GREMLIN Database
ACEK - Isocitrate dehydrogenase kinase/phosphatase
UniProt: P11071 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10026
Length: 578 (564)
Sequences: 390 (214)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
382_K403_D4.6330.99
494_R498_D4.5610.99
436_D440_E4.3090.99
39_D42_A4.2530.99
489_D546_R4.2340.99
410_I413_L3.9440.98
490_I517_E3.7780.97
501_A504_P3.7600.97
167_Q171_R3.6330.97
549_Q553_R3.6240.97
224_L236_I3.5840.96
448_L479_I3.2710.94
143_F159_D3.2510.94
349_S352_H3.2120.93
223_L246_A3.1430.92
350_A400_K3.1010.92
167_Q229_T3.0550.91
342_F353_V3.0020.91
328_L418_R2.9740.90
162_L200_L2.9610.90
154_M170_S2.9460.90
394_L403_D2.9090.89
550_N554_E2.9060.89
397_A400_K2.8770.89
166_W234_L2.8340.88
492_P498_D2.7550.86
20_Q95_R2.7540.86
202_Y509_S2.7250.86
75_D405_G2.5310.81
166_W226_I2.5030.80
405_G408_I2.4410.78
431_G527_R2.4340.78
435_R534_E2.4320.78
490_I499_E2.4010.77
238_T569_F2.3770.76
304_Y310_E2.3400.75
46_A258_M2.2990.74
34_R46_A2.2780.73
311_Q386_S2.2530.72
121_L378_F2.2420.72
394_L401_I2.2250.71
226_I234_L2.1920.70
305_L381_E2.1910.70
339_K396_E2.1670.69
304_Y330_G2.1600.69
382_K408_I2.1370.68
292_H332_D2.1100.67
300_E445_I2.0860.66
20_Q93_Y2.0520.65
270_W304_Y2.0490.65
523_C532_F2.0480.65
153_L173_I2.0310.64
11_Q472_V2.0150.63
225_P238_T1.9790.62
111_F544_Y1.9360.60
222_F569_F1.9250.60
113_H116_L1.9050.59
319_R339_K1.8980.58
324_L396_E1.8980.58
247_S470_R1.8930.58
20_Q116_L1.8900.58
489_D542_A1.8550.57
208_W562_A1.8320.56
380_L385_I1.8090.55
57_H60_L1.8000.54
247_S449_A1.7980.54
308_C384_H1.7850.54
382_K409_V1.7830.54
113_H292_H1.7760.53
240_L249_V1.7680.53
116_L378_F1.7560.52
157_I224_L1.7480.52
372_T458_M1.7450.52
157_I236_I1.7400.52
140_A143_F1.7350.51
75_D241_T1.7210.51
321_M345_Q1.6940.50
363_H481_Y1.6600.48
254_R487_F1.6580.48
113_H378_F1.6450.48
21_Y523_C1.6430.47
490_I505_W1.6360.47
345_Q507_S1.6310.47
426_L510_P1.6230.47
313_I502_S1.6180.46
229_T233_E1.6170.46
196_V222_F1.6130.46
391_E395_Q1.6120.46
313_I327_T1.6120.46
21_Y95_R1.6120.46
382_K387_P1.6040.46
287_I321_M1.5790.45
301_Y380_L1.5780.45
539_L544_Y1.5760.45
496_P517_E1.5750.44
446_R544_Y1.5670.44
385_I401_I1.5480.43
200_L333_R1.5410.43
208_W270_W1.5370.43
61_V387_P1.5280.42
499_E505_W1.5270.42
489_D492_P1.5200.42
236_I321_M1.5170.42
275_L482_M1.5090.42
100_E335_F1.5070.42
397_A408_I1.5050.42
95_R98_I1.5000.41
79_L101_S1.4910.41
115_S378_F1.4830.41
495_Y500_L1.4830.41
155_R159_D1.4820.41
387_P391_E1.4810.40
202_Y413_L1.4760.40
21_Y415_I1.4710.40
542_A557_V1.4610.40
252_F259_V1.4540.39
403_D408_I1.4530.39
103_F239_C1.4490.39
61_V107_Y1.4450.39
