GREMLIN Database
TDCD - Propionate kinase
UniProt: P11868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11172
Length: 402 (380)
Sequences: 4326 (2920)
Seq/√Len: 149.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_R127_E3.9541.00
336_R351_T3.3081.00
255_S258_D3.3061.00
348_E369_N3.2821.00
283_E331_S3.2531.00
185_R188_S3.0881.00
100_I140_A2.8081.00
364_I373_I2.7851.00
305_A341_H2.7361.00
272_I299_T2.6411.00
232_M299_T2.5641.00
261_R266_E2.5381.00
304_I338_V2.5341.00
211_C218_S2.5081.00
198_G317_R2.4791.00
302_H314_S2.4651.00
229_E239_D2.4251.00
158_G232_M2.3901.00
161_W292_R2.3571.00
353_M368_E2.3571.00
185_R362_E2.3571.00
180_R388_D2.2861.00
17_I63_A2.2631.00
93_I107_N2.1661.00
87_I126_I2.1611.00
347_L374_C2.1531.00
250_S257_G2.1471.00
153_E298_K2.1241.00
105_I130_Q2.1231.00
285_A290_H2.1151.00
301_V334_I2.1051.00
364_I375_A2.1041.00
284_K288_E2.0921.00
294_Q298_K2.0831.00
300_F327_I2.0791.00
348_E367_S2.0571.00
147_H218_S2.0561.00
237_S263_V1.9761.00
59_S62_G1.9601.00
102_D130_Q1.9571.00
154_A302_H1.9371.00
65_K69_F1.9331.00
19_F47_V1.9231.00
97_S388_D1.8891.00
179_H201_V1.8641.00
336_R340_E1.8551.00
206_N234_G1.8401.00
286_W297_I1.8171.00
40_S277_S1.7951.00
192_L197_S1.7931.00
162_K266_E1.7851.00
99_I392_L1.7761.00
285_A293_A1.7731.00
61_E131_Q1.7701.00
88_A115_A1.7631.00
107_N110_R1.7541.00
163_Y262_V1.7521.00
167_L252_T1.7401.00
283_E333_L1.7241.00
160_P271_G1.7201.00
312_A344_V1.7151.00
186_A375_A1.7121.00
27_C387_L1.6951.00
367_S370_A1.6891.00
245_M259_L1.6761.00
105_I123_L1.6671.00
105_I127_E1.6631.00
84_G385_I1.6541.00
201_V322_I1.6441.00
380_N383_K1.6421.00
301_V337_L1.6031.00
186_A322_I1.6011.00
6_V79_S1.5991.00
152_P291_E1.5981.00
366_S374_C1.5941.00
275_L290_H1.5871.00
384_M388_D1.5841.00
286_W294_Q1.5781.00
261_R265_K1.5741.00
250_S260_E1.5631.00
96_E391_H1.5611.00
200_V318_L1.5581.00
249_A259_L1.5571.00
279_L297_I1.5421.00
182_V324_T1.5391.00
297_I337_L1.5231.00
89_H174_F1.4951.00
108_I140_A1.4891.00
339_M374_C1.4841.00
337_L340_E1.4761.00
189_L375_A1.4601.00
106_D109_R1.4551.00
129_A133_F1.4481.00
202_A210_I1.4381.00
196_D215_N1.4341.00
19_F33_G1.4331.00
87_I140_A1.4241.00
228_L263_V1.4191.00
113_P251_Q1.4191.00
266_E270_L1.4121.00
106_D110_R1.4031.00
82_L389_A1.4021.00
199_L320_G1.3961.00
321_I347_L1.3891.00
15_S206_N1.3781.00
159_L163_Y1.3701.00
198_G214_R1.3691.00
192_L196_D1.3671.00
98_A104_V1.3651.00
254_Q262_V1.3601.00
