GREMLIN Database
UNG - Uracil-DNA glycosylase
UniProt: P12295 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11058
Length: 229 (217)
Sequences: 3440 (2154)
Seq/√Len: 146.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_G184_K3.3681.00
26_T139_L3.1521.00
162_L206_A3.1011.00
152_I159_V2.9291.00
211_E217_P2.9131.00
129_R132_Q2.8351.00
35_V129_R2.6641.00
169_Q184_K2.6591.00
48_F148_V2.6201.00
99_T204_V2.5311.00
40_P43_D2.4471.00
124_T167_H2.4121.00
181_H209_W2.3271.00
50_F116_R2.3171.00
166_S169_Q2.2611.00
43_D80_R2.2321.00
14_E19_Y2.1751.00
147_K150_S2.1511.00
52_E55_D2.1251.00
6_T54_G2.0741.00
185_A200_C2.0421.00
166_S170_K2.0311.00
38_Y69_P2.0111.00
73_H80_R1.9281.00
81_P108_H1.9191.00
100_I103_F1.8981.00
30_E129_R1.8951.00
176_D179_R1.8921.00
14_E17_Q1.8811.00
201_N204_V1.7851.00
99_T201_N1.7711.00
209_W213_R1.7111.00
44_V127_T1.7111.00
97_E105_R1.6891.00
112_E116_R1.6891.00
161_F180_H1.6531.00
98_N201_N1.6441.00
81_P110_Y1.6441.00
68_G131_G1.5981.00
208_Q212_Q1.5951.00
150_S174_I1.5831.00
146_D171_K1.5641.00
30_E35_V1.5631.00
36_T130_A1.5521.00
183_L202_H1.5471.00
85_I93_Y1.5401.00
31_R44_V1.5371.00
181_H213_R1.5231.00
43_D46_N1.5161.00
160_V206_A1.4971.00
46_N50_F1.4931.00
158_G213_R1.4921.00
134_H167_H1.4911.00
97_E104_T1.4881.00
23_T139_L1.4831.00
73_H110_Y1.4451.00
95_E199_G1.4431.00
147_K151_L1.4421.00
56_V152_I1.4421.00
10_V151_L1.4411.00
139_L142_E1.4221.00
73_H78_S1.4181.00
153_N176_D1.4121.00
160_V209_W1.4111.00
162_L202_H1.4041.00
191_L195_R1.3591.00
52_E56_V1.3501.00
57_K216_T1.3211.00
158_G209_W1.3001.00
46_N49_R1.3001.00
92_M203_F1.2981.00
28_A41_Q1.2981.00
67_H133_A1.2671.00
69_P130_A1.2491.00
177_K184_K1.2291.00
125_V134_H1.2231.00
150_S154_Q1.2151.00
208_Q211_E1.2141.00
31_R41_Q1.2101.00
100_I204_V1.2071.00
125_V142_E1.1961.00
193_A198_F1.1911.00
27_V31_R1.1871.00
108_H113_S1.1861.00
134_H137_A1.1671.00
157_E215_E1.1511.00
67_H87_P1.1420.99
137_A167_H1.1080.99
103_F221_M1.1050.99
24_L27_V1.0950.99
85_I109_G1.0940.99
205_L208_Q1.0890.99
113_S219_D1.0850.99
29_S34_G1.0820.99
46_N73_H1.0820.99
26_T30_E1.0810.99
186_P195_R1.0790.99
68_G71_Q1.0770.99
67_H71_Q1.0710.99
128_V135_S1.0690.99
50_F112_E1.0680.99
172_G182_V1.0530.99
6_T53_L1.0440.99
138_S142_E1.0410.99
10_V53_L1.0320.99
166_S194_H1.0250.99
125_V167_H1.0230.99
18_P22_N1.0180.99
103_F106_P1.0120.99
