BIOF - ECOLI - GREMLIN Contacts

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BIOF - 8-amino-7-oxononanoate synthase

UniProt:	P12998	Sequences: MSWQEKINAALDARRAADALRRRYPVAQGAGRWLVADDRQYLNFSSNDYLGLSHHPQIIRAWQQGAEQFGIGSGGSGHVSGYSVVHQALEEELAEWLGYSRALLFISGFAANQAVIAAMMAKEDRIAADRLSHASLLEAASLSPSQLRRFAHNDVTHLARLLASPCPGQQMVVTEGVFSMDGDSAPLAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10121
Length:	384 (357)
Sequences:	6387 (3902)
Seq/√Len:	206.5

ECOLI - BIOF KBL
BACSU - BIOF2 BIOF1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_Q	67_E	4.177	1.00
92_E	281_A	4.094	1.00
301_R	374_D	3.965	1.00
159_A	196_Q	3.881	1.00
151_A	157_H	3.777	1.00
195_Q	226_K	3.750	1.00
341_Q	382_G	3.465	1.00
186_P	189_E	3.214	1.00
157_H	161_L	3.060	1.00
174_T	178_F	3.002	1.00
92_E	277_R	2.857	1.00
278_A	281_A	2.855	1.00
301_R	370_M	2.775	1.00
172_V	194_T	2.766	1.00
305_G	377_L	2.555	1.00
159_A	197_H	2.524	1.00
294_K	298_L	2.514	1.00
92_E	284_R	2.449	1.00
247_C	252_A	2.316	1.00
159_A	163_A	2.313	1.00
60_R	64_Q	2.307	1.00
105_F	259_A	2.252	1.00
232_V	244_A	2.248	1.00
188_A	223_Q	2.245	1.00
247_C	251_V	2.212	1.00
157_H	160_R	2.186	1.00
155_V	193_V	2.183	1.00
286_D	290_A	2.134	1.00
215_Q	221_W	2.131	1.00
95_E	284_R	2.064	1.00
205_D	208_G	2.059	1.00
100_S	249_S	2.013	1.00
305_G	374_D	1.996	1.00
174_T	203_V	1.980	1.00
57_Q	278_A	1.973	1.00
286_D	289_D	1.918	1.00
127_A	161_L	1.881	1.00
369_E	372_D	1.873	1.00
325_V	334_L	1.861	1.00
189_E	192_Q	1.859	1.00
309_L	381_H	1.819	1.00
305_G	308_D	1.818	1.00
59_I	66_A	1.807	1.00
286_D	291_R	1.806	1.00
120_M	126_I	1.796	1.00
343_C	375_R	1.795	1.00
297_A	370_M	1.795	1.00
128_A	132_S	1.794	1.00
33_W	40_Q	1.731	1.00
116_I	173_V	1.715	1.00
337_K	340_Q	1.709	1.00
41_Y	339_R	1.680	1.00
102_A	246_L	1.677	1.00
55_H	282_V	1.666	1.00
214_E	221_W	1.658	1.00
64_Q	68_Q	1.657	1.00
57_Q	285_S	1.657	1.00
44_F	368_H	1.656	1.00
130_R	151_A	1.651	1.00
44_F	376_L	1.646	1.00
60_R	67_E	1.604	1.00
85_V	277_R	1.595	1.00
140_A	147_L	1.580	1.00
301_R	305_G	1.565	1.00
329_S	333_Q	1.560	1.00
309_L	377_L	1.555	1.00
96_W	217_R	1.554	1.00
136_L	173_V	1.552	1.00
126_I	140_A	1.549	1.00
138_E	260_R	1.546	1.00
234_F	276_L	1.539	1.00
194_T	201_L	1.514	1.00
302_F	364_L	1.513	1.00
