GREMLIN Database
ARGC - N-acetyl-gamma-glutamyl-phosphate reductase
UniProt: P11446 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10065
Length: 334 (285)
Sequences: 7097 (3625)
Seq/√Len: 214.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_K168_D3.6061.00
256_V300_L3.5511.00
5_L73_V3.2841.00
155_Y184_S3.0761.00
173_D248_K2.9141.00
271_R288_F2.9051.00
151_V320_C2.8611.00
271_R290_D2.8581.00
27_M321_A2.7951.00
98_V324_R2.5861.00
44_L57_D2.5231.00
252_T255_Q2.4701.00
177_W246_R2.4091.00
258_Q262_Q2.3621.00
75_V321_A2.3251.00
3_N28_N2.2821.00
159_A180_I2.2271.00
162_A243_I2.1371.00
24_H322_N2.0941.00
44_L59_P2.0861.00
158_A241_E2.0861.00
20_Y318_V2.0761.00
3_N30_T2.0691.00
77_F321_A2.0281.00
16_E19_T2.0261.00
311_K319_Q1.9831.00
159_A241_E1.9381.00
38_S62_P1.9221.00
162_A302_I1.8871.00
257_A261_Q1.8741.00
46_S57_D1.8691.00
149_I324_R1.8681.00
158_A306_E1.8631.00
181_N242_T1.8571.00
168_D263_A1.8551.00
169_A259_V1.8481.00
255_Q258_Q1.8361.00
155_Y182_A1.8361.00
17_L77_F1.8281.00
109_N130_Q1.8031.00
160_Q221_H1.7901.00
173_D246_R1.7651.00
86_H105_A1.7561.00
21_V27_M1.7531.00
278_P292_G1.7481.00
63_M88_L1.7351.00
205_Q212_H1.7271.00
4_T27_M1.7251.00
2_L325_F1.7191.00
163_L178_P1.6831.00
166_L247_L1.6741.00
269_L287_P1.6471.00
191_R195_I1.6421.00
253_Q257_A1.6171.00
235_F280_L1.5971.00
9_A32_L1.5811.00
4_T75_V1.5641.00
140_G323_I1.5501.00
179_V244_T1.5501.00
182_A241_E1.5501.00
257_A275_K1.5461.00
261_Q274_D1.5411.00
139_C142_K1.5391.00
162_A304_A1.5211.00
130_Q147_N1.5161.00
136_A323_I1.5041.00
243_I304_A1.5031.00
310_L315_A1.5031.00
195_I198_S1.4691.00
87_D91_Q1.4551.00
91_Q94_E1.4321.00
257_A274_D1.4311.00
141_N144_K1.4211.00
166_L300_L1.3981.00
260_L302_I1.3941.00
7_V78_L1.3931.00
64_S68_E1.3801.00
166_L260_L1.3741.00
83_E105_A1.3701.00
98_V147_N1.3701.00
3_N74_D1.3691.00
169_A255_Q1.3681.00
16_E237_R1.3581.00
93_L148_L1.3431.00
13_A314_A1.3401.00
287_P310_L1.3361.00
247_L300_L1.3321.00
138_W164_K1.3281.00
159_A243_I1.3251.00
75_V325_F1.3131.00
78_L89_A1.3091.00
253_Q295_V1.3011.00
258_Q261_Q1.2951.00
159_A218_I1.2921.00
243_I302_I1.2721.00
88_L91_Q1.2581.00
90_P94_E1.2541.00
246_R299_H1.2521.00
257_A272_L1.2481.00
5_L76_V1.2461.00
253_Q293_F1.2411.00
208_G213_R1.2361.00
250_G295_V1.2321.00
71_P95_A1.2301.00
33_T61_Q1.2261.00
204_L233_G1.2251.00
76_V97_C1.2121.00
3_N31_A1.1921.00
10_S60_L1.1841.00
180_I243_I1.1781.00
254_A258_Q1.1681.00
32_L58_L1.1681.00
287_P315_A1.1641.00
289_C306_E1.1541.00
225_D297_G1.1541.00
233_G280_L1.1541.00
189_A193_A1.1481.00
135_L160_Q1.1331.00
177_W299_H1.1291.00
110_D130_Q1.1251.00
132_A146_A1.1211.00
98_V149_I1.1191.00
240_L305_T1.1111.00
70_S92_F1.1081.00
187_S236_P1.1041.00
260_L272_L1.0991.00
163_L245_C1.0971.00
18_V45_I1.0921.00
158_A182_A1.0861.00
183_T233_G1.0831.00
245_C300_L1.0761.00
181_N244_T1.0721.00
279_A282_N1.0661.00
40_D43_K1.0661.00
162_A260_L1.0621.00
21_V29_I1.0601.00
18_V29_I1.0571.00
238_G308_N1.0491.00
273_Y290_D1.0421.00
170_D251_V1.0391.00
240_L280_L1.0351.00
245_C302_I1.0311.00
310_L318_V1.0221.00
