GREMLIN Database
ARLY - Argininosuccinate lyase
UniProt: P11447 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11223
Length: 457 (406)
Sequences: 10942 (5673)
Seq/√Len: 281.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_V55_Q3.8011.00
54_E102_K3.4451.00
38_V63_N3.3051.00
46_T211_Q3.2391.00
355_R358_E3.2361.00
42_K59_E3.1431.00
394_E398_Q2.9871.00
302_A331_A2.8561.00
42_K215_W2.8421.00
133_R180_E2.7521.00
32_Q123_D2.7491.00
417_I420_D2.7281.00
246_M299_V2.6971.00
136_Q177_A2.6731.00
357_Q361_Q2.6351.00
64_V95_K2.6271.00
138_A343_A2.6151.00
129_L184_Q2.5921.00
138_A347_D2.5631.00
125_V238_L2.5451.00
126_S187_L2.5381.00
28_R333_D2.5151.00
295_K338_C2.5071.00
165_F351_V2.4751.00
211_Q214_G2.3701.00
131_A340_H2.3531.00
189_R237_E2.3471.00
129_L180_E2.3391.00
142_T145_N2.2761.00
122_K191_D2.2621.00
51_T54_E2.2291.00
243_A303_L2.2261.00
45_V52_A2.1731.00
148_D353_R2.1461.00
191_D219_A2.1301.00
134_Q343_A2.1261.00
270_S350_Q2.1101.00
394_E409_E2.1001.00
343_A347_D2.0501.00
133_R184_Q2.0341.00
358_E362_Q2.0071.00
136_Q180_E1.9691.00
52_A56_A1.9591.00
141_E347_D1.9391.00
210_E214_G1.8911.00
400_K408_S1.8831.00
355_R359_A1.8761.00
131_A336_L1.8731.00
141_E145_N1.8531.00
180_E184_Q1.8461.00
185_D189_R1.8421.00
211_Q215_W1.8391.00
247_V300_Q1.8391.00
253_A292_I1.8391.00
298_R327_G1.8361.00
357_Q428_Q1.8241.00
138_A346_L1.8201.00
35_V123_D1.8111.00
132_N245_G1.8021.00
268_E352_K1.7951.00
182_R237_E1.7781.00
403_E422_Y1.7761.00
140_V177_A1.7301.00
56_A60_E1.7241.00
193_S213_A1.7221.00
426_S429_S1.7041.00
185_D188_K1.6961.00
38_V59_E1.6831.00
146_N149_A1.6731.00
222_T228_S1.6601.00
192_V220_S1.6501.00
179_D248_H1.6291.00
353_R357_Q1.6271.00
249_L292_I1.6161.00
134_Q344_L1.6041.00
136_Q173_V1.6031.00
418_D422_Y1.5981.00
407_L418_D1.5651.00
178_R227_D1.5511.00
253_A342_A1.5431.00
420_D423_P1.5411.00
236_L310_L1.5351.00
55_Q59_E1.5291.00
387_I390_E1.5281.00
292_I342_A1.4841.00
131_A343_A1.4741.00
42_K211_Q1.4711.00
298_R330_D1.4611.00
121_C328_L1.4531.00
400_K405_L1.4531.00
243_A307_M1.4471.00
407_L422_Y1.4461.00
143_A173_V1.4431.00
238_L332_L1.4411.00
197_C228_S1.4201.00
34_I88_V1.4061.00
305_G323_E1.4001.00
232_R321_M1.3991.00
142_T146_N1.3811.00
178_R233_D1.3751.00
124_T336_L1.3601.00
186_A241_A1.3561.00
43_A211_Q1.3531.00
270_S348_G1.3411.00
352_K355_R1.3341.00
181_S189_R1.3301.00
289_L345_V1.3291.00
258_F314_P1.3281.00
188_K219_A1.3271.00
13_D16_F1.3201.00
134_Q347_D1.3111.00
31_E35_V1.3101.00
354_P358_E1.3101.00
136_Q176_L1.3041.00
268_E350_Q1.2951.00
387_I415_Q1.2891.00
401_P404_D1.2881.00