187_H197_S1.3541.00
232_M272_I1.3541.00
93_I110_R1.3511.00
193_A196_D1.3471.00
201_V213_V1.3451.00
190_L375_A1.3431.00
312_A318_L1.3311.00
222_S311_H1.3311.00
248_V252_T1.3301.00
99_I137_T1.3211.00
156_L164_Y1.3191.00
161_W295_L1.3111.00
210_I222_S1.2921.00
200_V308_I1.2921.00
249_A256_L1.2911.00
318_L321_I1.2911.00
69_F73_K1.2841.00
153_E302_H1.2821.00
155_Y170_R1.2721.00
180_R384_M1.2701.00
87_I122_N1.2701.00
179_H211_C1.2661.00
316_R341_H1.2651.00
156_L299_T1.2521.00
305_A313_A1.2511.00
352_E355_N1.2421.00
281_V284_K1.2371.00
186_A190_L1.2351.00
309_A313_A1.2301.00
208_A300_F1.2291.00
339_M349_I1.2281.00
156_L161_W1.2231.00
161_W165_E1.2181.00
339_M347_L1.2141.00
306_R314_S1.2091.00
291_E294_Q1.2011.00
58_H62_G1.1961.00
209_S224_G1.1921.00
234_G277_S1.1891.00
102_D106_D1.1871.00
159_L237_S1.1861.00
100_I104_V1.1851.00
220_D306_R1.1681.00
156_L295_L1.1661.00
383_K387_L1.1621.00
35_A67_I1.1501.00
348_E371_R1.1481.00
208_A231_L1.1441.00
333_L337_L1.1431.00
275_L285_A1.1431.00
201_V211_C1.1401.00
240_V244_A1.1371.00
185_R189_L1.1270.99
258_D266_E1.1220.99
154_A219_V1.1130.99
133_F136_V1.1120.99
169_V244_A1.1060.99
180_R184_Q1.0980.99
370_A374_C1.0910.99
109_R112_S1.0900.99
294_Q337_L1.0890.99
269_L279_L1.0860.99
272_I295_L1.0820.99
301_V305_A1.0780.99
274_G292_R1.0780.99
32_S48_N1.0760.99
20_S32_S1.0740.99
152_P156_L1.0700.99
190_L320_G1.0670.99
210_I308_I1.0660.99
100_I126_I1.0660.99
239_D307_H1.0630.99
320_G375_A1.0610.99
157_Y229_E1.0600.99
108_I123_L1.0580.99
222_S307_H1.0570.99
23_D28_E1.0500.99
122_N125_G1.0410.99
204_L327_I1.0370.99
246_S260_E1.0350.99
317_R344_V1.0310.99
29_V32_S1.0280.99
353_M364_I1.0230.99
103_E107_N1.0200.99
273_S282_L1.0180.99
214_R315_L1.0140.99
183_S201_V1.0140.99
61_E65_K1.0120.99
139_V389_A1.0110.99
283_E334_I1.0030.99
6_V23_D1.0030.99
123_L127_E1.0000.99
183_S213_V0.9990.99
279_L327_I0.9900.99
184_Q387_L0.9890.99
246_S249_A0.9880.99
161_W271_G0.9820.99
186_A377_I0.9810.99
181_Y185_R0.9790.99
220_D314_S0.9790.99
204_L304_I0.9780.99
94_F107_N0.9740.99
37_G281_V0.9730.98
154_A314_S0.9720.98
35_A57_H0.9610.98
332_S355_N0.9580.98
184_Q384_M0.9580.98
254_Q258_D0.9560.98
66_A69_F0.9530.98
92_S164_Y0.9530.98
212_A315_L0.9500.98
189_L362_E0.9490.98
275_L293_A0.9460.98
199_L322_I0.9430.98
20_S29_V0.9420.98
150_M155_Y0.9410.98
285_A289_G0.9410.98
159_L262_V0.9390.98
23_D26_D0.9390.98
206_N277_S0.9340.98
210_I231_L0.9320.98
