GREMLIN Database
NADA - Quinolinate synthase A
UniProt: P11458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10630
Length: 347 (300)
Sequences: 2277 (1190)
Seq/√Len: 68.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_N81_S4.2731.00
32_K313_E3.2401.00
336_N340_D3.0341.00
239_A245_Q3.0061.00
257_R278_E2.9541.00
325_E328_R2.7741.00
248_A252_T2.7701.00
218_Y257_R2.7351.00
220_D257_R2.7191.00
172_K192_D2.7011.00
35_R39_E2.6871.00
225_V234_V2.6631.00
56_Q268_Y2.4941.00
94_T335_L2.4701.00
323_V328_R2.4511.00
328_R332_L2.4461.00
125_N149_R2.4341.00
103_T315_E2.4101.00
325_E329_E2.3751.00
182_G195_C2.3751.00
82_T315_E2.3681.00
225_V237_A2.3051.00
74_F77_K2.2811.00
251_K273_A2.2541.00
40_R315_E2.2371.00
103_T320_E2.2371.00
32_K35_R2.2331.00
108_T307_A2.2271.00
138_V142_T2.1321.00
332_L336_N2.0931.00
212_T236_M2.0491.00
253_L258_L2.0151.00
82_T105_L2.0101.00
34_K37_L1.9631.00
112_E117_L1.9301.00
222_A249_A1.9221.00
309_A313_E1.9091.00
70_E74_F1.9071.00
160_V185_V1.9041.00
70_E244_S1.8981.00
269_K273_A1.8891.00
29_Y309_A1.8601.00
234_V240_V1.7771.00
251_K274_V1.7651.00
215_Q238_D1.7531.00
60_E70_E1.7511.00
138_V150_A1.7381.00
208_T236_M1.7291.00
246_L270_M1.7161.00
256_Q276_D1.6780.99
212_T216_E1.6430.99
337_R340_D1.6400.99
76_A99_S1.6240.99
32_K309_A1.6230.99
222_A255_H1.6210.99
40_R103_T1.6110.99
314_Q318_N1.6100.99
311_A319_H1.5940.99
40_R82_T1.5920.99
126_A129_D1.5880.99
85_V95_A1.5740.99
160_V164_D1.5710.99
96_K320_E1.5590.99
60_E74_F1.5400.99
40_R81_S1.5140.99
250_A279_L1.5010.99
152_W165_H1.4900.99
222_A253_L1.4640.99
250_A274_V1.4480.98
82_T103_T1.4450.98
160_V188_Q1.4260.98
126_A130_A1.4240.98
135_T171_E1.4230.98
84_L105_L1.4210.98
330_R333_V1.4100.98
231_Q235_D1.3930.98
211_L223_I1.3910.98
165_H341_F1.3870.98
115_L118_G1.3860.98
163_I185_V1.3670.98
213_R217_E1.3490.98
97_I144_A1.3360.97
131_H194_L1.3290.97
310_E314_Q1.3260.97
96_K322_H1.3240.97
46_A58_A1.3240.97
45_V75_G1.3210.97
179_K197_Q1.3200.97
43_V80_A1.3160.97
125_N129_D1.3160.97
41_N82_T1.2900.97
131_H172_K1.2880.97
72_A85_V1.2880.97
86_A308_I1.2830.97
224_L250_A1.2800.97
135_T166_L1.2740.97
54_I308_I1.2740.97
202_V299_W1.2720.97
97_I328_R1.2690.96
256_Q278_E1.2600.96
248_A251_K1.2460.96
41_N80_A1.2420.96
114_S299_W1.2410.96
310_E313_E1.2400.96
253_L277_K1.2230.96
30_R34_K1.2100.95
224_L260_V1.2100.95
225_V261_A1.2090.95
161_E164_D1.1980.95
257_R280_L1.1930.95
187_K231_Q1.1920.95