240_V	276_L	1.504	1.00
163_A	197_H	1.502	1.00
114_A	261_H	1.497	1.00
289_D	293_E	1.495	1.00
94_A	102_A	1.494	1.00
127_A	170_Q	1.490	1.00
241_S	269_P	1.475	1.00
65_G	274_Q	1.467	1.00
337_K	341_Q	1.438	1.00
205_D	219_S	1.436	1.00
88_A	277_R	1.410	1.00
150_F	174_T	1.407	1.00
209_T	238_F	1.403	1.00
172_V	199_G	1.401	1.00
93_L	280_L	1.401	1.00
77_G	82_Y	1.399	1.00
59_I	63_Q	1.385	1.00
33_W	372_D	1.385	1.00
327_D	330_R	1.380	1.00
375_R	379_V	1.377	1.00
345_V	360_L	1.367	1.00
192_Q	226_K	1.361	1.00
304_A	308_D	1.346	1.00
301_R	373_I	1.327	1.00
125_R	148_R	1.320	1.00
282_V	286_D	1.315	1.00
171_M	202_M	1.310	1.00
148_R	161_L	1.309	1.00
115_V	245_V	1.304	1.00
249_S	253_D	1.299	1.00
155_V	186_P	1.298	1.00
63_Q	66_A	1.289	1.00
298_L	370_M	1.287	1.00
101_R	249_S	1.274	1.00
293_E	297_A	1.265	1.00
134_A	260_R	1.261	1.00
191_Q	227_P	1.260	1.00
336_E	340_Q	1.253	1.00
97_L	246_L	1.252	1.00
84_V	88_A	1.251	1.00
73_S	267_S	1.247	1.00
35_V	40_Q	1.247	1.00
193_V	197_H	1.235	1.00
158_L	172_V	1.234	1.00
328_N	358_A	1.229	1.00
57_Q	282_V	1.226	1.00
64_Q	67_E	1.226	1.00
300_T	304_A	1.204	1.00
155_V	189_E	1.200	1.00
191_Q	195_Q	1.193	1.00
87_Q	91_E	1.188	1.00
176_G	208_G	1.186	1.00
176_G	219_S	1.174	1.00
115_V	202_M	1.167	1.00
350_P	355_A	1.162	1.00
82_Y	87_Q	1.154	1.00
120_M	171_M	1.153	1.00
114_A	259_A	1.151	1.00
151_A	154_D	1.146	1.00
132_S	136_L	1.145	1.00
362_L	376_L	1.141	1.00
159_A	193_V	1.141	1.00
153_N	186_P	1.137	1.00
97_L	209_T	1.132	1.00
220_C	225_V	1.126	1.00
277_R	281_A	1.118	1.00
181_D	359_R	1.117	1.00
93_L	234_F	1.117	1.00
162_L	193_V	1.116	1.00
152_H	183_D	1.112	1.00
191_Q	201_L	1.110	1.00
298_L	301_R	1.108	1.00
101_R	252_A	1.101	1.00
172_V	193_V	1.097	1.00
162_L	199_G	1.096	1.00
302_F	306_V	1.089	1.00
302_F	362_L	1.083	1.00
298_L	373_I	1.076	1.00
91_E	95_E	1.070	1.00
303_R	316_S	1.069	1.00
190_I	201_L	1.065	1.00
161_L	164_S	1.064	1.00
85_V	274_Q	1.061	1.00
298_L	366_A	1.052	1.00
123_E	168_G	1.050	1.00
341_Q	379_V	1.044	1.00
217_R	221_W	1.038	1.00
343_C	376_L	1.036	1.00
160_R	164_S	1.034	1.00
120_M	124_D	1.034	1.00
93_L	244_A	1.032	1.00
94_A	246_L	1.025	1.00
274_Q	278_A	1.021	1.00
112_N	135_S	1.017	1.00
150_F	178_F	1.016	1.00
99_Y	246_L	1.015	1.00
331_A	358_A	1.014	1.00
