AROC - ECOLI - GREMLIN Contacts

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AROC - Chorismate synthase

UniProt:	P12008	Sequences: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLDIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10075
Length:	361 (341)
Sequences:	3153 (1531)
Seq/√Len:	82.9

ECOLI - AROC
BACSU - AROC
HALSA - AROC
SULSO - AROC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_K	86_E	4.777	1.00
226_L	281_S	3.614	1.00
40_D	143_K	3.192	1.00
242_G	249_F	3.184	1.00
211_A	336_L	3.169	1.00
44_D	142_K	3.168	1.00
306_N	310_E	3.147	1.00
85_I	132_A	3.091	1.00
247_D	272_H	2.972	1.00
201_D	257_S	2.919	1.00
214_V	286_I	2.873	1.00
144_Y	341_M	2.707	1.00
229_D	343_H	2.551	1.00
199_E	255_R	2.344	1.00
249_F	291_A	2.337	1.00
72_F	120_Y	2.267	1.00
212_S	285_Q	2.260	1.00
180_C	189_L	2.256	1.00
30_V	81_I	2.241	1.00
102_F	112_E	2.221	1.00
230_I	336_L	2.219	1.00
12_V	25_C	2.179	1.00
234_L	288_A	2.174	1.00
242_G	291_A	2.167	1.00
27_V	140_I	2.140	1.00
159_Q	253_A	2.107	1.00
65_V	83_L	2.101	1.00
301_P	313_E	2.076	1.00
211_A	340_L	2.075	1.00
244_E	289_H	2.071	1.00
15_F	82_G	2.029	1.00
37_T	40_D	1.991	1.00
234_L	336_L	1.987	1.00
156_C	181_P	1.971	1.00
153_I	337_A	1.951	1.00
224_D	232_H	1.937	1.00
195_A	199_E	1.928	1.00
62_P	88_T	1.896	1.00
35_P	75_V	1.886	1.00
288_A	336_L	1.864	1.00
269_Q	303_R	1.856	1.00
176_N	186_I	1.845	1.00
264_T	269_Q	1.837	1.00
185_K	188_A	1.836	1.00
172_Q	175_Q	1.833	1.00
107_A	278_G	1.832	1.00
159_Q	162_D	1.826	1.00
162_D	192_L	1.813	1.00
25_C	83_L	1.811	1.00
262_E	303_R	1.795	1.00
192_L	196_L	1.763	1.00
159_Q	164_P	1.759	1.00
130_E	134_R	1.750	1.00
208_T	289_H	1.729	1.00
229_D	232_H	1.729	1.00
196_L	203_I	1.728	1.00
22_A	84_L	1.695	1.00
251_V	259_N	1.690	1.00
301_P	315_I	1.686	1.00
237_I	332_A	1.676	1.00
36_L	140_I	1.666	1.00
210_V	285_Q	1.651	1.00
177_P	190_D	1.622	1.00
42_Q	46_D	1.614	1.00
149_F	344_L	1.589	1.00
22_A	68_L	1.569	1.00
265_K	311_E	1.545	1.00
229_D	346_R	1.539	1.00
15_F	24_G	1.528	1.00
187_D	190_D	1.500	0.99
276_I	286_I	1.494	0.99
10_F	30_V	1.487	0.99
83_L	136_A	1.469	0.99
254_L	259_N	1.464	0.99
205_A	325_G	1.452	0.99
206_K	289_H	1.452	0.99
292_L	332_A	1.450	0.99
146_A	152_E	1.445	0.99
250_D	253_A	1.443	0.99
158_T	208_T	1.443	0.99
41_L	139_A	1.433	0.99
97_A	317_K	1.429	0.99
290_M	332_A	1.421	0.99
260_R	302_G	1.414	0.99
234_L	290_M	1.410	0.99
263_I	268_F	1.407	0.99
30_V	140_I	1.391	0.99
174_E	179_F	1.389	0.99
71_V	81_I	1.380	0.99
21_L	66_K	1.376	0.99
109_Y	263_I	1.367	0.99
233_A	339_V	1.366	0.99
