GREMLIN Database
BGLB - 6-phospho-beta-glucosidase BglB
UniProt: P11988 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10114
Length: 470 (437)
Sequences: 6789 (4186)
Seq/√Len: 200.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_D101_A4.2211.00
377_Q446_K4.0571.00
111_D163_K3.6141.00
107_D163_K3.1891.00
392_V402_I3.1681.00
73_A116_A3.0861.00
66_P112_E3.0011.00
107_D159_R2.9521.00
444_R448_F2.9191.00
112_E115_Q2.8921.00
124_L156_V2.8891.00
60_D63_H2.8391.00
100_E104_A2.8231.00
104_A108_R2.7891.00
100_E159_R2.7361.00
90_F155_T2.7191.00
299_Y388_H2.6941.00
391_Q394_E2.6481.00
154_R158_T2.6051.00
235_T240_D2.6031.00
25_E63_H2.5511.00
12_G77_F2.4751.00
385_L407_S2.3501.00
343_R398_D2.3391.00
347_N398_D2.2971.00
383_A387_D2.2741.00
70_A116_A2.2661.00
213_C222_I2.2361.00
38_H56_D2.2351.00
147_D208_R2.2071.00
143_R284_D2.2021.00
429_Y443_T2.1831.00
61_F105_F2.1561.00
211_K215_S2.1521.00
379_D446_K2.1441.00
66_P108_R2.1431.00
110_F160_Y2.1231.00
79_C406_T2.0701.00
119_K165_A2.0411.00
452_A456_K2.0331.00
61_F80_L2.0111.00
69_I109_L1.9811.00
371_E375_S1.9671.00
84_I122_V1.9641.00
150_E212_A1.9141.00
114_A163_K1.9091.00
35_L131_Y1.9091.00
101_A104_A1.8901.00
265_G269_R1.8861.00
154_R212_A1.8611.00
82_I110_F1.8571.00
23_W30_I1.8491.00
31_S87_A1.8371.00
69_I116_A1.8331.00
200_H263_Y1.8211.00
343_R394_E1.8001.00
283_S286_E1.7981.00
154_R216_L1.7871.00
232_Y344_V1.7831.00
213_C220_A1.7791.00
107_D111_D1.7731.00
30_I35_L1.7661.00
208_R287_D1.7251.00
217_L220_A1.7021.00
112_E116_A1.6991.00
22_A25_E1.6931.00
14_T19_V1.6861.00
119_K166_L1.6701.00
111_D114_A1.6561.00
82_I109_L1.6391.00
340_V391_Q1.6351.00
70_A112_E1.6331.00
137_Y148_H1.6321.00
113_M118_I1.6131.00
110_F114_A1.6111.00
10_W458_R1.6091.00
343_R347_N1.6001.00
150_E208_R1.5911.00
107_D160_Y1.5901.00
348_T352_R1.5871.00
280_M285_A1.5861.00
299_Y341_G1.5841.00
346_L400_V1.5771.00
453_E456_K1.5751.00
132_G136_N1.5721.00
69_I112_E1.5701.00
260_R354_Q1.5661.00
65_Y108_R1.5571.00
262_Q289_K1.5481.00
9_L79_C1.5421.00
358_F403_M1.5271.00
17_N55_K1.5241.00
145_V148_H1.5221.00
79_C121_L1.5121.00
168_L225_M1.5101.00
141_A194_E1.4831.00
431_D439_S1.4811.00
157_F213_C1.4701.00
39_G43_K1.4611.00
64_R67_E1.4541.00
199_I254_F1.4521.00
162_H217_L1.4441.00
253_F267_M1.4391.00
103_L155_T1.4361.00
14_T80_L1.4341.00
69_I113_M1.4231.00
255_G295_I1.4161.00
248_N266_Y1.4121.00
72_F77_F1.4071.00
168_L294_F1.3951.00
362_N405_Y1.3941.00
350_W355_K1.3931.00
342_L392_V1.3901.00
90_F98_P1.3801.00
212_A215_S1.3801.00
82_I122_V1.3751.00
332_E367_K1.3711.00
35_L136_N1.3631.00
29_G93_G1.3611.00
407_S427_F1.3611.00
138_G142_N1.3561.00
121_L406_T1.3531.00
262_Q268_Q1.3481.00
74_E448_F1.3461.00
453_E457_T1.3301.00
346_L392_V1.3261.00
60_D64_R1.3171.00