78_F111_F1.4350.39
405_G411_R1.4350.39
485_V513_V1.4340.39
20_Q53_L1.4210.38
449_A518_F1.4170.38
501_A505_W1.4160.38
57_H540_F1.4160.38
497_E505_W1.4140.38
449_A470_R1.4050.37
331_F465_V1.4020.37
489_D541_R1.4010.37
424_I550_N1.3960.37
438_I523_C1.3880.37
83_K87_T1.3850.37
197_A426_L1.3840.36
21_Y438_I1.3830.36
251_G532_F1.3800.36
517_E532_F1.3790.36
20_Q121_L1.3740.36
210_V362_E1.3710.36
497_E503_E1.3710.36
513_V552_I1.3690.36
32_Q36_E1.3670.36
345_Q448_L1.3600.36
324_L397_A1.3580.35
245_E564_R1.3530.35
303_V538_D1.3450.35
283_L498_D1.3300.34
312_F335_F1.3280.34
20_Q57_H1.3240.34
95_R415_I1.3210.34
138_P275_L1.3030.33
493_P505_W1.2940.33
532_F537_A1.2920.33
23_R57_H1.2880.33
101_S166_W1.2860.33
16_G58_V1.2820.32
93_Y261_A1.2800.32
298_Y363_H1.2800.32
228_Q331_F1.2800.32
490_I496_P1.2770.32
93_Y415_I1.2720.32
370_A506_Y1.2690.32
337_V348_M1.2620.32
487_F518_F1.2600.32
251_G499_E1.2590.32
450_A560_V1.2580.32
273_E513_V1.2570.32
195_Q212_K1.2530.31
165_R418_R1.2500.31
252_F450_A1.2450.31
162_L228_Q1.2420.31
247_S341_R1.2270.30
298_Y345_Q1.2170.30
38_A230_D1.2150.30
238_T408_I1.2140.30
75_D306_Q1.2130.30
20_Q333_R1.2070.30
275_L510_P1.2070.30
343_A353_V1.2050.30
458_M467_R1.2020.30
204_N225_P1.2010.29
121_L266_A1.1990.29
212_K272_R1.1980.29
414_Y521_W1.1980.29
479_I499_E1.1970.29
522_L540_F1.1970.29
158_S169_K1.1970.29
173_I177_I1.1910.29
176_I262_P1.1910.29
167_Q319_R1.1890.29
351_A398_A1.1890.29
204_N451_A1.1880.29
93_Y289_C1.1820.29
20_Q378_F1.1770.29
543_D546_R1.1760.29
254_R539_L1.1750.29
445_I518_F1.1730.28
259_V458_M1.1710.28
492_P499_E1.1570.28
409_V525_D1.1540.28
302_L363_H1.1480.28
189_L235_F1.1470.28
397_A513_V1.1470.28
180_L195_Q1.1460.28
532_F538_D1.1440.27
238_T375_F1.1430.27
310_E339_K1.1430.27
424_I427_E1.1430.27
469_G485_V1.1390.27
519_R540_F1.1350.27
337_V396_E1.1330.27
30_G46_A1.1320.27
499_E522_L1.1300.27
439_E447_Q1.1290.27
295_T386_S1.1280.27
305_L328_L1.1280.27
261_A289_C1.1240.27
480_C484_E1.1220.27
313_I383_R1.1180.27
434_L538_D1.1170.27
355_A430_E1.1160.26
302_L375_F1.1150.26
245_E567_Q1.1120.26
90_L253_A1.1100.26
319_R324_L1.1060.26
176_I224_L1.1050.26
44_Q204_N1.1010.26
35_F202_Y1.1000.26
487_F539_L1.0970.26
20_Q332_D1.0920.26
347_E485_V1.0920.26
113_H118_P1.0910.26
100_E312_F1.0910.26
274_I439_E1.0890.26
241_T319_R1.0860.25
321_M441_Y1.0830.25
107_Y460_F1.0790.25
20_Q115_S1.0770.25
95_R540_F1.0750.25
25_L251_G1.0750.25
229_T339_K1.0740.25
301_Y437_A1.0690.25
375_F525_D1.0680.25
224_L391_E1.0670.25
494_R499_E1.0640.25
90_L93_Y1.0630.25
252_F468_H1.0630.25
353_V449_A1.0620.25
200_L266_A1.0610.25
20_Q90_L1.0610.25
