GREMLIN Database
AROC - Chorismate synthase
UniProt: P12008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10075
Length: 361 (341)
Sequences: 3153 (1531)
Seq/√Len: 82.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_K86_E4.7771.00
226_L281_S3.6141.00
40_D143_K3.1921.00
242_G249_F3.1841.00
211_A336_L3.1691.00
44_D142_K3.1681.00
306_N310_E3.1471.00
85_I132_A3.0911.00
247_D272_H2.9721.00
201_D257_S2.9191.00
214_V286_I2.8731.00
144_Y341_M2.7071.00
229_D343_H2.5511.00
199_E255_R2.3441.00
249_F291_A2.3371.00
72_F120_Y2.2671.00
212_S285_Q2.2601.00
180_C189_L2.2561.00
30_V81_I2.2411.00
102_F112_E2.2211.00
230_I336_L2.2191.00
12_V25_C2.1791.00
234_L288_A2.1741.00
242_G291_A2.1671.00
27_V140_I2.1401.00
159_Q253_A2.1071.00
65_V83_L2.1011.00
301_P313_E2.0761.00
211_A340_L2.0751.00
244_E289_H2.0711.00
15_F82_G2.0291.00
37_T40_D1.9911.00
234_L336_L1.9871.00
156_C181_P1.9711.00
153_I337_A1.9511.00
224_D232_H1.9371.00
195_A199_E1.9281.00
62_P88_T1.8961.00
35_P75_V1.8861.00
288_A336_L1.8641.00
269_Q303_R1.8561.00
176_N186_I1.8451.00
264_T269_Q1.8371.00
185_K188_A1.8361.00
172_Q175_Q1.8331.00
107_A278_G1.8321.00
159_Q162_D1.8261.00
162_D192_L1.8131.00
25_C83_L1.8111.00
262_E303_R1.7951.00
192_L196_L1.7631.00
159_Q164_P1.7591.00
130_E134_R1.7501.00
208_T289_H1.7291.00
229_D232_H1.7291.00
196_L203_I1.7281.00
22_A84_L1.6951.00
251_V259_N1.6901.00
301_P315_I1.6861.00
237_I332_A1.6761.00
36_L140_I1.6661.00
210_V285_Q1.6511.00
177_P190_D1.6221.00
42_Q46_D1.6141.00
149_F344_L1.5891.00
22_A68_L1.5691.00
265_K311_E1.5451.00
229_D346_R1.5391.00
15_F24_G1.5281.00
187_D190_D1.5000.99
276_I286_I1.4940.99
10_F30_V1.4870.99
83_L136_A1.4690.99
254_L259_N1.4640.99
205_A325_G1.4520.99
206_K289_H1.4520.99
292_L332_A1.4500.99
146_A152_E1.4450.99
250_D253_A1.4430.99
158_T208_T1.4430.99
41_L139_A1.4330.99
97_A317_K1.4290.99
290_M332_A1.4210.99
260_R302_G1.4140.99
234_L290_M1.4100.99
263_I268_F1.4070.99
30_V140_I1.3910.99
174_E179_F1.3890.99
71_V81_I1.3800.99
21_L66_K1.3760.99
109_Y263_I1.3670.99
233_A339_V1.3660.99
209_V332_A1.3610.99
54_R194_R1.3440.99
25_C137_A1.3400.99
123_G221_P1.3400.99
231_A235_M1.3340.99
276_I281_S1.3310.99
160_M323_C1.3280.99
142_K333_E1.3280.99
100_D308_F1.3220.99
234_L243_V1.3210.99
152_E212_S1.3170.98
36_L76_T1.3160.98
102_F307_R1.3160.98
243_V288_A1.3080.98
34_I144_Y1.3050.98
303_R313_E1.3030.98
194_R197_K1.2810.98
306_N312_V1.2700.98
178_F193_M1.2700.98
155_G329_V1.2640.98
201_D255_R1.2570.98
101_V312_V1.2560.98
154_R173_V1.2420.98
240_V292_L1.2400.98
221_P280_I1.2360.98
44_D139_A1.2340.98
191_E195_A1.2330.98
228_A232_H1.2280.98
47_R333_E1.2220.98
21_L86_E1.2100.97
25_C133_M1.2090.97
128_A324_V1.2090.97
112_E307_R1.2070.97
