GREMLIN Database
MOEA - Molybdopterin molybdenumtransferase
UniProt: P12281 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10153
Length: 411 (394)
Sequences: 5336 (4081)
Seq/√Len: 205.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_A244_A3.6121.00
213_L218_C3.5151.00
28_E38_R3.3111.00
42_S173_P3.1701.00
164_I172_V3.1431.00
234_R267_E3.1001.00
157_T160_E3.0871.00
75_P94_T3.0211.00
29_T171_E2.9281.00
332_R400_E2.8611.00
104_V136_I2.8011.00
154_T160_E2.7831.00
54_D138_R2.7281.00
91_P94_T2.6771.00
332_R398_W2.6601.00
394_E397_E2.5651.00
49_D139_R2.4631.00
338_R394_E2.4111.00
346_L385_V2.4001.00
64_R67_D2.3091.00
43_D151_P2.2761.00
197_G200_Q2.2681.00
335_T393_V2.2561.00
149_V167_L2.2551.00
49_D145_A2.2451.00
43_D148_V2.2091.00
338_R395_V2.1931.00
45_V148_V2.1891.00
295_C312_V2.1801.00
54_D139_R2.1501.00
43_D152_A2.1401.00
346_L388_R2.1191.00
32_L165_A2.1021.00
333_V401_V2.0891.00
118_E125_R2.0481.00
270_E288_K2.0321.00
40_L150_F2.0151.00
29_T173_P2.0061.00
221_I244_A1.9601.00
26_A176_R1.9021.00
382_C401_V1.8841.00
351_G382_C1.8831.00
49_D144_S1.8751.00
330_R400_E1.8711.00
351_G384_I1.8581.00
354_Q364_T1.8551.00
15_N19_S1.8351.00
162_P208_A1.8251.00
230_P264_I1.8201.00
10_L348_F1.7891.00
150_F160_E1.7861.00
144_S147_A1.7651.00
190_Q200_Q1.7611.00
62_A108_C1.7191.00
78_G96_I1.7171.00
313_Q317_A1.7021.00
30_L38_R1.6971.00
336_A362_E1.6881.00
230_P263_T1.6861.00
89_E106_E1.6811.00
55_N137_R1.6721.00
239_E243_Q1.6641.00
334_R398_W1.6621.00
113_M116_Q1.6491.00
308_F312_V1.6271.00
336_A364_T1.6221.00
21_V315_L1.6191.00
216_L308_F1.6111.00
63_V110_A1.5961.00
246_V316_L1.5951.00
117_T124_V1.5951.00
295_C315_L1.5951.00
248_I312_V1.5941.00
177_K219_E1.5911.00
65_L109_E1.5841.00
65_L110_A1.5771.00
179_R219_E1.5751.00
27_Q173_P1.5671.00
81_F258_A1.5641.00
333_V363_V1.5571.00
148_V151_P1.5501.00
34_Q214_E1.5491.00
352_V364_T1.5471.00
276_L311_L1.5281.00
77_A94_T1.5161.00
28_E176_R1.4791.00
182_L210_H1.4671.00
53_F103_P1.4621.00
31_P34_Q1.4541.00
208_A305_T1.4531.00
156_L160_E1.4501.00
227_R232_A1.4481.00
305_T377_F1.4331.00
44_V164_I1.3941.00
390_R397_E1.3891.00
230_P267_E1.3851.00
265_L294_F1.3781.00
352_V381_N1.3701.00
331_Q403_P1.3611.00
246_V295_C1.3531.00
112_V117_T1.3481.00
213_L220_V1.3431.00
9_S12_T1.3421.00
47_P169_I1.3381.00
334_R362_E1.3341.00
333_V353_L1.3321.00
111_V135_N1.3321.00
212_M308_F1.3271.00
112_V126_F1.3261.00
18_L318_K1.3221.00
384_I399_V1.3181.00
229_D232_A1.3181.00
10_L311_L1.3121.00