289_C304_A1.0181.00
194_A198_S1.0171.00
178_P245_C1.0171.00
247_L295_V1.0151.00
273_Y282_N1.0111.00
2_L75_V1.0081.00
108_V216_P1.0061.00
89_A99_V0.9951.00
13_A313_A0.9941.00
219_A225_D0.9841.00
131_A148_L0.9761.00
272_L293_F0.9731.00
231_H242_T0.9691.00
240_L303_V0.9691.00
130_Q146_A0.9601.00
161_L289_C0.9591.00
31_A61_Q0.9571.00
162_A165_P0.9541.00
166_L256_V0.9531.00
73_V76_V0.9511.00
24_H27_M0.9511.00
77_F317_A0.9501.00
183_T244_T0.9461.00
143_L323_I0.9431.00
249_S255_Q0.9411.00
137_E311_K0.9360.99
20_Y315_A0.9350.99
282_N290_D0.9340.99
155_Y214_H0.9300.99
91_Q95_A0.9250.99
7_V63_M0.9230.99
171_L248_K0.9200.99
139_C221_H0.9160.99
167_I172_L0.9120.99
137_E319_Q0.9080.99
89_A148_L0.9030.99
193_A198_S0.9000.99
67_S95_A0.8990.99
100_F321_A0.8950.99
163_L243_I0.8940.99
84_V87_D0.8920.99
193_A197_N0.8920.99
227_I244_T0.8910.99
244_T301_I0.8800.99
277_V303_V0.8740.99
203_S212_H0.8730.99
201_E209_V0.8720.99
286_L290_D0.8720.99
76_V92_F0.8680.99
169_A262_Q0.8660.99
171_L259_V0.8640.99
5_L31_A0.8640.99
169_A249_S0.8630.99
45_I60_L0.8590.99
108_V220_T0.8570.99
19_T23_R0.8540.99
75_V98_V0.8510.99
257_A293_F0.8440.99
254_A275_K0.8410.99
250_G298_E0.8400.99
203_S279_A0.8350.99
198_S236_P0.8340.99
212_H216_P0.8340.99
22_N56_V0.8290.99
164_K222_L0.8280.99
237_R309_L0.8280.99
158_A304_A0.8260.99
151_V313_A0.8250.99
80_T103_S0.8230.99
41_A62_P0.8130.99
321_A325_F0.8080.98
29_I58_L0.8080.98
29_I56_V0.8050.98
25_P53_K0.8030.98
68_E71_P0.8020.98
20_Y310_L0.7980.98
254_A257_A0.7930.98
108_V150_A0.7860.98
291_I302_I0.7830.98
170_D252_T0.7780.98
80_T84_V0.7770.98
247_L251_V0.7770.98
181_N231_H0.7760.98
80_T85_S0.7740.98
92_F99_V0.7710.98
215_Q219_A0.7670.98
247_L250_G0.7670.98
163_L180_I0.7590.98
29_I32_L0.7560.98
34_V45_I0.7560.98
164_K167_I0.7510.98
252_T295_V0.7510.98
30_T73_V0.7500.98
180_I241_E0.7480.97
100_F324_R0.7480.97
183_T231_H0.7460.97
83_E86_H0.7460.97
207_Y212_H0.7450.97
109_N220_T0.7420.97
242_T303_V0.7420.97
242_T301_I0.7400.97
157_T316_Q0.7380.97
283_V290_D0.7350.97
24_H287_P0.7320.97
92_F103_S0.7300.97
208_G211_T0.7290.97
238_G284_V0.7270.97
173_D177_W0.7270.97
102_L151_V0.7260.97
154_C188_G0.7250.97
75_V100_F0.7210.97
138_W263_A0.7210.97
170_D255_Q0.7140.97
23_R310_L0.7140.97
40_D60_L0.7120.97
186_V202_V0.7080.97
161_L263_A0.7070.96
250_G259_V0.7070.96
158_A305_T0.7040.96
247_L256_V0.7040.96
194_A197_N0.7030.96
160_Q222_L0.7020.96
251_V256_V0.7000.96
9_A60_L0.7000.96
6_I17_L0.6970.96
206_P240_L0.6960.96
3_N33_T0.6960.96
156_P160_Q0.6930.96
277_V292_G0.6920.96
293_F300_L0.6920.96
170_D259_V0.6870.96
138_W161_L0.6870.96
22_N53_K0.6870.96
102_L316_Q0.6860.96
199_F202_V0.6850.96
98_V325_F0.6850.96
183_T204_L0.6830.96
71_P94_E0.6830.96
46_S54_G0.6820.96
135_L161_L0.6800.96
61_Q68_E0.6800.96
156_P208_G0.6790.96
67_S91_Q0.6790.96
6_I29_I0.6780.96
9_A14_G0.6780.96
251_V259_V0.6770.96
253_Q256_V0.6760.95
6_I21_V0.6710.95
236_P284_V0.6700.95
206_P303_V0.6680.95
30_T33_T0.6670.95
27_M325_F0.6660.95
133_Y156_P0.6640.95
206_P231_H0.6630.95
144_K323_I0.6620.95
90_P99_V0.6590.95
