GREMLIN Database
BIOA - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
UniProt: P12995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10117
Length: 429 (380)
Sequences: 20764 (12455)
Seq/√Len: 638.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_K73_D4.3561.00
232_R236_D3.9671.00
386_Q419_R3.9421.00
36_E44_R3.5421.00
342_Q411_Q3.2971.00
191_M230_R3.1121.00
94_K325_A3.1011.00
31_S38_I3.0701.00
331_D334_Q2.8571.00
256_K262_H2.8541.00
342_Q407_P2.8071.00
63_Q329_S2.6571.00
335_Q339_I2.6321.00
66_A70_S2.6051.00
406_L409_Q2.5971.00
94_K328_E2.3771.00
48_G413_L2.3761.00
322_A325_A2.3201.00
230_R233_K2.3091.00
346_Q414_T2.3041.00
63_Q326_I2.2461.00
36_E409_Q2.2181.00
30_V40_S2.2131.00
382_F385_E2.1831.00
233_K237_R2.1831.00
353_A418_N2.1771.00
386_Q423_D2.1741.00
61_H326_I2.1691.00
63_Q322_A2.1631.00
338_D407_P2.1411.00
382_F423_D2.1261.00
38_I44_R2.1031.00
346_Q411_Q2.0181.00
94_K321_N1.9971.00
195_A237_R1.9681.00
136_R204_E1.9621.00
91_L320_A1.9431.00
65_N69_K1.8661.00
388_V416_A1.8591.00
344_R348_A1.8571.00
412_R416_A1.8501.00
341_V345_E1.8441.00
209_I243_I1.8271.00
382_F386_Q1.8241.00
39_L43_R1.8051.00
104_E290_R1.8021.00
105_C290_R1.8011.00
326_I330_G1.7981.00
290_R294_E1.7961.00
43_R387_G1.7951.00
86_A90_E1.7521.00
30_V74_A1.7381.00
109_A284_S1.7371.00
176_P193_G1.7321.00
357_A371_T1.7041.00
346_Q349_P1.7011.00
195_A199_A1.6911.00
36_E412_R1.6901.00
93_R97_A1.6901.00
344_R361_V1.6861.00
194_F231_I1.6761.00
68_M319_A1.6551.00
353_A422_Q1.6471.00
208_V235_C1.6361.00
136_R173_L1.6181.00
68_M72_I1.6141.00
210_I231_I1.6131.00
33_E62_P1.6041.00
116_V271_C1.6021.00
98_M328_E1.5921.00
256_K337_A1.5811.00
281_M316_A1.5661.00
348_A351_R1.5551.00
192_V196_R1.5481.00
198_M240_I1.5211.00
272_L285_A1.5201.00
339_I342_Q1.5141.00
35_C409_Q1.5051.00
277_T283_L1.5021.00
70_S74_A1.4981.00
94_K97_A1.4881.00
44_R412_R1.4841.00
344_R366_G1.4831.00
339_I410_L1.4791.00
126_Y292_V1.4751.00
90_E321_N1.4641.00
244_A260_C1.4461.00
226_E229_K1.4391.00
382_F420_A1.4351.00
141_R176_P1.4301.00
140_F227_W1.4241.00
35_C404_I1.4231.00
189_R224_H1.4191.00
118_V286_T1.4091.00
99_T287_L1.4091.00
346_Q415_A1.4051.00
383_F390_I1.4021.00
272_L287_L1.4021.00
138_L205_I1.3941.00
137_F207_A1.3871.00
106_V287_L1.3861.00
335_Q338_D1.3841.00
92_C108_L1.3821.00
232_R242_L1.3701.00
232_R235_C1.3661.00
386_Q420_A1.3631.00
62_P66_A1.3571.00
192_V195_A1.3481.00
321_N325_A1.3361.00
