GREMLIN Database
YGGC - Uncharacterized protein YggC
UniProt: P11664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11161
Length: 237 (185)
Sequences: 4706 (2928)
Seq/√Len: 215.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_Q122_D4.8761.00
129_D136_V4.5531.00
84_F114_N4.0271.00
201_A205_R2.9841.00
182_R204_A2.9821.00
113_E117_Q2.9631.00
110_K114_N2.9401.00
195_T198_V2.7491.00
47_F168_C2.7301.00
111_L149_V2.7161.00
124_T141_H2.6981.00
116_R167_F2.5701.00
75_A145_P2.3521.00
64_E148_I2.1771.00
92_D97_R2.1751.00
165_A220_Q2.1321.00
90_W93_A2.1141.00
107_D135_P2.0871.00
119_V169_D2.0581.00
89_S134_D2.0401.00
87_Y90_W1.9921.00
182_R200_E1.9851.00
81_M154_L1.8541.00
116_R163_E1.7991.00
149_V168_C1.7651.00
175_H218_S1.7571.00
87_Y134_D1.7221.00
187_S191_A1.6881.00
88_N100_K1.6371.00
96_L104_E1.6331.00
180_I183_E1.6231.00
118_V147_V1.6101.00
116_R120_E1.5801.00
164_L168_C1.5651.00
155_L171_S1.5641.00
129_D132_K1.5581.00
182_R186_I1.5471.00
128_Y133_H1.5431.00
49_C155_L1.5411.00
170_F223_L1.5001.00
60_T148_I1.4841.00
125_W140_L1.4731.00
114_N117_Q1.4701.00
62_F65_Y1.4681.00
196_R200_E1.4581.00
46_V146_L1.4311.00
90_W94_H1.4131.00
64_E78_T1.4051.00
124_T139_A1.3451.00
83_G125_W1.3371.00
44_T146_L1.3311.00
86_H90_W1.3181.00
59_L174_I1.3041.00
112_T116_R1.2981.00
183_E187_S1.2741.00
88_N134_D1.2611.00
51_P181_L1.2291.00
88_N98_P1.2271.00
171_S222_N1.2141.00
202_F207_D1.2101.00
80_P83_G1.2061.00
190_I199_A1.1961.00
81_M106_F1.1951.00
177_P180_I1.1951.00
77_Q144_A1.1661.00
157_D163_E1.1651.00
175_H226_E1.1611.00
215_L218_S1.1431.00
112_T163_E1.1321.00
178_A208_G1.1221.00
59_L63_W1.1001.00
109_A113_E1.0911.00
208_G211_V1.0831.00
45_V119_V1.0721.00
88_N133_H1.0591.00
162_L166_S1.0491.00
83_G140_L1.0441.00
132_K136_V1.0341.00
84_F111_L1.0301.00
42_R119_V1.0251.00
48_L60_T1.0241.00
186_I200_E1.0221.00
178_A211_V1.0101.00
155_L221_A1.0071.00
110_K137_E1.0051.00
127_Q138_D1.0031.00
109_A163_E1.0001.00
207_D210_N0.9931.00
87_Y135_P0.9901.00
102_A213_R0.9791.00
114_N123_C0.9771.00
190_I196_R0.9751.00
127_Q139_A0.9701.00
200_E204_A0.9621.00
178_A181_L0.9451.00
93_A96_L0.9380.99
68_Q76_I0.9380.99
64_E68_Q0.9360.99
93_A98_P0.9350.99
136_V139_A0.9260.99
60_T78_T0.9240.99
49_C173_F0.9230.99
130_R133_H0.9230.99
207_D211_V0.9130.99
211_V215_L0.9130.99
45_V147_V0.9050.99
91_L105_T0.8960.99
46_V148_I0.8910.99
46_V172_I0.8840.99
75_A144_A0.8790.99
157_D162_L0.8750.99
44_T170_F0.8700.99
110_K126_P0.8680.99
182_R208_G0.8670.99
117_Q120_E0.8610.99
110_K135_P0.8540.99
37_T41_Q0.8490.99
197_Q201_A0.8470.99
127_Q140_L0.8440.99
115_L149_V0.8380.99
198_V201_A0.8310.99
130_R185_L0.8300.99
186_I199_A0.8270.99
88_N96_L0.8260.99
88_N97_R0.8260.99
85_H106_F0.8220.99
86_H107_D0.8180.99
112_T164_L0.8150.99
46_V170_F0.8130.99
124_T140_L0.8080.98
68_Q74_P0.8040.98
37_T40_P0.7990.98
100_K130_R0.7980.98
204_A208_G0.7970.98
80_P140_L0.7970.98
201_A204_A0.7900.98
77_Q147_V0.7890.98
119_V167_F0.7870.98
114_N125_W0.7860.98
62_F66_L0.7850.98
218_S224_I0.7840.98
103_P156_L0.7830.98
67_A146_L0.7760.98
64_E76_I0.7760.98
60_T64_E0.7750.98
124_T138_D0.7690.98
