GREMLIN Database
FUCK - L-fuculokinase
UniProt: P11553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10350
Length: 482 (453)
Sequences: 12530 (8484)
Seq/√Len: 398.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_P214_R4.1551.00
120_V155_E3.9021.00
32_N36_K3.5011.00
28_A71_C3.3531.00
123_N155_E3.2871.00
388_Q392_Q3.1661.00
196_D199_Q2.9311.00
136_I203_S2.8561.00
395_E427_I2.8521.00
43_T70_D2.8271.00
419_Q423_N2.8171.00
106_L160_L2.7951.00
428_P471_Y2.7881.00
363_W375_F2.7781.00
415_T468_R2.7221.00
195_L220_L2.7021.00
41_A74_Q2.6821.00
454_N458_E2.6451.00
50_A108_P2.6231.00
43_T74_Q2.6061.00
404_E430_K2.5931.00
65_L177_R2.5621.00
222_E225_E2.5431.00
101_K165_H2.5261.00
455_S458_E2.5221.00
107_Y157_H2.4911.00
30_A75_I2.4511.00
62_D177_R2.4281.00
100_D163_R2.4251.00
201_D214_R2.3511.00
207_L214_R2.3251.00
196_D203_S2.2921.00
331_P334_M2.2551.00
166_A182_F2.2551.00
204_P208_Q2.2401.00
181_E219_R2.1971.00
250_G255_F2.1841.00
29_I439_V2.1451.00
19_L68_F2.1241.00
175_N249_A2.1181.00
14_E85_R2.0891.00
473_Q476_P2.0821.00
317_V379_A2.0721.00
62_D104_N2.0261.00
123_N127_L2.0091.00
132_R135_A2.0071.00
25_N42_S2.0061.00
231_Q234_A1.9991.00
275_E314_A1.9871.00
371_T374_H1.9801.00
407_L418_N1.9521.00
53_N56_W1.9381.00
17_L72_C1.9341.00
46_A63_A1.9191.00
232_N242_V1.9151.00
16_I447_W1.9051.00
395_E401_K1.9021.00
347_D374_H1.8951.00
21_C26_V1.8871.00
179_T246_V1.8551.00
15_V38_V1.8201.00
17_L28_A1.8181.00
183_T221_V1.8021.00
221_V225_E1.7951.00
151_V155_E1.7901.00
342_I374_H1.7881.00
136_I205_Q1.7821.00
247_I449_G1.7671.00
132_R136_I1.7631.00
321_V379_A1.7341.00
15_V30_A1.7291.00
226_Q229_T1.7261.00
98_L153_L1.7151.00
103_G176_H1.7151.00
100_D104_N1.7131.00
132_R205_Q1.6951.00
122_D126_R1.6861.00
338_E373_G1.6801.00
226_Q247_I1.6791.00
333_Q336_I1.6651.00
334_M338_E1.6371.00
332_W335_L1.6261.00
360_N367_T1.6031.00
119_A123_N1.5971.00
16_I452_E1.5961.00
14_E83_H1.5911.00
266_E404_E1.5901.00
423_N473_Q1.5711.00
428_P469_Y1.5691.00
125_E130_A1.5641.00
430_K469_Y1.5621.00
319_E323_K1.5621.00
264_Q282_A1.5481.00
198_Q284_V1.5411.00
97_A170_I1.5371.00
98_L216_L1.5181.00
377_R381_E1.5181.00
241_P244_I1.5171.00
392_Q395_E1.5081.00
159_Q162_E1.5071.00
60_S63_A1.4951.00
41_A75_I1.4881.00
175_N227_I1.4761.00
334_M337_E1.4721.00
41_A71_C1.4311.00
447_W453_F1.4271.00
62_D66_Q1.4231.00
65_L69_A1.4171.00
333_Q337_E1.4101.00