118_E127_T1.3111.00
90_W108_C1.3091.00
48_L202_Y1.3071.00
234_R238_I1.2971.00
114_Q255_V1.2951.00
317_A322_N1.2911.00
151_P154_T1.2831.00
226_I236_A1.2831.00
63_V68_I1.2811.00
64_R109_E1.2731.00
278_I311_L1.2711.00
12_T15_N1.2691.00
131_R134_Q1.2671.00
35_C172_V1.2621.00
66_A109_E1.2621.00
36_F214_E1.2611.00
284_F311_L1.2601.00
235_A239_E1.2601.00
47_P167_L1.2581.00
344_G389_D1.2551.00
181_A223_L1.2541.00
196_L199_G1.2491.00
78_G86_Y1.2451.00
306_L383_F1.2431.00
330_R402_E1.2421.00
249_S294_F1.2391.00
310_Q402_E1.2281.00
161_L207_L1.2211.00
81_F84_Q1.2181.00
98_I102_A1.2141.00
79_K257_E1.1951.00
79_K258_A1.1941.00
238_I268_L1.1941.00
161_L211_L1.1921.00
10_L278_I1.1911.00
138_R141_E1.1851.00
230_P234_R1.1851.00
97_R114_Q1.1821.00
285_A296_G1.1821.00
54_D106_E1.1811.00
337_S365_T1.1761.00
120_M125_R1.1751.00
216_L313_Q1.1731.00
363_V382_C1.1711.00
223_L244_A1.1701.00
223_L243_Q1.1661.00
179_R221_I1.1651.00
11_D346_L1.1571.00
192_P207_L1.1541.00
383_F404_F1.1501.00
335_T339_L1.1501.00
212_M309_Y1.1461.00
182_L213_L1.1421.00
16_E272_A1.1421.00
147_A375_S1.1401.00
110_A130_V1.1361.00
206_R222_N1.1281.00
348_F385_V1.1271.00
30_L35_C1.1241.00
241_D292_S1.1231.00
156_L161_L1.1201.00
351_G363_V1.1191.00
17_M286_F1.1161.00
36_F161_L1.1141.00
155_R322_N1.1121.00
31_P171_E1.1101.00
104_V111_V1.1051.00
190_Q196_L1.0981.00
223_L240_A1.0901.00
65_L132_S1.0891.00
180_V213_L1.0871.00
363_V401_V1.0851.00
113_M135_N1.0851.00
234_R268_L1.0841.00
353_L381_N1.0831.00
80_S96_I1.0761.00
39_I155_R1.0731.00
84_Q187_D1.0731.00
353_L363_V1.0711.00
80_S86_Y1.0681.00
247_V292_S1.0661.00
162_P374_F1.0661.00
97_R257_E1.0651.00
116_Q128_A1.0651.00
20_R286_F1.0621.00
183_F226_I1.0621.00
193_G202_Y1.0511.00
117_T126_F1.0471.00
232_A235_A1.0441.00
386_L393_V1.0381.00
57_A137_R1.0361.00
185_T261_T1.0351.00
286_F295_C1.0351.00
355_R359_G1.0261.00
158_T215_Q1.0261.00
353_L401_V1.0221.00
213_L308_F1.0221.00
309_Y313_Q1.0221.00
80_S85_P1.0151.00
39_I322_N1.0111.00
231_H235_A1.0091.00
184_S250_S1.0081.00
218_C316_L1.0061.00
119_Q122_N1.0041.00
279_K347_D1.0011.00
57_A135_N0.9961.00
263_T266_E0.9961.00
58_M113_M0.9881.00
58_M135_N0.9861.00
353_L382_C0.9791.00
120_M123_G0.9671.00
8_M16_E0.9661.00
35_C156_L0.9621.00
272_A288_K0.9590.99
337_S364_T0.9560.99
183_F236_A0.9510.99
221_I243_Q0.9500.99
99_M258_A0.9460.99
365_T384_I0.9430.99
352_V379_L0.9410.99
210_H214_E0.9390.99
180_V218_C0.9370.99
203_D206_R0.9330.99
246_V293_W0.9300.99
262_K274_W0.9290.99