209_V	332_A	1.361	0.99
54_R	194_R	1.344	0.99
25_C	137_A	1.340	0.99
123_G	221_P	1.340	0.99
231_A	235_M	1.334	0.99
276_I	281_S	1.331	0.99
160_M	323_C	1.328	0.99
142_K	333_E	1.328	0.99
100_D	308_F	1.322	0.99
234_L	243_V	1.321	0.99
152_E	212_S	1.317	0.98
36_L	76_T	1.316	0.98
102_F	307_R	1.316	0.98
243_V	288_A	1.308	0.98
34_I	144_Y	1.305	0.98
303_R	313_E	1.303	0.98
194_R	197_K	1.281	0.98
306_N	312_V	1.270	0.98
178_F	193_M	1.270	0.98
155_G	329_V	1.264	0.98
201_D	255_R	1.257	0.98
101_V	312_V	1.256	0.98
154_R	173_V	1.242	0.98
240_V	292_L	1.240	0.98
221_P	280_I	1.236	0.98
44_D	139_A	1.234	0.98
191_E	195_A	1.233	0.98
228_A	232_H	1.228	0.98
47_R	333_E	1.222	0.98
21_L	86_E	1.210	0.97
25_C	133_M	1.209	0.97
128_A	324_V	1.209	0.97
112_E	307_R	1.207	0.97
239_A	324_V	1.207	0.97
343_H	346_R	1.202	0.97
247_D	251_V	1.200	0.97
200_G	299_T	1.199	0.97
105_G	277_L	1.185	0.97
75_V	117_L	1.185	0.97
235_M	245_I	1.181	0.97
142_K	337_A	1.181	0.97
37_T	143_K	1.177	0.97
163_I	185_K	1.177	0.97
211_A	286_I	1.163	0.97
10_F	338_I	1.159	0.97
151_I	344_L	1.158	0.97
159_Q	206_K	1.156	0.97
91_R	94_D	1.145	0.96
211_A	214_V	1.143	0.96
27_V	83_L	1.142	0.96
10_F	27_V	1.136	0.96
192_L	255_R	1.136	0.96
252_V	291_A	1.133	0.96
220_E	343_H	1.123	0.96
218_L	344_L	1.117	0.96
182_D	185_K	1.112	0.96
292_L	324_V	1.111	0.96
36_L	40_D	1.109	0.96
292_L	328_A	1.094	0.95
297_S	316_T	1.091	0.95
192_L	195_A	1.087	0.95
262_E	269_Q	1.087	0.95
58_Q	89_D	1.084	0.95
257_S	298_I	1.081	0.95
247_D	254_L	1.080	0.95
190_D	194_R	1.079	0.95
141_A	338_I	1.067	0.95
199_E	300_V	1.064	0.95
40_D	43_H	1.064	0.95
268_F	284_Q	1.063	0.94
134_R	335_M	1.050	0.94
277_L	282_S	1.046	0.94
49_R	62_P	1.043	0.94
214_V	218_L	1.041	0.94
172_Q	183_P	1.041	0.94
237_I	335_M	1.038	0.94
10_F	141_A	1.038	0.94
206_K	249_F	1.038	0.94
304_T	314_M	1.035	0.94
202_S	295_T	1.034	0.94
304_T	312_V	1.017	0.93
230_I	288_A	1.016	0.93
336_L	340_L	1.010	0.93
240_V	290_M	1.004	0.93
233_A	335_M	1.004	0.93
17_E	77_T	1.003	0.93
113_Q	216_A	1.001	0.93
40_D	146_A	0.997	0.92
110_T	263_I	0.994	0.92
207_V	332_A	0.992	0.92
42_Q	45_L	0.990	0.92
96_S	120_Y	0.976	0.92
163_I	188_A	0.976	0.92
11_R	28_D	0.975	0.91
164_P	253_A	0.969	0.91
159_Q	252_V	0.969	0.91
208_T	287_I	0.966	0.91
33_G	75_V	0.959	0.91
109_Y	113_Q	0.955	0.91
303_R	311_E	0.946	0.90
232_H	236_S	0.944	0.90
49_R	60_R	0.935	0.90
100_D	306_N	0.934	0.90
157_L	325_G	0.932	0.90
58_Q	197_K	0.930	0.89
188_A	191_E	0.928	0.89
186_I	190_D	0.925	0.89
30_V	34_I	0.921	0.89
110_T	280_I	0.921	0.89
96_S	99_K	0.917	0.89
