ARGC - ECOLI - GREMLIN Contacts

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ARGC - N-acetyl-gamma-glutamyl-phosphate reductase

UniProt:	P11446	Sequences: MLNTLIVGASGYAGAELVTYVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLEAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGILETITCRLKSGVTQAQVAQVLQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10065
Length:	334 (285)
Sequences:	7097 (3625)
Seq/√Len:	214.8

ECOLI - ARGC USG DHAS
BACSU - ARGC DHAS
HALSA - Q9HPX0
SULSO - ARGC Q97WN3 Q97ZL8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
164_K	168_D	3.606	1.00
256_V	300_L	3.551	1.00
5_L	73_V	3.284	1.00
155_Y	184_S	3.076	1.00
173_D	248_K	2.914	1.00
271_R	288_F	2.905	1.00
151_V	320_C	2.861	1.00
271_R	290_D	2.858	1.00
27_M	321_A	2.795	1.00
98_V	324_R	2.586	1.00
44_L	57_D	2.523	1.00
252_T	255_Q	2.470	1.00
177_W	246_R	2.409	1.00
258_Q	262_Q	2.362	1.00
75_V	321_A	2.325	1.00
3_N	28_N	2.282	1.00
159_A	180_I	2.227	1.00
162_A	243_I	2.137	1.00
24_H	322_N	2.094	1.00
44_L	59_P	2.086	1.00
158_A	241_E	2.086	1.00
20_Y	318_V	2.076	1.00
3_N	30_T	2.069	1.00
77_F	321_A	2.028	1.00
16_E	19_T	2.026	1.00
311_K	319_Q	1.983	1.00
159_A	241_E	1.938	1.00
38_S	62_P	1.922	1.00
162_A	302_I	1.887	1.00
257_A	261_Q	1.874	1.00
46_S	57_D	1.869	1.00
149_I	324_R	1.868	1.00
158_A	306_E	1.863	1.00
181_N	242_T	1.857	1.00
168_D	263_A	1.855	1.00
169_A	259_V	1.848	1.00
255_Q	258_Q	1.836	1.00
155_Y	182_A	1.836	1.00
17_L	77_F	1.828	1.00
109_N	130_Q	1.803	1.00
160_Q	221_H	1.790	1.00
173_D	246_R	1.765	1.00
86_H	105_A	1.756	1.00
21_V	27_M	1.753	1.00
278_P	292_G	1.748	1.00
63_M	88_L	1.735	1.00
205_Q	212_H	1.727	1.00
4_T	27_M	1.725	1.00
2_L	325_F	1.719	1.00
163_L	178_P	1.683	1.00
166_L	247_L	1.674	1.00
269_L	287_P	1.647	1.00
191_R	195_I	1.642	1.00
253_Q	257_A	1.617	1.00
235_F	280_L	1.597	1.00
9_A	32_L	1.581	1.00
4_T	75_V	1.564	1.00
140_G	323_I	1.550	1.00
179_V	244_T	1.550	1.00
182_A	241_E	1.550	1.00
257_A	275_K	1.546	1.00
261_Q	274_D	1.541	1.00
139_C	142_K	1.539	1.00
162_A	304_A	1.521	1.00
130_Q	147_N	1.516	1.00
136_A	323_I	1.504	1.00
243_I	304_A	1.503	1.00
310_L	315_A	1.503	1.00
195_I	198_S	1.469	1.00
87_D	91_Q	1.455	1.00
91_Q	94_E	1.432	1.00
257_A	274_D	1.431	1.00
141_N	144_K	1.421	1.00
166_L	300_L	1.398	1.00
260_L	302_I	1.394	1.00
7_V	78_L	1.393	1.00
64_S	68_E	1.380	1.00
166_L	260_L	1.374	1.00
83_E	105_A	1.370	1.00
98_V	147_N	1.370	1.00
3_N	74_D	1.369	1.00
169_A	255_Q	1.368	1.00
16_E	237_R	1.358	1.00
93_L	148_L	1.343	1.00
13_A	314_A	1.340	1.00
287_P	310_L	1.336	1.00
247_L	300_L	1.332	1.00
138_W	164_K	1.328	1.00
159_A	243_I	1.325	1.00
75_V	325_F	1.313	1.00
78_L	89_A	1.309	1.00
253_Q	295_V	1.301	1.00
258_Q	261_Q	1.295	1.00
159_A	218_I	1.292	1.00