239_A324_V1.2070.97
343_H346_R1.2020.97
247_D251_V1.2000.97
200_G299_T1.1990.97
105_G277_L1.1850.97
75_V117_L1.1850.97
235_M245_I1.1810.97
142_K337_A1.1810.97
37_T143_K1.1770.97
163_I185_K1.1770.97
211_A286_I1.1630.97
10_F338_I1.1590.97
151_I344_L1.1580.97
159_Q206_K1.1560.97
91_R94_D1.1450.96
211_A214_V1.1430.96
27_V83_L1.1420.96
10_F27_V1.1360.96
192_L255_R1.1360.96
252_V291_A1.1330.96
220_E343_H1.1230.96
218_L344_L1.1170.96
182_D185_K1.1120.96
292_L324_V1.1110.96
36_L40_D1.1090.96
292_L328_A1.0940.95
297_S316_T1.0910.95
192_L195_A1.0870.95
262_E269_Q1.0870.95
58_Q89_D1.0840.95
257_S298_I1.0810.95
247_D254_L1.0800.95
190_D194_R1.0790.95
141_A338_I1.0670.95
199_E300_V1.0640.95
40_D43_H1.0640.95
268_F284_Q1.0630.94
134_R335_M1.0500.94
277_L282_S1.0460.94
49_R62_P1.0430.94
214_V218_L1.0410.94
172_Q183_P1.0410.94
237_I335_M1.0380.94
10_F141_A1.0380.94
206_K249_F1.0380.94
304_T314_M1.0350.94
202_S295_T1.0340.94
304_T312_V1.0170.93
230_I288_A1.0160.93
336_L340_L1.0100.93
240_V290_M1.0040.93
233_A335_M1.0040.93
17_E77_T1.0030.93
113_Q216_A1.0010.93
40_D146_A0.9970.92
110_T263_I0.9940.92
207_V332_A0.9920.92
42_Q45_L0.9900.92
96_S120_Y0.9760.92
163_I188_A0.9760.92
11_R28_D0.9750.91
164_P253_A0.9690.91
159_Q252_V0.9690.91
208_T287_I0.9660.91
33_G75_V0.9590.91
109_Y113_Q0.9550.91
303_R311_E0.9460.90
232_H236_S0.9440.90
49_R60_R0.9350.90
100_D306_N0.9340.90
157_L325_G0.9320.90
58_Q197_K0.9300.89
188_A191_E0.9280.89
186_I190_D0.9250.89
30_V34_I0.9210.89
110_T280_I0.9210.89
96_S99_K0.9170.89
187_D191_E0.9160.89
180_C186_I0.9150.89
150_G213_G0.9140.89
264_T311_E0.9090.88
156_C208_T0.9020.88
23_L132_A0.9000.88
98_I120_Y0.8970.88
154_R212_S0.8940.88
163_I192_L0.8930.87
32_P350_Q0.8920.87
192_L203_I0.8880.87
178_F186_I0.8860.87
25_C82_G0.8860.87
105_G273_A0.8840.87
23_L133_M0.8820.87
9_L346_R0.8810.87
196_L255_R0.8800.87
207_V292_L0.8800.87
254_L258_Q0.8760.86
185_K189_L0.8760.86
53_S56_T0.8750.86
220_E224_D0.8740.86
154_R170_W0.8720.86
247_D250_D0.8710.86
52_T56_T0.8710.86
130_E222_V0.8690.86
209_V288_A0.8660.86
295_T322_P0.8610.85
161_G192_L0.8590.85
67_I71_V0.8570.85
184_D188_A0.8560.85
161_G203_I0.8550.85
262_E270_S0.8550.85
163_I189_L0.8530.85
66_K84_L0.8520.85
134_R236_S0.8520.85
176_N183_P0.8500.85
154_R210_V0.8490.85
206_K242_G0.8450.84
110_T277_L0.8450.84
225_R238_N0.8400.84
226_L343_H0.8370.84
325_G328_A0.8310.83
157_L160_M0.8270.83
201_D300_V0.8260.83
101_V304_T0.8240.83
227_D241_K0.8230.83
72_F121_R0.8180.82
41_L67_I0.8160.82
93_Q96_S0.8160.82
155_G209_V0.8150.82
171_S175_Q0.8150.82
143_K146_A0.8140.82
180_C185_K0.8110.82
230_I339_V0.8110.82
209_V290_M0.8100.82
295_T324_V0.8100.82
273_A277_L0.8060.82
67_I136_A0.8060.82
17_E20_G0.8050.81