131_Q135_A1.4091.00
416_L420_I1.4021.00
179_T228_G1.3951.00
213_P216_L1.3921.00
415_T470_F1.3631.00
33_R452_E1.3571.00
99_V168_L1.3561.00
267_P402_A1.3521.00
271_S421_K1.3431.00
86_G446_G1.3401.00
152_W156_N1.3371.00
384_T420_I1.3361.00
39_A75_I1.3361.00
173_L177_R1.3331.00
415_T431_V1.3291.00
229_T243_G1.3281.00
423_N476_P1.3191.00
118_A122_D1.3081.00
384_T421_K1.3081.00
186_I200_R1.3071.00
93_G251_H1.3021.00
404_E428_P1.2971.00
26_V68_F1.2971.00
207_L217_F1.2951.00
101_K166_A1.2931.00
384_T424_M1.2921.00
132_R209_A1.2891.00
221_V227_I1.2891.00
19_L72_C1.2871.00
311_Q386_Q1.2791.00
120_V151_V1.2771.00
30_A79_L1.2681.00
154_K161_L1.2641.00
226_Q245_P1.2581.00
269_L421_K1.2531.00
175_N183_T1.2461.00
66_Q70_D1.2401.00
50_A63_A1.2311.00
147_L210_T1.2251.00
26_V67_R1.2241.00
388_Q425_L1.2231.00
80_T83_H1.2161.00
250_G445_F1.2141.00
95_D109_I1.2081.00
336_I340_R1.1991.00
157_H160_L1.1961.00
420_I424_M1.1961.00
205_Q208_Q1.1901.00
19_L28_A1.1881.00
418_N470_F1.1841.00
70_D74_Q1.1821.00
263_E266_E1.1791.00
103_G182_F1.1731.00
168_L182_F1.1641.00
31_V37_I1.1641.00
133_L141_A1.1611.00
263_E460_R1.1561.00
183_T227_I1.1501.00
68_F174_I1.1501.00
58_Q108_P1.1501.00
339_A416_L1.1491.00
313_L317_V1.1471.00
335_L338_E1.1461.00
15_V83_H1.1381.00
338_E372_R1.1371.00
127_L209_A1.1341.00
186_I220_L1.1281.00
161_L164_A1.1241.00
60_S108_P1.1241.00
342_I346_A1.1231.00
98_L164_A1.1231.00
431_V470_F1.1221.00
336_I339_A1.1211.00
413_R435_A1.1151.00
14_E33_R1.1141.00
325_F375_F1.1131.00
119_A122_D1.1131.00
121_M141_A1.1051.00
46_A50_A1.1051.00
385_A424_M1.1021.00
164_A216_L1.1001.00
16_I450_V1.0971.00
61_L97_A1.0961.00
122_D125_E1.0951.00
226_Q449_G1.0831.00
313_L316_G1.0831.00
406_L430_K1.0811.00
64_I170_I1.0791.00
31_V443_A1.0721.00
159_Q163_R1.0671.00
107_Y160_L1.0661.00
444_L459_A1.0631.00
330_T334_M1.0581.00
266_E406_L1.0541.00
116_R152_W1.0541.00
377_R416_L1.0541.00
448_Y459_A1.0531.00
120_V156_N1.0501.00
263_E457_E1.0501.00
265_N403_S1.0491.00
186_I195_L1.0471.00
366_V370_T1.0441.00
86_G450_V1.0431.00
89_V175_N1.0421.00
207_L212_I1.0401.00
361_A366_V1.0401.00
370_T374_H1.0371.00
98_L150_L1.0371.00
331_P336_I1.0331.00
87_I244_I1.0331.00
45_N67_R1.0301.00
388_Q424_M1.0291.00
391_L425_L1.0271.00
86_G247_I1.0251.00
298_E303_A1.0241.00
57_H113_K1.0171.00
28_A75_I1.0151.00
39_A77_S1.0141.00
433_D464_H1.0091.00
458_E461_A1.0031.00