22_A63_H1.3141.00
166_L221_K1.3091.00
92_Q95_E1.3081.00
224_N258_Q1.3051.00
165_A219_E1.3031.00
84_I156_V1.2961.00
450_W454_V1.2801.00
131_Y135_K1.2731.00
444_R449_G1.2701.00
262_Q354_Q1.2631.00
84_I89_I1.2431.00
389_L392_V1.2401.00
449_G452_A1.2341.00
189_E194_E1.2301.00
387_D390_V1.2271.00
170_F202_Q1.2241.00
94_D148_H1.2241.00
147_D150_E1.2191.00
170_F205_A1.2151.00
144_A147_D1.2131.00
191_G194_E1.2101.00
386_N390_V1.2041.00
281_T284_D1.2021.00
347_N400_V1.2021.00
103_L159_R1.1991.00
72_F428_I1.1971.00
176_S202_Q1.1931.00
70_A74_E1.1901.00
107_D162_H1.1691.00
143_R201_H1.1691.00
157_F209_A1.1671.00
61_F109_L1.1661.00
393_N397_A1.1651.00
371_E377_Q1.1611.00
94_D137_Y1.1601.00
140_W145_V1.1601.00
131_Y136_N1.1561.00
221_K356_P1.1551.00
285_A288_L1.1511.00
350_W401_D1.1501.00
59_I411_I1.1481.00
23_W28_K1.1421.00
65_Y112_E1.1341.00
129_M145_V1.1311.00
375_S446_K1.1271.00
5_P396_I1.1251.00
14_T82_I1.1201.00
256_D352_R1.1191.00
158_T216_L1.1151.00
432_R440_L1.1151.00
233_P244_A1.1111.00
157_F222_I1.1111.00
124_L149_F1.1101.00
256_D260_R1.1101.00
29_G132_G1.1071.00
238_P242_L1.0941.00
153_A209_A1.0921.00
150_E209_A1.0871.00
103_L107_D1.0781.00
210_V214_H1.0731.00
374_G443_T1.0731.00
233_P241_M1.0701.00
394_E397_A1.0701.00
393_N396_I1.0681.00
92_Q132_G1.0681.00
150_E154_R1.0671.00
248_N267_M1.0661.00
451_Y455_I1.0631.00
110_F163_K1.0611.00
213_C217_L1.0601.00
239_Q340_V1.0601.00
340_V344_V1.0591.00
144_A148_H1.0591.00
137_Y144_A1.0581.00
238_P241_M1.0581.00
213_C218_P1.0571.00
231_V247_E1.0561.00
228_G345_L1.0541.00
74_E444_R1.0531.00
4_F396_I1.0511.00
234_L306_S1.0501.00
98_P155_T1.0491.00
242_L246_E1.0451.00
12_G72_F1.0451.00
110_F122_V1.0451.00
107_D114_A1.0441.00
208_R212_A1.0441.00
201_H204_V1.0421.00
383_A386_N1.0411.00
92_Q97_E1.0411.00
370_V443_T1.0361.00
4_F393_N1.0321.00
212_A216_L1.0271.00
248_N252_M1.0251.00
22_A26_D1.0221.00
431_D441_T1.0201.00
57_V432_R1.0161.00
29_G91_P1.0151.00
330_S336_Q1.0111.00
282_E285_A1.0101.00
239_Q307_H1.0101.00
331_S364_L1.0071.00
324_P328_L1.0071.00
153_A212_A1.0041.00
64_R441_T1.0021.00
240_D307_H0.9971.00
57_V440_L0.9951.00
262_Q265_G0.9951.00
342_L359_I0.9951.00
155_T159_R0.9941.00
342_L402_I0.9941.00
148_H151_H0.9911.00
161_Q220_A0.9911.00
333_W365_G0.9881.00
121_L358_F0.9811.00
237_Q241_M0.9811.00
211_K290_H0.9730.99
329_K387_D0.9680.99
382_I450_W0.9650.99
121_L166_L0.9640.99
89_I155_T0.9630.99
269_R272_R0.9620.99
154_R217_L0.9600.99
367_K422_S0.9600.99
129_M139_G0.9590.99
146_I208_R0.9590.99
242_L245_M0.9580.99
329_K380_Y0.9530.99
9_L121_L0.9520.99
7_T403_M0.9510.99
19_V61_F0.9480.99
223_G296_S0.9400.99
247_E305_V0.9400.99
424_R432_R0.9390.99
241_M244_A0.9370.99
245_M248_N0.9360.99
156_V160_Y0.9360.99
324_P330_S0.9350.99
