GREMLIN Database
BIOH - Pimeloyl-[acyl-carrier protein] methyl ester esterase
UniProt: P13001 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10122
Length: 256 (238)
Sequences: 58783 (48071)
Seq/√Len: 3116.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_I101_A4.5211.00
8_T41_T4.5061.00
48_P67_A3.6271.00
32_I246_C3.1681.00
69_L91_I2.9561.00
205_Y231_A2.8521.00
241_H244_E2.8521.00
228_Y248_L2.7981.00
106_A207_D2.7651.00
77_I100_Q2.7521.00
200_L252_L2.6271.00
105_V245_F2.5611.00
75_K100_Q2.4841.00
230_F248_L2.4411.00
91_I95_H2.2181.00
205_Y229_I2.1721.00
69_L95_H2.1531.00
69_L73_P2.1421.00
69_L98_R2.0731.00
85_G107_S2.0681.00
72_A76_A2.0471.00
78_W88_A2.0381.00
7_Q26_A2.0161.00
35_E246_C1.9741.00
219_D225_S1.9631.00
15_H43_H1.9521.00
73_P98_R1.9431.00
39_H250_V1.9031.00
90_Q94_T1.8931.00
233_A241_H1.8731.00
15_H41_T1.8481.00
212_R229_I1.8311.00
92_A102_L1.8001.00
199_F222_W1.7291.00
77_I103_V1.7111.00
248_L251_A1.6961.00
217_M221_L1.6871.00
77_I253_K1.6861.00
20_H47_L1.6851.00
66_E94_T1.6831.00
200_L228_Y1.6781.00
8_T43_H1.6391.00
40_F77_I1.6321.00
65_A90_Q1.6311.00
88_A102_L1.5941.00
45_V68_V1.5931.00
62_A94_T1.5891.00
19_L47_L1.5821.00
20_H50_F1.5591.00
47_L87_V1.5301.00
24_L28_V1.5211.00
91_I99_V1.5021.00
68_V91_I1.4821.00
9_K44_L1.4571.00
19_L68_V1.4531.00
26_A46_D1.4401.00
26_A52_R1.4231.00
244_E248_L1.4191.00
95_H98_R1.4151.00
247_H251_A1.4071.00
104_T107_S1.3971.00
35_E250_V1.3841.00
89_S104_T1.3841.00
43_H71_Q1.3771.00
91_I98_R1.3651.00
73_P95_H1.3551.00
60_S63_D1.3531.00
81_W238_F1.3501.00
33_D44_L1.3401.00
103_V249_L1.3371.00
191_P194_N1.3341.00
90_Q93_L1.3281.00
23_G50_F1.3101.00
93_L191_P1.2551.00
18_L79_L1.2511.00
35_E38_S1.2511.00
103_V200_L1.2441.00
244_E247_H1.2411.00
230_F233_A1.2231.00
79_L105_V1.2171.00
16_L40_F1.2171.00
203_Y229_I1.2161.00
203_Y215_V1.2111.00
19_L88_A1.1981.00
82_S235_H1.1921.00
212_R216_P1.1851.00
18_L42_L1.1831.00
222_W225_S1.1801.00
76_A99_V1.1771.00
219_D227_S1.1591.00
203_Y227_S1.1531.00
202_L230_F1.1331.00
17_V72_A1.1191.00
216_P220_K1.1111.00
35_E243_A1.1021.00
23_G82_S1.0971.00
21_G82_S1.0921.00
205_Y232_K1.0871.00
26_A44_L1.0831.00
217_M220_K1.0601.00
28_V238_F1.0531.00
200_L226_E1.0451.00
45_V71_Q1.0441.00
79_L249_L1.0421.00
9_K33_D1.0401.00
159_R162_K1.0351.00
101_A198_P1.0341.00
80_G88_A1.0291.00
226_E248_L1.0251.00
193_Q221_L1.0201.00
129_Q133_S1.0181.00
172_E175_V1.0151.00
62_A90_Q1.0121.00
230_F244_E1.0101.00
234_A240_S1.0091.00
228_Y251_A1.0061.00
19_L78_W0.9971.00
245_F249_L0.9931.00
69_L94_T0.9891.00
37_S42_L0.9801.00