202_Y410_I1.0580.25
252_F264_P1.0560.25
101_S440_E1.0540.24
121_L332_D1.0540.24
259_V532_F1.0520.24
209_L393_L1.0470.24
95_R523_C1.0460.24
259_V483_T1.0440.24
20_Q289_C1.0440.24
113_H373_Q1.0420.24
318_I506_Y1.0400.24
433_Q469_G1.0390.24
341_R472_V1.0390.24
86_Y89_L1.0360.24
333_R378_F1.0360.24
356_C532_F1.0330.24
429_V433_Q1.0320.24
40_W512_D1.0300.24
542_A554_E1.0290.24
372_T479_I1.0290.24
292_H519_R1.0260.24
29_S375_F1.0240.23
238_T565_R1.0230.23
6_E78_F1.0220.23
423_N458_M1.0200.23
431_G434_L1.0190.23
398_A490_I1.0160.23
330_G410_I1.0160.23
510_P565_R1.0120.23
148_G153_L1.0080.23
21_Y93_Y1.0070.23
327_T520_H1.0070.23
45_Q530_P1.0060.23
55_D266_A1.0040.23
361_K459_L1.0040.23
20_Q113_H1.0020.23
508_V512_D1.0000.23
177_I339_K0.9970.23
240_L469_G0.9960.23
20_Q415_I0.9950.23
34_R258_M0.9950.23
344_P542_A0.9930.23
37_Q554_E0.9930.23
375_F569_F0.9930.23
405_G565_R0.9930.23
289_C297_S0.9930.23
78_F110_L0.9920.23
115_S222_F0.9890.22
499_E506_Y0.9890.22
90_L415_I0.9870.22
354_R380_L0.9750.22
59_G86_Y0.9720.22
231_D395_Q0.9690.22
345_Q498_D0.9650.22
435_R535_M0.9610.22
34_R43_V0.9580.21
176_I236_I0.9570.21
255_S556_H0.9550.21
32_Q61_V0.9530.21
342_F346_K0.9490.21
278_K282_E0.9470.21
246_A564_R0.9460.21
541_R549_Q0.9440.21
212_K482_M0.9430.21
222_F394_L0.9410.21
77_A534_E0.9410.21
115_S121_L0.9400.21
479_I505_W0.9390.21
202_Y406_E0.9380.21
359_L481_Y0.9360.21
370_A419_M0.9350.21
373_Q378_F0.9330.21
93_Y333_R0.9320.21
246_A500_L0.9310.21
440_E447_Q0.9300.21
167_Q233_E0.9300.21
51_I90_L0.9290.21
175_Y238_T0.9270.21
113_H121_L0.9260.21
119_E141_K0.9250.21
517_E522_L0.9240.21
319_R392_L0.9240.21
126_S377_N0.9210.20
205_K264_P0.9180.20
9_I70_N0.9170.20
390_M424_I0.9160.20
134_T351_A0.9130.20
278_K295_T0.9130.20
20_Q376_E0.9120.20
90_L95_R0.9120.20
343_A347_E0.9090.20
61_V236_I0.9070.20
304_Y381_E0.9050.20
223_L270_W0.9050.20
253_A400_K0.9050.20
37_Q388_A0.9040.20
143_F227_H0.9030.20
118_P540_F0.9000.20
270_W562_A0.9000.20
157_I177_I0.8990.20
495_Y498_D0.8960.20
311_Q547_A0.8950.20
449_A517_E0.8950.20
448_L522_L0.8940.20
206_A255_S0.8940.20
361_K372_T0.8930.20
382_K440_E0.8930.20
259_V267_L0.8920.20
352_H355_A0.8900.20
328_L381_E0.8880.19
57_H289_C0.8880.19
281_A298_Y0.8860.19
311_Q330_G0.8860.19
59_G202_Y0.8850.19
420_V560_V0.8840.19
57_H118_P0.8790.19
42_A108_C0.8770.19
86_Y263_L0.8750.19
90_L115_S0.8720.19
19_A57_H0.8710.19
353_V396_E0.8690.19
319_R388_A0.8690.19
411_R557_V0.8680.19
36_E163_R0.8680.19
238_T553_R0.8660.19
225_P420_V0.8650.19
202_Y242_T0.8640.19
542_A550_N0.8630.19
123_I418_R0.8630.19
447_Q564_R0.8620.19
23_R540_F0.8600.19