143_R281_T0.9340.99
210_V222_I0.9290.99
157_F220_A0.9250.99
366_A380_Y0.9210.99
411_I430_V0.9200.99
138_G141_A0.9170.99
28_K87_A0.9170.99
53_N422_S0.9150.99
192_E274_H0.9110.99
370_V374_G0.9070.99
104_A107_D0.9070.99
177_L198_A0.9050.99
95_E132_G0.8980.99
67_E70_A0.8970.99
153_A157_F0.8960.99
108_R111_D0.8950.99
333_W423_K0.8920.99
259_A355_K0.8900.99
27_G99_N0.8840.99
137_Y145_V0.8840.99
231_V244_A0.8800.99
364_L380_Y0.8800.99
152_Y156_V0.8790.99
236_C241_M0.8790.99
350_W354_Q0.8770.99
70_A73_A0.8700.99
365_G423_K0.8700.99
162_H220_A0.8690.99
223_G294_F0.8680.99
78_T458_R0.8670.99
270_F274_H0.8640.99
209_A212_A0.8570.99
211_K287_D0.8560.99
103_L156_V0.8550.99
245_M266_Y0.8550.99
159_R163_K0.8540.99
105_F109_L0.8520.99
77_F410_P0.8520.99
125_S129_M0.8500.99
107_D110_F0.8490.99
396_I402_I0.8470.99
3_A6_E0.8440.99
226_L255_G0.8440.99
324_P327_H0.8440.99
161_Q217_L0.8420.99
449_G453_E0.8410.99
114_A120_P0.8410.99
342_L391_Q0.8380.98
390_V394_E0.8380.98
283_S287_D0.8370.98
193_A278_I0.8340.98
371_E374_G0.8290.98
340_V394_E0.8270.98
297_F357_L0.8260.98
168_L296_S0.8250.98
256_D353_Y0.8240.98
329_K383_A0.8210.98
94_D136_N0.8200.98
376_I443_T0.8160.98
72_F118_I0.8150.98
206_S210_V0.8140.98
379_D383_A0.8130.98
370_V375_S0.8120.98
302_T336_Q0.8110.98
347_N351_D0.8100.98
301_M336_Q0.8100.98
74_E452_A0.8090.98
228_G297_F0.8080.98
338_D341_G0.8070.98
170_F176_S0.8060.98
208_R211_K0.8060.98
10_W389_L0.8040.98
94_D132_G0.8040.98
259_A292_V0.8030.98
146_I204_V0.8010.98
141_A189_E0.8000.98
302_T338_D0.7980.98
19_V59_I0.7960.98
32_T129_M0.7960.98
16_A85_A0.7950.98
269_R273_D0.7940.98
93_G132_G0.7930.98
169_T224_N0.7890.98
343_R391_Q0.7870.98
125_S128_E0.7860.98
77_F451_Y0.7850.98
142_N148_H0.7810.98
252_M352_R0.7780.98
234_L240_D0.7780.98
89_I156_V0.7770.98
193_A197_Q0.7770.98
454_V459_G0.7770.98
197_Q279_E0.7760.98
175_M227_L0.7760.98
181_F187_A0.7740.97
9_L119_K0.7740.97
5_P401_D0.7710.97
65_Y69_I0.7710.97
446_K449_G0.7710.97
302_T341_G0.7680.97
28_K31_S0.7650.97
231_V305_V0.7580.97
75_M444_R0.7580.97
57_V60_D0.7570.97
169_T206_S0.7570.97
306_S321_N0.7570.97
135_K181_F0.7530.97
265_G268_Q0.7520.97
350_W400_V0.7460.97
100_E107_D0.7420.97
347_N350_W0.7410.97
259_A295_I0.7410.97
98_P103_L0.7400.97
155_T158_T0.7400.97
149_F153_A0.7390.97
73_A117_G0.7390.97
199_I253_F0.7380.97
428_I444_R0.7380.97
68_D442_R0.7370.97
337_I366_A0.7370.97
413_L425_Y0.7360.97
245_M348_T0.7330.96
90_F95_E0.7330.96
102_G105_F0.7320.96
346_L402_I0.7300.96
122_V164_V0.7290.96
85_A128_E0.7280.96
161_Q216_L0.7270.96
24_Q30_I0.7250.96
355_K401_D0.7240.96
241_M245_M0.7220.96
94_D151_H0.7210.96
242_L340_V0.7180.96
169_T222_I0.7180.96
332_E366_A0.7180.96
141_A198_A0.7170.96
175_M179_A0.7140.96
395_A400_V0.7140.96
237_Q240_D0.7140.96
