GREMLIN Database
METH - Methionine synthase
UniProt: P13009 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10587
Length: 1227 (1149)
Sequences: 1362 (647)
Seq/√Len: 19.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_D446_K6.2431.00
750_V798_A6.2411.00
57_V107_A6.1821.00
65_A113_A5.3831.00
506_K510_E5.2971.00
112_R116_D5.2251.00
101_A172_E5.0331.00
72_F79_I4.9971.00
1062_A1163_M4.9601.00
467_I507_I4.8321.00
379_K382_E4.7941.00
502_R506_K4.5901.00
171_V207_L4.2431.00
180_I196_V4.1691.00
660_N685_Q4.1021.00
986_K990_E4.0961.00
661_K664_E4.0611.00
792_T796_V4.0341.00
822_E851_S3.9991.00
548_D552_E3.9751.00
69_N117_E3.9611.00
791_R795_E3.9091.00
550_K593_D3.8721.00
960_Y977_F3.7631.00
506_K509_T3.7071.00
496_R499_E3.6451.00
1121_S1124_E3.4971.00
525_I562_V3.4761.00
197_K206_E3.4531.00
1012_E1022_V3.3851.00
210_M242_T3.3841.00
794_K824_Q3.2961.00
547_E590_N3.2761.00
155_T158_G3.1850.99
928_R932_Q3.1670.99
1022_V1025_V3.1660.99
928_R1001_L3.1480.99
410_E439_D3.1070.99
397_I453_I3.0760.99
1012_E1050_K3.0620.99
172_E203_L3.0370.99
748_K776_E3.0060.99
119_T122_T3.0050.99
167_T199_E2.9960.99
1028_H1042_C2.9820.99
85_N90_A2.9480.99
194_F472_L2.9200.99
316_Q319_A2.9190.99
106_A109_K2.9160.99
502_R552_E2.9120.99
624_R630_R2.9060.99
105_F109_K2.8920.99
180_I193_V2.8790.99
562_V592_M2.8630.99
498_I548_D2.8420.99
537_N540_Q2.8370.99
27_I64_I2.8100.99
992_T1072_L2.7710.98
319_A323_R2.7610.98
1012_E1025_V2.7140.98
494_R548_D2.6980.98
133_L167_T2.6960.98
936_A1102_Y2.6920.98
1156_E1159_K2.6910.98
235_L243_F2.6780.98
1007_V1012_E2.6650.98
373_R377_E2.6630.98
906_L910_R2.6510.98
528_V620_I2.6440.98
997_G1099_F2.6300.98
546_C558_I2.6260.98
86_S103_I2.6080.98
78_I130_A2.5970.98
1024_N1150_T2.5940.98
168_K202_A2.5790.97
1016_D1019_R2.5790.97
448_I452_G2.5780.97
69_N114_C2.5220.97
30_Y66_A2.5200.97
537_N622_N2.5130.97
582_V620_I2.5010.97
259_Q816_N2.4710.97
653_E656_S2.4400.96
132_V272_H2.4400.96
942_R985_D2.4380.96
934_V999_V2.4120.96
467_I511_E2.3980.96
936_A1099_F2.3960.96
775_Y871_L2.3900.96
296_R300_Q2.3870.96
101_A169_A2.3410.95
1106_R1110_V2.3410.95
972_E975_R2.3220.95
775_Y867_V2.3190.95
1072_L1075_A2.3180.95
498_I552_E2.2780.95
60_K63_V2.2760.95
92_A97_E2.2750.95
251_P286_L2.2710.95
1077_E1089_K2.2680.95
90_A137_N2.2640.94
307_V325_V2.2550.94
164_R202_A2.2490.94
676_E731_Y2.2450.94
87_T90_A2.2320.94
618_D623_R2.2150.94
1075_A1079_Q2.2040.94
169_A172_E2.1920.93
934_V1103_L2.1810.93
160_V198_T2.1800.93
463_V511_E2.1780.93
232_Y266_E2.1690.93
558_I592_M2.1670.93
544_G547_E2.1560.93
433_I448_I2.1430.93
1149_A1169_F2.1320.92
88_T165_E2.1320.92