210_V218_G0.8570.19
305_L310_E0.8570.19
272_R433_Q0.8560.19
14_L450_A0.8530.19
227_H287_I0.8510.19
231_D386_S0.8500.18
206_A227_H0.8480.18
253_A286_A0.8470.18
387_P439_E0.8450.18
333_R415_I0.8440.18
153_L225_P0.8430.18
77_A82_V0.8420.18
249_V513_V0.8410.18
246_A274_I0.8410.18
43_V293_A0.8400.18
253_A313_I0.8400.18
100_E264_P0.8380.18
79_L289_C0.8360.18
290_Q460_F0.8330.18
95_R289_C0.8330.18
363_H522_L0.8320.18
144_H193_H0.8310.18
496_P522_L0.8310.18
372_T423_N0.8280.18
61_V433_Q0.8260.18
209_L438_I0.8190.18
295_T414_Y0.8180.18
339_K499_E0.8150.18
20_Q118_P0.8150.18
6_E79_L0.8130.18
86_Y101_S0.8130.18
225_P569_F0.8120.18
113_H127_Q0.8110.17
319_R528_I0.8100.17
16_G419_M0.8080.17
265_A362_E0.8070.17
43_V46_A0.8050.17
101_S289_C0.8030.17
53_L449_A0.8030.17
101_S260_Y0.8000.17
9_I212_K0.7970.17
446_R450_A0.7960.17
265_A437_A0.7940.17
33_Q56_H0.7940.17
47_M324_L0.7930.17
246_A517_E0.7920.17
232_G349_S0.7920.17
328_L335_F0.7920.17
21_Y65_L0.7910.17
208_W223_L0.7890.17
210_V496_P0.7880.17
413_L440_E0.7880.17
227_H465_V0.7870.17
298_Y389_L0.7870.17
311_Q383_R0.7860.17
216_P251_G0.7840.17
51_I359_L0.7830.17
206_A258_M0.7830.17
174_H178_R0.7830.17
438_I528_I0.7830.17
55_D251_G0.7810.17
305_L308_C0.7800.17
115_S118_P0.7740.17
34_R472_V0.7740.17
30_G34_R0.7740.17
399_E479_I0.7730.17
331_F508_V0.7730.17
111_F223_L0.7720.17
383_R388_A0.7690.16
20_Q60_L0.7690.16
352_H485_V0.7660.16
194_L213_L0.7640.16
403_D411_R0.7630.16
228_Q233_E0.7610.16
70_N493_P0.7600.16
429_V437_A0.7600.16
256_Y459_L0.7590.16
318_I524_A0.7580.16
425_W445_I0.7560.16
20_Q266_A0.7550.16
213_L446_R0.7540.16
18_D249_V0.7540.16
282_E472_V0.7530.16
100_E370_A0.7530.16
116_L373_Q0.7510.16
490_I506_Y0.7510.16
252_F286_A0.7470.16
264_P374_E0.7460.16
80_L236_I0.7440.16
146_D375_F0.7420.16
213_L252_F0.7420.16
429_V542_A0.7420.16
55_D90_L0.7420.16
370_A416_E0.7400.16
154_M554_E0.7390.16
210_V548_L0.7360.16
298_Y302_L0.7350.16
12_T184_L0.7330.16
165_R384_H0.7320.16
313_I388_A0.7310.16
210_V520_H0.7310.16
20_Q253_A0.7290.16
32_Q559_D0.7290.16
158_S166_W0.7280.15
15_Q438_I0.7280.15
479_I518_F0.7280.15
75_D553_R0.7270.15
303_V321_M0.7260.15
19_A95_R0.7260.15
395_Q550_N0.7250.15
369_M451_A0.7240.15
223_L439_E0.7240.15
19_A22_G0.7230.15
98_I292_H0.7230.15
149_W156_V0.7230.15
116_L121_L0.7220.15
490_I504_P0.7220.15
247_S517_E0.7220.15
76_A285_M0.7210.15
518_F522_L0.7200.15
185_G438_I0.7190.15
436_D565_R0.7190.15
159_D449_A0.7180.15
258_M552_I0.7170.15
75_D430_E0.7170.15
93_Y166_W0.7170.15
456_G473_F0.7160.15
456_G461_K0.7160.15
461_K473_F0.7160.15
406_E486_N0.7150.15
252_F372_T0.7150.15
80_L379_V0.7150.15