56_P	60_R	1.014	1.00
125_R	168_G	1.007	1.00
174_T	190_I	1.005	1.00
296_A	299_I	0.997	1.00
107_S	110_A	0.995	1.00
370_M	374_D	0.994	1.00
332_L	347_A	0.991	1.00
332_L	349_R	0.989	1.00
27_A	84_V	0.988	1.00
156_T	160_R	0.986	1.00
61_A	65_G	0.986	1.00
99_Y	247_C	0.984	1.00
58_I	275_A	0.968	1.00
128_A	140_A	0.965	1.00
69_F	84_V	0.965	1.00
338_L	379_V	0.963	1.00
215_Q	284_R	0.962	1.00
290_A	294_K	0.962	1.00
154_D	157_H	0.961	1.00
271_A	275_A	0.955	0.99
248_S	251_V	0.954	0.99
192_Q	196_Q	0.946	0.99
343_C	379_V	0.945	0.99
333_Q	336_E	0.942	0.99
125_R	167_P	0.940	0.99
350_P	358_A	0.938	0.99
62_W	275_A	0.937	0.99
86_H	273_A	0.937	0.99
87_Q	101_R	0.936	0.99
278_A	282_V	0.935	0.99
323_L	362_L	0.935	0.99
51_G	367_A	0.934	0.99
101_R	256_L	0.933	0.99
89_L	273_A	0.931	0.99
85_V	273_A	0.931	0.99
180_M	348_I	0.930	0.99
171_M	200_W	0.928	0.99
110_A	265_S	0.926	0.99
57_Q	60_R	0.925	0.99
77_G	90_E	0.925	0.99
305_G	309_L	0.925	0.99
99_Y	230_L	0.925	0.99
131_L	181_D	0.923	0.99
60_R	63_Q	0.923	0.99
32_R	372_D	0.922	0.99
202_M	231_V	0.919	0.99
42_L	372_D	0.919	0.99
184_S	223_Q	0.917	0.99
269_P	272_Q	0.915	0.99
364_L	373_I	0.913	0.99
184_S	212_I	0.907	0.99
96_W	280_L	0.903	0.99
294_K	297_A	0.902	0.99
89_L	276_L	0.901	0.99
158_L	190_I	0.899	0.99
294_K	370_M	0.897	0.99
365_T	368_H	0.897	0.99
254_Y	258_F	0.895	0.99
116_I	120_M	0.893	0.99
209_T	244_A	0.891	0.99
134_A	138_E	0.887	0.99
215_Q	289_D	0.883	0.99
194_T	199_G	0.882	0.99
238_F	283_I	0.878	0.99
75_G	79_V	0.878	0.99
45_S	346_T	0.877	0.99
372_D	375_R	0.875	0.99
326_G	358_A	0.870	0.99
26_V	34_L	0.870	0.99
174_T	187_L	0.869	0.99
185_A	190_I	0.869	0.99
128_A	149_R	0.868	0.99
55_H	58_I	0.868	0.99
325_V	330_R	0.867	0.99
331_A	347_A	0.867	0.99
191_Q	226_K	0.862	0.99
124_D	171_M	0.860	0.99
88_A	92_E	0.854	0.99
219_S	223_Q	0.854	0.99
124_D	168_G	0.852	0.99
378_E	382_G	0.849	0.99
66_A	271_A	0.848	0.99
131_L	359_R	0.847	0.99
82_Y	86_H	0.846	0.99
61_A	274_Q	0.842	0.99
44_F	373_I	0.842	0.99
121_A	124_D	0.837	0.99
299_I	321_Q	0.833	0.99
106_I	241_S	0.829	0.99
229_L	251_V	0.828	0.99
188_A	222_L	0.827	0.99
24_Y	339_R	0.826	0.99
42_L	343_C	0.821	0.98
302_F	321_Q	0.820	0.98
150_F	158_L	0.820	0.98
130_R	149_R	0.820	0.98
294_K	369_E	0.819	0.98