243_I	302_I	1.272	1.00
88_L	91_Q	1.258	1.00
90_P	94_E	1.254	1.00
246_R	299_H	1.252	1.00
257_A	272_L	1.248	1.00
5_L	76_V	1.246	1.00
253_Q	293_F	1.241	1.00
208_G	213_R	1.236	1.00
250_G	295_V	1.232	1.00
71_P	95_A	1.230	1.00
33_T	61_Q	1.226	1.00
204_L	233_G	1.225	1.00
76_V	97_C	1.212	1.00
3_N	31_A	1.192	1.00
10_S	60_L	1.184	1.00
180_I	243_I	1.178	1.00
254_A	258_Q	1.168	1.00
32_L	58_L	1.168	1.00
287_P	315_A	1.164	1.00
289_C	306_E	1.154	1.00
225_D	297_G	1.154	1.00
233_G	280_L	1.154	1.00
189_A	193_A	1.148	1.00
135_L	160_Q	1.133	1.00
177_W	299_H	1.129	1.00
110_D	130_Q	1.125	1.00
132_A	146_A	1.121	1.00
98_V	149_I	1.119	1.00
240_L	305_T	1.111	1.00
70_S	92_F	1.108	1.00
187_S	236_P	1.104	1.00
260_L	272_L	1.099	1.00
163_L	245_C	1.097	1.00
18_V	45_I	1.092	1.00
158_A	182_A	1.086	1.00
183_T	233_G	1.083	1.00
245_C	300_L	1.076	1.00
181_N	244_T	1.072	1.00
279_A	282_N	1.066	1.00
40_D	43_K	1.066	1.00
162_A	260_L	1.062	1.00
21_V	29_I	1.060	1.00
18_V	29_I	1.057	1.00
238_G	308_N	1.049	1.00
273_Y	290_D	1.042	1.00
170_D	251_V	1.039	1.00
240_L	280_L	1.035	1.00
245_C	302_I	1.031	1.00
310_L	318_V	1.022	1.00
289_C	304_A	1.018	1.00
194_A	198_S	1.017	1.00
178_P	245_C	1.017	1.00
247_L	295_V	1.015	1.00
273_Y	282_N	1.011	1.00
2_L	75_V	1.008	1.00
108_V	216_P	1.006	1.00
89_A	99_V	0.995	1.00
13_A	313_A	0.994	1.00
219_A	225_D	0.984	1.00
131_A	148_L	0.976	1.00
272_L	293_F	0.973	1.00
231_H	242_T	0.969	1.00
240_L	303_V	0.969	1.00
130_Q	146_A	0.960	1.00
161_L	289_C	0.959	1.00
31_A	61_Q	0.957	1.00
162_A	165_P	0.954	1.00
166_L	256_V	0.953	1.00
73_V	76_V	0.951	1.00
24_H	27_M	0.951	1.00
77_F	317_A	0.950	1.00
183_T	244_T	0.946	1.00
143_L	323_I	0.943	1.00
249_S	255_Q	0.941	1.00
137_E	311_K	0.936	0.99
20_Y	315_A	0.935	0.99
282_N	290_D	0.934	0.99
155_Y	214_H	0.930	0.99
91_Q	95_A	0.925	0.99
7_V	63_M	0.923	0.99
171_L	248_K	0.920	0.99
139_C	221_H	0.916	0.99
167_I	172_L	0.912	0.99
137_E	319_Q	0.908	0.99
89_A	148_L	0.903	0.99
193_A	198_S	0.900	0.99
67_S	95_A	0.899	0.99
100_F	321_A	0.895	0.99
163_L	243_I	0.894	0.99
84_V	87_D	0.892	0.99
193_A	197_N	0.892	0.99
227_I	244_T	0.891	0.99
244_T	301_I	0.880	0.99
277_V	303_V	0.874	0.99
203_S	212_H	0.873	0.99
201_E	209_V	0.872	0.99
286_L	290_D	0.872	0.99
76_V	92_F	0.868	0.99
169_A	262_Q	0.866	0.99
171_L	259_V	0.864	0.99
5_L	31_A	0.864	0.99
169_A	249_S	0.863	0.99
45_I	60_L	0.859	0.99
108_V	220_T	0.857	0.99
19_T	23_R	0.854	0.99
75_V	98_V	0.851	0.99
257_A	293_F	0.844	0.99
254_A	275_K	0.841	0.99
250_G	298_E	0.840	0.99
203_S	279_A	0.835	0.99
198_S	236_P	0.834	0.99
212_H	216_P	0.834	0.99
22_N	56_V	0.829	0.99
164_K	222_L	0.828	0.99
237_R	309_L	0.828	0.99
158_A	304_A	0.826	0.99
151_V	313_A	0.825	0.99
80_T	103_S	0.823	0.99