346_Q418_N1.3331.00
418_N422_Q1.3311.00
322_A326_I1.3301.00
120_M137_F1.3251.00
39_L45_L1.3241.00
342_Q346_Q1.3211.00
195_A230_R1.3201.00
256_K261_E1.3131.00
257_L261_E1.3111.00
96_V106_V1.3111.00
119_A271_C1.3071.00
283_L317_C1.3041.00
126_Y295_T1.2971.00
334_Q338_D1.2971.00
405_I410_L1.2941.00
339_I407_P1.2911.00
139_T174_F1.2871.00
61_H330_G1.2761.00
29_V37_L1.2721.00
33_E60_N1.2701.00
66_A69_K1.2601.00
210_I228_L1.2601.00
97_A328_E1.2601.00
90_E325_A1.2591.00
116_V209_I1.2541.00
136_R202_R1.2511.00
260_C270_L1.2501.00
123_A243_I1.2491.00
31_S74_A1.2411.00
262_H362_L1.2311.00
276_L283_L1.2291.00
269_I288_T1.2251.00
208_V231_I1.2131.00
57_H326_I1.2111.00
263_A362_L1.2101.00
226_E263_A1.2101.00
283_L320_A1.2081.00
266_A289_T1.2071.00
186_W190_D1.2001.00
409_Q412_R1.1851.00
65_N73_D1.1811.00
229_K233_K1.1811.00
68_M315_L1.1791.00
67_A322_A1.1771.00
154_V172_N1.1761.00
109_A286_T1.1701.00
276_L285_A1.1661.00
65_N72_I1.1661.00
195_A234_I1.1661.00
105_C294_E1.1601.00
60_N65_N1.1581.00
325_A329_S1.1541.00
69_K72_I1.1521.00
244_A265_I1.1471.00
190_D193_G1.1341.00
175_A197_L1.1331.00
415_A419_R1.1291.00
337_A341_V1.1291.00
241_L292_V1.1191.00
102_P266_A1.1131.00
383_F416_A1.1121.00
229_K264_E1.1041.00
108_L317_C1.1041.00
154_V209_I1.0911.00
252_G333_Q1.0811.00
269_I286_T1.0811.00
258_F272_L1.0781.00
383_F420_A1.0771.00
388_V413_L1.0731.00
191_M234_I1.0711.00
326_I329_S1.0691.00
345_E349_P1.0651.00
412_R415_A1.0641.00
36_E46_V1.0601.00
193_G196_R1.0591.00
30_V86_A1.0541.00
35_C46_V1.0531.00
407_P411_Q1.0531.00
33_E44_R1.0491.00
134_R239_G1.0471.00
113_S151_A1.0411.00
386_Q416_A1.0411.00
383_F388_V1.0341.00
235_C240_I1.0211.00
411_Q415_A1.0191.00
28_P40_S1.0171.00
199_A238_E1.0121.00
122_M286_T1.0121.00
91_L321_N1.0021.00
120_M154_V0.9901.00
278_G323_S0.9881.00
30_V42_G0.9871.00
33_E38_I0.9841.00
115_A271_C0.9791.00
233_K236_D0.9761.00
98_M257_L0.9751.00
333_Q336_V0.9711.00
30_V38_I0.9681.00
195_A233_K0.9651.00
195_A238_E0.9611.00
213_I362_L0.9611.00
196_R200_A0.9601.00
103_L287_L0.9561.00
255_G261_E0.9561.00
139_T209_I0.9561.00
187_D193_G0.9491.00
212_P244_A0.9441.00
57_H323_S0.9421.00
381_K385_E0.9391.00
56_I275_A0.9391.00
335_Q407_P0.9361.00
94_K98_M0.9361.00
408_Q411_Q0.9331.00
225_P229_K0.9321.00
135_Q204_E0.9311.00
334_Q337_A0.9261.00
198_M205_I0.9261.00
357_A369_E0.9241.00
207_A243_I0.9201.00
63_Q325_A0.9191.00
64_L319_A0.9181.00
318_A322_A0.9161.00