83_I138_Q0.9300.98
336_R355_N0.9290.98
312_A345_L0.9290.98
141_V177_T0.9280.98
305_A343_A0.9260.98
202_A308_I0.9250.98
187_H194_E0.9230.98
303_R307_H0.9210.98
163_Y248_V0.9120.98
210_I311_H0.9110.98
36_D280_R0.9070.98
297_I334_I0.9050.98
17_I67_I0.9050.98
287_H333_L0.8990.97
297_I301_V0.8980.97
306_R310_G0.8970.97
316_R340_E0.8940.97
42_N54_P0.8930.97
129_A138_Q0.8920.97
223_M226_T0.8910.97
298_K337_L0.8880.97
157_Y272_I0.8820.97
237_S240_V0.8800.97
305_A342_L0.8760.97
197_S215_N0.8760.97
178_S379_T0.8750.97
174_F218_S0.8750.97
152_P155_Y0.8740.97
229_E303_R0.8690.97
186_A199_L0.8660.97
24_A390_I0.8650.97
362_E378_P0.8610.97
334_I337_L0.8610.97
227_P264_N0.8590.97
20_S380_N0.8590.97
130_Q138_Q0.8590.97
155_Y164_Y0.8550.97
87_I108_I0.8540.97
281_V285_A0.8530.97
95_T148_Q0.8530.97
307_H311_H0.8430.96
45_L70_E0.8410.96
148_Q155_Y0.8370.96
352_E356_R0.8300.96
202_A321_I0.8200.96
347_L372_V0.8190.96
307_H310_G0.8160.96
290_H293_A0.8140.95
285_A288_E0.8080.95
254_Q259_L0.8080.95
126_I140_A0.8080.95
316_R343_A0.8030.95
7_V390_I0.8020.95
246_S263_V0.7980.95
41_E56_A0.7960.95
171_R229_E0.7940.95
356_R361_G0.7940.95
150_M220_D0.7900.95
279_L300_F0.7900.95
182_V201_V0.7890.95
340_E351_T0.7860.95
214_R219_V0.7860.95
84_G389_A0.7860.95
300_F334_I0.7840.94
356_R363_R0.7840.94
108_I126_I0.7830.94
159_L169_V0.7810.94
365_V376_V0.7800.94
223_M227_P0.7760.94
334_I338_V0.7750.94
71_L76_L0.7740.94
246_S256_L0.7740.94
152_P295_L0.7730.94
83_I136_V0.7730.94
283_E297_I0.7690.94
248_V262_V0.7690.94
320_G373_I0.7680.94
160_P164_Y0.7650.94
198_G344_V0.7650.94
101_T104_V0.7610.94
127_E130_Q0.7610.94
163_Y252_T0.7600.94
349_I367_S0.7590.93
29_V380_N0.7590.93
181_Y379_T0.7560.93
316_R344_V0.7560.93
146_F173_G0.7550.93
55_L66_A0.7540.93
112_S123_L0.7540.93
313_A344_V0.7510.93
68_A133_F0.7500.93
198_G215_N0.7480.93
57_H63_A0.7470.93
270_L277_S0.7460.93
187_H192_L0.7460.93
34_I44_F0.7450.93
6_V81_A0.7430.93
37_G42_N0.7430.93
321_I339_M0.7410.93
12_C17_I0.7380.93
301_V338_V0.7360.92
55_L58_H0.7330.92
273_S285_A0.7300.92
204_L208_A0.7260.92
197_S320_G0.7260.92
94_F104_V0.7230.92
95_T145_S0.7230.92
92_S168_G0.7220.92
231_L303_R0.7210.92
350_D354_N0.7190.92
85_H138_Q0.7150.91
83_I129_A0.7140.91
283_E287_H0.7130.91
282_L286_W0.7100.91
22_L380_N0.7090.91
351_T355_N0.7070.91
10_I129_A0.7060.91
74_R77_N0.7060.91
262_V267_S0.7030.91
128_S131_Q0.7020.91
366_S373_I0.7010.90