187_D	191_E	0.916	0.89
180_C	186_I	0.915	0.89
150_G	213_G	0.914	0.89
264_T	311_E	0.909	0.88
156_C	208_T	0.902	0.88
23_L	132_A	0.900	0.88
98_I	120_Y	0.897	0.88
154_R	212_S	0.894	0.88
163_I	192_L	0.893	0.87
32_P	350_Q	0.892	0.87
192_L	203_I	0.888	0.87
178_F	186_I	0.886	0.87
25_C	82_G	0.886	0.87
105_G	273_A	0.884	0.87
23_L	133_M	0.882	0.87
9_L	346_R	0.881	0.87
196_L	255_R	0.880	0.87
207_V	292_L	0.880	0.87
254_L	258_Q	0.876	0.86
185_K	189_L	0.876	0.86
53_S	56_T	0.875	0.86
220_E	224_D	0.874	0.86
154_R	170_W	0.872	0.86
247_D	250_D	0.871	0.86
52_T	56_T	0.871	0.86
130_E	222_V	0.869	0.86
209_V	288_A	0.866	0.86
295_T	322_P	0.861	0.85
161_G	192_L	0.859	0.85
67_I	71_V	0.857	0.85
184_D	188_A	0.856	0.85
161_G	203_I	0.855	0.85
262_E	270_S	0.855	0.85
163_I	189_L	0.853	0.85
66_K	84_L	0.852	0.85
134_R	236_S	0.852	0.85
176_N	183_P	0.850	0.85
154_R	210_V	0.849	0.85
206_K	242_G	0.845	0.84
110_T	277_L	0.845	0.84
225_R	238_N	0.840	0.84
226_L	343_H	0.837	0.84
325_G	328_A	0.831	0.83
157_L	160_M	0.827	0.83
201_D	300_V	0.826	0.83
101_V	304_T	0.824	0.83
227_D	241_K	0.823	0.83
72_F	121_R	0.818	0.82
41_L	67_I	0.816	0.82
93_Q	96_S	0.816	0.82
155_G	209_V	0.815	0.82
171_S	175_Q	0.815	0.82
143_K	146_A	0.814	0.82
180_C	185_K	0.811	0.82
230_I	339_V	0.811	0.82
209_V	290_M	0.810	0.82
295_T	324_V	0.810	0.82
273_A	277_L	0.806	0.82
67_I	136_A	0.806	0.82
17_E	20_G	0.805	0.81
211_A	288_A	0.805	0.81
247_D	259_N	0.803	0.81
186_I	189_L	0.802	0.81
165_L	185_K	0.802	0.81
170_W	173_V	0.801	0.81
166_D	185_K	0.793	0.80
71_V	143_K	0.789	0.80
224_D	229_D	0.789	0.80
117_L	123_G	0.788	0.80
157_L	326_I	0.785	0.80
299_T	317_K	0.782	0.80
14_T	134_R	0.782	0.80
203_I	255_R	0.779	0.79
14_T	130_E	0.777	0.79
68_L	84_L	0.777	0.79
227_D	245_I	0.777	0.79
64_Q	88_T	0.771	0.79
85_I	133_M	0.769	0.78
42_Q	64_Q	0.768	0.78
296_S	331_I	0.766	0.78
339_V	342_D	0.765	0.78
227_D	231_A	0.762	0.78
200_G	300_V	0.759	0.77
218_L	340_L	0.757	0.77
34_I	341_M	0.755	0.77
38_E	42_Q	0.754	0.77
55_Y	193_M	0.753	0.77
47_R	330_P	0.752	0.77
23_L	85_I	0.751	0.77
347_Q	350_Q	0.751	0.77
162_D	253_A	0.750	0.77
30_V	141_A	0.745	0.76
153_I	340_L	0.744	0.76
234_L	332_A	0.740	0.76
268_F	282_S	0.736	0.75
26_I	82_G	0.736	0.75
42_Q	49_R	0.732	0.75
160_M	193_M	0.731	0.75
328_A	332_A	0.731	0.75
229_D	339_V	0.730	0.75
194_R	198_K	0.729	0.75
38_E	66_K	0.729	0.75
81_I	140_I	0.726	0.74
128_A	238_N	0.724	0.74
55_Y	190_D	0.722	0.74
13_T	26_I	0.722	0.74
235_M	243_V	0.721	0.74
45_L	132_A	0.720	0.74
251_V	273_A	0.720	0.74
189_L	193_M	0.720	0.74