220_C	227_P	0.818	0.98
127_A	190_I	0.815	0.98
113_Q	261_H	0.815	0.98
241_S	268_M	0.813	0.98
127_A	158_L	0.812	0.98
212_I	318_S	0.812	0.98
232_V	246_L	0.811	0.98
235_G	243_A	0.810	0.98
156_T	189_E	0.807	0.98
296_A	300_T	0.800	0.98
245_V	255_L	0.797	0.98
62_W	66_A	0.797	0.98
220_C	230_L	0.796	0.98
375_R	378_E	0.795	0.98
176_G	205_D	0.793	0.98
184_S	318_S	0.793	0.98
213_G	218_G	0.792	0.98
155_V	190_I	0.791	0.98
116_I	202_M	0.789	0.98
61_A	278_A	0.786	0.98
221_W	289_D	0.786	0.98
62_W	71_I	0.785	0.98
89_L	277_R	0.784	0.98
376_L	380_L	0.784	0.98
116_I	171_M	0.783	0.98
333_Q	337_K	0.782	0.98
65_G	85_V	0.782	0.98
177_V	184_S	0.780	0.98
122_K	144_P	0.780	0.98
160_R	163_A	0.777	0.98
153_N	175_E	0.771	0.98
295_L	299_I	0.771	0.98
55_H	291_R	0.767	0.98
27_A	35_V	0.765	0.98
292_R	296_A	0.764	0.98
153_N	183_D	0.763	0.97
111_A	115_V	0.762	0.97
128_A	147_L	0.759	0.97
305_G	378_E	0.758	0.97
137_L	141_S	0.756	0.97
45_S	80_S	0.754	0.97
52_L	291_R	0.754	0.97
127_A	148_R	0.749	0.97
339_R	344_W	0.748	0.97
370_M	373_I	0.747	0.97
109_F	113_Q	0.746	0.97
208_G	219_S	0.745	0.97
57_Q	286_D	0.744	0.97
65_G	69_F	0.744	0.97
184_S	222_L	0.744	0.97
323_L	380_L	0.743	0.97
309_L	378_E	0.742	0.97
111_A	231_V	0.740	0.97
128_A	137_L	0.739	0.97
187_L	203_V	0.736	0.97
54_H	59_I	0.736	0.97
132_S	175_E	0.734	0.97
209_T	232_V	0.733	0.97
103_L	252_A	0.732	0.97
297_A	301_R	0.732	0.97
268_M	273_A	0.731	0.97
77_G	262_L	0.729	0.97
85_V	88_A	0.728	0.97
362_L	380_L	0.725	0.97
123_E	146_Q	0.724	0.97
285_S	289_D	0.724	0.97
49_Y	207_H	0.723	0.97
86_H	104_L	0.722	0.97
113_Q	117_A	0.720	0.96
103_L	256_L	0.718	0.96
156_T	159_A	0.717	0.96
83_S	86_H	0.715	0.96
53_S	74_G	0.713	0.96
281_A	285_S	0.712	0.96
56_P	59_I	0.710	0.96
125_R	170_Q	0.704	0.96
159_A	189_E	0.703	0.96
165_P	170_Q	0.700	0.96
290_A	293_E	0.699	0.96
170_Q	199_G	0.698	0.96
88_A	281_A	0.690	0.95
105_F	114_A	0.690	0.95
155_V	158_L	0.689	0.95
311_F	380_L	0.687	0.95
378_E	381_H	0.684	0.95
213_G	216_G	0.679	0.95
39_R	342_G	0.678	0.95
105_F	245_V	0.677	0.95
334_L	360_L	0.675	0.95
202_M	229_L	0.675	0.95
191_Q	225_V	0.672	0.95
66_A	71_I	0.671	0.95
195_Q	228_E	0.671	0.95
42_L	375_R	0.669	0.95
53_S	239_G	0.666	0.95
177_V	208_G	0.663	0.94
303_R	321_Q	0.662	0.94