91_K95_K1.2801.00
400_K404_D1.2801.00
38_V66_L1.2781.00
169_C172_Y1.2781.00
38_V42_K1.2741.00
28_R124_T1.2721.00
63_N67_E1.2711.00
165_F169_C1.2591.00
135_L343_A1.2571.00
140_V144_Q1.2531.00
33_D112_Q1.2511.00
121_C238_L1.2491.00
240_S244_I1.2481.00
239_L306_M1.2421.00
106_G208_D1.2411.00
129_L187_L1.2251.00
252_F342_A1.2211.00
172_Y316_A1.2141.00
144_Q147_Q1.2101.00
236_L244_I1.2101.00
127_E336_L1.2051.00
49_V105_T1.2051.00
304_T308_M1.2051.00
394_E405_L1.2011.00
68_D95_K1.1921.00
88_V92_L1.1921.00
292_I338_C1.1911.00
138_A141_E1.1891.00
63_N66_L1.1781.00
41_S50_L1.1761.00
93_I100_G1.1761.00
132_N176_L1.1741.00
239_L328_L1.1721.00
57_Q60_E1.1721.00
301_G305_G1.1591.00
149_A353_R1.1481.00
246_M335_W1.1441.00
300_Q308_M1.1421.00
23_L330_D1.1331.00
146_N353_R1.1281.00
165_F356_C1.1271.00
373_Y420_D1.1231.00
92_L103_L1.1221.00
245_G335_W1.1191.00
373_Y424_I1.1171.00
344_L347_D1.1151.00
245_G339_L1.1151.00
265_G355_R1.1131.00
135_L176_L1.0981.00
239_L331_A1.0971.00
34_I65_L1.0951.00
235_V328_L1.0931.00
183_L245_G1.0911.00
140_V173_V1.0911.00
403_E407_L1.0881.00
139_L252_F1.0861.00
306_M328_L1.0831.00
131_A134_Q1.0811.00
256_L289_L1.0811.00
36_G112_Q1.0721.00
56_A59_E1.0721.00
133_R137_S1.0701.00
46_T215_W1.0701.00
31_E66_L1.0661.00
296_C300_Q1.0611.00
135_L346_L1.0591.00
134_Q340_H1.0561.00
398_Q405_L1.0541.00
62_L65_L1.0491.00
39_A215_W1.0491.00
148_D166_A1.0461.00
213_A219_A1.0461.00
299_V335_W1.0461.00
151_M356_C1.0421.00
129_L133_R1.0421.00
147_Q166_A1.0421.00
370_L406_P1.0391.00
91_K94_D1.0381.00
128_L335_W1.0381.00
34_I66_L1.0381.00
59_E63_N1.0341.00
70_R95_K1.0331.00
170_L224_N1.0331.00
117_L325_K1.0331.00
106_G207_I1.0331.00
250_S293_R1.0311.00
13_D17_K1.0281.00
172_Y252_F1.0261.00
68_D91_K1.0231.00
298_R326_E1.0231.00
241_A245_G1.0201.00
238_L328_L1.0191.00
142_T169_C1.0111.00
57_Q61_A1.0091.00
64_V69_V1.0081.00
374_L388_V1.0061.00
61_A64_V1.0051.00
125_V187_L1.0011.00
32_Q119_L1.0001.00
124_T127_E0.9991.00
305_G327_G0.9971.00
198_G279_L0.9941.00
31_E123_D0.9871.00
81_A90_G0.9841.00
181_S188_K0.9841.00
159_R262_G0.9821.00
57_Q99_L0.9811.00
162_P360_A0.9791.00
142_T346_L0.9771.00
122_K187_L0.9731.00
117_L235_V0.9721.00
150_V431_L0.9651.00
149_A356_C0.9631.00
147_Q164_T0.9631.00
163_V200_L0.9601.00
122_K218_F0.9591.00
249_L342_A0.9581.00
187_L191_D0.9581.00
164_T431_L0.9571.00
52_A55_Q0.9571.00
185_D237_E0.9551.00
45_V56_A0.9521.00
117_L328_L0.9491.00
174_E178_R0.9421.00
27_Y31_E0.9421.00
132_N180_E0.9401.00
153_G163_V0.9401.00
393_V397_R0.9371.00
31_E70_R0.9341.00