218_Y280_L1.1910.95
297_C300_M1.1710.94
187_K235_D1.1620.94
72_A99_S1.1610.94
134_R194_L1.1610.94
250_A270_M1.1430.94
164_D189_T1.1330.93
31_E35_R1.1320.93
221_A259_I1.1270.93
167_D191_G1.1250.93
92_G106_M1.1190.93
71_M85_V1.1170.93
127_F174_I1.1050.93
179_K204_D1.0920.92
73_R77_K1.0860.92
157_S244_S1.0850.92
134_R172_K1.0810.92
89_R112_E1.0790.92
244_S248_A1.0750.92
146_V176_A1.0740.91
42_A84_L1.0710.91
73_R339_L1.0630.91
118_G199_A1.0630.91
162_L341_F1.0580.91
138_V176_A1.0580.91
215_Q236_M1.0470.90
206_F295_A1.0420.90
299_W302_M1.0370.90
264_R281_E1.0330.90
69_L73_R1.0320.90
134_R192_D1.0310.90
208_T212_T1.0300.90
201_I299_W1.0280.90
128_C136_V1.0210.89
106_M321_V1.0200.89
266_I270_M1.0180.89
224_L246_L1.0150.89
41_N79_P1.0120.89
183_R186_Q1.0100.89
84_L308_I1.0080.89
185_V193_I1.0030.88
206_F294_C0.9980.88
29_Y306_Q0.9950.88
121_V146_V0.9940.88
120_P123_E0.9910.88
164_D168_S0.9900.88
241_G246_L0.9860.88
119_C146_V0.9820.87
135_T168_S0.9780.87
140_A153_V0.9690.87
213_R216_E0.9630.86
324_D327_L0.9590.86
129_D149_R0.9550.86
184_Y234_V0.9530.86
329_E332_L0.9500.86
249_A258_L0.9490.85
121_V145_A0.9490.85
46_A55_Q0.9340.85
50_T54_I0.9310.84
114_S199_A0.9300.84
131_H134_R0.9220.84
327_L330_R0.9210.84
209_Q213_R0.9160.83
52_P56_Q0.9130.83
124_F176_A0.9130.83
206_F282_A0.9110.83
209_Q212_T0.9080.83
96_K323_V0.9070.83
42_A312_L0.9030.83
183_R231_Q0.9030.83
268_Y272_Q0.9000.82
258_L277_K0.9000.82
311_A318_N0.8970.82
133_D172_K0.8960.82
202_V205_E0.8940.82
184_Y240_V0.8860.81
42_A82_T0.8810.81
150_A334_P0.8790.81
109_L319_H0.8770.81
304_G307_A0.8760.81
223_I261_A0.8740.80
103_T322_H0.8720.80
329_E333_V0.8710.80
183_R187_K0.8670.80
70_E73_R0.8660.80
175_W182_G0.8650.80
45_V71_M0.8630.80
259_I282_A0.8620.79
48_Y269_K0.8600.79
142_T224_L0.8590.79
27_A31_E0.8570.79
274_V277_K0.8540.79
137_V162_L0.8540.79
36_L39_E0.8530.79
167_D171_E0.8520.79
43_V60_E0.8480.78
48_Y241_G0.8450.78
164_D190_G0.8430.78
148_A323_V0.8410.78
114_S201_I0.8410.78
274_V279_L0.8380.78
326_R330_R0.8320.77
40_R312_L0.8260.77
214_L259_I0.8250.76
114_S294_C0.8180.76
43_V78_H0.8170.76
137_V166_L0.8150.76
121_V149_R0.8120.75
171_E192_D0.8110.75
99_S150_A0.8090.75
183_R234_V0.8080.75
142_T199_A0.8060.75
269_K272_Q0.8050.75
214_L280_L0.8040.75
307_A310_E0.8010.74
69_L140_A0.8010.74
79_P82_T0.8010.74
157_S248_A0.7990.74
215_Q223_I0.7980.74
115_L299_W0.7970.74
241_G245_Q0.7960.74
52_P268_Y0.7950.74
