GREMLIN Database
ARGO - Arginine exporter protein ArgO
UniProt: P11667 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11159
Length: 211 (194)
Sequences: 11916 (8605)
Seq/√Len: 617.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_I112_I5.0851.00
84_G192_W3.5871.00
85_F89_K3.1421.00
182_I185_L2.8681.00
70_A73_T2.7551.00
81_L195_A2.5541.00
146_R150_L2.5131.00
109_W113_A2.4401.00
143_E146_R2.3561.00
38_M108_R2.2521.00
74_W78_A2.2291.00
181_R185_L2.2031.00
88_F185_L2.1781.00
30_G36_H2.1161.00
77_V199_A2.0861.00
82_W86_G2.0841.00
88_F188_G2.0771.00
49_V116_L2.0201.00
11_L132_V2.0191.00
25_F39_I1.9441.00
144_P147_W1.9191.00
86_G89_K1.9181.00
84_G188_G1.8421.00
189_C193_F1.8211.00
77_V195_A1.8131.00
143_E147_W1.7711.00
46_S120_W1.7671.00
22_Q43_C1.7671.00
9_L155_A1.7591.00
23_N163_L1.7021.00
81_L192_W1.6881.00
35_Y111_I1.6521.00
171_A175_R1.6321.00
67_W70_A1.6281.00
91_A185_L1.6241.00
156_S160_F1.6081.00
36_H164_A1.5771.00
16_I155_A1.5571.00
36_H40_A1.5031.00
92_M185_L1.4951.00
30_G164_A1.4851.00
146_R149_A1.4801.00
145_K149_A1.4641.00
113_A117_A1.4621.00
69_L73_T1.4551.00
70_A74_W1.4451.00
60_A64_Q1.4341.00
41_L112_I1.4261.00
81_L85_F1.4041.00
147_W150_L1.3941.00
182_I186_V1.3911.00
26_V30_G1.3501.00
29_Q39_I1.3451.00
17_L159_W1.3421.00
22_Q119_T1.3341.00
67_W71_L1.2991.00
27_M167_A1.2981.00
107_G110_K1.2921.00
116_L120_W1.2911.00
112_I116_L1.2761.00
25_F118_V1.2741.00
74_W77_V1.2621.00
79_F83_Y1.2611.00
37_I165_L1.2571.00
40_A164_A1.2491.00
74_W199_A1.2181.00
8_G12_G1.2071.00
47_D119_T1.2041.00
29_Q114_T1.1791.00
39_I115_M1.1721.00
89_K92_M1.1671.00
22_Q47_D1.1651.00
176_T179_A1.1561.00
145_K148_F1.1551.00
179_A182_I1.1491.00
84_G195_A1.1471.00
138_G141_D1.1431.00
25_F29_Q1.1421.00
162_G166_L1.1321.00
71_L75_G1.1271.00
22_Q118_V1.1271.00
192_W196_L1.1271.00
16_I156_S1.1251.00
159_W163_L1.1221.00
178_K182_I1.1201.00
22_Q156_S1.1021.00
110_K113_A1.0951.00
188_G192_W1.0891.00
169_W172_P1.0871.00
47_D125_V1.0801.00
23_N160_F1.0801.00
26_V160_F1.0681.00
178_K181_R1.0631.00
52_C56_F1.0621.00
42_L112_I1.0521.00
4_Y7_Q1.0501.00
6_F10_A1.0471.00
90_T184_N1.0431.00
44_A157_F1.0241.00
5_Y153_I1.0091.00
37_I161_F1.0081.00
24_A187_V1.0071.00
144_P148_F1.0011.00
110_K114_T0.9961.00
24_A28_N0.9961.00
31_I167_A0.9891.00
7_Q10_A0.9881.00
7_Q11_L0.9811.00
34_Q108_R0.9791.00
79_F82_W0.9781.00
193_F197_Q0.9751.00
47_D50_L0.9681.00
144_P149_A0.9531.00
49_V120_W0.9481.00
26_V164_A0.9471.00
50_L120_W0.9331.00
9_L13_A0.9311.00
34_Q38_M0.9071.00
186_V189_C0.8961.00
106_Q110_K0.8941.00
157_F161_F0.8871.00
13_A155_A0.8741.00
22_Q160_F0.8681.00
50_L126_Y0.8661.00
57_G64_Q0.8641.00
5_Y154_S0.8611.00
117_A121_L0.8521.00
92_M95_N0.8481.00
51_I129_T0.8421.00
28_N32_R0.8411.00
57_G62_L0.8351.00
175_R179_A0.8351.00
185_L189_C0.8351.00
121_L130_F0.8341.00
192_W195_A0.8341.00
160_F163_L0.8341.00
161_F165_L0.8341.00
43_C47_D0.8291.00
169_W173_R0.8281.00
12_G16_I0.8241.00
5_Y9_L0.8211.00
86_G90_T0.8171.00
78_A81_L0.8161.00
23_N159_W0.8151.00
42_L116_L0.8141.00
45_I116_L0.8091.00
23_N27_M0.8091.00
50_L130_F0.8051.00
111_I114_T0.8041.00
46_S116_L0.8031.00
11_L14_A0.7991.00
37_I164_A0.7951.00