378_A382_F0.9151.00
350_A414_T0.9141.00
28_P89_I0.9121.00
350_A418_N0.9121.00
251_F327_L0.9111.00
46_V409_Q0.9101.00
327_L332_W0.9091.00
231_I242_L0.9081.00
140_F223_Y0.9021.00
228_L263_A0.9011.00
66_A73_D0.9011.00
367_V396_L0.8981.00
63_Q66_A0.8971.00
327_L333_Q0.8961.00
222_M362_L0.8951.00
369_E395_K0.8891.00
119_A243_I0.8801.00
140_F177_A0.8791.00
153_S169_L0.8791.00
70_S318_A0.8751.00
340_E344_R0.8701.00
70_S73_D0.8701.00
57_H64_L0.8701.00
55_A278_G0.8691.00
113_S148_T0.8681.00
349_P352_D0.8671.00
122_M288_T0.8671.00
46_V412_R0.8661.00
188_E192_V0.8621.00
126_Y241_L0.8621.00
35_C406_L0.8601.00
202_R238_E0.8591.00
226_E230_R0.8531.00
40_S86_A0.8531.00
234_I238_E0.8491.00
48_G405_I0.8481.00
262_H337_A0.8451.00
98_M324_L0.8381.00
136_R205_I0.8351.00
100_P260_C0.8351.00
345_E348_A0.8301.00
332_W336_V0.8281.00
346_Q410_L0.8281.00
405_I413_L0.8241.00
123_A207_A0.8241.00
188_E230_R0.8241.00
358_D369_E0.8201.00
236_D266_A0.8131.00
257_L333_Q0.8091.00
63_Q67_A0.8061.00
364_A405_I0.8051.00
251_F324_L0.8001.00
281_M315_L0.7991.00
95_L287_L0.7971.00
90_E94_K0.7951.00
123_A241_L0.7921.00
249_T365_I0.7911.00
187_D191_M0.7881.00
177_A223_Y0.7871.00
87_P318_A0.7871.00
96_V103_L0.7851.00
342_Q345_E0.7801.00
187_D190_D0.7771.00
48_G388_V0.7711.00
239_G291_E0.7711.00
333_Q337_A0.7701.00
109_A115_A0.7681.00
46_V413_L0.7681.00
232_R265_I0.7671.00
348_A352_D0.7651.00
349_P418_N0.7581.00
230_R234_I0.7581.00
102_P270_L0.7571.00
338_D342_Q0.7561.00
135_Q171_E0.7551.00
260_C265_I0.7551.00
419_R423_D0.7541.00
110_D114_V0.7521.00
351_R356_V0.7521.00
176_P190_D0.7511.00
208_V240_I0.7501.00
360_R369_E0.7501.00
251_F272_L0.7501.00
53_W400_M0.7491.00
34_G404_I0.7471.00
133_A204_E0.7471.00
87_P321_N0.7471.00
173_L197_L0.7471.00
106_V285_A0.7461.00
212_P228_L0.7451.00
258_F270_L0.7421.00
235_C242_L0.7421.00
370_T379_L0.7381.00
291_E294_E0.7351.00
35_C402_P0.7351.00
380_Q392_P0.7351.00
379_L417_V0.7311.00
308_P311_M0.7311.00
193_G197_L0.7271.00
91_L317_C0.7261.00
377_A381_K0.7241.00
67_A319_A0.7241.00
359_V366_G0.7231.00
399_L417_V0.7231.00
251_F276_L0.7211.00
257_L328_E0.7181.00
222_M361_V0.7181.00
123_A269_I0.7161.00
29_V32_A0.7161.00
84_T89_I0.7141.00
198_M234_I0.7131.00
251_F257_L0.7121.00
120_M209_I0.7101.00
210_I242_L0.7091.00
205_I240_I0.7081.00
361_V366_G0.7071.00
87_P90_E0.7071.00
254_T262_H0.7061.00
85_H88_A0.7041.00
64_L278_G0.7021.00
223_Y226_E0.7021.00