26_D62_Y0.7120.96
14_T411_I0.7110.96
325_N328_L0.7090.96
120_P165_A0.7090.96
174_N227_L0.7080.96
454_V458_R0.7070.96
357_L400_V0.7070.96
203_L258_Q0.7030.96
203_L288_L0.7010.95
23_W56_D0.6980.95
157_F216_L0.6980.95
225_M298_S0.6960.95
64_R440_L0.6950.95
179_A184_V0.6950.95
147_D151_H0.6940.95
389_L407_S0.6920.95
340_V343_R0.6910.95
3_A393_N0.6910.95
90_F97_E0.6900.95
92_Q136_N0.6880.95
230_L344_V0.6870.95
114_A165_A0.6870.95
30_I38_H0.6860.95
267_M271_F0.6860.95
7_T458_R0.6820.95
55_K58_A0.6790.95
382_I446_K0.6780.95
143_R204_V0.6780.95
23_W85_A0.6770.95
19_V413_L0.6750.94
415_S425_Y0.6750.94
113_M117_G0.6750.94
149_F170_F0.6730.94
205_A209_A0.6730.94
261_G289_K0.6720.94
22_A62_Y0.6720.94
10_W78_T0.6700.94
114_A119_K0.6700.94
228_G255_G0.6660.94
389_L454_V0.6630.94
427_F451_Y0.6630.94
75_M427_F0.6600.94
226_L254_F0.6590.94
298_S360_V0.6590.94
262_Q285_A0.6560.94
232_Y302_T0.6560.94
237_Q307_H0.6560.94
201_H281_T0.6530.93
371_E443_T0.6510.93
90_F94_D0.6500.93
82_I113_M0.6490.93
272_R277_T0.6490.93
154_R215_S0.6480.93
44_M53_N0.6480.93
207_A288_L0.6470.93
356_P401_D0.6470.93
156_V167_W0.6460.93
295_I355_K0.6460.93
164_V167_W0.6440.93
193_A277_T0.6440.93
110_F164_V0.6440.93
158_T212_A0.6440.93
13_A406_T0.6440.93
143_R283_S0.6430.93
374_G441_T0.6410.93
299_Y342_L0.6400.93
356_P403_M0.6380.93
371_E376_I0.6370.93
375_S443_T0.6370.93
78_T119_K0.6370.93
121_L168_L0.6350.92
346_L395_A0.6340.92
282_E286_E0.6330.92
243_Q247_E0.6320.92
153_A156_V0.6320.92
113_M116_A0.6320.92
11_G406_T0.6310.92
9_L78_T0.6310.92
95_E151_H0.6310.92
297_F349_L0.6310.92
285_A289_K0.6300.92
333_W418_H0.6290.92
308_D311_I0.6290.92
72_F410_P0.6270.92
211_K291_T0.6240.92
221_K403_M0.6240.92
429_Y445_K0.6230.92
190_S193_A0.6210.92
66_P70_A0.6210.92
200_H280_M0.6200.92
358_F404_G0.6190.92
196_Y271_F0.6190.92
394_E398_D0.6160.91
392_V396_I0.6160.91
370_V373_D0.6160.91
133_L148_H0.6160.91
180_P187_A0.6160.91
375_S449_G0.6160.91
42_G52_E0.6150.91
269_R394_E0.6150.91
125_S176_S0.6150.91
114_A117_G0.6150.91
228_G251_W0.6140.91
55_K419_S0.6130.91
141_A197_Q0.6120.91
30_I131_Y0.6100.91
81_R171_N0.6100.91
248_N348_T0.6090.91
414_V432_R0.6080.91
151_H155_T0.6060.91
90_F151_H0.6050.91
69_I118_I0.6040.91
135_K189_E0.6040.91
429_Y441_T0.6030.90
146_I205_A0.6020.90
332_E423_K0.6020.90
197_Q201_H0.6010.90
440_L444_R0.6000.90
84_I110_F0.5990.90
216_L220_A0.5990.90
267_M270_F0.5990.90
234_L304_C0.5990.90
71_L428_I0.5980.90
379_D382_I0.5980.90
255_G349_L0.5980.90
330_S334_G0.5980.90
281_T285_A0.5960.90
410_P428_I0.5960.90
103_L160_Y0.5960.90
14_T410_P0.5960.90
124_L157_F0.5960.90
287_D290_H0.5960.90
19_V80_L0.5950.90
252_M348_T0.5950.90
71_L411_I0.5940.90
207_A291_T0.5940.90
228_G349_L0.5930.90
51_K422_S0.5920.90