41_A	62_P	0.813	0.99
321_A	325_F	0.808	0.98
29_I	58_L	0.808	0.98
29_I	56_V	0.805	0.98
25_P	53_K	0.803	0.98
68_E	71_P	0.802	0.98
20_Y	310_L	0.798	0.98
254_A	257_A	0.793	0.98
108_V	150_A	0.786	0.98
291_I	302_I	0.783	0.98
170_D	252_T	0.778	0.98
80_T	84_V	0.777	0.98
247_L	251_V	0.777	0.98
181_N	231_H	0.776	0.98
80_T	85_S	0.774	0.98
92_F	99_V	0.771	0.98
215_Q	219_A	0.767	0.98
247_L	250_G	0.767	0.98
163_L	180_I	0.759	0.98
29_I	32_L	0.756	0.98
34_V	45_I	0.756	0.98
164_K	167_I	0.751	0.98
252_T	295_V	0.751	0.98
30_T	73_V	0.750	0.98
180_I	241_E	0.748	0.97
100_F	324_R	0.748	0.97
183_T	231_H	0.746	0.97
83_E	86_H	0.746	0.97
207_Y	212_H	0.745	0.97
109_N	220_T	0.742	0.97
242_T	303_V	0.742	0.97
242_T	301_I	0.740	0.97
157_T	316_Q	0.738	0.97
283_V	290_D	0.735	0.97
24_H	287_P	0.732	0.97
92_F	103_S	0.730	0.97
208_G	211_T	0.729	0.97
238_G	284_V	0.727	0.97
173_D	177_W	0.727	0.97
102_L	151_V	0.726	0.97
154_C	188_G	0.725	0.97
75_V	100_F	0.721	0.97
138_W	263_A	0.721	0.97
170_D	255_Q	0.714	0.97
23_R	310_L	0.714	0.97
40_D	60_L	0.712	0.97
186_V	202_V	0.708	0.97
161_L	263_A	0.707	0.96
250_G	259_V	0.707	0.96
158_A	305_T	0.704	0.96
247_L	256_V	0.704	0.96
194_A	197_N	0.703	0.96
160_Q	222_L	0.702	0.96
251_V	256_V	0.700	0.96
9_A	60_L	0.700	0.96
6_I	17_L	0.697	0.96
206_P	240_L	0.696	0.96
3_N	33_T	0.696	0.96
156_P	160_Q	0.693	0.96
277_V	292_G	0.692	0.96
293_F	300_L	0.692	0.96
170_D	259_V	0.687	0.96
138_W	161_L	0.687	0.96
22_N	53_K	0.687	0.96
102_L	316_Q	0.686	0.96
199_F	202_V	0.685	0.96
98_V	325_F	0.685	0.96
183_T	204_L	0.683	0.96
71_P	94_E	0.683	0.96
46_S	54_G	0.682	0.96
135_L	161_L	0.680	0.96
61_Q	68_E	0.680	0.96
156_P	208_G	0.679	0.96
67_S	91_Q	0.679	0.96
6_I	29_I	0.678	0.96
9_A	14_G	0.678	0.96
251_V	259_V	0.677	0.96
253_Q	256_V	0.676	0.95
6_I	21_V	0.671	0.95
236_P	284_V	0.670	0.95
206_P	303_V	0.668	0.95
30_T	33_T	0.667	0.95
27_M	325_F	0.666	0.95
133_Y	156_P	0.664	0.95
206_P	231_H	0.663	0.95
144_K	323_I	0.662	0.95
90_P	99_V	0.659	0.95
214_H	230_P	0.658	0.95
171_L	251_V	0.657	0.95
159_A	214_H	0.656	0.95
227_I	299_H	0.656	0.95
205_Q	279_A	0.651	0.94
90_P	106_F	0.651	0.94
277_V	294_A	0.650	0.94
151_V	213_R	0.648	0.94
134_G	320_C	0.647	0.94
168_D	262_Q	0.642	0.94
180_I	218_I	0.641	0.94
166_L	245_C	0.640	0.94
256_V	293_F	0.637	0.94
69_F	72_G	0.634	0.94
227_I	301_I	0.630	0.93
64_S	67_S	0.628	0.93
61_Q	72_G	0.627	0.93
78_L	99_V	0.626	0.93
104_G	213_R	0.624	0.93
82_H	104_G	0.621	0.93
164_K	263_A	0.621	0.93
78_L	85_S	0.619	0.93
237_R	308_N	0.619	0.93
33_T	73_V	0.618	0.93
158_A	239_I	0.618	0.93
77_F	318_V	0.617	0.93
45_I	52_L	0.615	0.93
167_I	178_P	0.614	0.93
219_A	224_A	0.609	0.92
162_A	289_C	0.609	0.92
241_E	304_A	0.608	0.92
171_L	247_L	0.608	0.92
237_R	284_V	0.608	0.92