103_L270_L0.7001.00
49_M391_R0.6991.00
111_S114_V0.6971.00
87_P317_C0.6961.00
229_K263_A0.6931.00
88_A92_C0.6931.00
338_D341_V0.6931.00
122_M296_I0.6911.00
74_A86_A0.6891.00
365_I400_M0.6861.00
116_V151_A0.6861.00
46_V388_V0.6851.00
336_V340_E0.6851.00
71_Q74_A0.6841.00
150_G169_L0.6831.00
339_I364_A0.6831.00
50_S400_M0.6831.00
75_M78_V0.6831.00
272_L276_L0.6811.00
37_L389_W0.6811.00
369_E396_L0.6801.00
379_L420_A0.6801.00
43_R385_E0.6791.00
236_D242_L0.6781.00
340_E361_V0.6741.00
353_A421_V0.6731.00
213_I254_T0.6731.00
289_T292_V0.6711.00
100_P103_L0.6691.00
413_L416_A0.6681.00
119_A269_I0.6671.00
87_P91_L0.6661.00
121_K306_H0.6661.00
72_I315_L0.6651.00
379_L383_F0.6651.00
201_H204_E0.6641.00
383_F417_V0.6641.00
370_T421_V0.6631.00
292_V295_T0.6611.00
76_S281_M0.6601.00
408_Q412_R0.6601.00
371_T374_V0.6601.00
126_Y291_E0.6571.00
335_Q406_L0.6571.00
186_W189_R0.6571.00
94_K324_L0.6561.00
252_G327_L0.6561.00
99_T270_L0.6521.00
414_T418_N0.6501.00
228_L244_A0.6491.00
89_I93_R0.6461.00
359_V368_V0.6441.00
98_M258_F0.6431.00
399_L413_L0.6421.00
242_L265_I0.6401.00
175_A194_F0.6391.00
379_L397_I0.6381.00
243_I269_I0.6361.00
260_C267_P0.6331.00
288_T293_A0.6331.00
342_Q410_L0.6321.00
91_L283_L0.6311.00
420_A423_D0.6311.00
194_F208_V0.6291.00
112_G247_I0.6281.00
380_Q384_V0.6281.00
225_P263_A0.6271.00
32_A75_M0.6261.00
28_P84_T0.6261.00
71_Q87_P0.6241.00
225_P362_L0.6231.00
100_P261_E0.6221.00
122_M269_I0.6221.00
339_I405_I0.6221.00
216_G365_I0.6211.00
378_A381_K0.6211.00
343_L414_T0.6201.00
175_A193_G0.6181.00
247_I271_C0.6181.00
35_C405_I0.6171.00
388_V412_R0.6151.00
60_N72_I0.6141.00
273_G284_S0.6131.00
215_Q218_G0.6121.00
351_R358_D0.6121.00
368_V417_V0.6111.00
99_T258_F0.6111.00
196_R199_A0.6111.00
109_A114_V0.6101.00
57_H332_W0.6101.00
355_M371_T0.6091.00
44_R416_A0.6061.00
118_V306_H0.6051.00
191_M195_A0.6021.00
381_K384_V0.6021.00
50_S402_P0.6011.00
341_V344_R0.6011.00
336_V403_Y0.6011.00
67_A70_S0.5991.00
134_R240_I0.5991.00
216_G248_A0.5971.00
236_D291_E0.5961.00
91_L108_L0.5921.00
405_I409_Q0.5921.00
144_Y147_D0.5911.00
49_M389_W0.5911.00
74_A87_P0.5901.00
98_M256_K0.5901.00
192_V230_R0.5891.00
124_L149_F0.5891.00
251_F258_F0.5881.00
32_A37_L0.5861.00
141_R174_F0.5851.00
234_I237_R0.5851.00
198_M238_E0.5841.00
319_A322_A0.5841.00
343_L366_G0.5841.00
138_L194_F0.5831.00
72_I319_A0.5831.00
416_A420_A0.5831.00
102_P260_C0.5811.00
397_I417_V0.5811.00
