GREMLIN Database
NARI - Respiratory nitrate reductase 1 gamma chain
UniProt: P11350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10640
Length: 225 (218)
Sequences: 1075 (652)
Seq/√Len: 44.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_A107_L5.2101.00
98_G141_L3.1741.00
19_V196_L3.1581.00
7_F15_I2.9381.00
19_V200_F2.8801.00
128_L197_L2.7411.00
136_Q191_G2.7021.00
91_M148_A2.6731.00
194_L203_L2.6391.00
182_F186_L2.5771.00
20_F24_S2.5521.00
119_R127_I2.4571.00
75_W79_A2.4021.00
12_Y193_T2.3881.00
113_L119_R2.3711.00
77_Y83_I2.3501.00
82_P85_V2.3471.00
58_G104_G2.2741.00
59_I101_C2.1951.00
74_H154_S2.1931.00
18_A22_I2.1821.00
125_A197_L2.1381.00
54_L103_I2.1261.00
132_L197_L2.0270.99
62_I101_C1.9420.99
8_F189_V1.8770.99
61_G97_S1.8410.99
136_Q190_L1.8170.98
24_S207_W1.8100.98
188_L192_M1.7950.98
62_I98_G1.7410.98
105_G134_V1.7100.98
54_L100_L1.7090.98
17_G166_V1.6960.98
113_L127_I1.6810.97
35_W208_S1.6800.97
92_F96_A1.6300.97
85_V89_M1.6160.97
102_L134_V1.5960.97
60_L64_V1.5890.96
198_F206_I1.5880.96
142_L146_F1.5730.96
89_M93_A1.5430.96
124_G128_L1.5420.96
19_V22_I1.5280.96
109_L127_I1.5210.95
5_N178_D1.5160.95
22_I25_W1.5060.95
44_D115_S1.4990.95
212_E215_T1.4970.95
76_M80_W1.4740.95
84_E88_K1.4520.94
41_Q45_R1.4320.94
88_K92_F1.4170.93
96_A100_L1.3990.93
110_K114_F1.3940.93
106_V110_K1.3760.92
61_G93_A1.3610.92
76_M79_A1.3440.91
81_L85_V1.3410.91
74_H77_Y1.3160.90
102_L138_A1.3100.90
132_L135_I1.3090.90
44_D48_M1.3050.90
197_L201_S1.3040.90
43_L129_I1.2950.90
109_L113_L1.2720.89
101_C137_C1.2720.89
155_E160_V1.2710.89
163_A167_V1.2680.89
16_A192_M1.2680.89
115_S118_V1.2650.89
77_Y80_W1.2550.88
74_H83_I1.2530.88
43_L117_R1.2530.88
66_H111_R1.2450.88
11_I171_G1.2380.87
155_E158_K1.2370.87
99_V103_I1.2320.87
106_V134_V1.2310.87
189_V193_T1.2070.86
16_A196_L1.1930.85
24_S198_F1.1910.85
5_N185_R1.1890.85
74_H157_M1.1860.85
46_K210_P1.1700.84
132_L136_Q1.1690.84
109_L132_L1.1650.84
79_A82_P1.1560.84
155_E181_A1.1550.84
38_A123_T1.1550.84
47_G110_K1.1420.83
40_S43_L1.1410.83
86_K156_M1.1340.82
7_F85_V1.1190.82
20_F198_F1.1080.81
90_A95_G1.1080.81
212_E217_K1.0980.80
14_Y171_G1.0890.80
26_L31_G1.0830.79
47_G51_A1.0800.79
88_K151_M1.0780.79
132_L190_L1.0740.79
105_G109_L1.0640.78
139_L186_L1.0580.78
24_S204_I1.0580.78
68_F92_F1.0570.78
202_R213_Y1.0520.77
74_H160_V1.0490.77
