GREMLIN Database
MOEB - Molybdopterin-synthase adenylyltransferase
UniProt: P12282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10154
Length: 249 (219)
Sequences: 9199 (6220)
Seq/√Len: 420.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_N102_A3.5021.00
57_N104_T3.3661.00
91_R95_T3.3141.00
33_R59_T3.2341.00
84_Q92_D3.2211.00
85_P107_N3.2121.00
33_R57_N3.0031.00
63_F109_L2.8801.00
59_T122_H2.8611.00
126_L208_A2.5131.00
46_A126_L2.4421.00
80_A96_R2.3891.00
77_H89_S2.3771.00
47_S94_L2.3761.00
91_R105_P2.3441.00
207_E210_K2.3181.00
172_C175_C2.2451.00
81_T84_Q2.2171.00
124_L208_A2.2131.00
35_L122_H2.2101.00
36_I47_S2.1711.00
88_E107_N2.1651.00
152_G204_Q2.1511.00
76_L90_A2.1231.00
79_D99_P2.0661.00
152_G200_I2.0451.00
32_S212_L2.0251.00
125_V142_C2.0131.00
88_E105_P1.9671.00
59_T106_V1.9331.00
78_S96_R1.8971.00
87_V105_P1.8421.00
129_T134_V1.7391.00
116_A144_A1.7221.00
141_G145_A1.7141.00
87_V107_N1.7091.00
27_E31_D1.7041.00
120_A145_A1.6991.00
13_N17_I1.6801.00
110_L115_L1.6741.00
16_I23_F1.6621.00
39_L60_L1.6571.00
65_T85_P1.6501.00
59_T104_T1.6191.00
116_A145_A1.6181.00
21_F213_A1.5921.00
78_S93_A1.5881.00
159_G200_I1.5801.00
35_L61_L1.5411.00
51_A94_L1.5181.00
84_Q88_E1.5101.00
85_P88_E1.4781.00
11_R79_D1.4761.00
44_C76_L1.4531.00
21_F25_G1.4371.00
108_A114_E1.4331.00
49_Y198_G1.4241.00
81_T93_A1.3921.00
29_L209_I1.3741.00
93_A96_R1.3481.00
28_A32_S1.3361.00
45_A48_Q1.3301.00
47_S60_L1.3281.00
34_V124_L1.3141.00
163_V211_M1.3131.00
46_A128_C1.2981.00
33_R122_H1.2861.00
12_Y98_N1.2771.00
51_A101_I1.2731.00
15_Q26_Q1.2711.00
140_A174_R1.2611.00
39_L90_A1.2381.00
140_A144_A1.2211.00
78_S81_T1.2111.00
23_F27_E1.1991.00
94_L101_I1.1981.00
94_L103_I1.1941.00
37_V138_L1.1921.00
195_P206_M1.1791.00
98_N101_I1.1731.00
115_L141_G1.1721.00
91_R103_I1.1711.00
226_Y231_C1.1681.00
161_I203_L1.1661.00
139_N149_L1.1601.00
185_L189_E1.1491.00
139_N143_F1.1281.00
138_L149_L1.1111.00
84_Q89_S1.0991.00
88_E91_R1.0941.00
171_P175_C1.0831.00
48_Q52_S1.0811.00
48_Q75_T1.0751.00
116_A141_G1.0671.00
198_G202_S1.0591.00
111_D114_E1.0591.00
154_A197_I1.0541.00
95_T101_I1.0531.00
129_T138_L1.0511.00
227_D230_T1.0501.00
35_L59_T1.0451.00
70_N86_K1.0441.00
201_G205_A1.0381.00
174_R177_S1.0311.00
30_K100_H1.0271.00
77_H81_T1.0241.00
141_G144_A1.0231.00
124_L211_M1.0141.00
81_T92_D0.9901.00
199_V226_Y0.9871.00