1124_E1129_N2.1170.92
167_T196_V2.1160.92
296_R327_G2.1110.92
1064_T1067_L2.1100.92
33_N36_D2.1070.92
1069_E1088_V2.0800.91
792_T795_E2.0750.91
27_I67_I2.0720.91
65_A69_N2.0710.91
929_L1057_Y2.0660.91
626_D630_R2.0530.91
105_F172_E2.0520.91
242_T306_I2.0520.91
89_I154_I2.0490.91
89_I162_A2.0430.91
924_P1183_S2.0390.91
178_I196_V2.0290.90
1105_E1109_K2.0260.90
1047_V1058_I2.0210.90
340_C350_I2.0170.90
359_V432_M2.0130.90
680_E683_R2.0060.90
657_W661_K2.0060.90
122_T126_P2.0040.90
787_E791_R2.0030.90
775_Y868_A1.9810.89
790_L821_M1.9800.89
183_V189_A1.9680.89
83_T107_A1.9680.89
296_R328_L1.9590.89
65_A117_E1.9470.88
507_I511_E1.9440.88
255_R823_R1.9430.88
1073_A1088_V1.9390.88
467_I512_V1.9390.88
1069_E1073_A1.9320.88
1074_D1078_A1.9320.88
999_V1103_L1.9260.88
615_A634_L1.9220.88
547_E551_R1.9140.88
233_N349_N1.9100.87
523_P549_I1.9100.87
242_T270_T1.9090.87
200_F206_E1.8940.87
537_N541_D1.8920.87
167_T178_I1.8910.87
411_A415_R1.8850.87
101_A105_F1.8840.87
133_L166_S1.8820.87
91_M96_M1.8770.86
507_I512_V1.8720.86
114_C117_E1.8700.86
369_A372_K1.8670.86
10_A14_E1.8640.86
295_I321_M1.8560.86
548_D551_R1.8360.85
69_N118_W1.8310.85
193_V235_L1.8260.85
672_T675_I1.8210.85
109_K113_A1.8170.85
912_N1040_N1.8050.84
610_A613_R1.8010.84
495_A548_D1.7980.84
1014_Y1050_K1.7970.84
171_V199_E1.7930.84
370_K382_E1.7890.84
454_V473_L1.7840.83
926_A930_G1.7830.83
119_T124_E1.7830.83
793_A801_I1.7810.83
818_A830_L1.7770.83
164_R198_T1.7670.83
672_T727_Q1.7660.83
932_Q1001_L1.7580.83
794_K826_F1.7570.83
731_Y735_F1.7570.83
1007_V1050_K1.7520.82
465_A468_H1.7490.82
11_Q14_E1.7480.82
18_V325_V1.7480.82
935_E996_R1.7450.82
1010_D1025_V1.7440.82
800_L867_V1.7410.82
546_C592_M1.7390.82
1072_L1088_V1.7370.82
72_F115_A1.7370.82
236_R517_E1.7340.82
931_V1002_F1.7340.82
372_K376_K1.7220.81
73_E118_W1.7210.81
320_A324_A1.7210.81
193_V238_A1.7150.81
780_L792_T1.7150.81
944_Y1105_E1.7140.81
985_D989_A1.7130.81
550_K557_L1.7120.81
69_N73_E1.7100.81
16_I299_A1.7100.81
992_T1088_V1.7090.81
296_R324_A1.7050.81
502_R510_E1.7030.80
748_K798_A1.6970.80
790_L826_F1.6940.80
465_A469_H1.6910.80
1059_G1107_V1.6780.79
888_E892_I1.6780.79
30_Y63_V1.6750.79
680_E731_Y1.6720.79
64_I67_I1.6620.79
297_E301_A1.6600.79
1158_E1164_K1.6580.79
1005_N1014_Y1.6570.79
236_R266_E1.6540.78
687_T691_E1.6520.78
76_A318_I1.6470.78
1001_L1013_I1.6430.78
749_M867_V1.6380.78
928_R1002_F1.6360.78
927_H1001_L1.6340.78
108_A173_G1.6200.77
1011_I1028_H1.6090.76
681_E685_Q1.6070.76
1149_A1153_E1.6050.76
493_T497_K1.6000.76
19_L306_I1.5990.76
962_R965_E1.5910.76
58_L103_I1.5910.76
295_I307_V1.5850.75
812_D815_V1.5810.75