39_G42_G0.5910.90
235_T306_S0.5890.89
207_A290_H0.5860.89
37_P414_V0.5860.89
89_I103_L0.5850.89
58_A440_L0.5840.89
413_L416_A0.5830.89
253_F271_F0.5830.89
75_M448_F0.5800.89
7_T396_I0.5800.89
211_K214_H0.5790.89
30_I87_A0.5790.89
454_V457_T0.5780.89
66_P69_I0.5780.89
93_G133_L0.5750.88
223_G358_F0.5750.88
124_L153_A0.5740.88
181_F189_E0.5730.88
358_F406_T0.5720.88
300_Y361_E0.5720.88
4_F458_R0.5710.88
210_V292_V0.5700.88
32_T135_K0.5690.88
357_L402_I0.5690.88
80_L113_M0.5680.88
111_D162_H0.5660.87
328_L336_Q0.5650.87
76_G452_A0.5640.87
146_I150_E0.5640.87
61_F72_F0.5630.87
166_L358_F0.5630.87
184_V418_H0.5630.87
360_V403_M0.5620.87
36_Q188_E0.5620.87
108_R112_E0.5600.87
206_S258_Q0.5600.87
92_Q148_H0.5590.87
73_A115_Q0.5590.87
252_M256_D0.5580.87
161_Q218_P0.5570.87
323_I327_H0.5570.87
247_E250_R0.5560.87
64_R439_S0.5530.86
22_A28_K0.5520.86
232_Y338_D0.5510.86
306_S323_I0.5510.86
78_T455_I0.5510.86
229_G303_G0.5450.85
331_S366_A0.5440.85
57_V63_H0.5440.85
414_V421_M0.5430.85
185_G188_E0.5420.85
37_P55_K0.5420.85
43_K188_E0.5410.85
132_G148_H0.5410.85
246_E307_H0.5410.85
32_T125_S0.5400.85
61_F65_Y0.5400.85
409_G413_L0.5400.85
210_V290_H0.5390.85
172_E300_Y0.5370.85
349_L357_L0.5360.85
111_D115_Q0.5360.85
78_T459_G0.5350.84
137_Y142_N0.5350.84
344_V347_N0.5340.84
4_F10_W0.5340.84
72_F80_L0.5330.84
190_S195_V0.5320.84
121_L403_M0.5320.84
23_W38_H0.5300.84
132_G135_K0.5300.84
140_W170_F0.5290.84
382_I386_N0.5280.84
296_S360_V0.5270.84
77_F118_I0.5260.83
133_L145_V0.5260.83
204_V287_D0.5250.83
74_E449_G0.5240.83
14_T61_F0.5240.83
14_T413_L0.5230.83
29_G90_F0.5220.83
7_T78_T0.5210.83
376_I429_Y0.5210.83
249_R267_M0.5210.83
225_M294_F0.5210.83
196_Y274_H0.5190.83
255_G259_A0.5190.83
331_S334_G0.5180.82
385_L389_L0.5180.82
331_S365_G0.5170.82
280_M283_S0.5160.82
210_V213_C0.5150.82
204_V288_L0.5130.82
132_G137_Y0.5110.82
433_D441_T0.5110.82
346_L357_L0.5110.82
41_M44_M0.5110.82
424_R429_Y0.5080.81
33_S416_A0.5080.81
35_L39_G0.5080.81
44_M51_K0.5070.81
385_L451_Y0.5050.81
256_D262_Q0.5040.81
201_H279_E0.5040.81
408_W413_L0.5030.81
61_F69_I0.5020.81
315_A318_N0.5020.81
418_H423_K0.5020.81
36_Q186_L0.5010.80
181_F186_L0.5010.80
186_L189_E0.5010.80
169_T209_A0.5000.80
428_I448_F0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v02A 2 0.9447 100 0.116 Contact Map
2dgaA 5 0.9511 100 0.122 Contact Map
3ptmA 1 0.9468 100 0.123 Contact Map
1v08A 2 0.9468 100 0.124 Contact Map
2jf7A 5 0.934 100 0.124 Contact Map
3wq5A 1 0.9447 100 0.125 Contact Map
3w53A 1 0.9447 100 0.125 Contact Map
1cbgA 2 0.9468 100 0.128 Contact Map
4f66A 2 0.9723 100 0.129 Contact Map
4iplA 2 0.9617 100 0.129 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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