UNG - ECOLI - GREMLIN Contacts

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UNG - Uracil-DNA glycosylase

UniProt:	P12295	Sequences: MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAIPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQRGETPIDWMPVLPAESE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11058
Length:	229 (217)
Sequences:	3440 (2154)
Seq/√Len:	146.2

ECOLI - UNG
BACSU - UNG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_G	184_K	3.368	1.00
26_T	139_L	3.152	1.00
162_L	206_A	3.101	1.00
152_I	159_V	2.929	1.00
211_E	217_P	2.913	1.00
129_R	132_Q	2.835	1.00
35_V	129_R	2.664	1.00
169_Q	184_K	2.659	1.00
48_F	148_V	2.620	1.00
99_T	204_V	2.531	1.00
40_P	43_D	2.447	1.00
124_T	167_H	2.412	1.00
181_H	209_W	2.327	1.00
50_F	116_R	2.317	1.00
166_S	169_Q	2.261	1.00
43_D	80_R	2.232	1.00
14_E	19_Y	2.175	1.00
147_K	150_S	2.151	1.00
52_E	55_D	2.125	1.00
6_T	54_G	2.074	1.00
185_A	200_C	2.042	1.00
166_S	170_K	2.031	1.00
38_Y	69_P	2.011	1.00
73_H	80_R	1.928	1.00
81_P	108_H	1.919	1.00
100_I	103_F	1.898	1.00
30_E	129_R	1.895	1.00
176_D	179_R	1.892	1.00
14_E	17_Q	1.881	1.00
201_N	204_V	1.785	1.00
99_T	201_N	1.771	1.00
209_W	213_R	1.711	1.00
44_V	127_T	1.711	1.00
97_E	105_R	1.689	1.00
112_E	116_R	1.689	1.00
161_F	180_H	1.653	1.00
98_N	201_N	1.644	1.00
81_P	110_Y	1.644	1.00
68_G	131_G	1.598	1.00
208_Q	212_Q	1.595	1.00
150_S	174_I	1.583	1.00
146_D	171_K	1.564	1.00
30_E	35_V	1.563	1.00
36_T	130_A	1.552	1.00
183_L	202_H	1.547	1.00
85_I	93_Y	1.540	1.00
31_R	44_V	1.537	1.00
181_H	213_R	1.523	1.00
43_D	46_N	1.516	1.00
160_V	206_A	1.497	1.00
46_N	50_F	1.493	1.00
158_G	213_R	1.492	1.00
134_H	167_H	1.491	1.00
97_E	104_T	1.488	1.00
23_T	139_L	1.483	1.00
73_H	110_Y	1.445	1.00
95_E	199_G	1.443	1.00
147_K	151_L	1.442	1.00
56_V	152_I	1.442	1.00
10_V	151_L	1.441	1.00
139_L	142_E	1.422	1.00
73_H	78_S	1.418	1.00
153_N	176_D	1.412	1.00
160_V	209_W	1.411	1.00
162_L	202_H	1.404	1.00
191_L	195_R	1.359	1.00
52_E	56_V	1.350	1.00
57_K	216_T	1.321	1.00
158_G	209_W	1.300	1.00
46_N	49_R	1.300	1.00
92_M	203_F	1.298	1.00
28_A	41_Q	1.298	1.00
67_H	133_A	1.267	1.00
69_P	130_A	1.249	1.00
177_K	184_K	1.229	1.00
125_V	134_H	1.223	1.00
150_S	154_Q	1.215	1.00
208_Q	211_E	1.214	1.00
31_R	41_Q	1.210	1.00
100_I	204_V	1.207	1.00
125_V	142_E	1.196	1.00
193_A	198_F	1.191	1.00
27_V	31_R	1.187	1.00
108_H	113_S	1.186	1.00
134_H	137_A	1.167	1.00
157_E	215_E	1.151	1.00
67_H	87_P	1.142	0.99
137_A	167_H	1.108	0.99
103_F	221_M	1.105	0.99
24_L	27_V	1.095	0.99
85_I	109_G	1.094	0.99
205_L	208_Q	1.089	0.99
113_S	219_D	1.085	0.99
29_S	34_G	1.082	0.99
46_N	73_H	1.082	0.99
26_T	30_E	1.081	0.99
186_P	195_R	1.079	0.99
68_G	71_Q	1.077	0.99
67_H	71_Q	1.071	0.99
128_V	135_S	1.069	0.99
50_F	112_E	1.068	0.99
172_G	182_V	1.053	0.99