187_K234_V0.7950.74
50_T92_G0.7920.73
249_A253_L0.7870.73
172_K194_L0.7850.73
333_V337_R0.7840.73
310_E318_N0.7780.72
212_T215_Q0.7780.72
55_Q268_Y0.7730.72
34_K38_K0.7700.71
105_L315_E0.7690.71
159_A181_L0.7690.71
114_S202_V0.7670.71
119_C196_W0.7670.71
208_T233_I0.7630.71
149_R330_R0.7610.70
247_I266_I0.7570.70
105_L311_A0.7510.69
29_Y305_L0.7510.69
136_V174_I0.7500.69
199_A204_D0.7470.69
138_V334_P0.7470.69
270_M279_L0.7460.69
220_D256_Q0.7460.69
261_A282_A0.7440.69
208_T232_A0.7390.68
308_I311_A0.7390.68
275_P279_L0.7380.68
221_A257_R0.7370.68
97_I331_A0.7360.68
201_I206_F0.7350.68
28_Y31_E0.7350.68
76_A336_N0.7350.68
119_C176_A0.7330.68
31_E216_E0.7320.67
306_Q310_E0.7280.67
115_L201_I0.7260.67
56_Q272_Q0.7240.67
70_E157_S0.7240.67
222_A225_V0.7240.67
108_T302_M0.7210.66
124_F149_R0.7150.66
83_L95_A0.7140.66
323_V327_L0.7140.66
224_L258_L0.7120.65
84_L107_P0.7110.65
110_Q302_M0.7110.65
140_A162_L0.7080.65
186_Q195_C0.7070.65
121_V125_N0.7070.65
271_Q278_E0.7040.64
137_V152_W0.7020.64
54_I303_N0.7000.64
48_Y266_I0.6980.64
26_K53_E0.6930.63
202_V206_F0.6930.63
214_L217_E0.6900.63
314_Q319_H0.6890.63
123_E126_A0.6890.63
36_L313_E0.6890.63
118_G198_G0.6860.62
81_S101_E0.6830.62
186_Q193_I0.6820.62
44_M86_A0.6800.62
157_S246_L0.6800.62
45_V85_V0.6800.62
323_V332_L0.6780.62
78_H140_A0.6770.61
246_L266_I0.6760.61
128_C151_D0.6710.61
48_Y246_L0.6690.61
323_V334_P0.6680.60
115_L199_A0.6670.60
210_A293_S0.6660.60
186_Q192_D0.6650.60
152_W166_L0.6640.60
92_G128_C0.6600.59
128_C149_R0.6600.59
171_E191_G0.6560.59
297_C304_G0.6560.59
297_C303_N0.6540.59
108_T303_N0.6540.59
127_F134_R0.6530.59
137_V154_V0.6490.58
190_G193_I0.6480.58
326_R329_E0.6470.58
69_L157_S0.6450.58
202_V298_P0.6440.58
233_I238_D0.6420.57
124_F128_C0.6420.57
99_S102_K0.6410.57
144_A323_V0.6370.57
73_R245_Q0.6370.57
179_K199_A0.6370.57
127_F131_H0.6370.57
162_L340_D0.6370.57
124_F127_F0.6360.57
174_I194_L0.6340.56
327_L334_P0.6330.56
135_T173_I0.6330.56
30_R56_Q0.6320.56
163_I173_I0.6270.56
296_H299_W0.6260.55
300_M304_G0.6240.55
267_F271_Q0.6230.55
298_P302_M0.6190.55
97_I332_L0.6170.54
146_V196_W0.6120.54
121_V148_A0.6100.54
84_L315_E0.6080.53
250_A258_L0.6070.53
84_L311_A0.6060.53
148_A327_L0.6040.53
296_H301_A0.5980.52
315_E320_E0.5980.52
114_S118_G0.5980.52
38_K256_Q0.5970.52
30_R53_E0.5970.52
42_A105_L0.5960.52
50_T58_A0.5960.52
136_V150_A0.5960.52
138_V153_V0.5940.52