135_P138_D0.7630.98
85_H185_L0.7540.98
111_L115_L0.7540.98
83_G127_Q0.7520.98
117_Q123_C0.7490.98
45_V168_C0.7470.97
53_G227_M0.7460.97
106_F130_R0.7370.97
59_L225_V0.7300.97
206_T209_P0.7300.97
126_P135_P0.7280.97
156_L217_N0.7270.97
81_M108_V0.7230.97
100_K128_Y0.7210.97
183_E200_E0.7200.97
91_L128_Y0.7190.97
99_F102_A0.7190.97
178_A212_E0.7170.97
52_P130_R0.7120.97
179_Q183_E0.7120.97
48_L59_L0.7070.97
212_E216_M0.7060.96
198_V202_F0.7050.96
79_L142_V0.7020.96
78_T148_I0.7020.96
131_Q198_V0.7010.96
118_V123_C0.7000.96
173_F218_S0.6990.96
213_R216_M0.6990.96
64_E77_Q0.6950.96
107_D110_K0.6950.96
108_V112_T0.6950.96
130_R152_N0.6930.96
89_S92_D0.6930.96
208_G212_E0.6930.96
94_H97_R0.6910.96
127_Q136_V0.6850.96
127_Q135_P0.6830.96
40_P43_R0.6810.96
115_L168_C0.6810.96
177_P226_E0.6750.95
186_I196_R0.6710.95
74_P146_L0.6700.95
60_T80_P0.6700.95
61_T65_Y0.6680.95
79_L114_N0.6600.95
111_L164_L0.6580.95
157_D166_S0.6540.95
112_T115_L0.6530.95
110_K113_E0.6500.94
209_P212_E0.6490.94
166_S220_Q0.6480.94
180_I190_I0.6460.94
199_A203_Y0.6440.94
47_F155_L0.6410.94
138_D141_H0.6370.94
81_M111_L0.6340.94
178_A215_L0.6340.94
68_Q145_P0.6270.93
38_V41_Q0.6190.93
68_Q75_A0.6130.93
63_W148_I0.6120.93
99_F212_E0.6100.92
37_T42_R0.6090.92
211_V219_R0.6090.92
57_S61_T0.6020.92
185_L193_G0.6000.92
95_Q98_P0.5960.92
197_Q200_E0.5950.91
40_P120_E0.5920.91
86_H91_L0.5910.91
184_R188_R0.5900.91
128_Y176_A0.5880.91
77_Q142_V0.5870.91
102_A105_T0.5830.91
91_L98_P0.5830.91
112_T167_F0.5820.91
101_G209_P0.5820.91
189_K194_L0.5800.90
217_N220_Q0.5790.90
209_P213_R0.5790.90
153_W156_L0.5790.90
58_T82_D0.5770.90
91_L100_K0.5770.90
88_N91_L0.5740.90
124_T136_V0.5720.90
154_L168_C0.5720.90
84_F123_C0.5660.89
85_H91_L0.5650.89
52_P152_N0.5640.89
66_L69_Q0.5640.89
37_T148_I0.5640.89
85_H130_R0.5630.89
113_E116_R0.5620.89
199_A202_F0.5620.89
202_F208_G0.5610.89
214_V217_N0.5600.89
165_A171_S0.5600.89
52_P189_K0.5520.88
96_L100_K0.5490.88
87_Y137_E0.5480.88
100_K106_F0.5460.88
74_P145_P0.5450.87
91_L210_N0.5400.87
50_A54_T0.5350.87
101_G210_N0.5330.86
165_A169_D0.5330.86
175_H224_I0.5330.86
112_T168_C0.5290.86
52_P207_D0.5280.86
185_L189_K0.5260.86
83_G152_N0.5250.85
85_H101_G0.5240.85
172_I223_L0.5240.85
144_A147_V0.5220.85
124_T127_Q0.5200.85
54_T181_L0.5190.85
101_G105_T0.5170.85
100_K152_N0.5160.84
53_G98_P0.5140.84
185_L207_D0.5140.84
93_A97_R0.5110.84
173_F217_N0.5110.84
129_D134_D0.5110.84
130_R136_V0.5070.83
45_V167_F0.5060.83
49_C171_S0.5060.83
185_L202_F0.5030.83
69_Q74_P0.5020.83
57_S78_T0.5020.83
59_L62_F0.5010.83
66_L224_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ga8A 1 0.8903 100 0.457 Contact Map
3tqcA 2 0.9958 100 0.488 Contact Map
2jeoA 3 0.8017 100 0.555 Contact Map
1a7jA 5 0.7975 100 0.564 Contact Map
1rz3A 1 0.7468 99.9 0.58 Contact Map
4ne2A 2 0.9873 99.9 0.59 Contact Map
4bfzA 2 0.9958 99.9 0.594 Contact Map
1odfA 1 0.9241 99.9 0.595 Contact Map
1uj2A 3 0.8017 99.9 0.626 Contact Map
3c8uA 1 0.8565 99.9 0.642 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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