GREMLIN Database
ENTF - Enterobactin synthase component F
UniProt: P11454 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10264
Length: 1293 (1023)
Sequences: 16900 (14021)
Seq/√Len: 438.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
597_T614_M4.9631.00
879_L925_Q4.4421.00
802_L842_A4.3291.00
507_S533_L4.1311.00
505_G596_H3.7501.00
505_G811_Q3.6991.00
535_L544_L3.5811.00
61_R74_D3.4731.00
616_G811_Q3.3341.00
268_D297_G3.2981.00
550_D602_F3.0701.00
304_E312_R3.0511.00
980_I1016_L2.8621.00
1025_T1028_Q2.8581.00
487_R527_E2.8471.00
786_I842_A2.8321.00
741_P759_P2.8061.00
638_V663_K2.7061.00
983_A1012_L2.7031.00
34_E129_R2.6951.00
843_R851_E2.6871.00
491_V527_E2.6841.00
799_A853_L2.6761.00
496_L500_R2.6471.00
462_A487_R2.6291.00
464_Q468_T2.6091.00
976_S1043_D2.6061.00
970_R996_D2.5991.00
213_A402_D2.5741.00
787_L803_Y2.5621.00
998_D1001_A2.5511.00
756_S784_L2.5401.00
51_G156_I2.4981.00
259_W416_L2.4951.00
502_V530_A2.4931.00
786_I850_V2.4871.00
805_T835_M2.4661.00
394_I406_L2.4611.00
455_T463_E2.4481.00
619_A752_A2.4451.00
487_R587_A2.4161.00
493_L524_A2.4161.00
484_R488_E2.4121.00
306_L420_F2.4081.00
493_L520_L2.3961.00
784_L804_L2.3921.00
695_S724_E2.3891.00
680_Q684_E2.3761.00
263_L412_R2.3511.00
403_E407_I2.3271.00
907_G939_L2.3001.00
816_R819_L2.2981.00
973_K995_A2.2941.00
616_G619_A2.2611.00
996_D1036_A2.2491.00
509_A553_P2.2421.00
986_S1015_Q2.2421.00
464_Q467_K2.2381.00
998_D1033_S2.2311.00
240_A251_L2.2191.00
637_D688_T2.2161.00
193_D323_H2.1931.00
506_D530_A2.1771.00
909_L939_L2.1721.00
691_H754_D2.1621.00
502_V506_D2.1561.00
506_D554_S2.1471.00
597_T811_Q2.1401.00
200_Q316_Q2.1241.00
468_T471_A2.1211.00
975_G978_T2.1141.00
504_P596_H2.1121.00
974_A1043_D2.1111.00
910_V945_L2.1031.00
227_L392_I2.1011.00
1017_S1023_Q2.0921.00
600_I814_L2.0871.00
783_G827_D2.0781.00
862_I893_N2.0671.00
1034_T1037_K2.0661.00
908_Y959_P2.0621.00
491_V495_N2.0401.00
507_S600_I2.0361.00
244_S307_P2.0351.00
783_G805_T2.0241.00
799_A841_V2.0161.00
49_V53_A2.0061.00
622_N781_N2.0051.00
969_G992_V1.9961.00
36_T129_R1.9911.00
995_A1035_V1.9811.00
472_P480_L1.9761.00
256_A347_P1.9731.00
236_F248_R1.9731.00
518_L645_C1.9661.00
382_L392_I1.9501.00
223_D398_K1.9461.00
270_A295_P1.9381.00
875_V926_L1.9351.00
860_L869_L1.9341.00
307_P425_A1.9291.00
412_R438_E1.9291.00
619_A809_L1.9221.00
394_I410_A1.9171.00
637_D717_K1.9131.00
649_V691_H1.9101.00
54_Q152_Q1.9061.00