298_R334_T0.9281.00
156_H290_E0.9281.00
394_E397_R0.9241.00
395_A405_L0.9231.00
51_T102_K0.9221.00
240_S303_L0.9201.00
247_V310_L0.9201.00
326_E330_D0.9191.00
124_T332_L0.9101.00
390_E409_E0.9081.00
181_S185_D0.9071.00
125_V183_L0.9041.00
47_V208_D0.9001.00
209_R213_A0.8991.00
35_V215_W0.8981.00
60_E64_V0.8981.00
33_D36_G0.8961.00
66_L70_R0.8951.00
256_L349_I0.8931.00
159_R263_E0.8891.00
49_V208_D0.8891.00
64_V68_D0.8881.00
53_E56_A0.8881.00
270_S352_K0.8841.00
394_E408_S0.8801.00
302_A330_D0.8791.00
46_T52_A0.8791.00
249_L339_L0.8781.00
81_A87_W0.8771.00
139_L169_C0.8771.00
36_G115_T0.8761.00
154_Y159_R0.8731.00
239_L303_L0.8721.00
61_A65_L0.8711.00
265_G352_K0.8681.00
68_D73_P0.8681.00
28_R123_D0.8681.00
419_E423_P0.8651.00
291_L341_M0.8631.00
43_A47_V0.8631.00
136_Q140_V0.8621.00
145_N350_Q0.8611.00
27_Y71_A0.8601.00
67_E70_R0.8581.00
269_L349_I0.8551.00
242_A335_W0.8531.00
303_L307_M0.8521.00
163_V226_L0.8501.00
143_A170_L0.8491.00
406_P409_E0.8481.00
149_A351_V0.8461.00
191_D218_F0.8451.00
46_T208_D0.8431.00
139_L346_L0.8431.00
157_L258_F0.8421.00
32_Q120_W0.8401.00
53_E57_Q0.8381.00
61_A96_V0.8351.00
98_Q101_K0.8271.00
258_F264_A0.8261.00
360_A427_L0.8191.00
173_V177_A0.8150.99
174_E223_R0.8150.99
250_S311_K0.8130.99
159_R363_G0.8110.99
139_L173_V0.8080.99
404_D408_S0.8070.99
150_V360_A0.8060.99
123_D126_S0.8050.99
340_H344_L0.8050.99
193_S212_L0.8020.99
33_D88_V0.8010.99
137_S141_E0.8000.99
35_V66_L0.8000.99
115_T193_S0.7990.99
231_D248_H0.7970.99
167_H225_S0.7960.99
138_A142_T0.7940.99
394_E400_K0.7920.99
64_V70_R0.7880.99
145_N353_R0.7810.99
31_E71_A0.7810.99
35_V212_L0.7780.99
297_G305_G0.7720.99
403_E418_D0.7700.99
421_V425_L0.7700.99
40_W107_R0.7680.99
391_A405_L0.7660.99
176_L339_L0.7660.99
135_L339_L0.7640.99
262_G265_G0.7620.99
194_P228_S0.7590.99
237_E240_S0.7580.99
42_K46_T0.7560.99
168_W259_F0.7550.99
148_D428_Q0.7540.99
157_L261_T0.7540.99
20_N341_M0.7510.99
374_L387_I0.7490.99
391_A402_L0.7490.99
400_K409_E0.7480.99
247_V307_M0.7480.99
309_T323_E0.7470.99
45_V50_L0.7470.99
209_R221_A0.7460.99
209_R212_L0.7450.99
152_P264_A0.7440.99
41_S55_Q0.7440.99
70_R73_P0.7440.99
188_K191_D0.7430.99
361_Q403_E0.7430.99
146_N351_V0.7410.99
212_L215_W0.7400.99
16_F288_A0.7370.99
298_R302_A0.7330.99
151_M168_W0.7300.99
220_S223_R0.7270.99
66_L69_V0.7260.99
67_E71_A0.7220.99
193_S221_A0.7200.99
300_Q304_T0.7200.99
73_P94_D0.7200.99
212_L216_L0.7160.99
351_V356_C0.7140.99
29_L113_V0.7130.99
139_L176_L0.7080.99
16_F21_D0.7060.99
132_N339_L0.7050.99
230_S316_A0.7050.99
125_V186_A0.7040.98
