GREMLIN Database
YIAB - Inner membrane protein YiaB
UniProt: P11286 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11267
Length: 113 (106)
Sequences: 188 (88)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_M73_I4.1920.98
42_T70_V4.0190.98
25_I89_T3.4560.95
49_A63_F3.1050.91
14_V100_F2.9770.89
45_F67_C2.4390.76
28_P87_I2.2010.68
6_T105_G2.1720.67
39_V75_I2.0130.61
37_L64_T1.9640.59
24_W95_Y1.9180.57
39_V99_F1.8470.54
18_V100_F1.7250.49
13_V99_F1.7070.48
69_L73_I1.7030.48
20_L71_A1.6750.47
37_L41_M1.6300.45
28_P95_Y1.6300.45
6_T65_H1.6150.44
102_C105_G1.5840.43
20_L47_N1.4880.39
69_L72_L1.4630.38
35_Y64_T1.4390.37
79_F96_P1.3850.35
57_G89_T1.3800.35
7_V19_Y1.3650.34
38_G42_T1.3610.34
97_I101_V1.3570.34
45_F70_V1.3200.32
19_Y35_Y1.2910.31
11_L101_V1.2530.30
12_F109_L1.2410.30
48_Y60_D1.2080.28
30_L85_A1.2050.28
23_L26_S1.2000.28
60_D108_R1.1990.28
40_L43_A1.1860.28
26_S35_Y1.1760.27
24_W86_P1.1640.27
89_T96_P1.1330.26
11_L60_D1.1300.26
68_Q104_F1.1230.26
28_P40_L1.1170.25
45_F108_R1.0990.25
31_S35_Y1.0760.24
100_F105_G1.0760.24
20_L67_C1.0730.24
24_W37_L1.0670.24
59_L68_Q1.0560.24
42_T47_N1.0440.23
47_N71_A1.0240.23
72_L107_M1.0190.22
19_Y46_G1.0180.22
9_K54_E1.0100.22
59_L65_H0.9910.22
31_S74_T0.9850.21
38_G41_M0.9710.21
45_F78_L0.9560.21
96_P101_V0.9550.21
19_Y71_A0.9530.21
17_L29_L0.9460.20
18_V97_I0.9330.20
71_A75_I0.9320.20
48_Y78_L0.9310.20
28_P49_A0.9270.20
47_N61_D0.9100.19
67_C71_A0.9020.19
17_L20_L0.8920.19
42_T97_I0.8720.18
12_F48_Y0.8710.18
9_K60_D0.8650.18
50_Y67_C0.8420.18
50_Y61_D0.8300.17
98_A103_L0.8290.17
61_D74_T0.8280.17
54_E109_L0.8270.17
86_P96_P0.8030.17
13_V17_L0.8020.17
100_F108_R0.8010.17
30_L77_L0.7970.17
80_I87_I0.7830.16
31_S53_A0.7730.16
41_M70_V0.7720.16
69_L107_M0.7710.16
54_E65_H0.7650.16
39_V79_F0.7550.16
54_E101_V0.7530.16
8_A47_N0.7490.15
67_C105_G0.7450.15
96_P109_L0.7420.15
78_L109_L0.7360.15
28_P62_F0.7330.15
33_K85_A0.7260.15
80_I88_N0.7210.15
28_P63_F0.7190.15
20_L74_T0.7160.15
77_L101_V0.7080.15
6_T58_Q0.7080.15
47_N70_V0.7070.15
27_C74_T0.7020.14
72_L87_I0.6960.14
77_L85_A0.6890.14
24_W67_C0.6880.14
31_S77_L0.6810.14
51_L93_V0.6790.14
10_L106_Q0.6780.14
82_V93_V0.6760.14
83_L108_R0.6730.14
36_F50_Y0.6610.14
81_G109_L0.6550.13
66_I70_V0.6500.13
55_K82_V0.6500.13
10_L21_V0.6480.13
67_C107_M0.6470.13
57_G108_R0.6460.13
61_D102_C0.6300.13
16_A41_M0.6270.13
7_V108_R0.6230.13
25_I102_C0.6200.13
53_A76_G0.6180.13
61_D105_G0.6170.13
44_T63_F0.6140.13
51_L92_M0.6120.13
57_G80_I0.6050.13
31_S81_G0.5960.12
61_D86_P0.5890.12
56_L110_F0.5870.12
75_I107_M0.5850.12
37_L77_L0.5840.12
20_L73_I0.5830.12
16_A69_L0.5810.12
38_G96_P0.5780.12
12_F17_L0.5760.12
35_Y40_L0.5720.12
33_K88_N0.5700.12
37_L72_L0.5680.12
45_F71_A0.5640.12
21_V79_F0.5520.12
76_G83_L0.5510.12
23_L90_Y0.5510.12
41_M99_F0.5480.11
9_K24_W0.5400.11
10_L14_V0.5380.11
17_L21_V0.5380.11
43_A71_A0.5370.11
67_C100_F0.5330.11
42_T66_I0.5320.11
37_L96_P0.5310.11
57_G73_I0.5290.11
48_Y109_L0.5290.11
61_D97_I0.5260.11
42_T69_L0.5230.11
31_S63_F0.5190.11
41_M97_I0.5170.11
21_V58_Q0.5150.11
42_T100_F0.5060.11
6_T86_P0.5050.11
28_P57_G0.5040.11
10_L102_C0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p6vB 1 0.4779 9.3 0.95 Contact Map
4od4A 1 0.6903 7.2 0.952 Contact Map
3rceA 1 0.8584 5.9 0.954 Contact Map
2i68A 2 0.6726 4.7 0.956 Contact Map
3b4rA 2 0.5044 4.2 0.957 Contact Map
2m20A 2 0.4425 3.8 0.958 Contact Map
4fbzA 3 0.531 3.5 0.959 Contact Map
4o6yA 2 0.4602 3.4 0.959 Contact Map
4j7cI 2 0.8938 3.2 0.96 Contact Map
4qi1A 3 0.5044 2.3 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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