98_N198_F1.0110.99
133_A191_L1.0100.99
4_E8_H1.0100.99
125_V137_A1.0030.99
172_G175_I0.9970.99
93_Y106_P0.9930.99
183_L206_A0.9810.98
177_K182_V0.9710.98
191_L194_H0.9680.98
22_N25_Q0.9660.98
24_L28_A0.9620.98
194_H198_F0.9620.98
53_L152_I0.9580.98
87_P190_P0.9540.98
59_V161_F0.9460.98
172_G177_K0.9380.98
186_P196_G0.9380.98
25_Q28_A0.9330.98
38_Y130_A0.9290.98
53_L156_R0.9280.98
24_L41_Q0.9270.98
71_Q131_G0.9110.97
85_I90_L0.9100.97
38_Y68_G0.9010.97
183_L200_C0.8970.97
4_E49_R0.8950.97
28_A32_Q0.8920.97
12_A16_Q0.8860.97
104_T221_M0.8850.97
53_L151_L0.8820.97
129_R135_S0.8820.97
51_T56_V0.8800.97
160_V181_H0.8760.97
158_G215_E0.8660.97
96_L103_F0.8620.97
186_P194_H0.8620.97
29_S32_Q0.8590.96
87_P194_H0.8570.96
94_K98_N0.8480.96
25_Q29_S0.8460.96
162_L183_L0.8380.96
35_V132_Q0.8350.96
194_H197_F0.8320.96
6_T52_E0.8300.96
153_N174_I0.8290.96
27_V37_I0.8270.96
183_L205_L0.8250.96
17_Q143_T0.8180.95
48_F120_L0.8130.95
19_Y143_T0.8120.95
8_H49_R0.8110.95
21_L25_Q0.8070.95
185_A202_H0.8060.95
30_E139_L0.8040.95
9_D12_A0.8010.95
151_L155_H0.7980.95
20_F24_L0.7980.95
170_K173_A0.7940.94
117_Q218_I0.7840.94
151_L154_Q0.7830.94
71_Q87_P0.7810.94
85_I108_H0.7770.94
3_N15_K0.7760.94
106_P109_G0.7700.94
166_S186_P0.7630.93
79_V109_G0.7580.93
98_N199_G0.7530.93
31_R34_G0.7510.93
26_T142_E0.7460.92
36_T69_P0.7420.92
16_Q21_L0.7410.92
155_H159_V0.7400.92
69_P131_G0.7390.92
61_L171_K0.7380.92
201_N205_L0.7370.92
156_R159_V0.7350.92
53_L155_H0.7350.92
56_V120_L0.7300.92
87_P90_L0.7300.92
43_D50_F0.7230.91
94_K194_H0.7160.91
146_D149_I0.7150.91
43_D49_R0.7140.91
23_T142_E0.7130.91
68_G87_P0.7090.90
155_H158_G0.7090.90
156_R215_E0.7060.90
4_E53_L0.7060.90
57_K215_E0.7000.90
198_F201_N0.6990.90
93_Y109_G0.6980.90
144_F148_V0.6970.90
162_L185_A0.6950.90
5_L8_H0.6880.89
91_N192_S0.6830.89
186_P198_F0.6820.89
93_Y108_H0.6800.89
58_V117_Q0.6780.88
84_A90_L0.6760.88
152_I156_R0.6750.88
166_S191_L0.6730.88
22_N143_T0.6690.88
153_N179_R0.6670.88
85_I107_N0.6650.87
19_Y144_F0.6590.87
97_E103_F0.6590.87
14_E147_K0.6560.87
90_L94_K0.6560.87
186_P197_F0.6540.87
23_T27_V0.6520.86
173_A191_L0.6500.86
193_A196_G0.6500.86
97_E100_I0.6470.86
96_L202_H0.6460.86
124_T134_H0.6460.86
146_D150_S0.6440.86
153_N175_I0.6430.86
14_E144_F0.6410.85
105_R108_H0.6390.85
80_R110_Y0.6390.85
13_E17_Q0.6390.85
186_P192_S0.6380.85