595_H618_T1.8851.00
546_M609_R1.8821.00
981_A1035_V1.8821.00
257_A298_I1.8711.00
510_V522_L1.8701.00
637_D662_A1.8681.00
983_A1016_L1.8671.00
96_T99_A1.8571.00
7_L69_V1.8491.00
223_D403_E1.8461.00
877_Q884_Q1.8451.00
495_N588_P1.8401.00
51_G153_I1.8311.00
475_A663_K1.8291.00
490_V527_E1.8271.00
237_R384_P1.8161.00
878_A929_T1.8151.00
629_N780_W1.8121.00
117_L140_L1.8041.00
970_R995_A1.8021.00
638_V687_V1.8011.00
994_D997_A1.8001.00
886_V953_L1.7991.00
1007_L1010_M1.7991.00
979_I1019_Q1.7851.00
845_L851_E1.7721.00
668_E671_A1.7591.00
136_Y141_V1.7561.00
908_Y961_P1.7501.00
827_D833_E1.7481.00
546_M602_F1.7411.00
974_A995_A1.7371.00
984_F1035_V1.7341.00
999_F1004_G1.7321.00
256_A380_L1.7321.00
652_W754_D1.7271.00
784_L802_L1.7261.00
151_R285_T1.7241.00
489_Q517_F1.7231.00
225_L407_I1.7231.00
500_R573_T1.7211.00
758_Y774_P1.7201.00
45_A49_V1.7181.00
1012_L1029_V1.7141.00
487_R491_V1.7111.00
906_V940_L1.7101.00
667_A681_F1.7071.00
19_K64_E1.6961.00
487_R490_V1.6961.00
194_A326_Y1.6911.00
595_H616_G1.6901.00
745_L754_D1.6891.00
642_K693_V1.6771.00
1028_Q1041_I1.6771.00
643_T649_V1.6731.00
510_V521_A1.6721.00
457_L620_I1.6691.00
507_S531_A1.6681.00
470_D484_R1.6661.00
462_A527_E1.6601.00
521_A557_I1.6591.00
86_D124_Q1.6561.00
845_L849_A1.6531.00
691_H745_L1.6531.00
255_L417_I1.6511.00
652_W691_H1.6451.00
48_V120_H1.6391.00
758_Y849_A1.6371.00
256_A349_L1.6351.00
623_R754_D1.6351.00
1032_A1041_I1.6351.00
423_D426_L1.6341.00
974_A978_T1.6321.00
665_V681_F1.6301.00
427_L430_D1.6261.00
380_L394_I1.6221.00
481_F520_L1.6191.00
886_V945_L1.6191.00
149_I287_T1.6171.00
671_A677_A1.6151.00
653_E691_H1.6031.00
665_V687_V1.6011.00
268_D299_H1.6011.00
432_D439_Y1.6011.00
60_M71_Q1.6001.00
623_R652_W1.6001.00
539_Y547_M1.5991.00
593_Q596_H1.5981.00
982_A1019_Q1.5961.00
475_A685_Y1.5951.00
272_G345_F1.5931.00
88_R127_D1.5911.00
503_K506_D1.5891.00
204_L270_A1.5831.00
942_L945_L1.5811.00
445_L844_W1.5791.00
909_L941_Q1.5681.00
44_L153_I1.5671.00
987_L1012_L1.5611.00
640_A667_A1.5601.00
788_D792_H1.5571.00
472_P663_K1.5551.00
548_L553_P1.5551.00
305_T308_E1.5511.00
476_D516_V1.5411.00
462_A490_V1.5381.00
830_A833_E1.5381.00
212_P405_T1.5311.00
481_F516_V1.5221.00
419_Q432_D1.5211.00
1027_G1031_V1.5101.00
545_K549_E1.5071.00
691_H722_S1.5061.00
219_S399_Q1.5021.00
456_T459_A1.5001.00
720_F745_L1.4961.00
858_D955_R1.4901.00
979_I982_A1.4871.00
784_L842_A1.4861.00
674_D677_A1.4851.00