942_R988_S1.5750.75
164_R199_E1.5700.75
417_L431_I1.5630.74
119_T123_P1.5620.74
820_E823_R1.5610.74
442_E476_Y1.5610.74
8_L241_L1.5590.74
251_P298_W1.5590.74
66_A70_A1.5550.74
977_F981_N1.5540.74
582_V613_R1.5520.74
966_D969_V1.5510.74
232_Y267_C1.5500.74
581_A603_A1.5480.74
414_V418_N1.5450.73
494_R497_K1.5430.73
32_L63_V1.5420.73
410_E414_V1.5390.73
133_L178_I1.5380.73
88_T162_A1.5350.73
254_L272_H1.5290.73
788_K791_R1.5270.72
539_A616_V1.5240.72
26_M70_A1.5170.72
525_I592_M1.5170.72
418_N447_C1.5150.72
1007_V1025_V1.5000.71
992_T1076_F1.5000.71
197_K475_R1.4960.71
51_G94_Y1.4960.71
1152_W1157_V1.4950.71
942_R981_N1.4900.71
1010_D1027_H1.4900.71
965_E974_Q1.4880.70
432_M481_V1.4860.70
201_E475_R1.4840.70
941_L995_P1.4830.70
618_D630_R1.4760.70
132_V166_S1.4750.70
18_V322_S1.4740.70
1060_A1151_I1.4710.70
119_T126_P1.4650.69
1024_N1153_E1.4640.69
941_L1102_Y1.4610.69
548_D553_L1.4580.69
494_R498_I1.4580.69
300_Q328_L1.4570.69
585_Y589_R1.4560.69
913_D1006_R1.4540.69
611_E637_K1.4490.68
940_T1102_Y1.4480.68
1026_S1180_W1.4450.68
664_E703_V1.4410.68
366_T404_E1.4400.68
286_L291_M1.4390.68
921_Y924_P1.4320.67
750_V792_T1.4300.67
565_V579_I1.4230.67
137_N593_D1.4220.67
648_N651_Q1.4180.67
78_I177_L1.4180.67
467_I471_K1.4160.67
1015_R1019_R1.4150.66
11_Q128_Y1.4140.66
357_V396_Q1.4120.66
168_K203_L1.4120.66
748_K796_V1.4110.66
459_M463_V1.4050.66
108_A170_L1.4020.66
995_P1068_E1.3990.66
562_V595_G1.3960.65
286_L290_T1.3930.65
1072_L1076_F1.3920.65
232_Y265_A1.3920.65
618_D624_R1.3880.65
175_A178_I1.3840.65
539_A565_V1.3800.64
266_E333_L1.3780.64
956_L969_V1.3740.64
540_Q622_N1.3680.64
502_R553_L1.3650.64
210_M270_T1.3620.63
481_V592_M1.3620.63
938_I995_P1.3620.63
123_P126_P1.3600.63
199_E203_L1.3550.63
252_D286_L1.3550.63
280_A283_E1.3530.63
1014_Y1022_V1.3500.63
36_D60_K1.3500.63
1006_R1049_P1.3450.62
788_K792_T1.3420.62
57_V83_T1.3400.62
1015_R1023_I1.3400.62
130_A177_L1.3370.62
803_L817_V1.3320.62
778_V796_V1.3310.62
65_A110_L1.3310.62
801_I821_M1.3300.62
791_R824_Q1.3260.61
557_L593_D1.3200.61
214_T248_A1.3200.61
408_D411_A1.3130.61
981_N985_D1.3010.60
72_F114_C1.3000.60
494_R544_G1.3000.60
1092_A1175_A1.2990.60
879_F883_T1.2950.59
1047_V1182_F1.2940.59
925_V929_L1.2870.59
180_I192_A1.2860.59
53_N94_Y1.2840.59
614_D624_R1.2830.59
1122_N1126_I1.2820.59
105_F169_A1.2810.59
957_A969_V1.2800.59
505_Y516_P1.2790.58
86_S104_N1.2790.58
928_R931_V1.2780.58
103_I107_A1.2760.58
65_A114_C1.2640.58
652_A656_S1.2640.58
171_V203_L1.2630.57
197_K209_I1.2600.57
636_E639_R1.2530.57
228_T257_Y1.2520.57
101_A168_K1.2510.57
403_D490_Q1.2480.57