66_H187_H1.0480.77
20_F207_W1.0380.76
129_I197_L1.0270.76
77_Y154_S1.0210.75
112_R205_H1.0060.74
143_T159_L0.9910.73
31_G218_Y0.9870.73
122_T130_L0.9760.72
44_D118_V0.9650.71
28_Y83_I0.9640.71
64_V68_F0.9510.70
173_A176_H0.9480.70
111_R187_H0.9450.69
122_T127_I0.9410.69
139_L190_L0.9340.68
84_E151_M0.9330.68
109_L134_V0.9310.68
26_L57_I0.9310.68
131_S135_I0.9310.68
169_F172_G0.9280.68
193_T211_V0.9240.68
59_I64_V0.9120.67
50_L54_L0.9040.66
134_V138_A0.8960.65
119_R122_T0.8930.65
127_I131_S0.8920.65
38_A217_K0.8870.64
75_W160_V0.8870.64
114_F186_L0.8840.64
83_I160_V0.8790.64
153_G184_F0.8710.63
61_G100_L0.8670.63
65_G69_G0.8640.62
76_M160_V0.8630.62
63_F135_I0.8630.62
56_H205_H0.8550.61
86_K163_A0.8540.61
11_I169_F0.8520.61
32_Q35_W0.8490.61
113_L116_P0.8470.61
135_I190_L0.8420.60
6_M11_I0.8380.60
75_W78_E0.8370.60
158_K161_G0.8350.60
22_I26_L0.8320.59
85_V179_G0.8280.59
142_L183_I0.8270.59
217_K223_A0.8210.58
11_I22_I0.8180.58
10_D173_A0.8120.57
107_L110_K0.8070.57
48_M51_A0.7940.56
57_I61_G0.7920.56
103_I124_G0.7880.55
7_F11_I0.7840.55
20_F206_I0.7810.55
64_V67_F0.7750.54
172_G176_H0.7730.54
18_A169_F0.7710.54
204_I208_S0.7700.53
15_I18_A0.7660.53
134_V209_V0.7640.53
21_L207_W0.7600.53
53_N130_L0.7590.52
56_H112_R0.7580.52
18_A63_F0.7540.52
102_L137_C0.7500.52
140_G187_H0.7490.51
170_H178_D0.7470.51
117_R121_T0.7460.51
159_L180_V0.7370.50
61_G75_W0.7350.50
148_A153_G0.7340.50
61_G64_V0.7330.50
109_L194_L0.7330.50
11_I18_A0.7210.49
72_T86_K0.7200.49
83_I152_D0.7170.48
31_G217_K0.7160.48
165_S176_H0.7120.48
8_F177_L0.7120.48
105_G138_A0.7100.48
15_I107_L0.7080.48
165_S170_H0.7080.48
115_S212_E0.7070.47
67_F171_G0.7060.47
94_G162_W0.7040.47
116_P120_A0.7000.47
154_S157_M0.6980.47
40_S202_R0.6960.46
155_E184_F0.6960.46
35_W204_I0.6920.46
39_S43_L0.6900.46
114_F118_V0.6890.46
21_L25_W0.6890.46
215_T223_A0.6890.46
124_G131_S0.6860.45
79_A83_I0.6850.45
105_G133_L0.6840.45
60_L63_F0.6830.45
122_T196_L0.6690.44
33_Y218_Y0.6670.44
49_N212_E0.6660.44
51_A54_L0.6650.43
48_M53_N0.6610.43
125_A201_S0.6600.43
24_S206_I0.6580.43
83_I157_M0.6540.42
51_A93_A0.6530.42
177_L180_V0.6510.42
214_L217_K0.6470.42
40_S94_G0.6460.42
71_L163_A0.6440.41
209_V212_E0.6430.41
71_L167_V0.6410.41
59_I206_I0.6370.41
75_W80_W0.6370.41
52_S90_A0.6360.41
147_S166_V0.6350.41
97_S218_Y0.6340.41
28_Y35_W0.6280.40
25_W173_A0.6270.40
