GREMLIN Database
BGLG - Cryptic beta-glucoside bgl operon antiterminator
UniProt: P11989 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10116
Length: 278 (263)
Sequences: 3759 (3231)
Seq/√Len: 199.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_D148_Q4.4351.00
86_R136_E3.9011.00
230_Q265_M2.9951.00
190_Q246_R2.8531.00
188_K194_N2.8391.00
252_G258_K2.8381.00
40_R44_S2.7991.00
234_K241_W2.7211.00
107_K111_Q2.6721.00
240_A272_E2.6481.00
234_K261_P2.6421.00
182_E254_Q2.5271.00
244_A268_A2.4501.00
78_R144_R2.3941.00
135_E154_V2.3591.00
44_S47_E2.2741.00
9_L15_V2.2661.00
29_R33_F2.2341.00
9_L17_I2.1311.00
42_N45_G2.1141.00
187_I205_L2.0971.00
39_E43_S2.0791.00
16_V24_K2.0461.00
43_S49_E2.0251.00
23_E35_K2.0021.00
215_R263_E1.9981.00
79_I137_A1.9981.00
186_L250_F1.9911.00
40_R43_S1.9801.00
101_H160_H1.9491.00
39_E45_G1.9231.00
22_R26_V1.8911.00
82_L140_I1.8741.00
43_S47_E1.8321.00
219_H257_R1.8261.00
248_A264_I1.8251.00
40_R45_G1.8081.00
245_E261_P1.7901.00
244_A264_I1.7471.00
40_R47_E1.7421.00
240_A244_A1.7041.00
9_L13_V1.7021.00
120_L155_G1.6971.00
82_L136_E1.6761.00
39_E44_S1.6661.00
41_I44_S1.6341.00
181_R202_Y1.6331.00
187_I271_I1.6231.00
240_A271_I1.6211.00
9_L14_V1.5821.00
198_E274_V1.5811.00
249_I252_G1.5621.00
232_A236_N1.5511.00
191_F243_C1.5401.00
135_E151_K1.5201.00
132_Q135_E1.5101.00
227_E265_M1.4871.00
26_V29_R1.4841.00
109_F149_L1.4831.00
12_N15_V1.4781.00
109_F150_P1.4601.00
138_L142_D1.4551.00
10_N18_D1.4491.00
185_Q189_F1.4371.00
244_A248_A1.4361.00
45_G49_E1.4311.00
184_L202_Y1.4191.00
245_E264_I1.4141.00
187_I243_C1.4021.00
83_A137_A1.3991.00
248_A267_L1.3991.00
242_Q245_E1.3981.00
201_S274_V1.3881.00
213_S217_L1.3811.00
183_M247_I1.3651.00
44_S49_E1.3631.00
138_L154_V1.3381.00
97_S160_H1.3231.00
72_V76_C1.3111.00
43_S46_I1.3061.00
134_G154_V1.2991.00
195_Y271_I1.2901.00
208_H270_N1.2741.00
22_R33_F1.2711.00
212_L216_I1.2661.00
27_M33_F1.2341.00
233_V268_A1.2291.00
83_A133_L1.2211.00
97_S101_H1.2011.00
223_N262_A1.1911.00
75_T145_L1.1711.00
222_I266_F1.1691.00
48_K52_L1.1621.00
228_S262_A1.1611.00
150_P153_E1.1601.00
22_R29_R1.1581.00
230_Q261_P1.1581.00
39_E47_E1.1541.00
241_W268_A1.1541.00
131_F154_V1.1441.00
212_L259_I1.1441.00
69_P72_V1.1421.00
82_L86_R1.1411.00
106_I110_Q1.1291.00
84_Q90_L1.1271.00
79_I83_A1.1271.00
209_L212_L1.1251.00
245_E249_I1.1231.00
202_Y206_V1.1081.00
80_I99_T1.1051.00
75_T144_R1.1011.00
244_A247_I1.0881.00
93_S97_S1.0831.00
130_E158_A1.0811.00
39_E49_E1.0781.00
231_Q235_Q1.0771.00
131_F158_A1.0671.00
136_E139_T1.0651.00
187_I244_A1.0611.00
241_W261_P1.0311.00
178_Q254_Q1.0281.00
142_D145_L1.0281.00
212_L260_S1.0181.00
180_M206_V1.0141.00
262_A265_M0.9891.00
176_V213_S0.9771.00
14_V17_I0.9760.99
180_M183_M0.9750.99
102_C157_I0.9750.99
134_G158_A0.9710.99
244_A267_L0.9690.99
18_D22_R0.9680.99
