GREMLIN Database
UDP - Uridine phosphorylase
UniProt: P12758 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11045
Length: 253 (214)
Sequences: 4863 (3325)
Seq/√Len: 227.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_T219_V3.3971.00
206_C213_A3.2171.00
82_A211_L3.1961.00
133_D212_R2.8841.00
40_K56_E2.7531.00
111_T153_V2.7111.00
88_T212_R2.7041.00
141_V153_V2.6861.00
199_S215_M2.5381.00
112_A155_V2.5351.00
112_A131_V2.4561.00
110_T156_T2.3821.00
56_E61_P2.2961.00
32_E36_A2.2481.00
46_S51_T2.2461.00
141_V145_K2.2121.00
99_Q193_M2.0981.00
21_L88_T2.0931.00
157_A192_V2.0551.00
138_T142_E2.0231.00
112_A129_P1.9421.00
140_L214_G1.9341.00
109_V137_T1.8571.00
71_G201_T1.8091.00
125_P128_F1.8081.00
43_K54_R1.7951.00
79_E209_Q1.7941.00
87_R211_L1.7711.00
103_N106_D1.6991.00
33_K239_S1.6721.00
137_T153_V1.6601.00
95_T194_N1.6541.00
71_G158_S1.6531.00
24_V67_T1.6441.00
79_E83_Q1.6281.00
83_Q209_Q1.6151.00
134_F138_T1.6111.00
102_I152_H1.6021.00
50_F66_S1.5891.00
78_V205_M1.5891.00
239_S243_K1.5841.00
108_L194_N1.5501.00
156_T194_N1.5381.00
140_L248_A1.5201.00
196_E199_S1.5191.00
144_A151_T1.5131.00
137_T214_G1.5051.00
28_P66_S1.5031.00
115_R204_T1.5031.00
136_C214_G1.4961.00
101_H152_H1.4491.00
24_V89_F1.4301.00
194_N219_V1.4241.00
236_Q240_H1.4211.00
25_P31_V1.4141.00
156_T217_A1.4051.00
154_G193_M1.4031.00
43_K46_S1.3921.00
109_V151_T1.3691.00
39_D56_E1.3671.00
147_I247_E1.3531.00
78_V89_F1.3351.00
113_S203_L1.3101.00
44_L51_T1.3011.00
52_T65_C1.2881.00
113_S199_S1.2771.00
54_R63_I1.2721.00
57_L246_V1.2691.00
230_N233_T1.2541.00
26_G30_R1.2521.00
222_N225_Q1.2481.00
114_V129_P1.2471.00
116_L159_S1.2291.00
58_D247_E1.2281.00
143_A147_I1.2231.00
138_T141_V1.2061.00
115_R200_A1.2011.00
135_E212_R1.1951.00
143_A248_A1.1931.00
45_A54_R1.1791.00
143_A146_S1.1721.00
21_L60_K1.1681.00
45_A84_L1.1551.00
97_A102_I1.1551.00
52_T63_I1.1541.00
74_T202_L1.1461.00
109_V141_V1.1451.00
139_A248_A1.1421.00
44_L65_C1.1361.00
147_I243_K1.1351.00
103_N227_E1.1201.00
97_A222_N1.1191.00
89_F206_C1.1161.00
65_C77_A1.1141.00
106_D152_H1.1071.00
152_H193_M1.1011.00
34_I64_V1.0951.00
185_E189_A1.0951.00
142_E145_K1.0921.00
22_A86_I1.0811.00
33_K242_V1.0761.00
141_V151_T1.0671.00
240_H243_K1.0621.00
97_A219_V1.0571.00
82_A209_Q1.0551.00
108_L193_M1.0471.00
82_A89_F1.0371.00
109_V214_G1.0221.00
103_N225_Q1.0141.00
114_V157_A1.0061.00
74_T78_V1.0041.00
35_A53_W1.0021.00
110_T132_A0.9911.00
137_T141_V0.9841.00
143_A247_E0.9811.00
116_L161_T0.9701.00
138_T145_K0.9701.00
88_T136_C0.9551.00
48_R80_E0.9551.00
91_R202_L0.9451.00
99_Q102_I0.9431.00
74_T201_T0.9431.00
139_A143_A0.9361.00
33_K36_A0.9341.00
119_A123_F0.9321.00
31_V64_V0.9271.00
25_P92_I0.9261.00
135_E139_A0.9231.00
76_I205_M0.9221.00
232_E236_Q0.9120.99
37_L246_V0.9110.99
120_S204_T0.9090.99
129_P155_V0.9070.99
75_S205_M0.9040.99
168_R183_S0.9030.99
203_L213_A0.9020.99
57_L62_V0.8960.99
105_G237_T0.8950.99
146_S247_E0.8950.99
134_F137_T0.8880.99
103_N222_N0.8870.99
21_L249_A0.8820.99
161_T168_R0.8800.99
110_T217_A0.8750.99
119_A205_M0.8740.99
243_K247_E0.8730.99
132_A203_L0.8730.99
56_E59_G0.8730.99
28_P35_A0.8720.99
158_S199_S0.8640.99
29_D32_E0.8640.99
39_D59_G0.8620.99
98_I192_V0.8590.99
132_A137_T0.8590.99
121_L127_E0.8540.99
54_R61_P0.8530.99
214_G248_A0.8450.99
38_M55_A0.8430.99
29_D46_S0.8340.99
137_T140_L0.8300.99
110_T194_N0.8240.99
238_E242_V0.8230.99
105_G229_P0.8220.99
113_S215_M0.8210.99
144_A244_I0.8190.99
107_V244_I0.8160.99
75_S79_E0.8140.99