261_G300_I1.4831.00
195_A199_E1.4811.00
463_E467_K1.4801.00
295_P331_I1.4781.00
250_D314_A1.4781.00
681_F685_Y1.4751.00
539_Y646_S1.4741.00
623_R722_S1.4731.00
825_I835_M1.4721.00
1005_H1026_P1.4711.00
1005_H1008_L1.4651.00
100_L123_I1.4641.00
895_A903_R1.4631.00
873_D891_V1.4631.00
524_A528_A1.4591.00
519_T654_F1.4581.00
1007_L1026_P1.4551.00
338_A341_D1.4491.00
299_H304_E1.4431.00
978_T982_A1.4411.00
1005_H1009_A1.4371.00
114_G117_L1.4341.00
977_E995_A1.4321.00
39_V130_W1.4311.00
980_I1035_V1.4261.00
691_H694_P1.4231.00
865_Q933_H1.4221.00
50_A53_A1.4211.00
254_A309_L1.4201.00
44_L132_W1.4191.00
623_R691_H1.4181.00
461_V465_A1.4171.00
613_V810_A1.4161.00
12_P68_E1.4161.00
36_T366_Q1.4161.00
460_L621_V1.4131.00
643_T691_H1.4101.00
1005_H1010_M1.4081.00
895_A898_T1.4051.00
208_A211_S1.4021.00
649_V754_D1.4001.00
257_A271_A1.3941.00
97_A131_Y1.3941.00
755_V804_L1.3901.00
248_R390_L1.3861.00
255_L420_F1.3831.00
918_D921_A1.3821.00
472_P482_S1.3821.00
531_A597_T1.3801.00
193_D325_R1.3791.00
196_F320_M1.3761.00
62_F140_L1.3741.00
521_A525_I1.3711.00
55_A152_Q1.3701.00
533_L551_A1.3691.00
301_A304_E1.3691.00
60_M73_V1.3671.00
875_V929_T1.3641.00
1016_L1022_R1.3611.00
559_T562_Q1.3611.00
38_E128_N1.3601.00
973_K1036_A1.3561.00
541_D545_K1.3551.00
472_P475_A1.3551.00
1011_K1015_Q1.3541.00
649_V722_S1.3491.00
791_M803_Y1.3481.00
981_A995_A1.3471.00
263_L409_H1.3441.00
414_K418_A1.3441.00
722_S754_D1.3401.00
88_R124_Q1.3381.00
785_R829_F1.3361.00
560_D578_N1.3361.00
461_V523_H1.3341.00
640_A682_F1.3311.00
980_I1039_A1.3261.00
458_S617_Q1.3241.00
584_Q588_P1.3221.00
110_R113_S1.3221.00
592_S596_H1.3211.00
969_G994_D1.3201.00
407_I411_E1.3201.00
479_Y489_Q1.3171.00
550_D816_R1.3161.00
495_N584_Q1.3151.00
85_I121_Q1.3131.00
877_Q885_A1.3131.00
230_E418_A1.3121.00
623_R753_V1.3111.00
669_P672_H1.3051.00
502_V508_V1.3051.00
228_K389_D1.3031.00
300_I304_E1.3021.00
801_D837_R1.3001.00
416_L431_V1.2991.00
651_V753_V1.2981.00
976_S979_I1.2911.00
41_S122_L1.2901.00
505_G597_T1.2891.00
477_A668_E1.2891.00
502_V528_A1.2881.00
445_L796_P1.2871.00
56_D173_P1.2861.00
637_D689_T1.2851.00
786_I802_L1.2851.00
191_Q195_A1.2851.00
689_T718_Q1.2781.00
883_E912_Q1.2761.00
638_V665_V1.2751.00
1009_A1013_A1.2741.00
420_F431_V1.2731.00
460_L625_L1.2691.00
909_L922_L1.2691.00
973_K977_E1.2681.00
239_L421_A1.2671.00
94_H98_Q1.2631.00
827_D835_M1.2611.00
541_D565_R1.2601.00
