.7640.32
124_A133_S0.7640.32
87_Q221_E0.7610.32
208_Q297_S0.7590.32
79_A82_K0.7570.32
34_Y161_W0.7520.32
97_L167_Y0.7490.31
31_K35_N0.7420.31
53_Y274_E0.7410.31
116_P134_T0.7380.31
46_E73_L0.7360.31
107_L263_K0.7360.31
69_Y112_A0.7320.30
70_D112_A0.7290.30
155_D253_E0.7260.30
84_A275_A0.7250.30
34_Y288_R0.7240.30
96_V299_I0.7220.30
222_W281_A0.7180.30
90_P286_D0.7180.30
186_Q192_V0.7090.29
240_Y264_I0.7090.29
29_R142_S0.7080.29
96_V176_P0.7040.29
185_E230_S0.7030.29
60_I76_D0.7010.29
22_I26_L0.6970.28
110_L146_A0.6960.28
26_L32_N0.6940.28
35_N88_G0.6930.28
250_I279_D0.6920.28
250_I296_R0.6920.28
222_W258_C0.6910.28
218_C222_W0.6910.28
193_C222_W0.6910.28
215_C222_W0.6910.28
222_W255_C0.6910.28
190_C222_W0.6910.28
222_W232_C0.6910.28
222_W229_C0.6910.28
263_K283_L0.6900.28
247_Q302_F0.6890.28
118_M123_L0.6890.28
216_N226_R0.6850.28
238_L243_L0.6810.27
64_Q200_S0.6800.27
64_Q263_K0.6790.27
242_S248_A0.6760.27
133_S152_V0.6720.27
106_L166_L0.6720.27
152_V202_V0.6670.27
23_P26_L0.6670.27
96_V260_T0.6670.27
225_V240_Y0.6660.27
86_A132_A0.6640.27
163_A198_V0.6620.26
92_L144_L0.6600.26
163_A263_K0.6540.26
41_L157_A0.6530.26
32_N208_Q0.6530.26
187_R233_E0.6520.26
159_F263_K0.6510.26
217_L261_Y0.6510.26
144_L217_L0.6510.26
175_I303_L0.6510.26
34_Y192_V0.6500.26
22_I205_G0.6490.26
22_I210_L0.6470.26
22_I223_H0.6440.25
65_E68_L0.6390.25
55_R105_K0.6380.25
36_R176_P0.6370.25
242_S245_D0.6360.25
199_S264_I0.6340.25
57_A216_N0.6310.25
90_P172_A0.6290.25
40_R263_K0.6280.25
93_D147_S0.6270.25
22_I29_R0.6260.25
224_V228_K0.6260.25
213_L224_V0.6250.24
128_N259_D0.6240.24
34_Y304_F0.6230.24
94_I185_E0.6200.24
165_S217_L0.6200.24
128_N156_K0.6190.24
89_K256_D0.6190.24
209_G267_Q0.6190.24
227_V291_Q0.6170.24
25_L177_G0.6110.24
204_I208_Q0.6100.24
278_D281_A0.6090.24
202_V241_W0.6090.24
123_L126_I0.6080.24
162_A253_E0.6070.24
267_Q273_I0.6060.24
253_E264_I0.6040.23
267_Q271_P0.6020.23
86_A137_L0.6020.23
110_L254_S0.6010.23
140_M175_I0.6000.23
201_M259_D0.5980.23
25_L32_N0.5970.23
194_G251_K0.5960.23
98_P107_L0.5950.23
262_L298_S0.5940.23
148_D151_S0.5900.23
91_P176_P0.5900.23
59_L105_K0.5900.23
55_R291_Q0.5870.23
66_V131_K0.5860.23
162_A279_D0.5830.22
26_L267_Q0.5830.22
240_Y287_A0.5800.22
92_L111_I0.5800.22
160_I278_D0.5780.22
172_A220_T0.5780.22
110_L250_I0.5770.22
28_P173_N0.5760.22
104_Q142_S0.5730.22
53_Y209_G0.5730.22
144_L166_L0.5730.22
102_H245_D0.5700.22
26_L174_L0.5700.22
75_M171_M0.5650.21
123_L127_E0.5650.21
166_L266_Y0.5620.21
122_A150_S0.5620.21
103_W163_A0.5600.21
278_D296_R0.5600.21
53_Y289_M0.5570.21
39_E281_A0.5560.21
32_N204_I0.5560.21
188_Q216_N0.5550.21
223_H298_S0.5540.21
123_L236_G0.5490.21
95_H200_S0.5470.21
221_E302_F0.5460.21
36_R112_A0.5450.21
144_L262_L0.5430.20
66_V70_D0.5420.20
109_A113_E0.5420.20
32_N292_E0.5420.20
194_G226_R0.5400.20
214_H277_A0.5400.20
126_I177_G0.5390.20
213_L243_L0.5380.20
104_Q141_A0.5370.20
112_A132_A0.5340.20
67_V245_D0.5330.20
212_Y263_K0.5320.20
147_S216_N0.5310.20
51_G117_E0.5300.20
84_A216_N0.5290.20
202_V275_A0.5280.20
113_E166_L0.5280.20
198_V278_D0.5260.20
224_V233_E0.5230.20
151_S254_S0.5220.20
125_V186_Q0.5200.19
170_Q174_L0.5190.19
144_L160_I0.5190.19
213_L297_S0.5170.19
182_E268_E0.5170.19
196_M224_V0.5140.19
53_Y225_V0.5130.19
57_A60_I0.5130.19
115_K178_K0.5110.19
22_I265_L0.5090.19
57_A263_K0.5050.19
44_L278_D0.5050.19
40_R279_D0.5050.19
59_L151_S0.5020.19
53_Y161_W0.5020.19
56_F169_A0.5000.19
79_A117_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fiyA 1 0.9061 100 0.124 Contact Map
4cgyA 1 0.4434 95.7 0.926 Contact Map
1twfI 1 0.2816 93.5 0.934 Contact Map
4c2mI 1 0.2557 92.9 0.936 Contact Map
3h0gI 1 0.246 91.1 0.939 Contact Map
2vjeB 1 0.1974 82.1 0.947 Contact Map
1qypA 1 0.1748 80.7 0.948 Contact Map
3qt1I 1 0.123 79.4 0.948 Contact Map
1tfiA 1 0.1521 78.7 0.949 Contact Map
1chcA 1 0.2201 78.6 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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