GREMLIN Database
BIOF - 8-amino-7-oxononanoate synthase
UniProt: P12998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10121
Length: 384 (357)
Sequences: 6387 (3902)
Seq/√Len: 206.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_Q67_E4.1771.00
92_E281_A4.0941.00
301_R374_D3.9651.00
159_A196_Q3.8811.00
151_A157_H3.7771.00
195_Q226_K3.7501.00
341_Q382_G3.4651.00
186_P189_E3.2141.00
157_H161_L3.0601.00
174_T178_F3.0021.00
92_E277_R2.8571.00
278_A281_A2.8551.00
301_R370_M2.7751.00
172_V194_T2.7661.00
305_G377_L2.5551.00
159_A197_H2.5241.00
294_K298_L2.5141.00
92_E284_R2.4491.00
247_C252_A2.3161.00
159_A163_A2.3131.00
60_R64_Q2.3071.00
105_F259_A2.2521.00
232_V244_A2.2481.00
188_A223_Q2.2451.00
247_C251_V2.2121.00
157_H160_R2.1861.00
155_V193_V2.1831.00
286_D290_A2.1341.00
215_Q221_W2.1311.00
95_E284_R2.0641.00
205_D208_G2.0591.00
100_S249_S2.0131.00
305_G374_D1.9961.00
174_T203_V1.9801.00
57_Q278_A1.9731.00
286_D289_D1.9181.00
127_A161_L1.8811.00
369_E372_D1.8731.00
325_V334_L1.8611.00
189_E192_Q1.8591.00
309_L381_H1.8191.00
305_G308_D1.8181.00
59_I66_A1.8071.00
286_D291_R1.8061.00
120_M126_I1.7961.00
343_C375_R1.7951.00
297_A370_M1.7951.00
128_A132_S1.7941.00
33_W40_Q1.7311.00
116_I173_V1.7151.00
337_K340_Q1.7091.00
41_Y339_R1.6801.00
102_A246_L1.6771.00
55_H282_V1.6661.00
214_E221_W1.6581.00
64_Q68_Q1.6571.00
57_Q285_S1.6571.00
44_F368_H1.6561.00
130_R151_A1.6511.00
44_F376_L1.6461.00
60_R67_E1.6041.00
85_V277_R1.5951.00
140_A147_L1.5801.00
301_R305_G1.5651.00
329_S333_Q1.5601.00
309_L377_L1.5551.00
96_W217_R1.5541.00
136_L173_V1.5521.00
126_I140_A1.5491.00
138_E260_R1.5461.00
234_F276_L1.5391.00
194_T201_L1.5141.00
302_F364_L1.5131.00
240_V276_L1.5041.00
163_A197_H1.5021.00
114_A261_H1.4971.00
289_D293_E1.4951.00
94_A102_A1.4941.00
127_A170_Q1.4901.00
241_S269_P1.4751.00
65_G274_Q1.4671.00
337_K341_Q1.4381.00
205_D219_S1.4361.00
88_A277_R1.4101.00
150_F174_T1.4071.00
209_T238_F1.4031.00
172_V199_G1.4011.00
93_L280_L1.4011.00
77_G82_Y1.3991.00
59_I63_Q1.3851.00
33_W372_D1.3851.00
327_D330_R1.3801.00
375_R379_V1.3771.00
345_V360_L1.3671.00
192_Q226_K1.3611.00
304_A308_D1.3461.00
301_R373_I1.3271.00
125_R148_R1.3201.00
282_V286_D1.3151.00
171_M202_M1.3101.00
148_R161_L1.3091.00
115_V245_V1.3041.00
249_S253_D1.2991.00
155_V186_P1.2981.00
63_Q66_A1.2891.00
298_L370_M1.2871.00
101_R249_S1.2741.00
293_E297_A1.2651.00
134_A260_R1.2611.00
191_Q227_P1.2601.00
336_E340_Q1.2531.00
97_L246_L1.2521.00
84_V88_A1.2511.00
73_S267_S1.2471.00
35_V40_Q1.2471.00
193_V197_H1.2351.00
158_L172_V1.2341.00
328_N358_A1.2291.00
57_Q282_V1.2261.00
64_Q67_E1.2261.00
300_T304_A1.2041.00
155_V189_E1.2001.00
191_Q195_Q1.1931.00
87_Q91_E1.1881.00
176_G208_G1.1861.00
176_G219_S1.1741.00
115_V202_M1.1671.00
350_P355_A1.1621.00
82_Y87_Q1.1541.00
120_M171_M1.1531.00
114_A259_A1.1511.00