216_P229_I0.9691.00
17_V76_A0.9661.00
65_A87_V0.9651.00
105_V237_P0.9631.00
243_A247_H0.9621.00
81_W236_A0.9601.00
202_L248_L0.9541.00
203_Y212_R0.9541.00
155_R159_R0.9511.00
154_A157_D0.9511.00
233_A240_S0.9491.00
9_K37_S0.9461.00
76_A98_R0.9371.00
40_F253_K0.9341.00
105_V238_F0.9331.00
72_A91_I0.9331.00
174_D178_G0.9301.00
216_P227_S0.9231.00
160_A164_T0.9231.00
58_A63_D0.9221.00
46_D51_G0.9201.00
158_A162_K0.9141.00
233_A237_P0.9131.00
126_A130_Q0.9051.00
34_E37_S0.9041.00
216_P219_D0.8981.00
30_R44_L0.8941.00
178_G181_E0.8891.00
159_R163_K0.8891.00
69_L72_A0.8871.00
15_H76_A0.8871.00
177_N181_E0.8791.00
161_L165_V0.8771.00
92_A99_V0.8721.00
47_L83_L0.8691.00
228_Y244_E0.8641.00
136_F139_T0.8601.00
65_A94_T0.8601.00
13_N41_T0.8541.00
33_D42_L0.8531.00
78_W99_V0.8451.00
11_Q41_T0.8451.00
164_T167_A0.8411.00
31_C34_E0.8401.00
15_H40_F0.8391.00
175_V178_G0.8381.00
63_D66_E0.8351.00
64_M83_L0.8281.00
16_L79_L0.8251.00
126_A129_Q0.8211.00
16_L42_L0.8151.00
70_Q73_P0.8141.00
158_A161_L0.8141.00
90_Q191_P0.8141.00
180_L183_L0.8121.00
215_V227_S0.8091.00
160_A163_K0.8071.00
32_I35_E0.7981.00
157_D160_A0.7921.00
26_A45_V0.7891.00
106_A237_P0.7891.00
19_L45_V0.7871.00
174_D177_N0.7871.00
130_Q134_D0.7861.00
102_L199_F0.7851.00
179_G182_I0.7841.00
230_F241_H0.7811.00
176_L179_G0.7761.00
70_Q74_D0.7751.00
80_G85_G0.7751.00
163_K166_L0.7691.00
178_G182_I0.7651.00
20_H45_V0.7601.00
101_A252_L0.7591.00
201_R225_S0.7571.00
106_A204_G0.7551.00
66_E69_L0.7511.00
93_L194_N0.7491.00
16_L253_K0.7481.00
48_P64_M0.7451.00
214_V217_M0.7421.00
65_A91_I0.7391.00
40_F250_V0.7331.00
46_D52_R0.7271.00
196_S223_P0.7261.00
66_E70_Q0.7261.00
147_Q150_G0.7251.00
16_L77_I0.7251.00
76_A100_Q0.7221.00
22_W83_L0.7221.00
81_W106_A0.7171.00
246_C250_V0.7171.00
99_V197_M0.7161.00
137_Q141_E0.7151.00
17_V68_V0.7141.00
101_A253_K0.7121.00
158_A165_V0.7111.00
213_K216_P0.7111.00
34_E38_S0.7081.00
92_A197_M0.7071.00
18_L29_W0.7061.00
155_R158_A0.7061.00
156_Q160_A0.7061.00
27_E30_R0.7051.00
62_A66_E0.7041.00
205_Y212_R0.7031.00
106_A203_Y0.7031.00
86_L108_S0.7021.00
162_K165_V0.6961.00
135_D139_T0.6901.00
89_S109_P0.6901.00
47_L64_M0.6881.00
232_K241_H0.6881.00
29_W33_D0.6871.00
13_N77_I0.6851.00
128_F132_L0.6851.00
103_V253_K0.6841.00
17_V78_W0.6751.00
138_R141_E0.6731.00
242_P246_C0.6721.00
204_G237_P0.6691.00
10_G41_T0.6671.00
149_M152_E0.6651.00
173_V177_N0.6641.00
139_T142_R0.6641.00
156_Q159_R0.6641.00
12_G41_T0.6631.00
140_V144_L0.6611.00
38_S250_V0.6591.00
81_W105_V0.6541.00
79_L103_V0.6521.00