97_E102_G0.6380.85
146_D174_I0.6370.85
117_Q219_D0.6370.85
186_P191_L0.6370.85
128_V133_A0.6360.85
73_H112_E0.6360.85
68_G133_A0.6350.85
106_P113_S0.6340.85
126_L145_T0.6340.85
38_Y71_Q0.6330.85
137_A142_E0.6330.85
73_H76_A0.6330.85
153_N180_H0.6320.85
38_Y128_V0.6270.84
46_N112_E0.6250.84
59_V159_V0.6230.84
204_V208_Q0.6210.84
82_G85_I0.6210.84
72_A78_S0.6200.84
8_H12_A0.6190.83
148_V151_L0.6190.83
68_G130_A0.6130.83
162_L200_C0.6120.83
55_D116_R0.6070.82
10_V155_H0.6070.82
211_E216_T0.6070.82
38_Y131_G0.6070.82
38_Y67_H0.6060.82
81_P113_S0.6050.82
22_N139_L0.6030.82
50_F75_L0.5980.81
36_T70_G0.5970.81
58_V206_A0.5950.81
45_F48_F0.5950.81
60_I121_L0.5940.81
169_Q172_G0.5920.81
13_E151_L0.5920.81
207_N218_I0.5910.81
103_F219_D0.5900.80
15_K19_Y0.5850.80
5_L9_D0.5810.79
207_N210_L0.5800.79
85_I105_R0.5780.79
81_P112_E0.5780.79
149_I175_I0.5770.79
192_S196_G0.5740.79
113_S116_R0.5740.79
3_N48_F0.5740.79
3_N144_F0.5730.78
76_A124_T0.5720.78
82_G109_G0.5710.78
10_V147_K0.5660.78
15_K20_F0.5660.78
93_Y105_R0.5630.77
149_I171_K0.5610.77
13_E16_Q0.5610.77
20_F144_F0.5600.77
6_T56_V0.5590.77
43_D73_H0.5590.77
114_W121_L0.5580.77
162_L198_F0.5570.76
120_L148_V0.5550.76
206_A218_I0.5550.76
104_T108_H0.5530.76
31_R37_I0.5530.76
37_I197_F0.5520.76
11_L48_F0.5470.75
4_E9_D0.5440.75
76_A121_L0.5440.75
167_H170_K0.5410.74
96_L113_S0.5380.74
51_T115_A0.5380.74
48_F159_V0.5310.73
96_L100_I0.5290.73
158_G181_H0.5290.73
28_A31_R0.5280.73
21_L24_L0.5230.72
47_A122_L0.5220.72
186_P193_A0.5190.71
122_L126_L0.5160.71
59_V149_I0.5160.71
79_V86_P0.5150.71
85_I106_P0.5140.71
108_H221_M0.5140.71
37_I130_A0.5130.70
117_Q221_M0.5110.70
171_K174_I0.5110.70
192_S195_R0.5100.70
162_L209_W0.5080.70
20_F41_Q0.5070.70
176_D180_H0.5070.70
50_F115_A0.5050.69
93_Y110_Y0.5050.69
14_E143_T0.5050.69
23_T30_E0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uf7A 1 0.9738 100 -0.015 Contact Map
3tr7A 1 0.9563 100 0.008 Contact Map
3zoqA 1 0.9651 100 0.015 Contact Map
3fciA 1 0.9694 100 0.016 Contact Map
3cxmA 1 0.9913 100 0.018 Contact Map
2booA 1 0.9869 100 0.021 Contact Map
2j8xA 1 0.9607 100 0.023 Contact Map
3wdfA 1 0.9432 100 0.028 Contact Map
1udgA 1 0.9563 100 0.035 Contact Map
4wpkA 1 0.9563 100 0.065 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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