244_A271_I0.9680.99
195_Y274_V0.9670.99
248_A259_I0.9660.99
72_V103_Q0.9640.99
87_L136_E0.9630.99
15_V18_D0.9570.99
74_A77_D0.9550.99
102_C141_I0.9540.99
76_C80_I0.9520.99
135_E139_T0.9500.99
139_T148_Q0.9500.99
141_I149_L0.9460.99
30_G33_F0.9450.99
31_I38_G0.9400.99
84_Q87_L0.9390.99
83_A161_L0.9380.99
114_L150_P0.9370.99
251_I255_Y0.9360.99
24_K29_R0.9360.99
230_Q241_W0.9340.99
212_L215_R0.9340.99
75_T140_I0.9320.99
227_E262_A0.9290.99
161_L165_Q0.9280.99
241_W245_E0.9280.99
94_I164_A0.9250.99
131_F155_G0.9250.99
95_Y99_T0.9240.99
30_G42_N0.9220.99
134_G137_A0.9110.99
106_I149_L0.9080.99
205_L267_L0.9060.99
14_V32_G0.9020.99
186_L189_F0.8950.99
247_I271_I0.8940.99
182_E250_F0.8870.99
41_I45_G0.8870.99
76_C102_C0.8840.99
77_D95_Y0.8820.99
77_D96_I0.8810.99
265_M268_A0.8800.99
41_I47_E0.8780.99
26_V33_F0.8750.99
240_A268_A0.8710.99
128_P131_F0.8700.99
74_A78_R0.8660.99
43_S48_K0.8610.99
120_L156_F0.8530.99
186_L247_I0.8490.99
126_L151_K0.8490.99
247_I250_F0.8430.99
79_I140_I0.8430.99
207_T211_F0.8420.99
13_V17_I0.8410.98
250_F254_Q0.8400.98
44_S48_K0.8390.98
28_G33_F0.8390.98
75_T79_I0.8340.98
188_K195_Y0.8330.98
164_A212_L0.8300.98
180_M209_L0.8300.98
103_Q107_K0.8300.98
40_R46_I0.8290.98
138_L141_I0.8280.98
187_I191_F0.8230.98
173_V177_T0.8160.98
170_M173_V0.8150.98
72_V106_I0.8150.98
137_A140_I0.8080.98
186_L190_Q0.8070.98
158_A162_V0.8050.98
35_K39_E0.8050.98
228_S236_N0.8050.98
243_C247_I0.8050.98
232_A235_Q0.7980.98
138_L157_I0.7930.98
11_N18_D0.7930.98
183_M271_I0.7890.98
41_I49_E0.7890.98
190_Q243_C0.7890.98
272_E275_R0.7870.98
12_N159_M0.7870.98
81_S84_Q0.7820.98
131_F135_E0.7810.98
129_K132_Q0.7780.98
13_V18_D0.7760.97
81_S95_Y0.7720.97
270_N273_R0.7710.97
182_E185_Q0.7640.97
239_Q244_A0.7590.97
123_I155_G0.7540.97
216_I257_R0.7500.97
136_E140_I0.7480.97
204_R273_R0.7470.97
39_E46_I0.7440.97
107_K110_Q0.7360.97
71_E144_R0.7350.96
254_Q257_R0.7340.96
77_D81_S0.7320.96
213_S255_Y0.7310.96
110_Q146_G0.7300.96
242_Q246_R0.7300.96
59_G62_S0.7290.96
201_S205_L0.7280.96
211_F214_W0.7280.96
137_A161_L0.7260.96
230_Q262_A0.7240.96
82_L133_L0.7230.96
68_I103_Q0.7190.96
213_S257_R0.7170.96
11_N15_V0.7150.96
153_E266_F0.7150.96
188_K198_E0.7150.96
72_V75_T0.7140.96
142_D149_L0.7100.96
17_I21_Q0.7090.96
239_Q242_Q0.7090.96
101_H105_A0.7080.96
233_V265_M0.7070.96
240_A275_R0.7030.95
249_I253_L0.7030.95
45_G48_K0.7020.95
228_S232_A0.7000.95
41_I48_K0.6980.95
87_L133_L0.6930.95
179_L183_M0.6920.95
45_G108_R0.6910.95
25_V29_R0.6910.95
184_L201_S0.6870.95
141_I145_L0.6840.95
237_Y272_E0.6830.95
85_E88_G0.6810.95
117_N155_G0.6800.95
105_A109_F0.6790.95
87_L90_L0.6790.95
115_L153_E0.6770.94
204_R274_V0.6740.94
183_M250_F0.6740.94
76_C99_T0.6710.94
108_R156_F0.6660.94
208_H266_F0.6650.94
33_F36_R0.6640.94
241_W244_A0.6640.94
27_M32_G0.6630.94