234_R264_I0.9270.99
236_A239_E0.9250.99
61_Y119_Q0.9180.99
7_L282_K0.9170.99
191_L194_Q0.9170.99
99_M257_E0.9170.99
175_I320_S0.9160.99
38_R177_K0.9120.99
278_I307_T0.9120.99
232_A236_A0.9080.99
64_R92_A0.9070.99
41_A175_I0.9070.99
196_L202_Y0.9060.99
160_E378_S0.9050.99
36_F211_L0.9020.99
27_Q41_A0.9020.99
46_S167_L0.9000.99
16_E19_S0.8980.99
42_S169_I0.8970.99
350_R369_Q0.8970.99
182_L220_V0.8960.99
52_G201_I0.8950.99
168_G202_Y0.8930.99
309_Y328_P0.8930.99
90_W96_I0.8920.99
302_V350_R0.8900.99
61_Y114_Q0.8880.99
86_Y96_I0.8860.99
176_R245_D0.8840.99
65_L68_I0.8780.99
214_E220_V0.8740.99
337_S395_V0.8720.99
68_I71_G0.8700.99
61_Y117_T0.8690.99
78_G88_G0.8690.99
385_V400_E0.8670.99
231_H234_R0.8620.99
226_I232_A0.8590.99
209_V308_F0.8580.99
36_F215_Q0.8580.99
109_E132_S0.8570.99
184_S206_R0.8560.99
8_M13_A0.8520.99
114_Q117_T0.8470.99
12_T16_E0.8450.99
184_S224_G0.8420.99
141_E370_G0.8400.99
181_A247_V0.8390.99
156_L164_I0.8300.99
286_F293_W0.8280.99
57_A141_E0.8280.99
340_K392_N0.8260.98
330_R385_V0.8240.98
75_P91_P0.8170.98
11_D15_N0.8100.98
338_R392_N0.8090.98
37_G215_Q0.8060.98
75_P123_G0.8060.98
63_V112_V0.8040.98
230_P233_L0.8030.98
178_V218_C0.8020.98
54_D104_V0.8010.98
276_L284_F0.8010.98
67_D74_L0.7970.98
307_T311_L0.7960.98
48_L196_L0.7960.98
88_G96_I0.7950.98
99_M114_Q0.7950.98
191_L203_D0.7940.98
164_I169_I0.7930.98
150_F154_T0.7920.98
203_D207_L0.7900.98
288_K291_N0.7900.98
210_H220_V0.7890.98
233_L264_I0.7880.98
265_L287_G0.7870.98
214_E219_E0.7840.98
142_D373_I0.7810.98
190_Q194_Q0.7780.98
238_I290_S0.7770.98
368_H373_I0.7770.98
68_I110_A0.7770.98
246_V319_L0.7770.98
351_G401_V0.7760.98
152_A175_I0.7730.98
273_F286_F0.7720.98
298_P303_S0.7710.98
44_V173_P0.7690.98
212_M305_T0.7670.98
38_R174_V0.7660.98
103_P198_D0.7600.97
183_F247_V0.7600.97
76_V124_V0.7590.97
380_G404_F0.7580.97
310_Q348_F0.7540.97
254_S283_P0.7540.97
236_A240_A0.7520.97
240_A247_V0.7510.97
382_C404_F0.7510.97
387_E390_R0.7510.97
137_R298_P0.7510.97
297_L312_V0.7510.97
18_L314_P0.7510.97
190_Q197_G0.7510.97
288_K293_W0.7450.97
80_S98_I0.7380.97
241_D247_V0.7360.97
187_D227_R0.7360.97
334_R396_G0.7350.97
181_A240_A0.7340.97
182_L209_V0.7320.97
363_V384_I0.7310.97
233_L260_Y0.7310.97
355_R361_L0.7310.97
188_E228_D0.7290.97
282_K303_S0.7280.97
253_V296_G0.7280.97
29_T42_S0.7270.97
240_A244_A0.7250.97
65_L130_V0.7160.96
351_G381_N0.7150.96
143_I149_V0.7140.96
284_F307_T0.7130.96
309_Y383_F0.7130.96
191_L207_L0.7130.96
76_V95_C0.7090.96