66_V77_H0.9801.00
22_D25_G0.9781.00
52_S97_I0.9561.00
199_V203_L0.9551.00
127_D138_L0.9501.00
33_R104_T0.9471.00
53_A209_I0.9361.00
150_V211_M0.9301.00
136_N178_R0.9291.00
64_D70_N0.9281.00
51_A58_L0.9141.00
186_T189_E0.9051.00
119_I122_H0.8971.00
39_L87_V0.8971.00
124_L150_V0.8931.00
92_D96_R0.8921.00
48_Q93_A0.8851.00
131_N134_V0.8831.00
37_V61_L0.8801.00
64_D86_K0.8751.00
28_A214_G0.8751.00
172_C176_L0.8721.00
66_V89_S0.8711.00
47_S90_A0.8671.00
81_T89_S0.8571.00
24_D28_A0.8561.00
35_L119_I0.8561.00
126_L204_Q0.8541.00
104_T121_E0.8501.00
49_Y202_S0.8431.00
45_A198_G0.8431.00
125_V138_L0.8421.00
136_N140_A0.8411.00
15_Q72_Q0.8401.00
37_V110_L0.8361.00
172_C177_S0.8331.00
44_C48_Q0.8321.00
115_L137_Q0.8291.00
136_N174_R0.8281.00
137_Q141_G0.8241.00
127_D135_R0.8211.00
108_A117_A0.8161.00
63_F107_N0.8161.00
170_E173_Y0.8141.00
25_G213_A0.8071.00
142_C149_L0.8061.00
26_Q30_K0.8011.00
18_L157_M0.7991.00
139_N172_C0.7971.00
206_M228_A0.7901.00
71_L82_V0.7811.00
112_D140_A0.7801.00
48_Q97_I0.7791.00
150_V208_A0.7761.00
49_Y205_A0.7731.00
167_Q170_E0.7691.00
119_I141_G0.7681.00
154_A192_V0.7671.00
34_V55_V0.7621.00
173_Y176_L0.7621.00
124_L212_L0.7621.00
112_D137_Q0.7611.00
89_S92_D0.7511.00
121_E147_V0.7501.00
76_L94_L0.7481.00
92_D95_T0.7461.00
161_I200_I0.7461.00
171_P176_L0.7441.00
171_P221_G0.7431.00
114_E118_L0.7421.00
42_L204_Q0.7401.00
224_V231_C0.7371.00
44_C77_H0.7351.00
41_G197_I0.7351.00
28_A31_D0.7321.00
34_V208_A0.7321.00
170_E177_S0.7301.00
27_E30_K0.7291.00
95_T102_A0.7271.00
192_V197_I0.7241.00
58_L94_L0.7221.00
110_L114_E0.7151.00
169_G173_Y0.7151.00
170_E174_R0.7151.00
47_S58_L0.7121.00
117_A120_A0.7081.00
160_Q163_V0.7061.00
39_L47_S0.7051.00
185_L190_A0.7041.00
119_I145_A0.6961.00
157_M229_M0.6951.00
10_L16_I0.6941.00
125_V147_V0.6881.00
228_A231_C0.6881.00
174_R179_L0.6881.00
178_R181_G0.6811.00
163_V207_E0.6791.00
165_T170_E0.6771.00
61_L118_L0.6771.00
10_L13_N0.6761.00
32_S123_D0.6731.00
206_M226_Y0.6691.00
68_L79_D0.6681.00
46_A201_G0.6670.99
127_D151_S0.6590.99
196_L228_A0.6580.99
49_Y75_T0.6570.99
195_P209_I0.6550.99
52_S72_Q0.6550.99
123_D147_V0.6500.99
88_E92_D0.6490.99
24_D27_E0.6460.99
110_L137_Q0.6440.99
12_Y101_I0.6430.99
193_M206_M0.6420.99
50_L58_L0.6420.99
10_L68_L0.6420.99
150_V163_V0.6410.99
66_V76_L0.6340.99
29_L56_G0.6340.99
15_Q53_A0.6320.99
53_A194_A0.6320.99