151_A154_D1.1461.00
132_S136_L1.1451.00
362_L376_L1.1411.00
159_A193_V1.1411.00
153_N186_P1.1371.00
97_L209_T1.1321.00
220_C225_V1.1261.00
277_R281_A1.1181.00
181_D359_R1.1171.00
93_L234_F1.1171.00
162_L193_V1.1161.00
152_H183_D1.1121.00
191_Q201_L1.1101.00
298_L301_R1.1081.00
101_R252_A1.1011.00
172_V193_V1.0971.00
162_L199_G1.0961.00
302_F306_V1.0891.00
302_F362_L1.0831.00
298_L373_I1.0761.00
91_E95_E1.0701.00
303_R316_S1.0691.00
190_I201_L1.0651.00
161_L164_S1.0641.00
85_V274_Q1.0611.00
298_L366_A1.0521.00
123_E168_G1.0501.00
341_Q379_V1.0441.00
217_R221_W1.0381.00
343_C376_L1.0361.00
160_R164_S1.0341.00
120_M124_D1.0341.00
93_L244_A1.0321.00
94_A246_L1.0251.00
274_Q278_A1.0211.00
112_N135_S1.0171.00
150_F178_F1.0161.00
99_Y246_L1.0151.00
331_A358_A1.0141.00
56_P60_R1.0141.00
125_R168_G1.0071.00
174_T190_I1.0051.00
296_A299_I0.9971.00
107_S110_A0.9951.00
370_M374_D0.9941.00
332_L347_A0.9911.00
332_L349_R0.9891.00
27_A84_V0.9881.00
156_T160_R0.9861.00
61_A65_G0.9861.00
99_Y247_C0.9841.00
58_I275_A0.9681.00
128_A140_A0.9651.00
69_F84_V0.9651.00
338_L379_V0.9631.00
215_Q284_R0.9621.00
290_A294_K0.9621.00
154_D157_H0.9611.00
271_A275_A0.9550.99
248_S251_V0.9540.99
192_Q196_Q0.9460.99
343_C379_V0.9450.99
333_Q336_E0.9420.99
125_R167_P0.9400.99
350_P358_A0.9380.99
62_W275_A0.9370.99
86_H273_A0.9370.99
87_Q101_R0.9360.99
278_A282_V0.9350.99
323_L362_L0.9350.99
51_G367_A0.9340.99
101_R256_L0.9330.99
89_L273_A0.9310.99
85_V273_A0.9310.99
180_M348_I0.9300.99
171_M200_W0.9280.99
110_A265_S0.9260.99
57_Q60_R0.9250.99
77_G90_E0.9250.99
305_G309_L0.9250.99
99_Y230_L0.9250.99
131_L181_D0.9230.99
60_R63_Q0.9230.99
32_R372_D0.9220.99
202_M231_V0.9190.99
42_L372_D0.9190.99
184_S223_Q0.9170.99
269_P272_Q0.9150.99
364_L373_I0.9130.99
184_S212_I0.9070.99
96_W280_L0.9030.99
294_K297_A0.9020.99
89_L276_L0.9010.99
158_L190_I0.8990.99
294_K370_M0.8970.99
365_T368_H0.8970.99
254_Y258_F0.8950.99
116_I120_M0.8930.99
209_T244_A0.8910.99
134_A138_E0.8870.99
215_Q289_D0.8830.99
194_T199_G0.8820.99
238_F283_I0.8780.99
75_G79_V0.8780.99
45_S346_T0.8770.99
372_D375_R0.8750.99
326_G358_A0.8700.99
26_V34_L0.8700.99
174_T187_L0.8690.99
185_A190_I0.8690.99
128_A149_R0.8680.99
55_H58_I0.8680.99
325_V330_R0.8670.99
331_A347_A0.8670.99
191_Q226_K0.8620.99
124_D171_M0.8600.99
88_A92_E0.8540.99
219_S223_Q0.8540.99
124_D168_G0.8520.99
378_E382_G0.8490.99
66_A271_A0.8480.99
131_L359_R0.8470.99
82_Y86_H0.8460.99
61_A274_Q0.8420.99
44_F373_I0.8420.99
121_A124_D0.8370.99
299_I321_Q0.8330.99
106_I241_S0.8290.99
229_L251_V0.8280.99
188_A222_L0.8270.99
24_Y339_R0.8260.99
42_L343_C0.8210.98
302_F321_Q0.8200.98
150_F158_L0.8200.98
130_R149_R0.8200.98
294_K369_E0.8190.98
220_C227_P0.8180.98
127_A190_I0.8150.98
113_Q261_H0.8150.98
241_S268_M0.8130.98
127_A158_L0.8120.98
212_I318_S0.8120.98
232_V246_L0.8110.98
235_G243_A0.8100.98