214_H230_P0.6580.95
171_L251_V0.6570.95
159_A214_H0.6560.95
227_I299_H0.6560.95
205_Q279_A0.6510.94
90_P106_F0.6510.94
277_V294_A0.6500.94
151_V213_R0.6480.94
134_G320_C0.6470.94
168_D262_Q0.6420.94
180_I218_I0.6410.94
166_L245_C0.6400.94
256_V293_F0.6370.94
69_F72_G0.6340.94
227_I301_I0.6300.93
64_S67_S0.6280.93
61_Q72_G0.6270.93
78_L99_V0.6260.93
104_G213_R0.6240.93
82_H104_G0.6210.93
164_K263_A0.6210.93
78_L85_S0.6190.93
237_R308_N0.6190.93
33_T73_V0.6180.93
158_A239_I0.6180.93
77_F318_V0.6170.93
45_I52_L0.6150.93
167_I178_P0.6140.93
219_A224_A0.6090.92
162_A289_C0.6090.92
241_E304_A0.6080.92
171_L247_L0.6080.92
237_R284_V0.6080.92
158_A289_C0.6060.92
31_A73_V0.6040.92
263_A270_V0.6040.92
78_L92_F0.6020.92
70_S73_V0.6000.92
170_D248_K0.6000.92
141_N145_E0.5970.92
300_L303_V0.5960.91
109_N131_A0.5960.91
278_P303_V0.5940.91
172_L245_C0.5910.91
12_Y194_A0.5910.91
158_A308_N0.5900.91
180_I228_F0.5880.91
135_L316_Q0.5850.91
2_L74_D0.5840.91
92_F95_A0.5830.91
256_V295_V0.5800.90
137_E140_G0.5800.90
179_V242_T0.5790.90
249_S298_E0.5720.90
204_L231_H0.5720.90
280_L284_V0.5680.89
290_D305_T0.5670.89
185_G237_R0.5670.89
90_P93_L0.5660.89
10_S40_D0.5650.89
83_E103_S0.5650.89
215_Q226_V0.5640.89
167_I171_L0.5640.89
18_V22_N0.5640.89
203_S216_P0.5620.89
140_G144_K0.5620.89
159_A304_A0.5610.89
238_G283_V0.5610.89
260_L270_V0.5560.88
195_I201_E0.5550.88
92_F97_C0.5550.88
179_V246_R0.5540.88
84_V103_S0.5530.88
21_V318_V0.5530.88
73_V97_C0.5530.88
260_L293_F0.5530.88
18_V34_V0.5530.88
107_R154_C0.5520.88
106_F131_A0.5510.88
152_P157_T0.5510.88
173_D298_E0.5500.88
21_V321_A0.5480.88
218_I224_A0.5470.88
159_A182_A0.5460.87
193_A196_S0.5440.87
273_Y292_G0.5430.87
20_Y23_R0.5430.87
69_F73_V0.5420.87
85_S106_F0.5420.87
4_T29_I0.5420.87
77_F100_F0.5410.87
143_L146_A0.5400.87
7_V80_T0.5390.87
103_S317_A0.5380.87
316_Q320_C0.5380.87
206_P279_A0.5380.87
296_Q299_H0.5370.87
64_S91_Q0.5360.87
277_V280_L0.5350.86
4_T321_A0.5330.86
67_S70_S0.5310.86
107_R188_G0.5310.86
68_E72_G0.5310.86
233_G236_P0.5310.86
186_V199_F0.5290.86
180_I226_V0.5260.86
146_A149_I0.5250.85
261_Q272_L0.5240.85
157_T306_E0.5230.85
172_L247_L0.5230.85
183_T235_F0.5210.85
287_P319_Q0.5200.85
138_W160_Q0.5190.85
142_K145_E0.5170.85
19_T22_N0.5160.84
202_V232_L0.5160.84
81_A104_G0.5130.84
179_V227_I0.5130.84
227_I296_Q0.5090.84
152_P316_Q0.5070.83
139_C220_T0.5040.83
196_S205_Q0.5040.83
96_G147_N0.5040.83
69_F92_F0.5030.83
86_H109_N0.5010.83
184_S188_G0.5010.83
3_N73_V0.5010.83
203_S281_K0.5000.83
162_A241_E0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vknA 4 0.9641 100 0.151 Contact Map
1xygA 4 0.976 100 0.213 Contact Map
2nqtA 4 0.9521 100 0.219 Contact Map
3dr3A 4 0.988 100 0.234 Contact Map
2ozpA 4 0.9731 100 0.239 Contact Map
3uw3A 2 0.8802 100 0.315 Contact Map
2ep5A 4 0.9042 100 0.32 Contact Map
1t4bA 2 0.8743 100 0.32 Contact Map
2yv3A 2 0.8563 100 0.321 Contact Map
4dplA 4 0.9042 100 0.328 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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