6_T	53_L	1.044	0.99
138_S	142_E	1.041	0.99
10_V	53_L	1.032	0.99
166_S	194_H	1.025	0.99
125_V	167_H	1.023	0.99
18_P	22_N	1.018	0.99
103_F	106_P	1.012	0.99
98_N	198_F	1.011	0.99
133_A	191_L	1.010	0.99
4_E	8_H	1.010	0.99
125_V	137_A	1.003	0.99
172_G	175_I	0.997	0.99
93_Y	106_P	0.993	0.99
183_L	206_A	0.981	0.98
177_K	182_V	0.971	0.98
191_L	194_H	0.968	0.98
22_N	25_Q	0.966	0.98
24_L	28_A	0.962	0.98
194_H	198_F	0.962	0.98
53_L	152_I	0.958	0.98
87_P	190_P	0.954	0.98
59_V	161_F	0.946	0.98
172_G	177_K	0.938	0.98
186_P	196_G	0.938	0.98
25_Q	28_A	0.933	0.98
38_Y	130_A	0.929	0.98
53_L	156_R	0.928	0.98
24_L	41_Q	0.927	0.98
71_Q	131_G	0.911	0.97
85_I	90_L	0.910	0.97
38_Y	68_G	0.901	0.97
183_L	200_C	0.897	0.97
4_E	49_R	0.895	0.97
28_A	32_Q	0.892	0.97
12_A	16_Q	0.886	0.97
104_T	221_M	0.885	0.97
53_L	151_L	0.882	0.97
129_R	135_S	0.882	0.97
51_T	56_V	0.880	0.97
160_V	181_H	0.876	0.97
158_G	215_E	0.866	0.97
96_L	103_F	0.862	0.97
186_P	194_H	0.862	0.97
29_S	32_Q	0.859	0.96
87_P	194_H	0.857	0.96
94_K	98_N	0.848	0.96
25_Q	29_S	0.846	0.96
162_L	183_L	0.838	0.96
35_V	132_Q	0.835	0.96
194_H	197_F	0.832	0.96
6_T	52_E	0.830	0.96
153_N	174_I	0.829	0.96
27_V	37_I	0.827	0.96
183_L	205_L	0.825	0.96
17_Q	143_T	0.818	0.95
48_F	120_L	0.813	0.95
19_Y	143_T	0.812	0.95
8_H	49_R	0.811	0.95
21_L	25_Q	0.807	0.95
185_A	202_H	0.806	0.95
30_E	139_L	0.804	0.95
9_D	12_A	0.801	0.95
151_L	155_H	0.798	0.95
20_F	24_L	0.798	0.95
170_K	173_A	0.794	0.94
117_Q	218_I	0.784	0.94
151_L	154_Q	0.783	0.94
71_Q	87_P	0.781	0.94
85_I	108_H	0.777	0.94
3_N	15_K	0.776	0.94
106_P	109_G	0.770	0.94
166_S	186_P	0.763	0.93
79_V	109_G	0.758	0.93
98_N	199_G	0.753	0.93
31_R	34_G	0.751	0.93
26_T	142_E	0.746	0.92
36_T	69_P	0.742	0.92
16_Q	21_L	0.741	0.92
155_H	159_V	0.740	0.92
69_P	131_G	0.739	0.92
61_L	171_K	0.738	0.92
201_N	205_L	0.737	0.92
156_R	159_V	0.735	0.92
53_L	155_H	0.735	0.92
56_V	120_L	0.730	0.92
87_P	90_L	0.730	0.92
43_D	50_F	0.723	0.91
94_K	194_H	0.716	0.91
146_D	149_I	0.715	0.91
43_D	49_R	0.714	0.91
23_T	142_E	0.713	0.91
68_G	87_P	0.709	0.90
155_H	158_G	0.709	0.90
156_R	215_E	0.706	0.90
4_E	53_L	0.706	0.90
57_K	215_E	0.700	0.90
198_F	201_N	0.699	0.90
93_Y	109_G	0.698	0.90
144_F	148_V	0.697	0.90
162_L	185_A	0.695	0.90
5_L	8_H	0.688	0.89
91_N	192_S	0.683	0.89
186_P	198_F	0.682	0.89
93_Y	108_H	0.680	0.89
58_V	117_Q	0.678	0.88
84_A	90_L	0.676	0.88
152_I	156_R	0.675	0.88
166_S	191_L	0.673	0.88
22_N	143_T	0.669	0.88
153_N	179_R	0.667	0.88
85_I	107_N	0.665	0.87
19_Y	144_F	0.659	0.87
97_E	103_F	0.659	0.87
14_E	147_K	0.656	0.87
90_L	94_K	0.656	0.87
186_P	197_F	0.654	0.87
23_T	27_V	0.652	0.86
173_A	191_L	0.650	0.86
193_A	196_G	0.650	0.86
97_E	100_I	0.647	0.86
96_L	202_H	0.646	0.86
124_T	134_H	0.646	0.86
146_D	150_S	0.644	0.86
153_N	175_I	0.643	0.86