63_A66_Q0.9971.00
135_A286_T0.9971.00
383_L411_G0.9941.00
15_V79_L0.9911.00
433_D466_Q0.9901.00
123_N126_R0.9891.00
447_W452_E0.9851.00
17_L30_A0.9841.00
147_L193_Q0.9821.00
68_F72_C0.9761.00
247_I450_V0.9751.00
150_L167_W0.9751.00
69_A73_R0.9721.00
133_L193_Q0.9701.00
326_W372_R0.9691.00
337_E340_R0.9671.00
90_T438_T0.9671.00
332_W336_I0.9661.00
229_T245_P0.9651.00
200_R222_E0.9641.00
268_V408_V0.9621.00
338_E341_L0.9621.00
184_T189_A0.9611.00
176_H182_F0.9611.00
283_Q302_Q0.9611.00
335_L376_Y0.9561.00
351_M363_W0.9551.00
16_I86_G0.9521.00
282_A304_G0.9501.00
267_P279_V0.9491.00
37_I40_R0.9441.00
135_A198_Q0.9431.00
195_L199_Q0.9361.00
411_G417_W0.9351.00
198_Q286_T0.9331.00
165_H215_R0.9331.00
31_V440_A0.9321.00
120_V123_N0.9281.00
356_L359_Q0.9241.00
17_L84_I0.9221.00
444_L463_I0.9221.00
104_N177_R0.9191.00
332_W338_E0.9181.00
158_P162_E0.9171.00
98_L167_W0.9161.00
343_A346_A0.9151.00
32_N38_V0.9141.00
30_A84_I0.9131.00
263_E403_S0.9061.00
453_F459_A0.9051.00
404_E469_Y0.9041.00
164_A167_W0.9041.00
412_S435_A0.9031.00
129_S209_A0.9031.00
21_C174_I0.9031.00
82_C241_P0.8991.00
277_L391_L0.8951.00
172_S184_T0.8951.00
107_Y153_L0.8901.00
160_L163_R0.8881.00
433_D465_Y0.8861.00
96_G167_W0.8851.00
180_G231_Q0.8831.00
85_R450_V0.8831.00
345_G348_G0.8801.00
425_L428_P0.8791.00
123_N151_V0.8781.00
153_L160_L0.8751.00
275_E387_L0.8741.00
89_V174_I0.8721.00
88_A247_I0.8721.00
337_E341_L0.8711.00
186_I222_E0.8701.00
151_V154_K0.8681.00
189_A202_F0.8671.00
52_E56_W0.8611.00
331_P338_E0.8601.00
89_V178_L0.8561.00
405_L425_L0.8551.00
186_I298_E0.8551.00
363_W379_A0.8491.00
94_V191_T0.8461.00
202_F217_F0.8441.00
183_T219_R0.8431.00
280_R304_G0.8411.00
121_M148_Y0.8391.00
256_A408_V0.8371.00
453_F462_Q0.8351.00
354_D359_Q0.8341.00
84_I244_I0.8321.00
221_V248_S0.8321.00
392_Q396_K0.8311.00
201_D219_R0.8291.00
366_V375_F0.8291.00
341_L373_G0.8271.00
147_L194_M0.8271.00
351_M355_L0.8261.00
448_Y455_S0.8261.00
169_F192_S0.8231.00
195_L200_R0.8211.00
44_P319_E0.8171.00
21_C68_F0.8161.00
129_S132_R0.8151.00
232_N243_G0.8141.00
229_T242_V0.8141.00
391_L395_E0.8141.00
43_T71_C0.8131.00
45_N59_W0.8111.00
119_A156_N0.8101.00
344_P349_V0.8091.00
316_G319_E0.8081.00
448_Y456_P0.8071.00
336_I414_N0.8071.00
40_R436_E0.8061.00
201_D204_P0.8051.00
289_L396_K0.8041.00
279_V394_L0.7931.00
99_V103_G0.7901.00
287_S397_I0.7891.00