124_F136_V0.5940.52
184_Y195_C0.5910.51
246_L260_V0.5910.51
315_E319_H0.5910.51
128_C174_I0.5890.51
133_D171_E0.5880.51
31_E34_K0.5880.51
184_Y188_Q0.5870.51
122_E126_A0.5860.51
211_L261_A0.5840.50
210_A294_C0.5840.50
132_P172_K0.5820.50
120_P124_F0.5820.50
214_L218_Y0.5770.50
309_A314_Q0.5770.50
55_Q265_G0.5760.49
142_T150_A0.5760.49
27_A56_Q0.5760.49
239_A320_E0.5750.49
112_E115_L0.5750.49
123_E127_F0.5750.49
260_V302_M0.5740.49
33_I309_A0.5740.49
135_T182_G0.5710.49
32_K310_E0.5710.49
266_I269_K0.5700.49
294_C297_C0.5700.49
300_M303_N0.5700.49
245_Q250_A0.5690.49
281_E295_A0.5680.49
37_L44_M0.5640.48
50_T106_M0.5610.48
174_I198_G0.5610.48
278_E281_E0.5610.48
154_V158_I0.5610.48
135_T191_G0.5590.47
28_Y310_E0.5590.47
89_R117_L0.5590.47
124_F146_V0.5570.47
97_I323_V0.5510.46
184_Y187_K0.5490.46
150_A176_A0.5490.46
69_L94_T0.5460.46
170_G191_G0.5460.46
106_M109_L0.5460.46
57_L296_H0.5450.46
89_R116_D0.5440.46
89_R323_V0.5410.45
218_Y278_E0.5390.45
168_S171_E0.5380.45
294_C298_P0.5380.45
46_A54_I0.5370.45
222_A258_L0.5360.45
134_R174_I0.5330.44
89_R106_M0.5330.44
297_C301_A0.5330.44
267_F281_E0.5320.44
48_Y182_G0.5280.44
51_D301_A0.5280.44
97_I330_R0.5270.44
297_C306_Q0.5260.44
207_K210_A0.5260.44
33_I311_A0.5250.43
114_S206_F0.5240.43
204_D230_P0.5240.43
50_T112_E0.5230.43
29_Y32_K0.5220.43
205_E298_P0.5210.43
294_C299_W0.5200.43
250_A260_V0.5180.43
131_H174_I0.5180.43
58_A61_T0.5180.43
101_E122_E0.5170.42
160_V163_I0.5170.42
333_V340_D0.5160.42
69_L339_L0.5160.42
46_A86_A0.5150.42
28_Y32_K0.5140.42
130_A216_E0.5140.42
215_Q259_I0.5130.42
77_K252_T0.5120.42
152_W341_F0.5120.42
172_K191_G0.5100.42
255_H277_K0.5100.42
140_A303_N0.5090.42
140_A341_F0.5090.42
241_G269_K0.5080.41
105_L319_H0.5080.41
43_V82_T0.5060.41
143_S146_V0.5050.41
265_G301_A0.5040.41
51_D54_I0.5020.41
118_G299_W0.5020.41
154_V224_L0.5020.41
166_L186_Q0.5010.41
308_I336_N0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wzuA 1 0.781 100 0.166 Contact Map
4p3xA 1 0.8732 100 0.176 Contact Map
2ekcA 1 0.6369 80.6 0.968 Contact Map
2q5cA 2 0.5072 70.9 0.971 Contact Map
1tqxA 2 0.5648 49.9 0.974 Contact Map
3navA 2 0.6686 48.3 0.975 Contact Map
4ht3A 1 0.683 48.2 0.975 Contact Map
1rd5A 6 0.6744 40.6 0.976 Contact Map
3ig4A 4 0.5101 31.3 0.977 Contact Map
1wa3A 3 0.5504 27.4 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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