153_N	178_F	0.662	0.94
210_G	237_G	0.660	0.94
312_T	326_G	0.659	0.94
115_V	231_V	0.657	0.94
100_S	248_S	0.656	0.94
291_R	294_K	0.655	0.94
212_I	222_L	0.655	0.94
79_V	346_T	0.654	0.94
150_F	153_N	0.652	0.94
102_A	244_A	0.649	0.94
330_R	333_Q	0.647	0.94
99_Y	248_S	0.646	0.94
307_Q	313_L	0.644	0.94
279_S	283_I	0.644	0.94
233_T	243_A	0.644	0.94
125_R	165_P	0.642	0.93
283_I	292_R	0.640	0.93
79_V	348_I	0.637	0.93
96_W	284_R	0.637	0.93
241_S	272_Q	0.636	0.93
58_I	279_S	0.634	0.93
97_L	280_L	0.634	0.93
129_D	152_H	0.634	0.93
298_L	364_L	0.633	0.93
69_F	85_V	0.632	0.93
229_L	247_C	0.631	0.93
334_L	338_L	0.631	0.93
120_M	202_M	0.630	0.93
374_D	377_L	0.629	0.93
214_E	289_D	0.629	0.93
62_W	274_Q	0.629	0.93
96_W	283_I	0.628	0.93
377_L	381_H	0.628	0.93
92_E	280_L	0.625	0.92
214_E	222_L	0.621	0.92
306_V	362_L	0.619	0.92
106_I	110_A	0.618	0.92
130_R	147_L	0.616	0.92
217_R	284_R	0.614	0.92
371_Q	375_R	0.613	0.92
51_G	365_T	0.610	0.92
214_E	293_E	0.609	0.92
120_M	145_S	0.609	0.92
31_G	34_L	0.608	0.91
306_V	380_L	0.605	0.91
116_I	136_L	0.604	0.91
97_L	102_A	0.602	0.91
88_A	91_E	0.602	0.91
73_S	270_P	0.602	0.91
29_G	54_H	0.602	0.91
335_A	347_A	0.600	0.91
203_V	220_C	0.599	0.91
107_S	241_S	0.598	0.91
188_A	192_Q	0.597	0.91
177_V	318_S	0.595	0.91
162_L	170_Q	0.595	0.91
275_A	279_S	0.594	0.90
128_A	136_L	0.594	0.90
194_T	228_E	0.594	0.90
137_L	149_R	0.594	0.90
130_R	357_T	0.593	0.90
103_L	262_L	0.593	0.90
348_I	352_T	0.591	0.90
207_H	236_K	0.591	0.90
177_V	212_I	0.590	0.90
252_A	256_L	0.589	0.90
25_P	84_V	0.588	0.90
192_Q	195_Q	0.588	0.90
162_L	197_H	0.587	0.90
205_D	230_L	0.584	0.90
235_G	266_T	0.584	0.90
294_K	366_A	0.584	0.90
138_E	141_S	0.582	0.90
282_V	291_R	0.581	0.90
113_Q	139_A	0.581	0.90
148_R	164_S	0.580	0.89
266_T	352_T	0.579	0.89
119_M	229_L	0.577	0.89
169_Q	200_W	0.577	0.89
303_R	307_Q	0.577	0.89
42_L	376_L	0.577	0.89
96_W	209_T	0.576	0.89
48_D	53_S	0.576	0.89
301_R	377_L	0.576	0.89
222_L	317_C	0.575	0.89
97_L	244_A	0.575	0.89
216_G	292_R	0.574	0.89
303_R	317_C	0.574	0.89
91_E	101_R	0.574	0.89
33_W	36_A	0.573	0.89
324_I	359_R	0.572	0.89
28_Q	35_V	0.572	0.89
124_D	169_Q	0.572	0.89
328_N	355_A	0.571	0.89
334_L	337_K	0.571	0.89
305_G	381_H	0.571	0.89
306_V	377_L	0.570	0.89