164_R168_K1.2470.56
1005_N1050_K1.2410.56
1048_A1052_S1.2410.56
431_I448_I1.2380.56
100_S169_A1.2370.56
1009_D1042_C1.2290.55
927_H932_Q1.2240.55
28_Q284_Y1.2200.55
166_S272_H1.2170.55
515_P555_H1.2160.55
169_A175_A1.2140.54
751_I767_G1.2100.54
517_E555_H1.1990.53
299_A325_V1.1990.53
118_W124_E1.1990.53
89_I137_N1.1960.53
119_T127_R1.1930.53
1142_C1180_W1.1900.53
684_Q731_Y1.1900.53
193_V196_V1.1900.53
91_M100_S1.1860.53
463_V503_R1.1830.52
254_L298_W1.1820.52
1015_R1018_T1.1790.52
990_E1076_F1.1690.52
320_A323_R1.1660.51
751_I831_L1.1650.51
11_Q15_R1.1640.51
233_N341_R1.1640.51
1028_H1180_W1.1630.51
168_K172_E1.1590.51
688_R739_S1.1570.51
968_V971_V1.1530.51
52_N91_M1.1530.51
1087_M1090_A1.1490.50
12_L241_L1.1490.50
132_V254_L1.1470.50
964_L974_Q1.1470.50
433_I441_I1.1440.50
1102_Y1106_R1.1430.50
987_L992_T1.1400.50
200_F207_L1.1390.50
1069_E1072_L1.1360.49
680_E684_Q1.1310.49
1015_R1021_H1.1310.49
291_M295_I1.1290.49
494_R541_D1.1280.49
506_K511_E1.1260.49
1081_D1084_N1.1260.49
97_E100_S1.1250.49
1005_N1055_A1.1240.49
1011_I1047_V1.1230.49
400_I431_I1.1230.49
1085_K1089_K1.1220.49
847_E884_R1.1190.48
628_T631_L1.1160.48
938_I991_K1.1130.48
92_A137_N1.1090.48
528_V619_V1.1080.48
118_W122_T1.1080.48
925_V1057_Y1.1050.48
323_R326_E1.1040.47
169_A173_G1.1020.47
291_M321_M1.1000.47
614_D618_D1.0980.47
1145_H1148_K1.0980.47
213_G245_L1.0970.47
138_R153_N1.0910.47
420_I431_I1.0900.47
287_D290_T1.0900.47
414_V443_K1.0860.46
983_M1084_N1.0850.46
1007_V1022_V1.0800.46
956_L973_A1.0780.46
118_W123_P1.0750.46
37_F53_N1.0750.46
256_Q298_W1.0710.45
1144_E1147_E1.0710.45
29_S316_Q1.0700.45
987_L993_L1.0690.45
99_L102_E1.0690.45
690_I736_I1.0680.45
369_A573_D1.0650.45
1076_F1084_N1.0630.45
54_D85_N1.0630.45
304_L307_V1.0600.45
378_E412_A1.0600.45
359_V397_I1.0580.45
1163_M1176_S1.0580.45
495_A499_E1.0580.45
348_L1002_F1.0580.45
857_V866_V1.0570.44
307_V321_M1.0570.44
738_A742_Q1.0560.44
32_L60_K1.0560.44
17_L128_Y1.0540.44
1157_V1161_T1.0540.44
965_E968_V1.0500.44
464_D467_I1.0420.44
12_L268_Y1.0400.43
228_T245_L1.0360.43
243_F265_A1.0340.43
211_I240_A1.0310.43
91_M581_A1.0310.43
1128_E1133_I1.0300.43
992_T1075_A1.0280.43
908_A911_D1.0280.43
1006_R1052_S1.0270.43
122_T125_K1.0260.43
659_V663_L1.0250.42
869_A882_R1.0250.42
299_A328_L1.0250.42
562_V565_V1.0220.42
358_N396_Q1.0200.42
936_A1106_R1.0190.42
472_L476_Y1.0190.42
908_A912_N1.0190.42
910_R1042_C1.0160.42
987_L1088_V1.0150.42
280_A894_H1.0150.42
8_L17_L1.0100.42
986_K1076_F1.0100.42
745_T776_E1.0020.41
931_V1159_K1.0000.41
233_N347_P0.9980.41
215_I222_T0.9970.41
792_T798_A0.9970.41
929_L1001_L0.9960.41