106_L163_R0.7891.00
184_T218_P0.7861.00
380_L420_I0.7861.00
85_R452_E0.7851.00
200_R303_A0.7841.00
115_P142_F0.7811.00
125_E141_A0.7801.00
61_L108_P0.7791.00
150_L194_M0.7791.00
260_A408_V0.7781.00
393_M396_K0.7781.00
93_G188_M0.7771.00
76_N80_T0.7761.00
269_L275_E0.7751.00
342_I345_G0.7741.00
263_E461_A0.7731.00
380_L414_N0.7691.00
93_G308_P0.7671.00
384_T417_W0.7661.00
345_G349_V0.7661.00
31_V434_D0.7661.00
342_I347_D0.7651.00
208_Q214_R0.7601.00
426_D474_T0.7601.00
121_M143_S0.7591.00
253_T276_I0.7591.00
343_A347_D0.7581.00
205_Q209_A0.7571.00
171_S249_A0.7541.00
289_L397_I0.7521.00
184_T220_L0.7511.00
269_L387_L0.7511.00
230_L244_I0.7511.00
99_V182_F0.7461.00
87_I230_L0.7461.00
329_E334_M0.7461.00
151_V211_G0.7451.00
69_A234_A0.7411.00
407_L421_K0.7401.00
63_A67_R0.7401.00
458_E462_Q0.7401.00
331_P335_L0.7391.00
136_I196_D0.7391.00
18_V88_A0.7361.00
281_S285_D0.7351.00
260_A268_V0.7331.00
335_L339_A0.7311.00
62_D173_L0.7301.00
412_S418_N0.7301.00
321_V375_F0.7261.00
112_W274_W0.7251.00
360_N364_Q0.7251.00
230_L240_L0.7251.00
276_I310_M0.7251.00
69_A177_R0.7251.00
351_M378_A0.7231.00
119_A155_E0.7221.00
23_A111_S0.7221.00
256_A438_T0.7201.00
381_E420_I0.7181.00
137_S206_I0.7181.00
79_L83_H0.7181.00
86_G245_P0.7161.00
299_L302_Q0.7151.00
407_L429_V0.7151.00
21_C67_R0.7151.00
133_L206_I0.7141.00
100_D106_L0.7131.00
166_A216_L0.7111.00
240_L243_G0.7111.00
187_T250_G0.7111.00
101_K163_R0.7101.00
459_A463_I0.7101.00
262_A268_V0.7061.00
100_D165_H0.7031.00
33_R85_R0.7031.00
66_Q69_A0.7021.00
43_T67_R0.7001.00
321_V325_F0.6991.00
309_G390_N0.6981.00
175_N179_T0.6981.00
262_A266_E0.6971.00
393_M397_I0.6971.00
314_A383_L0.6971.00
240_L244_I0.6961.00
471_Y474_T0.6951.00
252_D273_T0.6931.00
98_L106_L0.6931.00
70_D73_R0.6921.00
330_T333_Q0.6911.00
267_P405_L0.6901.00
419_Q473_Q0.6891.00
62_D105_L0.6891.00
457_E460_R0.6891.00
196_D201_D0.6881.00
58_Q116_R0.6881.00
173_L176_H0.6871.00
34_Q462_Q0.6871.00
99_V166_A0.6861.00
200_R298_E0.6861.00
444_L462_Q0.6850.99
269_L405_L0.6850.99
103_G165_H0.6830.99
405_L427_I0.6830.99
343_A349_V0.6830.99
403_S427_I0.6810.99
342_I363_W0.6790.99
234_A243_G0.6780.99
203_S206_I0.6780.99
465_Y469_Y0.6770.99
381_E385_A0.6760.99
405_L429_V0.6760.99
407_L431_V0.6750.99
124_I210_T0.6720.99
321_V376_Y0.6710.99
39_A76_N0.6670.99
29_I37_I0.6670.99
345_G350_K0.6650.99
65_L234_A0.6620.99