50_L119_T0.7951.00
88_F192_W0.7921.00
131_V135_S0.7901.00
150_L153_I0.7891.00
62_L65_S0.7861.00
10_A14_A0.7721.00
180_Q184_N0.7681.00
89_K93_S0.7661.00
45_I49_V0.7641.00
19_L124_H0.7621.00
65_S69_L0.7591.00
173_R179_A0.7581.00
65_S68_L0.7551.00
85_F192_W0.7511.00
105_K109_W0.7451.00
38_M111_I0.7411.00
16_I160_F0.7351.00
144_P151_G0.7331.00
5_Y151_G0.7321.00
75_G78_A0.7311.00
197_Q200_R0.7271.00
40_A44_A0.7261.00
37_I40_A0.7251.00
75_G121_L0.7241.00
26_V39_I0.7201.00
44_A156_S0.7181.00
29_Q32_R0.7181.00
40_A161_F0.7171.00
16_I23_N0.7171.00
166_L170_L0.7061.00
84_G88_F0.7051.00
71_L74_W0.7041.00
27_M163_L0.7031.00
68_L71_L0.7011.00
50_L125_V0.6961.00
59_S63_M0.6951.00
82_W85_F0.6941.00
147_W151_G0.6931.00
166_L169_W0.6911.00
129_T156_S0.6891.00
30_G167_A0.6851.00
173_R176_T0.6831.00
39_I111_I0.6821.00
8_G134_G0.6811.00
159_W162_G0.6791.00
128_D132_V0.6791.00
23_N118_V0.6771.00
46_S119_T0.6751.00
196_L200_R0.6661.00
145_K150_L0.6641.00
50_L54_G0.6611.00
26_V43_C0.6611.00
14_A18_P0.6591.00
54_G59_S0.6591.00
173_R177_A0.6581.00
16_I47_D0.6521.00
47_D156_S0.6511.00
50_L59_S0.6501.00
22_Q125_V0.6491.00
77_V81_L0.6471.00
76_G127_L0.6431.00
142_V145_K0.6391.00
56_F60_A0.6311.00
13_A17_L0.6301.00
16_I159_W0.6291.00
47_D129_T0.6281.00
179_A183_I0.6271.00
141_D145_K0.6241.00
35_Y108_R0.6241.00
92_M181_R0.6221.00
11_L15_M0.6211.00
21_P122_N0.6141.00
18_P23_N0.6141.00
194_I197_Q0.6121.00
54_G126_Y0.6121.00
108_R112_I0.6061.00
158_L162_G0.6041.00
51_I160_F0.6041.00
91_A94_S0.6041.00
119_T125_V0.6001.00
47_D160_F0.5991.00
81_L199_A0.5981.00
35_Y38_M0.5961.00
6_F9_L0.5931.00
33_R161_F0.5921.00
154_S158_L0.5881.00
43_C119_T0.5861.00
8_G136_L0.5861.00
60_A63_M0.5861.00
87_A188_G0.5781.00
18_P184_N0.5771.00
129_T160_F0.5771.00
15_M132_V0.5761.00
149_A153_I0.5761.00
163_L167_A0.5741.00
48_L52_C0.5711.00
160_F164_A0.5711.00
183_I187_V0.5701.00
165_L169_W0.5701.00
186_V190_V0.5691.00
102_E105_K0.5681.00
126_Y130_F0.5661.00
33_R169_W0.5631.00
88_F189_C0.5621.00
21_P124_H0.5561.00
39_I118_V0.5531.00
44_A160_F0.5521.00
66_P70_A0.5511.00
78_A82_W0.5480.99
125_V156_S0.5480.99
174_L179_A0.5470.99
33_R168_A0.5450.99
111_I115_M0.5450.99
162_G165_L0.5450.99
167_A170_L0.5380.99
172_P175_R0.5380.99
65_S70_A0.5380.99
50_L115_M0.5360.99
21_P87_A0.5360.99
138_G146_R0.5340.99
28_N184_N0.5330.99
49_V52_C0.5330.99
114_T118_V0.5330.99
170_L174_L0.5310.99
15_M125_V0.5230.99
86_G114_T0.5220.99
87_A185_L0.5220.99
22_Q26_V0.5210.99
44_A47_D0.5210.99
69_L79_F0.5200.99
9_L12_G0.5180.99
43_C125_V0.5140.99
145_K152_T0.5130.99
33_R165_L0.5120.99
142_V147_W0.5080.99
115_M128_D0.5050.99
18_P160_F0.5030.99
54_G129_T0.5020.99
35_Y107_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9147 18.2 0.936 Contact Map
3o7qA 1 0.9289 15.7 0.938 Contact Map
1pw4A 1 0.4882 8 0.946 Contact Map
4x5mA 2 0.4408 7.8 0.946 Contact Map
3wdoA 1 0.8863 7.6 0.946 Contact Map
4w6vA 1 0.455 7 0.947 Contact Map
4pypA 1 0.9479 6.7 0.948 Contact Map
3giaA 1 0.4455 6.5 0.948 Contact Map
2gfpA 2 0.9384 6 0.949 Contact Map
4xnjA 1 0.9384 5.5 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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