233_D248_H0.7020.98
152_P365_A0.7010.98
369_E430_C0.7010.98
238_L242_A0.6980.98
361_Q401_P0.6950.98
47_V211_Q0.6930.98
175_M231_D0.6930.98
253_A289_L0.6920.98
398_Q409_E0.6910.98
428_Q432_D0.6890.98
300_Q307_M0.6860.98
90_G94_D0.6840.98
235_V306_M0.6820.98
171_A251_R0.6820.98
96_V99_L0.6820.98
226_L316_A0.6780.98
39_A42_K0.6770.98
68_D72_R0.6760.98
175_M248_H0.6750.98
122_K219_A0.6730.98
354_P357_Q0.6720.98
176_L179_D0.6720.98
195_L212_L0.6710.98
267_V349_I0.6700.98
20_N319_K0.6700.98
390_E394_E0.6690.98
42_K55_Q0.6690.98
50_L105_T0.6680.98
339_L343_A0.6680.98
391_A406_P0.6680.98
192_V222_T0.6680.98
137_S140_V0.6660.98
141_E144_Q0.6660.98
227_D233_D0.6650.98
49_V106_G0.6640.98
128_L332_L0.6630.98
54_E99_L0.6620.98
38_V55_Q0.6610.98
118_K234_H0.6600.98
149_A357_Q0.6590.98
54_E97_G0.6590.98
386_H390_E0.6580.98
121_C332_L0.6580.98
14_Q18_Q0.6580.98
345_V349_I0.6570.98
178_R192_V0.6550.98
182_R233_D0.6540.98
57_Q96_V0.6540.98
127_E131_A0.6530.98
236_L306_M0.6530.98
99_L102_K0.6500.97
370_L421_V0.6500.97
58_L99_L0.6480.97
152_P360_A0.6480.97
191_D213_A0.6480.97
146_N165_F0.6470.97
266_F359_A0.6460.97
420_D424_I0.6430.97
254_E293_R0.6430.97
16_F20_N0.6430.97
144_Q148_D0.6430.97
23_L326_E0.6420.97
149_A164_T0.6390.97
65_L69_V0.6390.97
252_F346_L0.6390.97
304_T307_M0.6390.97
227_D248_H0.6380.97
122_K126_S0.6380.97
133_R177_A0.6350.97
133_R136_Q0.6350.97
75_Q78_E0.6330.97
297_G308_M0.6320.97
179_D244_I0.6310.97
299_V331_A0.6300.97
41_S58_L0.6290.97
181_S184_Q0.6280.97
54_E57_Q0.6280.97
98_Q386_H0.6270.97
58_L65_L0.6260.97
405_L409_E0.6260.97
236_L307_M0.6250.97
154_Y263_E0.6250.97
96_V103_L0.6240.97
182_R189_R0.6240.97
59_E66_L0.6230.97
143_A147_Q0.6220.97
259_F315_L0.6210.97
355_R362_Q0.6210.97
151_M163_V0.6200.97
128_L242_A0.6160.97
295_K334_T0.6160.97
120_W332_L0.6150.96
62_L66_L0.6110.96
416_V420_D0.6110.96
423_P429_S0.6110.96
261_T264_A0.6100.96
221_A225_S0.6100.96
297_G309_T0.6100.96
169_C356_C0.6070.96
134_Q138_A0.6060.96
74_Q87_W0.6050.96
120_W329_F0.6040.96
58_L96_V0.6040.96
256_L342_A0.5980.96
181_S192_V0.5970.96
195_L221_A0.5960.96
45_V59_E0.5960.96
126_S218_F0.5960.96
30_A69_V0.5950.96
25_F326_E0.5950.96
125_V129_L0.5920.96
191_D220_S0.5920.96
423_P426_S0.5910.96
176_L249_L0.5910.96
388_V392_V0.5900.96
21_D24_R0.5900.96
131_A339_L0.5900.96
17_K20_N0.5890.96
236_L240_S0.5880.95
243_A247_V0.5870.95
327_G330_D0.5870.95
77_L84_I0.5870.95
58_L92_L0.5860.95
179_D182_R0.5850.95
360_A365_A0.5840.95
24_R124_T0.5840.95
273_V348_G0.5810.95
364_Y402_L0.5810.95
164_T432_D0.5780.95