279_K345_R0.7060.96
44_V169_I0.7060.96
142_D302_V0.7050.96
184_S225_I0.7040.96
195_P202_Y0.7030.96
277_A388_R0.7000.96
349_Q365_T0.6970.96
373_I376_S0.6960.96
77_A91_P0.6950.96
224_G236_A0.6950.96
230_P260_Y0.6930.96
261_T294_F0.6920.96
100_T115_E0.6910.95
46_S49_D0.6910.95
68_I74_L0.6900.95
67_D92_A0.6900.95
24_L176_R0.6900.95
213_L216_L0.6890.95
341_K386_L0.6890.95
237_F247_V0.6880.95
68_I73_P0.6880.95
274_W285_A0.6850.95
393_V397_E0.6820.95
77_A90_W0.6820.95
79_K97_R0.6810.95
17_M315_L0.6780.95
366_T380_G0.6770.95
262_K266_E0.6740.95
27_Q175_I0.6730.95
170_A192_P0.6710.95
71_G129_E0.6710.95
82_A102_A0.6680.95
331_Q361_L0.6670.95
76_V119_Q0.6670.95
189_L203_D0.6660.94
354_Q362_E0.6640.94
90_W94_T0.6630.94
99_M102_A0.6630.94
9_S277_A0.6620.94
271_I285_A0.6600.94
289_L293_W0.6600.94
375_S379_L0.6600.94
249_S261_T0.6590.94
264_I268_L0.6580.94
370_G373_I0.6560.94
67_D93_G0.6560.94
50_V142_D0.6560.94
110_A132_S0.6550.94
14_L18_L0.6530.94
262_K285_A0.6520.94
66_A132_S0.6510.94
33_V210_H0.6500.94
43_D154_T0.6490.94
16_E20_R0.6480.94
40_L172_V0.6470.94
52_G140_G0.6470.94
271_I287_G0.6470.94
85_P199_G0.6460.94
212_M216_L0.6460.94
272_A286_F0.6450.93
184_S203_D0.6450.93
8_M273_F0.6440.93
61_Y124_V0.6400.93
85_P103_P0.6390.93
159_A305_T0.6390.93
249_S253_V0.6370.93
21_V319_L0.6370.93
21_V293_W0.6360.93
203_D225_I0.6360.93
65_L69_A0.6350.93
33_V214_E0.6340.93
210_H222_N0.6330.93
81_F99_M0.6320.93
50_V143_I0.6310.93
74_L124_V0.6300.93
40_L43_D0.6280.93
339_L384_I0.6280.93
54_D136_I0.6270.93
183_F223_L0.6250.92
183_F224_G0.6240.92
283_P371_S0.6240.92
315_L319_L0.6220.92
141_E372_H0.6220.92
248_I308_F0.6190.92
341_K347_D0.6180.92
189_L202_Y0.6160.92
191_L225_I0.6150.92
282_K345_R0.6150.92
150_F164_I0.6150.92
187_D225_I0.6130.92
9_S388_R0.6120.92
48_L52_G0.6100.91
100_T283_P0.6090.91
110_A134_Q0.6060.91
350_R373_I0.6050.91
260_Y263_T0.6020.91
363_V399_V0.6010.91
181_A224_G0.6000.91
77_A96_I0.5980.91
38_R176_R0.5950.90
142_D375_S0.5950.90
10_L346_L0.5930.90
181_A221_I0.5900.90
187_D258_A0.5900.90
336_A354_Q0.5870.90
64_R108_C0.5860.90
213_L219_E0.5840.90
351_G399_V0.5840.90
112_V130_V0.5830.90
237_F264_I0.5830.90
24_L175_I0.5820.89
64_R91_P0.5810.89
82_A99_M0.5800.89
135_N141_E0.5790.89
208_A304_A0.5780.89
179_R244_A0.5780.89
205_N250_S0.5780.89
385_V388_R0.5770.89
69_A72_Q0.5770.89
176_R179_R0.5760.89
27_Q176_R0.5760.89
61_Y95_C0.5750.89
170_A193_G0.5740.89
70_S129_E0.5740.89
124_V127_T0.5730.89
302_V377_F0.5730.89
53_F201_I0.5710.89