103_V252_L0.6511.00
23_G83_L0.6471.00
78_W91_I0.6451.00
33_D37_S0.6441.00
30_R34_E0.6441.00
141_E145_A0.6431.00
247_H250_V0.6411.00
142_R146_L0.6411.00
179_G183_L0.6401.00
104_T201_R0.6391.00
125_L129_Q0.6391.00
101_A200_L0.6381.00
138_R142_R0.6371.00
202_L245_F0.6371.00
46_D53_S0.6351.00
162_K166_L0.6341.00
13_N100_Q0.6271.00
47_L50_F0.6241.00
206_L232_K0.6221.00
176_L180_L0.6191.00
172_E178_G0.6171.00
140_V143_F0.6111.00
128_F131_Q0.6101.00
127_G130_Q0.6101.00
142_R145_A0.6031.00
32_I245_F0.6031.00
28_V81_W0.6021.00
124_V127_G0.6011.00
186_V189_R0.5991.00
9_K34_E0.5981.00
80_G84_G0.5971.00
171_P174_D0.5971.00
163_K167_A0.5931.00
65_A69_L0.5891.00
188_L191_P0.5891.00
13_N40_F0.5831.00
124_V128_F0.5821.00
125_L132_L0.5821.00
16_L36_L0.5801.00
207_D235_H0.5781.00
39_H42_L0.5771.00
143_F147_Q0.5751.00
139_T143_F0.5731.00
18_L44_L0.5721.00
249_L253_K0.5691.00
36_L249_L0.5691.00
61_L90_Q0.5681.00
76_A91_I0.5681.00
127_G131_Q0.5651.00
72_A98_R0.5651.00
130_Q133_S0.5621.00
63_D67_A0.5621.00
215_V219_D0.5591.00
144_L149_M0.5591.00
125_L128_F0.5581.00
103_V202_L0.5561.00
29_W32_I0.5541.00
226_E251_A0.5541.00
24_L236_A0.5531.00
237_P245_F0.5521.00
246_C251_A0.5501.00
95_H99_V0.5491.00
201_R215_V0.5471.00
190_Q193_Q0.5471.00
7_Q30_R0.5461.00
18_L36_L0.5461.00
64_M87_V0.5461.00
17_V45_V0.5451.00
82_S236_A0.5441.00
181_E184_K0.5431.00
143_F146_L0.5431.00
172_E179_G0.5431.00
139_T144_L0.5421.00
64_M67_A0.5411.00
201_R227_S0.5411.00
161_L164_T0.5391.00
136_F140_V0.5371.00
61_L87_V0.5371.00
124_V129_Q0.5361.00
105_V202_L0.5341.00
143_F148_T0.5341.00
172_E180_L0.5281.00
12_G15_H0.5271.00
83_L87_V0.5251.00
8_T15_H0.5241.00
127_G132_L0.5241.00
13_N75_K0.5211.00
71_Q74_D0.5201.00
89_S107_S0.5181.00
202_L228_Y0.5181.00
135_D138_R0.5171.00
129_Q134_D0.5161.00
92_A195_V0.5131.00
238_F245_F0.5121.00
86_L89_S0.5111.00
29_W79_L0.5091.00
75_K98_R0.5061.00
50_F64_M0.5061.00
206_L231_A0.5061.00
32_I36_L0.5061.00
21_G81_W0.5041.00
175_V179_G0.5041.00
88_A104_T0.5041.00
198_P224_H0.5041.00
203_Y210_V0.5001.00
94_T191_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nmwA 1 0.9922 100 0.109 Contact Map
1womA 1 0.9844 100 0.18 Contact Map
4inzA 1 0.9805 100 0.186 Contact Map
1ehyA 1 0.9336 100 0.187 Contact Map
2pujA 4 0.9844 100 0.19 Contact Map
3om8A 4 0.957 100 0.191 Contact Map
3oosA 1 0.9805 100 0.195 Contact Map
2xuaA 2 0.9531 100 0.202 Contact Map
3w06A 1 0.9844 100 0.203 Contact Map
3bf7A 1 0.9531 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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