544_G551_R0.9950.41
681_E684_Q0.9930.41
137_N162_A0.9930.41
786_A816_N0.9930.41
441_I609_P0.9900.40
937_S988_S0.9900.40
1005_N1012_E0.9890.40
70_A315_P0.9880.40
1060_A1157_V0.9880.40
778_V792_T0.9860.40
1014_Y1019_R0.9850.40
28_Q53_N0.9840.40
167_T195_A0.9840.40
839_K852_G0.9820.40
494_R552_E0.9820.40
7_Q128_Y0.9820.40
299_A324_A0.9800.40
876_R880_V0.9780.40
280_A840_A0.9780.40
1070_D1073_A0.9780.40
115_A129_V0.9760.39
400_I417_L0.9730.39
529_A619_V0.9720.39
582_V634_L0.9720.39
778_V798_A0.9700.39
543_I590_N0.9700.39
738_A741_E0.9690.39
164_R171_V0.9690.39
198_T202_A0.9680.39
1033_T1040_N0.9670.39
254_L271_A0.9660.39
58_L106_A0.9640.39
291_M307_V0.9630.39
474_R509_T0.9630.39
586_Y617_E0.9630.39
125_K322_S0.9630.39
365_V407_L0.9630.39
168_K199_E0.9620.39
986_K992_T0.9600.39
112_R115_A0.9590.38
1064_T1176_S0.9530.38
18_V76_A0.9530.38
241_L528_V0.9530.38
359_V559_S0.9510.38
161_A198_T0.9510.38
369_A373_R0.9510.38
929_L932_Q0.9510.38
565_V620_I0.9500.38
921_Y1183_S0.9480.38
369_A527_A0.9470.38
484_A501_C0.9450.38
213_G248_A0.9450.38
406_M844_V0.9420.37
400_I429_V0.9410.37
821_M830_L0.9390.37
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359_V727_Q0.5070.17
443_K636_E0.5060.17
323_R539_A0.5060.17
731_Y1157_V0.5060.17
107_A1152_W0.5060.17
366_T1128_E0.5060.17
676_E684_Q0.5060.17
1011_I1022_V0.5050.17
169_A415_R0.5050.17
51_G225_G0.5050.17
910_R1010_D0.5050.17
358_N887_Y0.5040.16
778_V985_D0.5040.16
163_Y189_A0.5040.16
297_E820_E0.5040.16
572_N719_V0.5040.16
257_Y418_N0.5030.16
679_T728_A0.5030.16
1115_A1118_E0.5030.16
169_A372_K0.5030.16
653_E657_W0.5030.16
175_A488_Q0.5030.16
254_L557_L0.5030.16
55_L99_L0.5030.16
202_A907_E0.5030.16
791_R800_L0.5030.16
243_F298_W0.5020.16
984_L1095_L0.5020.16
203_L206_E0.5020.16
167_T197_K0.5020.16
209_I1156_E0.5020.16
103_I166_S0.5020.16
193_V209_I0.5020.16
433_I998_V0.5020.16
649_A652_A0.5020.16
98_S378_E0.5020.16
396_Q1107_V0.5020.16
103_I787_E0.5020.16
356_F454_V0.5020.16
657_W665_Y0.5010.16
175_A1018_T0.5010.16
177_L565_V0.5010.16
107_A1052_S0.5000.16
1006_R1042_C0.5000.16
709_G713_M0.5000.16
527_A532_I0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cczA 1 0.4963 100 0.658 Contact Map
3bulA 1 0.4703 100 0.687 Contact Map
1q7zA 1 0.4531 100 0.741 Contact Map
1mskA 1 0.2665 100 0.801 Contact Map
2o2kA 2 0.2632 100 0.804 Contact Map
4m3pA 4 0.2893 100 0.848 Contact Map
3k13A 1 0.2339 100 0.885 Contact Map
4o1eA 2 0.2192 100 0.909 Contact Map
2yciX 2 0.2184 100 0.91 Contact Map
1f6yA 2 0.2078 100 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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