17_G81_L0.6270.40
28_Y31_G0.6240.40
108_L112_R0.6240.40
25_W169_F0.6230.40
194_L214_L0.6200.39
90_A144_I0.6180.39
34_T129_I0.6130.39
165_S172_G0.6080.38
32_Q43_L0.6060.38
66_H73_P0.6040.38
114_F146_F0.6020.38
48_M184_F0.6000.37
5_N195_F0.5990.37
96_A214_L0.5980.37
69_G104_G0.5960.37
45_R218_Y0.5950.37
74_H137_C0.5920.37
112_R122_T0.5920.37
156_M221_V0.5910.37
48_M108_L0.5870.36
111_R205_H0.5850.36
12_Y16_A0.5840.36
213_Y216_R0.5840.36
103_I106_V0.5800.36
158_K179_G0.5790.36
81_L89_M0.5780.35
57_I60_L0.5770.35
100_L104_G0.5770.35
18_A99_V0.5770.35
61_G223_A0.5760.35
29_D33_Y0.5760.35
37_A43_L0.5760.35
67_F71_L0.5730.35
83_I154_S0.5730.35
21_L168_T0.5660.34
34_T219_Q0.5650.34
187_H205_H0.5650.34
5_N139_L0.5640.34
10_D165_S0.5640.34
26_L29_D0.5640.34
63_F166_V0.5620.34
126_D202_R0.5610.34
87_Q221_V0.5610.34
38_A42_M0.5610.34
117_R120_A0.5610.34
139_L166_V0.5610.34
106_V146_F0.5550.33
84_E152_D0.5550.33
43_L121_T0.5520.33
92_F95_G0.5520.33
125_A166_V0.5520.33
123_T131_S0.5520.33
68_F201_S0.5500.33
125_A128_L0.5470.33
55_F65_G0.5470.33
22_I208_S0.5470.33
66_H126_D0.5450.33
84_E105_G0.5450.33
72_T164_Q0.5420.32
59_I192_M0.5390.32
63_F96_A0.5380.32
53_N57_I0.5360.32
95_G152_D0.5360.32
12_Y196_L0.5340.32
98_G102_L0.5330.32
123_T127_I0.5330.32
180_V188_L0.5320.31
109_L125_A0.5310.31
59_I63_F0.5290.31
95_G103_I0.5290.31
37_A141_L0.5280.31
18_A178_D0.5270.31
153_G181_A0.5270.31
147_S150_H0.5260.31
12_Y189_V0.5240.31
117_R207_W0.5240.31
43_L207_W0.5190.30
179_G185_R0.5160.30
155_E221_V0.5150.30
66_H140_G0.5140.30
127_I220_L0.5120.30
129_I194_L0.5110.30
33_Y39_S0.5110.30
23_G126_D0.5110.30
69_G94_G0.5100.30
28_Y218_Y0.5100.30
10_D24_S0.5050.29
21_L182_F0.5050.29
145_P186_L0.5050.29
85_V93_A0.5040.29
127_I201_S0.5010.29
38_A177_L0.5010.29
61_G84_E0.5000.29
37_A45_R0.5000.29
68_F72_T0.5000.29
26_L33_Y0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q16C 2 0.9911 100 0.323 Contact Map
2l2tA 2 0.1822 33.1 0.953 Contact Map
2wswA 3 0.8978 15.3 0.96 Contact Map
2ks1B 1 0.1822 11.7 0.962 Contact Map
2kluA 1 0.2311 10.3 0.963 Contact Map
4c7rA 3 0.9022 8.2 0.964 Contact Map
2m20A 2 0.2533 8.2 0.964 Contact Map
2l9uA 2 0.1778 4.9 0.968 Contact Map
2a65A 2 0.5022 4.1 0.969 Contact Map
1iijA 1 0.1422 3.3 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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