156_T189_E0.8070.98
296_A300_T0.8000.98
245_V255_L0.7970.98
62_W66_A0.7970.98
220_C230_L0.7960.98
375_R378_E0.7950.98
176_G205_D0.7930.98
184_S318_S0.7930.98
213_G218_G0.7920.98
155_V190_I0.7910.98
116_I202_M0.7890.98
61_A278_A0.7860.98
221_W289_D0.7860.98
62_W71_I0.7850.98
89_L277_R0.7840.98
376_L380_L0.7840.98
116_I171_M0.7830.98
333_Q337_K0.7820.98
65_G85_V0.7820.98
177_V184_S0.7800.98
122_K144_P0.7800.98
160_R163_A0.7770.98
153_N175_E0.7710.98
295_L299_I0.7710.98
55_H291_R0.7670.98
27_A35_V0.7650.98
292_R296_A0.7640.98
153_N183_D0.7630.97
111_A115_V0.7620.97
128_A147_L0.7590.97
305_G378_E0.7580.97
137_L141_S0.7560.97
45_S80_S0.7540.97
52_L291_R0.7540.97
127_A148_R0.7490.97
339_R344_W0.7480.97
370_M373_I0.7470.97
109_F113_Q0.7460.97
208_G219_S0.7450.97
57_Q286_D0.7440.97
65_G69_F0.7440.97
184_S222_L0.7440.97
323_L380_L0.7430.97
309_L378_E0.7420.97
111_A231_V0.7400.97
128_A137_L0.7390.97
187_L203_V0.7360.97
54_H59_I0.7360.97
132_S175_E0.7340.97
209_T232_V0.7330.97
103_L252_A0.7320.97
297_A301_R0.7320.97
268_M273_A0.7310.97
77_G262_L0.7290.97
85_V88_A0.7280.97
362_L380_L0.7250.97
123_E146_Q0.7240.97
285_S289_D0.7240.97
49_Y207_H0.7230.97
86_H104_L0.7220.97
113_Q117_A0.7200.96
103_L256_L0.7180.96
156_T159_A0.7170.96
83_S86_H0.7150.96
53_S74_G0.7130.96
281_A285_S0.7120.96
56_P59_I0.7100.96
125_R170_Q0.7040.96
159_A189_E0.7030.96
165_P170_Q0.7000.96
290_A293_E0.6990.96
170_Q199_G0.6980.96
88_A281_A0.6900.95
105_F114_A0.6900.95
155_V158_L0.6890.95
311_F380_L0.6870.95
378_E381_H0.6840.95
213_G216_G0.6790.95
39_R342_G0.6780.95
105_F245_V0.6770.95
334_L360_L0.6750.95
202_M229_L0.6750.95
191_Q225_V0.6720.95
66_A71_I0.6710.95
195_Q228_E0.6710.95
42_L375_R0.6690.95
53_S239_G0.6660.95
177_V208_G0.6630.94
303_R321_Q0.6620.94
153_N178_F0.6620.94
210_G237_G0.6600.94
312_T326_G0.6590.94
115_V231_V0.6570.94
100_S248_S0.6560.94
291_R294_K0.6550.94
212_I222_L0.6550.94
79_V346_T0.6540.94
150_F153_N0.6520.94
102_A244_A0.6490.94
330_R333_Q0.6470.94
99_Y248_S0.6460.94
307_Q313_L0.6440.94
279_S283_I0.6440.94
233_T243_A0.6440.94
125_R165_P0.6420.93
283_I292_R0.6400.93
79_V348_I0.6370.93
96_W284_R0.6370.93
241_S272_Q0.6360.93
58_I279_S0.6340.93
97_L280_L0.6340.93
129_D152_H0.6340.93
298_L364_L0.6330.93
69_F85_V0.6320.93
229_L247_C0.6310.93
334_L338_L0.6310.93
120_M202_M0.6300.93
374_D377_L0.6290.93
214_E289_D0.6290.93
62_W274_Q0.6290.93
96_W283_I0.6280.93
377_L381_H0.6280.93
92_E280_L0.6250.92
214_E222_L0.6210.92
306_V362_L0.6190.92
106_I110_A0.6180.92
130_R147_L0.6160.92
217_R284_R0.6140.92
371_Q375_R0.6130.92
51_G365_T0.6100.92
214_E293_E0.6090.92
120_M145_S0.6090.92
31_G34_L0.6080.91
306_V380_L0.6050.91
116_I136_L0.6040.91
97_L102_A0.6020.91
88_A91_E0.6020.91
73_S270_P0.6020.91
29_G54_H0.6020.91
335_A347_A0.6000.91
203_V220_C0.5990.91
107_S241_S0.5980.91
188_A192_Q0.5970.91