628_Q660_A1.2591.00
623_R653_E1.2581.00
649_V652_W1.2551.00
652_W745_L1.2541.00
691_H696_M1.2531.00
455_T459_A1.2501.00
876_M907_G1.2481.00
440_A444_Q1.2471.00
219_S397_N1.2461.00
458_S592_S1.2461.00
440_A443_A1.2451.00
512_L521_A1.2451.00
156_I168_A1.2431.00
298_I313_L1.2421.00
441_Q444_Q1.2401.00
549_E609_R1.2371.00
976_S1042_I1.2341.00
981_A993_Q1.2251.00
623_R752_A1.2241.00
104_D135_R1.2241.00
641_Q666_M1.2201.00
1010_M1026_P1.2171.00
642_K692_F1.2171.00
104_D107_Q1.2161.00
207_P341_D1.2151.00
1013_A1029_V1.2151.00
194_A198_A1.2151.00
99_A103_A1.2131.00
303_Q429_G1.2121.00
558_T562_Q1.2121.00
252_A351_I1.2101.00
702_A733_E1.2061.00
1028_Q1031_V1.2051.00
509_A548_L1.2031.00
726_L744_N1.2011.00
258_L416_L1.2001.00
235_E418_A1.1991.00
1000_F1030_M1.1991.00
61_R114_G1.1981.00
12_P182_Q1.1951.00
657_P662_A1.1941.00
819_L823_R1.1911.00
697_L721_C1.1901.00
315_A319_K1.1891.00
1009_A1026_P1.1881.00
785_R827_D1.1851.00
923_Q927_R1.1821.00
550_D609_R1.1811.00
349_L413_L1.1811.00
258_L309_L1.1811.00
891_V907_G1.1761.00
465_A487_R1.1751.00
476_D479_Y1.1731.00
642_K754_D1.1721.00
551_A602_F1.1691.00
450_V781_N1.1671.00
911_S941_Q1.1671.00
227_L410_A1.1631.00
34_E366_Q1.1611.00
862_I867_I1.1611.00
235_E422_A1.1591.00
475_A480_L1.1591.00
225_L403_E1.1571.00
970_R1036_A1.1561.00
722_S752_A1.1551.00
254_A313_L1.1551.00
1005_H1016_L1.1511.00
40_D157_Y1.1461.00
615_V810_A1.1461.00
841_V856_S1.1451.00
452_I781_N1.1441.00
50_A156_I1.1441.00
426_L430_D1.1421.00
804_L838_T1.1401.00
652_W722_S1.1401.00
751_A809_L1.1401.00
252_A390_L1.1381.00
817_P821_A1.1381.00
111_V139_L1.1371.00
40_D43_L1.1351.00
474_L516_V1.1321.00
259_W413_L1.1321.00
869_L891_V1.1311.00
196_F319_K1.1291.00
539_Y949_A1.1291.00
642_K696_M1.1281.00
620_I753_V1.1271.00
693_V754_D1.1261.00
875_V878_A1.1261.00
53_A76_A1.1261.00
430_D792_H1.1261.00
221_S399_Q1.1251.00
349_L382_L1.1251.00
783_G833_E1.1251.00
45_A80_E1.1251.00
686_G715_T1.1231.00
628_Q656_W1.1231.00
1015_Q1019_Q1.1211.00
36_T364_Q1.1211.00
640_A681_F1.1171.00
458_S526_V1.1171.00
779_V782_T1.1151.00
624_L659_I1.1131.00
474_L519_T1.1131.00
923_Q939_L1.1111.00
517_F559_T1.1101.00
727_P730_L1.1101.00
895_A900_G1.1091.00
4_H70_W1.1091.00
796_P844_W1.1091.00
653_E745_L1.1081.00
614_M814_L1.1081.00
411_E435_L1.1061.00
1016_L1042_I1.1061.00
751_A804_L1.1041.00
441_Q445_L1.1041.00
615_V752_A1.1011.00
623_R696_M1.1001.00
225_L410_A1.1001.00
462_A491_V1.0971.00