242_V245_P0.6590.99
459_A462_Q0.6580.99
279_V398_G0.6550.99
69_A72_C0.6550.99
91_T188_M0.6530.99
404_E427_I0.6510.99
319_E322_R0.6490.99
99_V173_L0.6490.99
44_P322_R0.6480.99
223_A249_A0.6470.99
187_T297_C0.6460.99
385_A388_Q0.6420.99
110_I116_R0.6410.99
26_V45_N0.6400.99
172_S182_F0.6390.99
16_I85_R0.6390.99
14_E452_E0.6390.99
349_V370_T0.6390.99
72_C75_I0.6380.99
444_L448_Y0.6380.99
103_G166_A0.6380.99
336_I415_T0.6360.99
331_P339_A0.6360.99
348_G351_M0.6330.99
97_A109_I0.6310.99
99_V176_H0.6310.99
275_E421_K0.6300.99
166_A176_H0.6270.99
463_I466_Q0.6270.99
343_A350_K0.6260.99
455_S461_A0.6260.99
229_T232_N0.6260.99
377_R420_I0.6260.99
141_A193_Q0.6260.99
332_W339_A0.6240.99
419_Q422_A0.6230.99
402_A427_I0.6220.99
344_P350_K0.6220.99
336_I380_L0.6210.99
447_W451_G0.6190.99
68_F71_C0.6190.99
117_T148_Y0.6180.99
187_T223_A0.6170.99
346_A350_K0.6170.99
78_E81_E0.6160.99
171_S188_M0.6150.99
128_I206_I0.6150.99
426_D476_P0.6140.99
261_G463_I0.6140.99
194_M217_F0.6140.99
278_M306_Y0.6120.99
414_N417_W0.6120.99
151_V161_L0.6110.99
226_Q450_V0.6100.99
150_L216_L0.6100.99
92_F112_W0.6100.99
251_H254_Q0.6090.99
96_G146_T0.6070.99
62_D108_P0.6070.99
329_E372_R0.6040.99
97_A105_L0.6040.99
341_L344_P0.6030.99
453_F456_P0.6030.99
311_Q390_N0.6030.99
326_W335_L0.6000.99
61_L109_I0.5990.99
91_T170_I0.5990.99
143_S357_S0.5980.99
457_E461_A0.5980.99
284_V305_L0.5970.99
37_I434_D0.5970.99
31_V439_V0.5970.99
261_G460_R0.5950.99
222_E298_E0.5940.99
148_Y193_Q0.5940.99
151_V210_T0.5930.99
340_R416_L0.5920.99
87_I246_V0.5910.99
124_I148_Y0.5910.99
275_E311_Q0.5910.99
154_K211_G0.5910.99
448_Y453_F0.5910.99
335_L373_G0.5890.98
460_R464_H0.5870.98
434_D440_A0.5870.98
16_I453_F0.5860.98
374_H377_R0.5860.98
415_T419_Q0.5860.98
145_N191_T0.5860.98
419_Q470_F0.5840.98
206_I210_T0.5840.98
344_P347_D0.5840.98
253_T270_S0.5840.98
110_I153_L0.5830.98
131_Q134_Q0.5830.98
277_L390_N0.5820.98
266_E403_S0.5820.98
81_E84_I0.5820.98
315_S319_E0.5820.98
118_A143_S0.5810.98
76_N81_E0.5810.98
161_L165_H0.5800.98
227_I248_S0.5780.98
266_E460_R0.5770.98
257_L278_M0.5760.98
219_R225_E0.5760.98
338_E376_Y0.5760.98
284_V293_A0.5750.98
351_M382_G0.5740.98
320_W323_K0.5730.98
181_E221_V0.5730.98
245_P450_V0.5720.98
269_L277_L0.5720.98
51_M57_H0.5700.98
318_L336_I0.5690.98
139_V145_N0.5690.98
271_S407_L0.5670.98
327_T372_R0.5660.98
208_Q213_P0.5640.98