211_A288_A0.8050.81
247_D259_N0.8030.81
186_I189_L0.8020.81
165_L185_K0.8020.81
170_W173_V0.8010.81
166_D185_K0.7930.80
71_V143_K0.7890.80
224_D229_D0.7890.80
117_L123_G0.7880.80
157_L326_I0.7850.80
299_T317_K0.7820.80
14_T134_R0.7820.80
203_I255_R0.7790.79
14_T130_E0.7770.79
68_L84_L0.7770.79
227_D245_I0.7770.79
64_Q88_T0.7710.79
85_I133_M0.7690.78
42_Q64_Q0.7680.78
296_S331_I0.7660.78
339_V342_D0.7650.78
227_D231_A0.7620.78
200_G300_V0.7590.77
218_L340_L0.7570.77
34_I341_M0.7550.77
38_E42_Q0.7540.77
55_Y193_M0.7530.77
47_R330_P0.7520.77
23_L85_I0.7510.77
347_Q350_Q0.7510.77
162_D253_A0.7500.77
30_V141_A0.7450.76
153_I340_L0.7440.76
234_L332_A0.7400.76
268_F282_S0.7360.75
26_I82_G0.7360.75
42_Q49_R0.7320.75
160_M193_M0.7310.75
328_A332_A0.7310.75
229_D339_V0.7300.75
194_R198_K0.7290.75
38_E66_K0.7290.75
81_I140_I0.7260.74
128_A238_N0.7240.74
55_Y190_D0.7220.74
13_T26_I0.7220.74
235_M243_V0.7210.74
45_L132_A0.7200.74
251_V273_A0.7200.74
189_L193_M0.7200.74
206_K252_V0.7190.74
130_E133_M0.7160.73
207_V328_A0.7140.73
110_T282_S0.7130.73
250_D254_L0.7130.73
46_D49_R0.7120.73
134_R222_V0.7120.73
15_F26_I0.7120.73
224_D346_R0.7080.72
281_S286_I0.7070.72
12_V338_I0.7030.72
206_K291_A0.7020.72
67_I83_L0.6990.71
27_V30_V0.6990.71
20_G121_R0.6980.71
193_M323_C0.6980.71
111_Y126_S0.6950.71
292_L331_I0.6950.71
196_L199_E0.6940.71
55_Y178_F0.6910.71
24_G68_L0.6910.71
214_V344_L0.6890.70
195_A198_K0.6890.70
257_S300_V0.6880.70
235_M288_A0.6830.70
10_F341_M0.6790.69
27_V141_A0.6790.69
166_D182_D0.6770.69
44_D47_R0.6770.69
264_T303_R0.6740.69
98_I314_M0.6650.68
12_V137_A0.6650.68
255_R258_Q0.6640.68
42_Q65_V0.6630.67
76_T143_K0.6620.67
32_P347_Q0.6620.67
264_T267_G0.6610.67
105_G296_S0.6590.67
68_L82_G0.6580.67
83_L140_I0.6570.67
142_K153_I0.6520.66
227_D243_V0.6510.66
112_E120_Y0.6510.66
276_I282_S0.6490.66
125_R130_E0.6490.66
188_A192_L0.6480.66
14_T225_R0.6460.65
90_Q94_D0.6440.65
225_R228_A0.6410.65
286_I340_L0.6400.65
191_E194_R0.6400.65
214_V280_I0.6380.64
92_S121_R0.6360.64
220_E346_R0.6340.64
209_V336_L0.6290.63
230_I234_L0.6290.63
89_D93_Q0.6260.63
33_G117_L0.6230.63
335_M339_V0.6230.63
193_M196_L0.6220.63
251_V254_L0.6220.63
14_T125_R0.6220.63
228_A236_S0.6210.62
99_K120_Y0.6210.62
263_I277_L0.6190.62
76_T140_I0.6190.62
156_C210_V0.6170.62
128_A331_I0.6160.62
158_T164_P0.6160.62
41_L83_L0.6150.62
97_A101_V0.6140.62
52_T57_T0.6130.61
273_A286_I0.6120.61
224_D343_H0.6120.61
201_D258_Q0.6120.61
12_V27_V0.6100.61
24_G82_G0.6090.61
152_E213_G0.6080.61
38_E64_Q0.6080.61
60_R89_D0.6050.60
37_T43_H0.6040.60
36_L67_I0.6010.60
165_L181_P0.5980.59
244_E248_G0.5980.59
296_S316_T0.5980.59
165_L168_K0.5970.59
77_T121_R0.5950.59
210_V287_I0.5940.59