68_L82_V0.6310.99
211_M218_P0.6290.99
58_L101_I0.6290.99
61_L110_L0.6280.99
170_E175_C0.6280.99
21_F26_Q0.6260.99
64_D130_D0.6260.99
197_I202_S0.6250.99
65_T107_N0.6240.99
171_P174_R0.6210.99
175_C178_R0.6200.99
13_N16_I0.6170.99
46_A204_Q0.6160.99
45_A75_T0.6140.99
60_L103_I0.6140.99
139_N175_C0.6100.99
87_V103_I0.6080.99
79_D82_V0.6080.99
209_I213_A0.6020.99
81_T96_R0.6010.99
215_Y229_M0.6000.99
168_D171_P0.6000.99
60_L90_A0.6000.99
177_S180_F0.5970.99
55_V212_L0.5950.99
45_A49_Y0.5930.99
33_R121_E0.5890.99
164_F200_I0.5880.99
29_L55_V0.5870.99
15_Q18_L0.5830.99
150_V204_Q0.5790.99
28_A213_A0.5780.99
196_L199_V0.5780.99
16_I26_Q0.5760.99
32_S55_V0.5740.98
116_A120_A0.5730.98
135_R153_A0.5710.98
51_A103_I0.5710.98
176_L180_F0.5680.98
131_N135_R0.5640.98
70_N130_D0.5640.98
34_V212_L0.5640.98
44_C75_T0.5630.98
171_P178_R0.5630.98
127_D130_D0.5620.98
174_R178_R0.5590.98
169_G174_R0.5580.98
56_G98_N0.5570.98
11_R100_H0.5560.98
64_D69_S0.5540.98
219_A224_V0.5540.98
159_G193_M0.5520.98
174_R180_F0.5480.98
34_V126_L0.5470.98
44_C66_V0.5470.98
208_A212_L0.5430.98
179_L183_N0.5420.98
148_P211_M0.5420.98
156_R190_A0.5410.98
165_T169_G0.5410.98
146_K168_D0.5390.98
172_C178_R0.5370.98
47_S76_L0.5360.98
119_I142_C0.5350.98
45_A202_S0.5340.98
217_K230_T0.5300.97
62_D87_V0.5300.97
45_A201_G0.5300.97
192_V196_L0.5290.97
21_F193_M0.5290.97
93_A97_I0.5260.97
70_N73_R0.5260.97
175_C179_L0.5250.97
183_N186_T0.5250.97
114_E117_A0.5240.97
86_K130_D0.5230.97
40_G43_G0.5230.97
73_R86_K0.5210.97
32_S208_A0.5200.97
199_V202_S0.5190.97
33_R123_D0.5170.97
73_R130_D0.5160.97
76_L93_A0.5150.97
67_S70_N0.5150.97
64_D73_R0.5150.97
173_Y177_S0.5140.97
222_K225_M0.5130.97
151_S162_T0.5120.97
36_I50_L0.5120.97
176_L179_L0.5100.97
134_V137_Q0.5090.97
156_R196_L0.5060.97
114_E137_Q0.5060.97
36_I43_G0.5020.97
167_Q171_P0.5010.96
28_A212_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zud1 2 0.9598 100 0.145 Contact Map
1jw9B 2 0.9639 100 0.146 Contact Map
1tt5B 1 0.9839 100 0.203 Contact Map
4gslA 2 0.9839 100 0.208 Contact Map
2nvuB 1 0.9839 100 0.211 Contact Map
3h5nA 3 0.9799 100 0.212 Contact Map
3h8vA 2 0.8153 100 0.224 Contact Map
3ruiA 2 0.9799 100 0.236 Contact Map
1y8qA 1 0.9277 100 0.251 Contact Map
1y8qB 1 0.9197 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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