70_L74_A0.6620.94
83_A140_I0.6620.94
210_K214_W0.6560.94
266_F270_N0.6500.93
179_L255_Y0.6490.93
46_I50_Y0.6480.93
215_R222_I0.6470.93
74_A144_R0.6440.93
252_G255_Y0.6390.93
191_F247_I0.6390.93
24_K33_F0.6390.93
233_V269_I0.6380.93
152_D155_G0.6360.92
80_I137_A0.6360.92
109_F153_E0.6350.92
191_F195_Y0.6280.92
204_R270_N0.6280.92
176_V206_V0.6250.92
214_W218_E0.6240.92
185_Q188_K0.6240.92
14_V26_V0.6230.92
87_L130_E0.6230.92
180_M184_L0.6200.91
118_P159_M0.6200.91
245_E248_A0.6170.91
46_I49_E0.6160.91
251_I257_R0.6150.91
230_Q234_K0.6150.91
21_Q24_K0.6140.91
130_E159_M0.6140.91
241_W264_I0.6140.91
54_S57_L0.6130.91
16_V26_V0.6110.91
177_T206_V0.6100.91
25_V28_G0.6080.91
10_N13_V0.6070.91
184_L271_I0.6050.90
81_S85_E0.6040.90
110_Q139_T0.6010.90
10_N19_D0.6000.90
101_H153_E0.6000.90
93_S164_A0.5980.90
26_V30_G0.5970.90
78_R82_L0.5910.89
90_L94_I0.5880.89
134_G161_L0.5870.89
186_L246_R0.5860.89
140_I143_K0.5850.89
116_P152_D0.5850.89
79_I82_L0.5830.89
179_L209_L0.5830.89
185_Q196_Q0.5810.89
184_L187_I0.5810.89
212_L270_N0.5800.89
178_Q182_E0.5800.89
227_E233_V0.5780.88
227_E231_Q0.5770.88
184_L188_K0.5770.88
25_V46_I0.5740.88
38_G41_I0.5740.88
195_Y201_S0.5720.88
21_Q26_V0.5710.88
128_P158_A0.5710.88
122_D127_Y0.5700.88
222_I262_A0.5690.88
181_R185_Q0.5690.88
104_F108_R0.5670.87
183_M244_A0.5650.87
91_Q165_Q0.5640.87
234_K268_A0.5610.87
90_L161_L0.5610.87
49_E52_L0.5610.87
135_E148_Q0.5600.87
163_S211_F0.5570.87
79_I141_I0.5520.86
131_F151_K0.5480.86
216_I260_S0.5460.85
172_D175_G0.5450.85
200_L204_R0.5450.85
231_Q234_K0.5440.85
232_A237_Y0.5420.85
109_F114_L0.5420.85
191_F194_N0.5370.84
76_C79_I0.5330.84
156_F228_S0.5320.84
117_N123_I0.5310.84
228_S265_M0.5290.84
234_K237_Y0.5290.84
72_V110_Q0.5280.83
108_R153_E0.5280.83
54_S58_N0.5280.83
128_P162_V0.5280.83
86_R132_Q0.5230.83
227_E264_I0.5220.83
125_R131_F0.5210.83
122_D151_K0.5200.83
83_A136_E0.5200.83
23_E26_V0.5190.82
68_I72_V0.5180.82
83_A87_L0.5170.82
106_I141_I0.5160.82
244_A257_R0.5160.82
26_V31_I0.5160.82
203_Q211_F0.5140.82
90_L93_S0.5130.82
157_I160_H0.5130.82
56_E73_M0.5130.82
117_N120_L0.5120.82
154_V158_A0.5100.81
131_F162_V0.5060.81
176_V180_M0.5060.81
207_T262_A0.5050.81
63_E66_S0.5040.81
241_W272_E0.5030.80
141_I147_V0.5030.80
140_I144_R0.5030.80
210_K257_R0.5010.80
243_C246_R0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6iA 2 0.9676 100 0.321 Contact Map
1h99A 2 0.7878 100 0.37 Contact Map
3sqnA 2 0.9317 100 0.434 Contact Map
3rioA 1 0.5971 99.9 0.593 Contact Map
3ufeA 2 0.3849 99.8 0.67 Contact Map
3nufA 2 0.4137 95.5 0.889 Contact Map
1auuA 2 0.1978 74.8 0.924 Contact Map
1l1cA 2 0.1978 72.9 0.925 Contact Map
2l0kA 1 0.2338 16.1 0.95 Contact Map
4h0eA 2 0.1367 14 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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