14_E	144_F	0.641	0.85
105_R	108_H	0.639	0.85
80_R	110_Y	0.639	0.85
13_E	17_Q	0.639	0.85
186_P	192_S	0.638	0.85
97_E	102_G	0.638	0.85
146_D	174_I	0.637	0.85
117_Q	219_D	0.637	0.85
186_P	191_L	0.637	0.85
128_V	133_A	0.636	0.85
73_H	112_E	0.636	0.85
68_G	133_A	0.635	0.85
106_P	113_S	0.634	0.85
126_L	145_T	0.634	0.85
38_Y	71_Q	0.633	0.85
137_A	142_E	0.633	0.85
73_H	76_A	0.633	0.85
153_N	180_H	0.632	0.85
38_Y	128_V	0.627	0.84
46_N	112_E	0.625	0.84
59_V	159_V	0.623	0.84
204_V	208_Q	0.621	0.84
82_G	85_I	0.621	0.84
72_A	78_S	0.620	0.84
8_H	12_A	0.619	0.83
148_V	151_L	0.619	0.83
68_G	130_A	0.613	0.83
162_L	200_C	0.612	0.83
55_D	116_R	0.607	0.82
10_V	155_H	0.607	0.82
211_E	216_T	0.607	0.82
38_Y	131_G	0.607	0.82
38_Y	67_H	0.606	0.82
81_P	113_S	0.605	0.82
22_N	139_L	0.603	0.82
50_F	75_L	0.598	0.81
36_T	70_G	0.597	0.81
58_V	206_A	0.595	0.81
45_F	48_F	0.595	0.81
60_I	121_L	0.594	0.81
169_Q	172_G	0.592	0.81
13_E	151_L	0.592	0.81
207_N	218_I	0.591	0.81
103_F	219_D	0.590	0.80
15_K	19_Y	0.585	0.80
5_L	9_D	0.581	0.79
207_N	210_L	0.580	0.79
85_I	105_R	0.578	0.79
81_P	112_E	0.578	0.79
149_I	175_I	0.577	0.79
192_S	196_G	0.574	0.79
113_S	116_R	0.574	0.79
3_N	48_F	0.574	0.79
3_N	144_F	0.573	0.78
76_A	124_T	0.572	0.78
82_G	109_G	0.571	0.78
10_V	147_K	0.566	0.78
15_K	20_F	0.566	0.78
93_Y	105_R	0.563	0.77
149_I	171_K	0.561	0.77
13_E	16_Q	0.561	0.77
20_F	144_F	0.560	0.77
6_T	56_V	0.559	0.77
43_D	73_H	0.559	0.77
114_W	121_L	0.558	0.77
162_L	198_F	0.557	0.76
120_L	148_V	0.555	0.76
206_A	218_I	0.555	0.76
104_T	108_H	0.553	0.76
31_R	37_I	0.553	0.76
37_I	197_F	0.552	0.76
11_L	48_F	0.547	0.75
4_E	9_D	0.544	0.75
76_A	121_L	0.544	0.75
167_H	170_K	0.541	0.74
96_L	113_S	0.538	0.74
51_T	115_A	0.538	0.74
48_F	159_V	0.531	0.73
96_L	100_I	0.529	0.73
158_G	181_H	0.529	0.73
28_A	31_R	0.528	0.73
21_L	24_L	0.523	0.72
47_A	122_L	0.522	0.72
186_P	193_A	0.519	0.71
122_L	126_L	0.516	0.71
59_V	149_I	0.516	0.71
79_V	86_P	0.515	0.71
85_I	106_P	0.514	0.71
108_H	221_M	0.514	0.71
37_I	130_A	0.513	0.70
117_Q	221_M	0.511	0.70
171_K	174_I	0.511	0.70
192_S	195_R	0.510	0.70
162_L	209_W	0.508	0.70
20_F	41_Q	0.507	0.70
176_D	180_H	0.507	0.70
50_F	115_A	0.505	0.69
93_Y	110_Y	0.505	0.69
14_E	143_T	0.505	0.69
23_T	30_E	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3uf7A	1	0.9738	100	-0.015	Contact Map
3tr7A	1	0.9563	100	0.008	Contact Map
3zoqA	1	0.9651	100	0.015	Contact Map
3fciA	1	0.9694	100	0.016	Contact Map
3cxmA	1	0.9913	100	0.018	Contact Map
2booA	1	0.9869	100	0.021	Contact Map
2j8xA	1	0.9607	100	0.023	Contact Map
3wdfA	1	0.9432	100	0.028	Contact Map
1udgA	1	0.9563	100	0.035	Contact Map
4wpkA	1	0.9563	100	0.065	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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