177_V318_S0.5950.91
162_L170_Q0.5950.91
275_A279_S0.5940.90
128_A136_L0.5940.90
194_T228_E0.5940.90
137_L149_R0.5940.90
130_R357_T0.5930.90
103_L262_L0.5930.90
348_I352_T0.5910.90
207_H236_K0.5910.90
177_V212_I0.5900.90
252_A256_L0.5890.90
25_P84_V0.5880.90
192_Q195_Q0.5880.90
162_L197_H0.5870.90
205_D230_L0.5840.90
235_G266_T0.5840.90
294_K366_A0.5840.90
138_E141_S0.5820.90
282_V291_R0.5810.90
113_Q139_A0.5810.90
148_R164_S0.5800.89
266_T352_T0.5790.89
119_M229_L0.5770.89
169_Q200_W0.5770.89
303_R307_Q0.5770.89
42_L376_L0.5770.89
96_W209_T0.5760.89
48_D53_S0.5760.89
301_R377_L0.5760.89
222_L317_C0.5750.89
97_L244_A0.5750.89
216_G292_R0.5740.89
303_R317_C0.5740.89
91_E101_R0.5740.89
33_W36_A0.5730.89
324_I359_R0.5720.89
28_Q35_V0.5720.89
124_D169_Q0.5720.89
328_N355_A0.5710.89
334_L337_K0.5710.89
305_G381_H0.5710.89
306_V377_L0.5700.89
77_G265_S0.5700.89
92_E95_E0.5680.88
124_D143_S0.5670.88
184_S219_S0.5660.88
61_A64_Q0.5660.88
195_Q227_P0.5630.88
150_F172_V0.5630.88
311_F334_L0.5630.88
86_H267_S0.5600.88
153_N174_T0.5600.88
126_I143_S0.5580.88
155_V159_A0.5560.87
326_G331_A0.5550.87
176_G212_I0.5540.87
327_D331_A0.5510.87
240_V272_Q0.5500.87
289_D292_R0.5490.87
133_H236_K0.5480.87
302_F376_L0.5480.87
325_V331_A0.5480.87
170_Q198_N0.5470.87
191_Q194_T0.5470.87
52_L282_V0.5460.86
114_A118_A0.5450.86
25_P87_Q0.5440.86
335_A339_R0.5440.86
291_R298_L0.5430.86
212_I219_S0.5430.86
62_W271_A0.5420.86
106_I268_M0.5400.86
304_A307_Q0.5400.86
29_G32_R0.5380.86
240_V275_A0.5370.86
132_S178_F0.5360.85
68_Q88_A0.5350.85
297_A300_T0.5320.85
167_P170_Q0.5320.85
231_V243_A0.5320.85
41_Y344_W0.5310.85
332_L336_E0.5300.85
52_L58_I0.5290.85
65_G68_Q0.5290.85
151_A160_R0.5280.85
338_L345_V0.5280.85
70_G271_A0.5270.84
336_E339_R0.5270.84
76_S108_G0.5250.84
106_I243_A0.5240.84
133_H207_H0.5230.84
99_Y220_C0.5230.84
58_I62_W0.5220.84
68_Q84_V0.5220.84
59_I67_E0.5220.84
338_L376_L0.5200.84
89_L104_L0.5200.84
97_L230_L0.5180.83
132_S140_A0.5170.83
295_L298_L0.5150.83
174_T201_L0.5150.83
377_L380_L0.5140.83
349_R352_T0.5140.83
212_I296_A0.5140.83
316_S319_A0.5130.83
62_W65_G0.5130.83
316_S321_Q0.5130.83
345_V362_L0.5120.83
183_D359_R0.5110.83
115_V229_L0.5100.83
200_W251_V0.5080.82
264_Y352_T0.5070.82
299_I319_A0.5050.82
71_I271_A0.5040.82
151_A161_L0.5040.82
206_A233_T0.5030.82
133_H179_S0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w8tA 2 0.9948 100 0.461 Contact Map
3wy7A 2 0.9453 100 0.465 Contact Map
1bs0A 2 0.9948 100 0.5 Contact Map
3kkiA 2 0.9661 100 0.511 Contact Map
2bwnA 2 1 100 0.512 Contact Map
1fc4A 2 0.9948 100 0.518 Contact Map
3tqxA 2 0.9974 100 0.536 Contact Map
3a2bA 2 0.9948 100 0.547 Contact Map
4iw7A 2 0.8464 100 0.574 Contact Map
1vefA 2 0.9089 100 0.65 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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