116_L157_A0.8140.99
149_A244_I0.8110.99
89_F211_L0.8100.99
139_A142_E0.8060.99
236_Q239_S0.8030.99
98_I195_Y0.8000.99
50_F77_A0.7990.99
135_E138_T0.7890.99
136_C140_L0.7860.98
31_V53_W0.7790.98
71_G200_A0.7770.98
142_E146_S0.7760.98
140_L143_A0.7710.98
76_I79_E0.7670.98
229_P233_T0.7610.98
165_G168_R0.7590.98
131_V207_A0.7580.98
108_L219_V0.7580.98
81_L86_I0.7570.98
196_E215_M0.7560.98
37_L243_K0.7500.98
134_F141_V0.7470.98
58_D246_V0.7460.98
50_F69_I0.7460.98
82_A86_I0.7440.98
27_D30_R0.7380.98
71_G117_D0.7360.98
109_V153_V0.7340.98
104_V230_N0.7320.98
98_I223_R0.7300.98
33_K37_L0.7260.97
41_P53_W0.7250.97
111_T155_V0.7250.97
79_E205_M0.7240.97
38_M41_P0.7220.97
201_T205_M0.7180.97
94_T220_I0.7170.97
85_G211_L0.7140.97
185_E188_Q0.7140.97
52_T80_E0.7070.97
239_S242_V0.7030.97
133_D136_C0.7020.97
235_K239_S0.6970.97
22_A63_I0.6960.97
75_S201_T0.6960.97
36_A239_S0.6960.97
37_L239_S0.6910.97
99_Q152_H0.6890.97
103_N150_T0.6830.96
118_G123_F0.6810.96
131_V134_F0.6790.96
100_P224_T0.6770.96
195_Y223_R0.6770.96
71_G119_A0.6690.96
110_T113_S0.6670.96
130_A204_T0.6650.96
111_T134_F0.6640.96
50_F65_C0.6640.96
199_S217_A0.6600.96
115_R118_G0.6560.95
65_C81_L0.6490.95
97_A104_V0.6440.95
102_I219_V0.6410.95
67_T78_V0.6390.95
195_Y221_V0.6380.95
184_M223_R0.6360.95
138_T153_V0.6340.95
24_V78_V0.6220.94
220_I238_E0.6220.94
111_T131_V0.6210.94
76_I80_E0.6200.94
165_G208_S0.6190.94
143_A244_I0.6140.94
203_L214_G0.6120.93
30_R91_R0.6110.93
134_F153_V0.6110.93
244_I248_A0.6100.93
90_L136_C0.6090.93
82_A87_R0.6080.93
94_T234_M0.6080.93
111_T137_T0.6050.93
166_Q169_Y0.6040.93
94_T238_E0.6030.93
32_E51_T0.6020.93
95_T217_A0.6010.93
227_E231_A0.6000.93
34_I92_I0.5990.93
31_V66_S0.5990.93
36_A41_P0.5980.93
119_A201_T0.5980.93
128_F204_T0.5960.93
133_D139_A0.5940.92
110_T203_L0.5930.92
34_I38_M0.5920.92
149_A243_K0.5920.92
73_S76_I0.5910.92
25_P34_I0.5900.92
48_R209_Q0.5890.92
114_V192_V0.5890.92
149_A240_H0.5890.92
91_R94_T0.5850.92
41_P44_L0.5840.92
95_T108_L0.5830.92
45_A52_T0.5810.92
113_S156_T0.5800.92
145_K150_T0.5780.91
80_E83_Q0.5770.91
71_G160_D0.5740.91
158_S215_M0.5740.91
157_A184_M0.5740.91
52_T84_L0.5730.91
69_I76_I0.5720.91
76_I208_S0.5710.91
224_T227_E0.5690.91
46_S49_E0.5680.91
199_S203_L0.5640.90
107_V218_G0.5630.90
235_K238_E0.5610.90
218_G238_E0.5600.90
164_P168_R0.5600.90
232_E235_K0.5590.90
107_V240_H0.5560.90
216_V245_V0.5550.90
105_G233_T0.5520.89
186_E189_A0.5490.89
131_V155_V0.5430.89
114_V131_V0.5420.89
82_A85_G0.5390.88
72_P160_D0.5380.88
109_V144_A0.5360.88
113_S213_A0.5320.88
162_F197_M0.5290.87
136_C248_A0.5280.87
26_G91_R0.5280.87
35_A64_V0.5270.87
100_P185_E0.5270.87
120_S123_F0.5260.87
121_L126_L0.5250.87
183_S186_E0.5190.86
75_S119_A0.5180.86
227_E230_N0.5160.86
43_K51_T0.5160.86
106_D150_T0.5150.86
54_R84_L0.5150.86
132_A214_G0.5120.86
28_P32_E0.5110.86
70_G160_D0.5110.86
69_I123_F0.5080.85
113_S200_A0.5040.85
96_G196_E0.5030.85
29_D235_K0.5010.84
114_V155_V0.5010.84
38_M64_V0.5010.84
118_G121_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bjeA 2 0.9881 100 0.202 Contact Map
3phcA 5 0.9328 100 0.24 Contact Map
3eufA 2 0.9921 100 0.257 Contact Map
2b94A 4 0.9091 100 0.257 Contact Map
3mb8A 4 0.9407 100 0.26 Contact Map
3qpbA 6 0.9684 100 0.265 Contact Map
4r31A 5 1 100 0.265 Contact Map
3p0fA 2 0.9881 100 0.279 Contact Map
4m7wA 5 0.917 100 0.28 Contact Map
4r2xC 3 0.9802 100 0.281 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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