56_I403_Y0.5801.00
215_Q221_R0.5801.00
356_V421_V0.5791.00
339_I406_L0.5791.00
138_L175_A0.5791.00
336_V364_A0.5751.00
343_L410_L0.5751.00
350_A353_A0.5741.00
417_V421_V0.5731.00
139_T172_N0.5721.00
186_W197_L0.5721.00
138_L197_L0.5721.00
335_Q410_L0.5721.00
132_E206_A0.5701.00
56_I327_L0.5691.00
30_V33_E0.5681.00
64_L323_S0.5671.00
67_A325_A0.5671.00
140_F175_A0.5671.00
212_P249_T0.5661.00
416_A419_R0.5651.00
99_T272_L0.5631.00
136_R201_H0.5601.00
134_R204_E0.5601.00
328_E331_D0.5581.00
194_F234_I0.5561.00
72_I76_S0.5551.00
28_P86_A0.5541.00
269_I292_V0.5531.00
156_D174_F0.5511.00
27_Y30_V0.5511.00
360_R367_V0.5501.00
372_H375_N0.5501.00
33_E36_E0.5481.00
96_V287_L0.5481.00
194_F230_R0.5471.00
124_L167_G0.5461.00
342_Q414_T0.5441.00
248_A365_I0.5441.00
62_P73_D0.5431.00
140_F210_I0.5411.00
360_R396_L0.5411.00
102_P289_T0.5401.00
257_L324_L0.5401.00
96_V104_E0.5380.99
140_F231_I0.5370.99
29_V83_I0.5370.99
337_A340_E0.5360.99
71_Q75_M0.5360.99
29_V75_M0.5350.99
231_I240_I0.5350.99
31_S44_R0.5340.99
136_R171_E0.5330.99
46_V405_I0.5330.99
68_M76_S0.5320.99
189_R193_G0.5320.99
257_L327_L0.5310.99
96_V99_T0.5290.99
64_L322_A0.5290.99
194_F227_W0.5290.99
158_D163_S0.5260.99
197_L200_A0.5260.99
70_S322_A0.5250.99
313_N316_A0.5250.99
391_R394_G0.5250.99
270_L287_L0.5240.99
330_G335_Q0.5230.99
90_E93_R0.5230.99
229_K232_R0.5220.99
83_I389_W0.5220.99
411_Q414_T0.5220.99
388_V420_A0.5210.99
120_M150_G0.5210.99
162_H174_F0.5210.99
413_L417_V0.5190.99
218_G221_R0.5190.99
324_L328_E0.5170.99
99_T106_V0.5150.99
368_V399_L0.5150.99
385_E423_D0.5120.99
356_V368_V0.5120.99
212_P260_C0.5120.99
199_A237_R0.5120.99
100_P104_E0.5110.99
273_G310_F0.5080.99
210_I244_A0.5070.99
387_G416_A0.5060.99
32_A55_A0.5060.99
410_L414_T0.5060.99
402_P405_I0.5030.99
410_L413_L0.5020.99
63_Q330_G0.5020.99
267_P270_L0.5020.99
191_M194_F0.5010.99
412_R419_R0.5010.99
65_N278_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e3qA 3 0.9907 100 0.359 Contact Map
4a0gA 2 0.9837 100 0.362 Contact Map
3hmuA 2 0.986 100 0.372 Contact Map
4uoxA 3 0.9557 100 0.374 Contact Map
4atqA 7 0.9534 100 0.374 Contact Map
3oksA 2 0.9487 100 0.38 Contact Map
3i5tA 2 0.986 100 0.381 Contact Map
1s0aA 2 0.9953 100 0.381 Contact Map
1z7dA 2 0.8695 100 0.387 Contact Map
4ffcA 4 0.951 100 0.39 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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