324_V331_I0.5940.59
245_I288_A0.5920.59
165_L182_D0.5920.59
345_L348_R0.5900.58
230_I243_V0.5890.58
244_E249_F0.5870.58
155_G333_E0.5840.58
68_L86_E0.5840.58
200_G315_I0.5830.58
79_T111_Y0.5820.57
12_V335_M0.5820.57
36_L143_K0.5820.57
27_V139_A0.5790.57
239_A328_A0.5790.57
166_D169_D0.5760.57
72_F119_D0.5750.57
263_I305_I0.5750.57
237_I331_I0.5750.57
197_K200_G0.5750.57
158_T289_H0.5740.56
164_P250_D0.5740.56
14_T133_M0.5740.56
126_S130_E0.5740.56
44_D135_V0.5730.56
158_T287_I0.5720.56
156_C165_L0.5710.56
34_I143_K0.5710.56
137_A338_I0.5690.56
39_A43_H0.5670.55
158_T206_K0.5660.55
47_R174_E0.5660.55
341_M345_L0.5650.55
165_L180_C0.5620.55
238_N328_A0.5610.55
17_E121_R0.5610.55
239_A292_L0.5610.55
12_V83_L0.5600.55
45_L136_A0.5600.55
49_R52_T0.5590.54
299_T316_T0.5570.54
130_E236_S0.5560.54
69_S82_G0.5550.54
320_H327_R0.5540.54
211_A230_I0.5530.54
324_V328_A0.5520.54
222_V236_S0.5520.54
30_V144_Y0.5510.53
36_L71_V0.5500.53
265_K305_I0.5500.53
73_E120_Y0.5490.53
38_E143_K0.5490.53
60_R88_T0.5490.53
72_F77_T0.5480.53
41_L143_K0.5480.53
223_F238_N0.5470.53
33_G116_G0.5470.53
43_H46_D0.5460.53
53_S176_N0.5460.53
155_G332_A0.5460.53
151_I214_V0.5440.52
163_I196_L0.5430.52
83_L133_M0.5410.52
20_G77_T0.5390.52
222_V225_R0.5390.52
125_R134_R0.5380.52
82_G133_M0.5380.52
13_T28_D0.5360.51
36_L43_H0.5350.51
30_V338_I0.5350.51
273_A282_S0.5340.51
116_G123_G0.5330.51
215_P344_L0.5330.51
114_K220_E0.5330.51
25_C238_N0.5320.51
65_V71_V0.5320.51
259_N273_A0.5310.51
277_L297_S0.5310.51
160_M325_G0.5310.51
296_S299_T0.5300.51
10_F345_L0.5300.51
344_L348_R0.5290.51
285_Q288_A0.5290.51
228_A276_I0.5250.50
193_M197_K0.5240.50
188_A195_A0.5230.50
97_A100_D0.5210.49
35_P143_K0.5200.49
240_V243_V0.5180.49
52_T194_R0.5170.49
31_P345_L0.5160.49
77_T119_D0.5150.49
189_L192_L0.5130.48
32_P79_T0.5130.48
306_N309_G0.5120.48
38_E67_I0.5120.48
35_P148_K0.5110.48
155_G207_V0.5090.48
142_K146_A0.5090.48
297_S331_I0.5080.48
91_R96_S0.5070.48
334_A338_I0.5070.48
183_P186_I0.5070.48
56_T59_R0.5060.47
267_G311_E0.5050.47
222_V232_H0.5050.47
206_K287_I0.5040.47
273_A281_S0.5030.47
338_I341_M0.5020.47
218_L343_H0.5010.47
14_T222_V0.5000.47
45_L215_P0.5000.47
112_E117_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ob9A 2 0.8615 100 0.03 Contact Map
1r53A 4 0.7562 100 0.04 Contact Map
1sq1A 4 0.7867 100 0.04 Contact Map
1um0A 4 0.9889 100 0.044 Contact Map
2o11A 4 0.9529 100 0.067 Contact Map
4ecdA 3 0.7202 100 0.068 Contact Map
1q1lA 4 0.8587 100 0.072 Contact Map
1qxoA 4 0.9723 100 0.079 Contact Map
2ltmA 1 0.2825 36.2 0.977 Contact Map
2ekmA 3 0.1496 18 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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