103_E106_D0.7000.90
162_K274_G0.7000.90
153_E341_H0.6990.90
275_L282_L0.6990.90
318_L372_V0.6990.90
245_M263_V0.6990.90
183_S199_L0.6970.90
24_A27_C0.6960.90
312_A372_V0.6920.90
150_M221_T0.6920.90
73_K77_N0.6910.90
187_H196_D0.6910.90
353_M356_R0.6910.90
44_F54_P0.6880.90
169_V247_W0.6880.90
292_R295_L0.6840.89
210_I304_I0.6800.89
204_L300_F0.6780.89
295_L299_T0.6750.89
303_R306_R0.6730.89
225_M247_W0.6710.88
13_G18_K0.6700.88
21_V80_V0.6600.88
72_E77_N0.6590.88
237_S242_F0.6580.87
286_W289_G0.6570.87
279_L331_S0.6560.87
78_D135_G0.6560.87
60_Y63_A0.6540.87
151_A214_R0.6520.87
37_G40_S0.6520.87
256_L259_L0.6510.87
335_R354_N0.6510.87
159_L263_V0.6500.87
154_A220_D0.6480.87
186_A189_L0.6460.87
80_V133_F0.6410.86
89_H122_N0.6410.86
149_T217_Q0.6400.86
302_H306_R0.6400.86
73_K76_L0.6370.86
232_M300_F0.6370.86
200_V312_A0.6350.86
18_K326_G0.6350.86
92_S155_Y0.6350.86
327_I334_I0.6330.85
300_F304_I0.6320.85
98_A101_T0.6290.85
366_S370_A0.6280.85
177_T180_R0.6260.85
323_F338_V0.6260.85
246_S250_S0.6260.85
70_E73_K0.6250.85
158_G299_T0.6240.85
246_S257_G0.6220.84
219_V314_S0.6220.84
68_A72_E0.6220.84
97_S142_F0.6210.84
301_V304_I0.6210.84
200_V315_L0.6190.84
84_G142_F0.6180.84
162_K167_L0.6180.84
349_I365_V0.6170.84
163_Y254_Q0.6170.84
151_A154_A0.6160.84
313_A316_R0.6140.84
40_S43_A0.6130.84
163_Y169_V0.6110.83
318_L345_L0.6110.83
33_G73_K0.6100.83
127_E131_Q0.6100.83
161_W164_Y0.6090.83
149_T218_S0.6090.83
160_P163_Y0.6080.83
25_S390_I0.6070.83
197_S375_A0.6060.83
219_V315_L0.6060.83
20_S356_R0.6040.83
220_D302_H0.6030.83
186_A350_D0.6020.82
9_V385_I0.6020.82
258_D261_R0.6020.82
315_L318_L0.5990.82
163_Y167_L0.5980.82
193_A197_S0.5980.82
283_E286_W0.5980.82
298_K301_V0.5970.82
249_A252_T0.5960.82
43_A57_H0.5950.82
350_D353_M0.5940.82
367_S374_C0.5920.81
35_A63_A0.5900.81
198_G316_R0.5900.81
97_S180_R0.5890.81
182_V186_A0.5880.81
60_Y206_N0.5870.81
194_E213_V0.5870.81
7_V389_A0.5870.81
83_I133_F0.5860.81
226_T243_G0.5860.81
297_I333_L0.5850.81
325_G365_V0.5850.81
250_S256_L0.5830.80
150_M154_A0.5830.80
179_H183_S0.5820.80
273_S296_A0.5810.80
312_A315_L0.5780.80
249_A254_Q0.5770.80
199_L213_V0.5770.80
364_I374_C0.5770.80
16_S206_N0.5760.80
309_A314_S0.5760.80
65_K131_Q0.5750.80
33_G74_R0.5730.79
135_G138_Q0.5730.79
183_S187_H0.5720.79
305_A314_S0.5700.79
130_Q135_G0.5700.79
229_E306_R0.5700.79
272_I296_A0.5700.79
342_L347_L0.5680.79
99_I138_Q0.5650.78