206_K	252_V	0.719	0.74
130_E	133_M	0.716	0.73
207_V	328_A	0.714	0.73
110_T	282_S	0.713	0.73
250_D	254_L	0.713	0.73
46_D	49_R	0.712	0.73
134_R	222_V	0.712	0.73
15_F	26_I	0.712	0.73
224_D	346_R	0.708	0.72
281_S	286_I	0.707	0.72
12_V	338_I	0.703	0.72
206_K	291_A	0.702	0.72
67_I	83_L	0.699	0.71
27_V	30_V	0.699	0.71
20_G	121_R	0.698	0.71
193_M	323_C	0.698	0.71
111_Y	126_S	0.695	0.71
292_L	331_I	0.695	0.71
196_L	199_E	0.694	0.71
55_Y	178_F	0.691	0.71
24_G	68_L	0.691	0.71
214_V	344_L	0.689	0.70
195_A	198_K	0.689	0.70
257_S	300_V	0.688	0.70
235_M	288_A	0.683	0.70
10_F	341_M	0.679	0.69
27_V	141_A	0.679	0.69
166_D	182_D	0.677	0.69
44_D	47_R	0.677	0.69
264_T	303_R	0.674	0.69
98_I	314_M	0.665	0.68
12_V	137_A	0.665	0.68
255_R	258_Q	0.664	0.68
42_Q	65_V	0.663	0.67
76_T	143_K	0.662	0.67
32_P	347_Q	0.662	0.67
264_T	267_G	0.661	0.67
105_G	296_S	0.659	0.67
68_L	82_G	0.658	0.67
83_L	140_I	0.657	0.67
142_K	153_I	0.652	0.66
227_D	243_V	0.651	0.66
112_E	120_Y	0.651	0.66
276_I	282_S	0.649	0.66
125_R	130_E	0.649	0.66
188_A	192_L	0.648	0.66
14_T	225_R	0.646	0.65
90_Q	94_D	0.644	0.65
225_R	228_A	0.641	0.65
286_I	340_L	0.640	0.65
191_E	194_R	0.640	0.65
214_V	280_I	0.638	0.64
92_S	121_R	0.636	0.64
220_E	346_R	0.634	0.64
209_V	336_L	0.629	0.63
230_I	234_L	0.629	0.63
89_D	93_Q	0.626	0.63
33_G	117_L	0.623	0.63
335_M	339_V	0.623	0.63
193_M	196_L	0.622	0.63
251_V	254_L	0.622	0.63
14_T	125_R	0.622	0.63
228_A	236_S	0.621	0.62
99_K	120_Y	0.621	0.62
263_I	277_L	0.619	0.62
76_T	140_I	0.619	0.62
156_C	210_V	0.617	0.62
128_A	331_I	0.616	0.62
158_T	164_P	0.616	0.62
41_L	83_L	0.615	0.62
97_A	101_V	0.614	0.62
52_T	57_T	0.613	0.61
273_A	286_I	0.612	0.61
224_D	343_H	0.612	0.61
201_D	258_Q	0.612	0.61
12_V	27_V	0.610	0.61
24_G	82_G	0.609	0.61
152_E	213_G	0.608	0.61
38_E	64_Q	0.608	0.61
60_R	89_D	0.605	0.60
37_T	43_H	0.604	0.60
36_L	67_I	0.601	0.60
165_L	181_P	0.598	0.59
244_E	248_G	0.598	0.59
296_S	316_T	0.598	0.59
165_L	168_K	0.597	0.59
77_T	121_R	0.595	0.59
210_V	287_I	0.594	0.59
324_V	331_I	0.594	0.59
245_I	288_A	0.592	0.59
165_L	182_D	0.592	0.59
345_L	348_R	0.590	0.58
230_I	243_V	0.589	0.58
244_E	249_F	0.587	0.58
155_G	333_E	0.584	0.58
68_L	86_E	0.584	0.58
200_G	315_I	0.583	0.58
79_T	111_Y	0.582	0.57
12_V	335_M	0.582	0.57
36_L	143_K	0.582	0.57
27_V	139_A	0.579	0.57
239_A	328_A	0.579	0.57
166_D	169_D	0.576	0.57
72_F	119_D	0.575	0.57
263_I	305_I	0.575	0.57
237_I	331_I	0.575	0.57
197_K	200_G	0.575	0.57
158_T	289_H	0.574	0.56
164_P	250_D	0.574	0.56
14_T	133_M	0.574	0.56
126_S	130_E	0.574	0.56