158_A	289_C	0.606	0.92
31_A	73_V	0.604	0.92
263_A	270_V	0.604	0.92
78_L	92_F	0.602	0.92
70_S	73_V	0.600	0.92
170_D	248_K	0.600	0.92
141_N	145_E	0.597	0.92
300_L	303_V	0.596	0.91
109_N	131_A	0.596	0.91
278_P	303_V	0.594	0.91
172_L	245_C	0.591	0.91
12_Y	194_A	0.591	0.91
158_A	308_N	0.590	0.91
180_I	228_F	0.588	0.91
135_L	316_Q	0.585	0.91
2_L	74_D	0.584	0.91
92_F	95_A	0.583	0.91
256_V	295_V	0.580	0.90
137_E	140_G	0.580	0.90
179_V	242_T	0.579	0.90
249_S	298_E	0.572	0.90
204_L	231_H	0.572	0.90
280_L	284_V	0.568	0.89
290_D	305_T	0.567	0.89
185_G	237_R	0.567	0.89
90_P	93_L	0.566	0.89
10_S	40_D	0.565	0.89
83_E	103_S	0.565	0.89
215_Q	226_V	0.564	0.89
167_I	171_L	0.564	0.89
18_V	22_N	0.564	0.89
203_S	216_P	0.562	0.89
140_G	144_K	0.562	0.89
159_A	304_A	0.561	0.89
238_G	283_V	0.561	0.89
260_L	270_V	0.556	0.88
195_I	201_E	0.555	0.88
92_F	97_C	0.555	0.88
179_V	246_R	0.554	0.88
84_V	103_S	0.553	0.88
21_V	318_V	0.553	0.88
73_V	97_C	0.553	0.88
260_L	293_F	0.553	0.88
18_V	34_V	0.553	0.88
107_R	154_C	0.552	0.88
106_F	131_A	0.551	0.88
152_P	157_T	0.551	0.88
173_D	298_E	0.550	0.88
21_V	321_A	0.548	0.88
218_I	224_A	0.547	0.88
159_A	182_A	0.546	0.87
193_A	196_S	0.544	0.87
273_Y	292_G	0.543	0.87
20_Y	23_R	0.543	0.87
69_F	73_V	0.542	0.87
85_S	106_F	0.542	0.87
4_T	29_I	0.542	0.87
77_F	100_F	0.541	0.87
143_L	146_A	0.540	0.87
7_V	80_T	0.539	0.87
103_S	317_A	0.538	0.87
316_Q	320_C	0.538	0.87
206_P	279_A	0.538	0.87
296_Q	299_H	0.537	0.87
64_S	91_Q	0.536	0.87
277_V	280_L	0.535	0.86
4_T	321_A	0.533	0.86
67_S	70_S	0.531	0.86
107_R	188_G	0.531	0.86
68_E	72_G	0.531	0.86
233_G	236_P	0.531	0.86
186_V	199_F	0.529	0.86
180_I	226_V	0.526	0.86
146_A	149_I	0.525	0.85
261_Q	272_L	0.524	0.85
157_T	306_E	0.523	0.85
172_L	247_L	0.523	0.85
183_T	235_F	0.521	0.85
287_P	319_Q	0.520	0.85
138_W	160_Q	0.519	0.85
142_K	145_E	0.517	0.85
19_T	22_N	0.516	0.84
202_V	232_L	0.516	0.84
81_A	104_G	0.513	0.84
179_V	227_I	0.513	0.84
227_I	296_Q	0.509	0.84
152_P	316_Q	0.507	0.83
139_C	220_T	0.504	0.83
196_S	205_Q	0.504	0.83
96_G	147_N	0.504	0.83
69_F	92_F	0.503	0.83
86_H	109_N	0.501	0.83
184_S	188_G	0.501	0.83
3_N	73_V	0.501	0.83
203_S	281_K	0.500	0.83
162_A	241_E	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vknA	4	0.9641	100	0.151	Contact Map
1xygA	4	0.976	100	0.213	Contact Map
2nqtA	4	0.9521	100	0.219	Contact Map
3dr3A	4	0.988	100	0.234	Contact Map
2ozpA	4	0.9731	100	0.239	Contact Map
3uw3A	2	0.8802	100	0.315	Contact Map
2ep5A	4	0.9042	100	0.32	Contact Map
1t4bA	2	0.8743	100	0.32	Contact Map
2yv3A	2	0.8563	100	0.321	Contact Map
4dplA	4	0.9042	100	0.328	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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