64_L129_A0.5650.78
248_V254_Q0.5650.78
286_W337_L0.5650.78
332_S336_R0.5640.78
313_A341_H0.5640.78
178_S324_T0.5640.78
107_N111_V0.5630.78
189_L364_I0.5630.78
331_S334_I0.5630.78
318_L344_V0.5630.78
223_M228_L0.5620.78
147_H211_C0.5620.78
192_L319_D0.5620.78
109_R123_L0.5610.78
150_M170_R0.5600.78
93_I103_E0.5590.78
70_E74_R0.5590.78
269_L282_L0.5590.78
262_V266_E0.5570.77
295_L298_K0.5570.77
275_L281_V0.5560.77
17_I35_A0.5550.77
122_N174_F0.5550.77
275_L292_R0.5540.77
108_I141_V0.5530.77
80_V136_V0.5520.77
333_L336_R0.5520.77
69_F72_E0.5510.77
365_V374_C0.5500.76
147_H150_M0.5490.76
259_L262_V0.5480.76
105_I108_I0.5460.76
387_L390_I0.5450.76
282_L285_A0.5440.76
340_E343_A0.5440.76
17_I121_A0.5430.76
83_I131_Q0.5420.75
312_A317_R0.5410.75
157_Y224_G0.5400.75
169_V225_M0.5390.75
148_Q170_R0.5370.75
92_S111_V0.5360.75
260_E264_N0.5360.75
335_R349_I0.5350.75
204_L323_F0.5350.75
146_F213_V0.5350.75
364_I368_E0.5330.74
45_L66_A0.5330.74
282_L297_I0.5330.74
388_D391_H0.5320.74
99_I139_V0.5310.74
158_G229_E0.5310.74
88_A145_S0.5310.74
27_C383_K0.5310.74
228_L243_G0.5300.74
111_V123_L0.5300.74
385_I389_A0.5300.74
165_E292_R0.5300.74
66_A70_E0.5290.74
94_F111_V0.5280.74
249_A253_N0.5280.74
363_R376_V0.5260.73
14_S18_K0.5240.73
279_L282_L0.5230.73
122_N243_G0.5230.73
99_I102_D0.5220.73
348_E370_A0.5210.73
269_L297_I0.5210.73
198_G315_L0.5200.72
22_L27_C0.5160.72
86_R143_D0.5160.72
179_H213_V0.5160.72
22_L29_V0.5140.72
237_S267_S0.5140.72
182_V377_I0.5140.72
93_I168_G0.5130.71
105_I109_R0.5120.71
125_G129_A0.5110.71
272_I292_R0.5100.71
115_A119_N0.5090.71
227_P311_H0.5090.71
195_D215_N0.5080.71
308_I321_I0.5050.70
128_S132_L0.5050.70
42_N56_A0.5040.70
146_F227_P0.5040.70
232_M303_R0.5040.70
328_G335_R0.5030.70
186_A320_G0.5020.70
89_H117_L0.5020.70
104_V108_I0.5020.70
246_S259_L0.5020.70
183_S194_E0.5010.70
183_S324_T0.5010.70
165_E274_G0.5000.70
302_H341_H0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sk3A 2 0.9552 100 0.056 Contact Map
4h0pA 2 0.9826 100 0.069 Contact Map
4h0oA 6 0.9478 100 0.085 Contact Map
2e1zA 2 0.9801 100 0.145 Contact Map
2iirA 2 0.9726 100 0.155 Contact Map
1g99A 2 0.9677 100 0.161 Contact Map
3khyA 2 0.9502 100 0.211 Contact Map
3r9pA 2 0.9403 100 0.346 Contact Map
4ijnA 2 0.9254 100 0.498 Contact Map
1sazA 3 0.8706 100 0.537 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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