GREMLIN Database
BIOC - Malonyl-[acyl-carrier protein] O-methyltransferase
UniProt: P12999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10119
Length: 251 (207)
Sequences: 15410 (11698)
Seq/√Len: 813.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_H66_Q3.4031.00
74_P91_A2.7691.00
125_E128_R2.7281.00
127_Y180_Y2.5961.00
66_Q88_H2.5861.00
51_C69_A2.5081.00
68_T104_F2.4901.00
80_A89_Y2.4701.00
57_S67_V2.4141.00
126_L136_V2.3701.00
47_L104_F2.3451.00
77_L89_Y2.3371.00
70_L92_G2.3191.00
105_D131_R2.2891.00
50_G112_A2.2651.00
74_P78_V2.2651.00
107_A126_L2.2331.00
118_N121_T2.1921.00
77_L81_R2.1881.00
130_V134_G2.1701.00
77_L91_A2.1321.00
68_T90_L2.1221.00
44_T106_L2.1151.00
107_A130_V2.0771.00
58_R84_D2.0551.00
99_L104_F2.0211.00
125_E129_V2.0081.00
79_Q82_Q1.8811.00
45_H68_T1.8201.00
120_S124_R1.8191.00
51_C57_S1.8141.00
71_D77_L1.8041.00
109_S112_A1.7761.00
58_R83_K1.7471.00
41_R44_T1.7251.00
215_P218_L1.7121.00
130_V136_V1.6721.00
32_D59_H1.6641.00
219_T222_Q1.6231.00
120_S177_G1.5841.00
215_P219_T1.5611.00
46_V60_W1.5581.00
84_D89_Y1.5521.00
92_G98_P1.5301.00
45_H131_R1.5261.00
68_T88_H1.5061.00
44_T65_A1.4611.00
94_I116_C1.4511.00
49_A126_L1.4401.00
121_T124_R1.4251.00
58_R62_E1.4121.00
112_A116_C1.4091.00
218_L222_Q1.4041.00
33_A36_A1.3921.00
46_V106_L1.3911.00
59_H62_E1.3901.00
172_E176_N1.3861.00
49_A94_I1.3741.00
120_S174_S1.3701.00
57_S69_A1.3601.00
75_P78_V1.3571.00
51_C80_A1.3371.00
116_C122_A1.3311.00
78_V81_R1.3201.00
122_A126_L1.3191.00
45_H104_F1.3171.00
14_G73_S1.3151.00
78_V82_Q1.2621.00
69_A89_Y1.2461.00
56_M108_W1.2431.00
21_E83_K1.2421.00
193_D196_S1.2361.00
33_A37_M1.2251.00
21_E53_P1.2221.00
14_G75_P1.2211.00
173_Q177_G1.2191.00
59_H63_R1.2081.00
130_V180_Y1.2071.00
101_T128_R1.2061.00
32_D36_A1.1881.00
93_D96_S1.1861.00
72_L93_D1.1851.00
47_L107_A1.1781.00
48_D69_A1.1671.00
119_L174_S1.1671.00
94_I112_A1.1541.00
152_A156_V1.1471.00
167_P170_E1.1301.00
84_D87_D1.1281.00
97_L125_E1.1271.00
70_L97_L1.1251.00
90_L99_L1.1221.00
33_A185_Q1.1081.00
168_P172_E1.1071.00
98_P125_E1.0951.00
107_A129_V1.0921.00
36_A63_R1.0831.00
50_G109_S1.0811.00
34_L137_A1.0771.00
113_V140_T1.0761.00
97_L129_V1.0721.00
151_Q154_Q1.0681.00
37_M183_H1.0501.00
18_A79_Q1.0471.00
45_H105_D1.0441.00
56_M110_N1.0431.00
126_L130_V1.0361.00
197_A200_S1.0341.00
113_V116_C1.0231.00
100_A103_T1.0161.00
61_R86_A1.0111.00
193_D197_A1.0091.00
69_A80_A0.9931.00
149_L152_A0.9871.00
71_D76_M0.9811.00
153_W157_D0.9701.00
150_H154_Q0.9661.00
92_G97_L0.9651.00
37_M185_Q0.9651.00
43_Y65_A0.9551.00
48_D67_V0.9541.00
113_V138_F0.9511.00
44_T105_D0.9501.00
124_R178_V0.9461.00
203_G206_A0.9431.00
32_D63_R0.9331.00
184_I187_I0.9311.00
154_Q157_D0.9261.00
27_Q30_S0.9261.00
95_E116_C0.9211.00
152_A155_A0.9191.00
200_S204_I0.9041.00
21_E79_Q0.8951.00
110_N139_T0.8941.00
121_T125_E0.8891.00
68_T99_L0.8861.00
60_W108_W0.8801.00
216_R219_T0.8751.00
19_H23_H0.8661.00
204_I207_T0.8651.00
199_R203_G0.8641.00
79_Q83_K0.8641.00
47_L129_V0.8461.00
81_R85_A0.8461.00
127_Y178_V0.8411.00
82_Q85_A0.8341.00
101_T125_E0.8341.00
197_A201_L0.8321.00
123_L175_L0.8241.00
73_S76_M0.8241.00
103_T131_R0.8201.00
45_H103_T0.8201.00
51_C71_D0.8191.00
38_L137_A0.8161.00
46_V67_V0.8161.00
57_S87_D0.8151.00
120_S178_V0.8081.00
31_A56_M0.8041.00
111_L141_L0.7921.00
205_G208_H0.7851.00
173_Q176_N0.7841.00
106_L135_V0.7771.00