652_W696_M1.0961.00
633_L662_A1.0951.00
810_A824_F1.0931.00
925_Q929_T1.0911.00
14_I289_P1.0911.00
244_S311_T1.0891.00
731_C742_L1.0881.00
9_A181_Y1.0871.00
122_L132_W1.0851.00
1032_A1037_K1.0841.00
490_V524_A1.0831.00
643_T692_F1.0821.00
694_P730_L1.0811.00
634_T637_D1.0801.00
200_Q319_K1.0801.00
1009_A1029_V1.0771.00
555_L573_T1.0771.00
984_F1004_G1.0761.00
235_E421_A1.0731.00
641_Q664_L1.0721.00
546_M550_D1.0711.00
62_F139_L1.0701.00
734_W742_L1.0691.00
196_F200_Q1.0671.00
233_D390_L1.0661.00
542_D546_M1.0651.00
505_G530_A1.0641.00
751_A755_V1.0621.00
692_F697_L1.0591.00
402_D405_T1.0581.00
653_E754_D1.0561.00
380_L392_I1.0561.00
627_M652_W1.0561.00
743_H759_P1.0551.00
63_T72_W1.0521.00
690_T716_L1.0511.00
985_S992_V1.0511.00
379_E395_L1.0501.00
32_Y131_Y1.0501.00
224_I395_L1.0501.00
1012_L1038_L1.0491.00
500_R555_L1.0491.00
922_L939_L1.0481.00
401_Y406_L1.0481.00
177_V180_E1.0481.00
512_L557_I1.0471.00
396_A406_L1.0471.00
623_R755_V1.0461.00
207_P210_L1.0411.00
446_N781_N1.0411.00
624_L656_W1.0381.00
718_Q743_H1.0361.00
698_A727_P1.0361.00
1016_L1024_V1.0341.00
199_E202_R1.0341.00
253_L349_L1.0341.00
995_A1036_A1.0331.00
657_P664_L1.0301.00
261_G264_C1.0291.00
1016_L1020_V1.0271.00
522_L654_F1.0271.00
728_A732_R1.0271.00
223_D396_A1.0251.00
893_N903_R1.0251.00
246_V250_D1.0251.00
461_V487_R1.0251.00
1022_R1042_I1.0241.00
879_L922_L1.0241.00
459_A462_A1.0231.00
777_Y849_A1.0221.00
489_Q492_A1.0211.00
1013_A1017_S1.0211.00
539_Y933_H1.0181.00
858_D873_D1.0161.00
785_R805_T1.0151.00
97_A123_I1.0141.00
648_D748_P1.0121.00
526_V598_A1.0111.00
516_V520_L1.0111.00
104_D121_Q1.0091.00
32_Y133_Y1.0091.00
252_A382_L1.0091.00
694_P754_D1.0071.00
531_A600_I1.0061.00
786_I794_V1.0061.00
588_P592_S1.0051.00
513_P559_T1.0051.00
238_Q243_L1.0051.00
756_S775_I1.0011.00
496_L575_L0.9991.00
748_P754_D0.9991.00
408_Q412_R0.9981.00
482_S485_E0.9981.00
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Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dg8A 1 0.3805 100 0.57 Contact Map
4iz6A 2 0.4563 100 0.592 Contact Map
4r0mB 1 0.4532 100 0.605 Contact Map
1amuA 1 0.3906 100 0.632 Contact Map
4d4iA 1 0.3666 100 0.639 Contact Map
3tsyA 2 0.5205 100 0.655 Contact Map
3g7sA 2 0.3627 100 0.66 Contact Map
4gr5A 1 0.3542 100 0.664 Contact Map
3wvnA 1 0.2931 100 0.667 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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