44_D	135_V	0.573	0.56
158_T	287_I	0.572	0.56
156_C	165_L	0.571	0.56
34_I	143_K	0.571	0.56
137_A	338_I	0.569	0.56
39_A	43_H	0.567	0.55
158_T	206_K	0.566	0.55
47_R	174_E	0.566	0.55
341_M	345_L	0.565	0.55
165_L	180_C	0.562	0.55
238_N	328_A	0.561	0.55
17_E	121_R	0.561	0.55
239_A	292_L	0.561	0.55
12_V	83_L	0.560	0.55
45_L	136_A	0.560	0.55
49_R	52_T	0.559	0.54
299_T	316_T	0.557	0.54
130_E	236_S	0.556	0.54
69_S	82_G	0.555	0.54
320_H	327_R	0.554	0.54
211_A	230_I	0.553	0.54
324_V	328_A	0.552	0.54
222_V	236_S	0.552	0.54
30_V	144_Y	0.551	0.53
36_L	71_V	0.550	0.53
265_K	305_I	0.550	0.53
73_E	120_Y	0.549	0.53
38_E	143_K	0.549	0.53
60_R	88_T	0.549	0.53
72_F	77_T	0.548	0.53
41_L	143_K	0.548	0.53
223_F	238_N	0.547	0.53
33_G	116_G	0.547	0.53
43_H	46_D	0.546	0.53
53_S	176_N	0.546	0.53
155_G	332_A	0.546	0.53
151_I	214_V	0.544	0.52
163_I	196_L	0.543	0.52
83_L	133_M	0.541	0.52
20_G	77_T	0.539	0.52
222_V	225_R	0.539	0.52
125_R	134_R	0.538	0.52
82_G	133_M	0.538	0.52
13_T	28_D	0.536	0.51
36_L	43_H	0.535	0.51
30_V	338_I	0.535	0.51
273_A	282_S	0.534	0.51
116_G	123_G	0.533	0.51
215_P	344_L	0.533	0.51
114_K	220_E	0.533	0.51
25_C	238_N	0.532	0.51
65_V	71_V	0.532	0.51
259_N	273_A	0.531	0.51
277_L	297_S	0.531	0.51
160_M	325_G	0.531	0.51
296_S	299_T	0.530	0.51
10_F	345_L	0.530	0.51
344_L	348_R	0.529	0.51
285_Q	288_A	0.529	0.51
228_A	276_I	0.525	0.50
193_M	197_K	0.524	0.50
188_A	195_A	0.523	0.50
97_A	100_D	0.521	0.49
35_P	143_K	0.520	0.49
240_V	243_V	0.518	0.49
52_T	194_R	0.517	0.49
31_P	345_L	0.516	0.49
77_T	119_D	0.515	0.49
189_L	192_L	0.513	0.48
32_P	79_T	0.513	0.48
306_N	309_G	0.512	0.48
38_E	67_I	0.512	0.48
35_P	148_K	0.511	0.48
155_G	207_V	0.509	0.48
142_K	146_A	0.509	0.48
297_S	331_I	0.508	0.48
91_R	96_S	0.507	0.48
334_A	338_I	0.507	0.48
183_P	186_I	0.507	0.48
56_T	59_R	0.506	0.47
267_G	311_E	0.505	0.47
222_V	232_H	0.505	0.47
206_K	287_I	0.504	0.47
273_A	281_S	0.503	0.47
338_I	341_M	0.502	0.47
218_L	343_H	0.501	0.47
14_T	222_V	0.500	0.47
45_L	215_P	0.500	0.47
112_E	117_L	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ob9A	2	0.8615	100	0.03	Contact Map
1r53A	4	0.7562	100	0.04	Contact Map
1sq1A	4	0.7867	100	0.04	Contact Map
1um0A	4	0.9889	100	0.044	Contact Map
2o11A	4	0.9529	100	0.067	Contact Map
4ecdA	3	0.7202	100	0.068	Contact Map
1q1lA	4	0.8587	100	0.072	Contact Map
1qxoA	4	0.9723	100	0.079	Contact Map
2ltmA	1	0.2825	36.2	0.977	Contact Map
2ekmA	3	0.1496	18	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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