26_A175_I0.5710.89
20_R288_K0.5710.89
63_V74_L0.5700.89
322_N325_S0.5700.89
347_D350_R0.5690.88
209_V248_I0.5670.88
264_I267_E0.5650.88
175_I321_G0.5640.88
185_T228_D0.5640.88
300_N371_S0.5640.88
28_E177_K0.5640.88
24_L319_L0.5620.88
226_I233_L0.5600.88
17_M311_L0.5600.88
104_V107_G0.5580.87
142_D166_S0.5580.87
165_A207_L0.5570.87
55_N372_H0.5570.87
149_V163_V0.5560.87
30_L174_V0.5560.87
68_I130_V0.5560.87
69_A73_P0.5560.87
66_A92_A0.5550.87
20_R270_E0.5540.87
56_S300_N0.5530.87
77_A86_Y0.5520.87
252_G261_T0.5520.87
293_W315_L0.5520.87
255_V275_K0.5510.87
18_L21_V0.5500.87
55_N262_K0.5500.87
247_V294_F0.5500.87
8_M12_T0.5500.87
263_T267_E0.5480.87
154_T157_T0.5460.86
42_S152_A0.5460.86
178_V319_L0.5450.86
71_G127_T0.5450.86
355_R358_D0.5440.86
298_P347_D0.5440.86
354_Q358_D0.5430.86
117_T127_T0.5420.86
137_R262_K0.5420.86
265_L289_L0.5410.86
317_A320_S0.5410.86
390_R393_V0.5410.86
52_G139_R0.5410.86
58_M137_R0.5410.86
87_H90_W0.5400.86
346_L387_E0.5390.86
75_P122_N0.5390.86
113_M134_Q0.5390.86
259_D282_K0.5380.86
238_I242_S0.5380.86
335_T397_E0.5380.86
81_F257_E0.5370.85
287_G296_G0.5370.85
303_S371_S0.5360.85
335_T399_V0.5360.85
189_L201_I0.5360.85
353_L403_P0.5350.85
56_S98_I0.5330.85
23_P319_L0.5320.85
210_H213_L0.5300.85
95_C124_V0.5290.85
293_W319_L0.5270.84
58_M100_T0.5260.84
192_P202_Y0.5240.84
216_L317_A0.5240.84
284_F370_G0.5240.84
213_L316_L0.5240.84
333_V354_Q0.5230.84
217_G220_V0.5230.84
40_L154_T0.5230.84
47_P145_A0.5220.84
99_M253_V0.5220.84
100_T188_E0.5220.84
137_R300_N0.5210.84
196_L200_Q0.5210.84
80_S84_Q0.5200.84
228_D252_G0.5200.84
387_E400_E0.5200.84
316_L320_S0.5180.83
283_P298_P0.5180.83
14_L311_L0.5180.83
256_G299_G0.5140.83
240_A243_Q0.5130.83
11_D14_L0.5100.82
10_L14_L0.5100.82
147_A379_L0.5090.82
310_Q383_F0.5070.82
40_L151_P0.5060.82
58_M300_N0.5050.82
33_V36_F0.5050.82
88_G94_T0.5040.82
151_P323_T0.5030.82
159_A374_F0.5020.81
163_V374_F0.5020.81
317_A325_S0.5010.81
23_P318_K0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g8lA 2 0.9805 100 0.113 Contact Map
1uz5A 1 0.9392 100 0.138 Contact Map
4pd0A 2 0.9684 100 0.145 Contact Map
1wu2A 2 0.9173 100 0.154 Contact Map
3rfqA 5 0.3504 100 0.675 Contact Map
1jljA 3 0.3698 100 0.684 Contact Map
4lhbA 4 0.3479 100 0.704 Contact Map
3iwtA 4 0.3625 100 0.711 Contact Map
1y5eA 4 0.3528 100 0.712 Contact Map
4xcwA 3 0.3869 100 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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