15_V82_C0.5630.98
212_I217_F0.5630.98
259_G437_T0.5620.98
383_L417_W0.5620.98
339_A377_R0.5620.98
428_P472_P0.5610.98
420_I474_T0.5590.98
168_L176_H0.5580.98
192_S202_F0.5570.98
234_A240_L0.5560.98
67_R70_D0.5560.98
208_Q211_G0.5540.98
93_G191_T0.5540.98
345_G377_R0.5540.98
84_I240_L0.5530.98
24_T27_R0.5530.98
181_E229_T0.5520.98
116_R156_N0.5500.98
340_R415_T0.5500.98
281_S307_N0.5490.98
161_L211_G0.5490.98
59_W111_S0.5480.98
95_D111_S0.5480.98
95_D170_I0.5470.98
62_D65_L0.5460.98
58_Q107_Y0.5450.98
353_C359_Q0.5450.98
317_V342_I0.5440.97
448_Y451_G0.5440.97
23_A112_W0.5390.97
440_A444_L0.5390.97
252_D410_G0.5390.97
257_L296_T0.5380.97
224_G449_G0.5380.97
56_W116_R0.5370.97
322_R332_W0.5350.97
57_H111_S0.5340.97
98_L107_Y0.5310.97
339_A376_Y0.5310.97
230_L241_P0.5300.97
385_A420_I0.5290.97
222_E302_Q0.5280.97
161_L213_P0.5270.97
387_L421_K0.5270.97
60_S66_Q0.5260.97
279_V402_A0.5260.97
106_L164_A0.5250.97
43_T46_A0.5230.97
105_L108_P0.5230.97
344_P348_G0.5220.97
430_K465_Y0.5220.97
56_W110_I0.5220.97
18_V439_V0.5220.97
92_F109_I0.5210.97
125_E129_S0.5200.97
319_E332_W0.5200.97
386_Q389_R0.5200.97
137_S193_Q0.5190.97
77_S81_E0.5190.97
29_I40_R0.5180.97
462_Q465_Y0.5160.97
294_G306_Y0.5150.97
421_K425_L0.5150.97
64_I109_I0.5150.97
422_A429_V0.5140.96
460_R463_I0.5130.96
412_S431_V0.5130.96
456_P460_R0.5120.96
347_D370_T0.5120.96
346_A349_V0.5100.96
309_G312_W0.5100.96
403_S428_P0.5100.96
231_Q243_G0.5100.96
271_S411_G0.5100.96
223_A250_G0.5090.96
94_V112_W0.5090.96
104_N163_R0.5090.96
96_G153_L0.5080.96
277_L387_L0.5080.96
347_D350_K0.5070.96
59_W92_F0.5060.96
258_F444_L0.5060.96
273_T410_G0.5060.96
90_T442_A0.5050.96
41_A76_N0.5050.96
29_I440_A0.5050.96
185_D248_S0.5050.96
99_V165_H0.5030.96
270_S408_V0.5030.96
133_L210_T0.5030.96
198_Q201_D0.5020.96
355_L359_Q0.5010.96
224_G448_Y0.5000.96
234_A239_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9606 100 0.137 Contact Map
2itmA 2 0.9419 100 0.165 Contact Map
3hz6A 1 0.9544 100 0.168 Contact Map
3qdkA 2 0.9647 100 0.174 Contact Map
3ifrA 2 0.9564 100 0.174 Contact Map
3wxlA 2 0.9668 100 0.18 Contact Map
3ezwA 3 0.9564 100 0.18 Contact Map
2w40A 3 0.9585 100 0.187 Contact Map
4bc3A 1 0.9627 100 0.192 Contact Map
3h3nX 3 0.9544 100 0.193 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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