77_G	265_S	0.570	0.89
92_E	95_E	0.568	0.88
124_D	143_S	0.567	0.88
184_S	219_S	0.566	0.88
61_A	64_Q	0.566	0.88
195_Q	227_P	0.563	0.88
150_F	172_V	0.563	0.88
311_F	334_L	0.563	0.88
86_H	267_S	0.560	0.88
153_N	174_T	0.560	0.88
126_I	143_S	0.558	0.88
155_V	159_A	0.556	0.87
326_G	331_A	0.555	0.87
176_G	212_I	0.554	0.87
327_D	331_A	0.551	0.87
240_V	272_Q	0.550	0.87
289_D	292_R	0.549	0.87
133_H	236_K	0.548	0.87
302_F	376_L	0.548	0.87
325_V	331_A	0.548	0.87
170_Q	198_N	0.547	0.87
191_Q	194_T	0.547	0.87
52_L	282_V	0.546	0.86
114_A	118_A	0.545	0.86
25_P	87_Q	0.544	0.86
335_A	339_R	0.544	0.86
291_R	298_L	0.543	0.86
212_I	219_S	0.543	0.86
62_W	271_A	0.542	0.86
106_I	268_M	0.540	0.86
304_A	307_Q	0.540	0.86
29_G	32_R	0.538	0.86
240_V	275_A	0.537	0.86
132_S	178_F	0.536	0.85
68_Q	88_A	0.535	0.85
297_A	300_T	0.532	0.85
167_P	170_Q	0.532	0.85
231_V	243_A	0.532	0.85
41_Y	344_W	0.531	0.85
332_L	336_E	0.530	0.85
52_L	58_I	0.529	0.85
65_G	68_Q	0.529	0.85
151_A	160_R	0.528	0.85
338_L	345_V	0.528	0.85
70_G	271_A	0.527	0.84
336_E	339_R	0.527	0.84
76_S	108_G	0.525	0.84
106_I	243_A	0.524	0.84
133_H	207_H	0.523	0.84
99_Y	220_C	0.523	0.84
58_I	62_W	0.522	0.84
68_Q	84_V	0.522	0.84
59_I	67_E	0.522	0.84
338_L	376_L	0.520	0.84
89_L	104_L	0.520	0.84
97_L	230_L	0.518	0.83
132_S	140_A	0.517	0.83
295_L	298_L	0.515	0.83
174_T	201_L	0.515	0.83
377_L	380_L	0.514	0.83
349_R	352_T	0.514	0.83
212_I	296_A	0.514	0.83
316_S	319_A	0.513	0.83
62_W	65_G	0.513	0.83
316_S	321_Q	0.513	0.83
345_V	362_L	0.512	0.83
183_D	359_R	0.511	0.83
115_V	229_L	0.510	0.83
200_W	251_V	0.508	0.82
264_Y	352_T	0.507	0.82
299_I	319_A	0.505	0.82
71_I	271_A	0.504	0.82
151_A	161_L	0.504	0.82
206_A	233_T	0.503	0.82
133_H	179_S	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2w8tA	2	0.9948	100	0.461	Contact Map
3wy7A	2	0.9453	100	0.465	Contact Map
1bs0A	2	0.9948	100	0.5	Contact Map
3kkiA	2	0.9661	100	0.511	Contact Map
2bwnA	2	1	100	0.512	Contact Map
1fc4A	2	0.9948	100	0.518	Contact Map
3tqxA	2	0.9974	100	0.536	Contact Map
3a2bA	2	0.9948	100	0.547	Contact Map
4iw7A	2	0.8464	100	0.574	Contact Map
1vefA	2	0.9089	100	0.65	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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