41_S59_E0.5780.95
359_A362_Q0.5770.95
81_A86_S0.5770.95
68_D71_A0.5720.95
302_A327_G0.5720.95
405_L408_S0.5700.95
182_R185_D0.5670.95
174_E177_A0.5670.95
50_L54_E0.5660.94
330_D334_T0.5660.94
142_T349_I0.5650.94
293_R320_D0.5650.94
250_S308_M0.5640.94
36_G116_D0.5640.94
41_S103_L0.5640.94
174_E224_N0.5610.94
102_K105_T0.5610.94
292_I345_V0.5610.94
132_N183_L0.5600.94
353_R356_C0.5600.94
62_L69_V0.5590.94
366_N430_C0.5590.94
172_Y175_M0.5580.94
288_A345_V0.5580.94
74_Q91_K0.5560.94
416_V424_I0.5560.94
150_V427_L0.5540.94
154_Y264_A0.5530.94
328_L332_L0.5530.94
125_V190_L0.5520.94
186_A238_L0.5510.94
130_T134_Q0.5500.94
38_V215_W0.5500.94
176_L245_G0.5490.94
71_A75_Q0.5490.94
88_V116_D0.5480.93
169_C349_I0.5460.93
253_A293_R0.5440.93
168_W255_D0.5440.93
50_L58_L0.5430.93
175_M230_S0.5430.93
156_H319_K0.5430.93
177_A181_S0.5420.93
400_K406_P0.5400.93
151_M259_F0.5400.93
35_V39_A0.5400.93
301_G304_T0.5390.93
213_A216_L0.5380.93
297_G311_K0.5380.93
364_Y395_A0.5370.93
240_S243_A0.5360.93
129_L241_A0.5360.93
186_A190_L0.5360.93
36_G195_L0.5360.93
19_F338_C0.5350.93
182_R244_I0.5340.93
299_V334_T0.5340.93
396_I399_G0.5320.92
140_V143_A0.5290.92
32_Q35_V0.5290.92
237_E244_I0.5280.92
23_L28_R0.5280.92
407_L421_V0.5270.92
178_R237_E0.5260.92
188_K192_V0.5240.92
65_L71_A0.5240.92
186_A189_R0.5230.92
163_V167_H0.5210.92
19_F292_I0.5190.92
308_M312_G0.5190.92
213_A221_A0.5190.92
40_W212_L0.5180.91
109_R194_P0.5180.91
274_T287_D0.5180.91
58_L61_A0.5180.91
168_W316_A0.5180.91
129_L132_N0.5170.91
258_F315_L0.5170.91
414_S417_I0.5160.91
54_E58_L0.5160.91
45_V51_T0.5150.91
28_R127_E0.5140.91
213_A218_F0.5130.91
429_S432_D0.5120.91
186_A237_E0.5120.91
146_N166_A0.5110.91
310_L321_M0.5110.91
14_Q17_K0.5100.91
292_I296_C0.5100.91
404_D407_L0.5080.91
242_A245_G0.5070.91
244_I248_H0.5070.91
260_N269_L0.5060.90
390_E397_R0.5060.90
194_P229_V0.5050.90
233_D236_L0.5050.90
358_E361_Q0.5040.90
57_Q97_G0.5030.90
366_N425_L0.5030.90
152_P359_A0.5010.90
210_E213_A0.5010.90
93_I101_K0.5010.90
18_Q337_D0.5000.90
61_A66_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tj7A 4 0.9956 100 0.127 Contact Map
2e9fA 4 0.9759 100 0.127 Contact Map
1k7wA 4 0.9737 100 0.136 Contact Map
1re5A 4 0.9562 100 0.208 Contact Map
1q5nA 4 0.9212 100 0.212 Contact Map
1c3cA 4 0.9125 100 0.229 Contact Map
3c8tA 4 0.9125 100 0.232 Contact Map
2pfmA 4 0.9278 100 0.244 Contact Map
4eeiA 4 0.9015 100 0.254 Contact Map
1vdkA 4 0.9081 100 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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