149_L153_W0.7771.00
48_D108_W0.7751.00
152_A157_D0.7641.00
61_R87_D0.7611.00
153_W156_V0.7611.00
150_H153_W0.7571.00
170_E174_S0.7521.00
195_L198_M0.7501.00
170_E173_Q0.7481.00
57_S89_Y0.7451.00
46_V108_W0.7431.00
58_R85_A0.7361.00
155_A158_E0.7361.00
187_I191_F0.7351.00
19_H22_Q0.7341.00
208_H211_E0.7331.00
200_S203_G0.7321.00
104_F129_V0.7261.00
217_I221_S0.7231.00
198_M201_L0.7211.00
20_Y23_H0.7201.00
113_V123_L0.7191.00
49_A122_A0.7161.00
99_L103_T0.7131.00
109_S116_C0.7071.00
216_R222_Q0.7071.00
175_L178_V0.7061.00
53_P76_M0.7031.00
127_Y179_H0.6971.00
44_T131_R0.6771.00
47_L70_L0.6741.00
194_A198_M0.6691.00
95_E118_N0.6691.00
28_R32_D0.6671.00
40_Q44_T0.6631.00
147_P150_H0.6621.00
43_Y46_V0.6621.00
66_Q86_A0.6621.00
199_R202_K0.6611.00
123_L178_V0.6611.00
215_P222_Q0.6601.00
111_L114_Q0.6581.00
207_T211_E0.6571.00
95_E121_T0.6551.00
198_M202_K0.6541.00
211_E215_P0.6521.00
164_R170_E0.6481.00
124_R128_R0.6481.00
185_Q189_L0.6441.00
29_Q32_D0.6421.00
216_R220_R0.6421.00
48_D70_L0.6401.00
217_I220_R0.6391.00
74_P81_R0.6391.00
113_V122_A0.6351.00
166_L170_E0.6341.00
202_K205_G0.6331.00
207_T210_H0.6301.00
169_D172_E0.6291.00
54_G80_A0.6281.00
96_S125_E0.6281.00
92_G96_S0.6211.00
202_K206_A0.6211.00
17_A75_P0.6181.00
192_D196_S0.6171.00
114_Q140_T0.6161.00
204_I208_H0.6151.00
147_P151_Q0.6141.00
128_R131_R0.6101.00
16_A19_H0.6071.00
50_G72_L0.6041.00
56_M60_W0.6041.00
184_I188_T0.6021.00
56_M139_T0.6011.00
31_A35_L0.6011.00
178_V181_Q0.6001.00
146_L149_L0.5991.00
55_W59_H0.5981.00
70_L90_L0.5961.00
90_L98_P0.5951.00
39_P135_V0.5951.00
58_R61_R0.5931.00
40_Q43_Y0.5921.00
51_C70_L0.5871.00
111_L139_T0.5861.00
33_A187_I0.5841.00
34_L110_N0.5811.00
13_F17_A0.5801.00
58_R87_D0.5791.00
75_P79_Q0.5781.00
37_M40_Q0.5761.00
13_F19_H0.5761.00
81_R89_Y0.5701.00
72_L91_A0.5691.00
95_E117_G0.5681.00
206_A209_L0.5681.00
109_S138_F0.5651.00
148_E152_A0.5631.00
148_E155_A0.5621.00
94_I122_A0.5621.00
111_L115_W0.5611.00
149_L156_V0.5581.00
176_N182_H0.5551.00
35_L63_R0.5551.00
135_V138_F0.5541.00
187_I190_W0.5531.00
196_S199_R0.5511.00
172_E184_I0.5491.00
151_Q155_A0.5471.00
49_A70_L0.5461.00
29_Q33_A0.5461.00
45_H102_A0.5451.00
203_G207_T0.5441.00
136_V175_L0.5431.00
95_E122_A0.5421.00
45_H65_A0.5411.00
99_L129_V0.5411.00
179_H182_H0.5401.00
163_N166_L0.5391.00
28_R59_H0.5381.00
107_A136_V0.5361.00
201_L206_A0.5351.00
198_M204_I0.5341.00
77_L80_A0.5341.00
103_T129_V0.5331.00
94_I97_L0.5311.00
149_L155_A0.5311.00
146_L152_A0.5311.00
169_D173_Q0.5281.00
81_R88_H0.5251.00
146_L150_H0.5231.00
35_L59_H0.5221.00
15_R19_H0.5211.00
17_A79_Q0.5201.00
97_L104_F0.5191.00
154_Q158_E0.5181.00
174_S177_G0.5171.00
113_V119_L0.5151.00
18_A21_E0.5141.00
189_L192_D0.5131.00
13_F114_Q0.5121.00
14_G17_A0.5111.00
115_W141_L0.5101.00
18_A22_Q0.5071.00
196_S200_S0.5031.00
150_H157_D0.5031.00
106_L134_G0.5031.00
136_V180_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p35A 2 0.9124 100 0.344 Contact Map
3ccfA 1 0.9004 100 0.362 Contact Map
2yqzA 1 0.9602 100 0.376 Contact Map
4hg2A 1 0.9004 100 0.4 Contact Map
1vl5A 1 0.8765 100 0.402 Contact Map
4pneA 2 0.9482 100 0.407 Contact Map
1xxlA 1 0.8964 100 0.414 Contact Map
2o57A 2 0.9641 100 0.423 Contact Map
3egeA 1 0.8685 100 0.431 Contact Map
3busA 1 0.8805 100 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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