220_L352_H0.7140.15
57_H292_H0.7140.15
80_L409_V0.7130.15
224_L231_D0.7130.15
222_F297_S0.7130.15
486_N504_P0.7110.15
202_Y375_F0.7110.15
19_A292_H0.7110.15
545_W563_Y0.7110.15
118_P376_E0.7070.15
82_V274_I0.7060.15
521_W563_Y0.7060.15
327_T504_P0.7050.15
297_S381_E0.7020.15
304_Y384_H0.7010.15
359_L375_F0.7000.15
309_N345_Q0.7000.15
354_R414_Y0.7000.15
208_W297_S0.6980.15
30_G258_M0.6980.15
240_L531_L0.6980.15
274_I375_F0.6970.15
473_F478_E0.6960.15
461_K478_E0.6960.15
456_G478_E0.6960.15
79_L260_Y0.6960.15
100_E410_I0.6950.15
327_T470_R0.6950.15
105_S471_V0.6930.15
356_C385_I0.6920.15
58_V65_L0.6920.15
359_L486_N0.6920.15
205_K416_E0.6910.15
301_Y366_V0.6910.15
159_D244_A0.6910.15
79_L251_G0.6890.15
492_P517_E0.6870.15
239_C485_V0.6850.15
156_V570_S0.6850.15
458_M513_V0.6850.15
148_G151_S0.6850.15
479_I506_Y0.6850.15
259_V314_E0.6840.15
112_D152_L0.6840.15
341_R450_A0.6840.15
228_Q293_A0.6830.14
95_R166_W0.6820.14
153_L565_R0.6810.14
23_R95_R0.6810.14
93_Y253_A0.6780.14
230_D541_R0.6780.14
202_Y390_M0.6760.14
444_A497_E0.6750.14
162_L296_E0.6750.14
469_G551_R0.6750.14
20_Q373_Q0.6750.14
6_E385_I0.6750.14
321_M560_V0.6730.14
248_I468_H0.6720.14
156_V274_I0.6690.14
106_V234_L0.6680.14
46_A552_I0.6680.14
438_I522_L0.6680.14
498_D504_P0.6670.14
252_F363_H0.6660.14
256_Y268_V0.6650.14
349_S355_A0.6650.14
176_I380_L0.6640.14
32_Q103_F0.6630.14
208_W356_C0.6630.14
370_A490_I0.6630.14
274_I376_E0.6610.14
202_Y391_E0.6610.14
441_Y470_R0.6610.14
61_V154_M0.6600.14
19_A98_I0.6590.14
244_A321_M0.6590.14
265_A285_M0.6580.14
170_S225_P0.6580.14
21_Y290_Q0.6580.14
472_V499_E0.6570.14
253_A520_H0.6570.14
97_E197_A0.6570.14
45_Q231_D0.6560.14
227_H396_E0.6550.14
302_L378_F0.6550.14
351_A550_N0.6530.14
395_Q570_S0.6520.14
38_A541_R0.6510.14
12_T126_S0.6490.14
460_F496_P0.6480.14
381_E384_H0.6480.14
255_S327_T0.6470.14
313_I470_R0.6470.14
345_Q531_L0.6470.14
208_W304_Y0.6450.14
95_R266_A0.6440.14
538_D541_R0.6430.14
96_F280_T0.6420.14
22_G101_S0.6420.14
498_D560_V0.6410.14
210_V472_V0.6410.14
350_A354_R0.6400.14
281_A418_R0.6400.14
19_A321_M0.6390.14
40_W514_F0.6390.14
41_H224_L0.6370.14
283_L496_P0.6370.14
247_S292_H0.6360.14
510_P549_Q0.6350.13
95_R200_L0.6350.13
251_G517_E0.6350.13
47_M560_V0.6340.13
95_R246_A0.6340.13
492_P529_G0.6330.13
19_A23_R0.6330.13
260_Y424_I0.6320.13
345_Q470_R0.6320.13
508_V514_F0.6320.13
118_P332_D0.6300.13
281_A363_H0.6300.13
424_I552_I0.6290.13
101_S251_G0.6280.13
196_V418_R0.6280.13
395_Q411_R0.6270.13
359_L446_R0.6250.13
441_Y444_A0.6240.13
206_A222_F0.6230.13
235_F401_I0.6230.13
484_E544_Y0.6220.13
103_F139_L0.6210.13
197_A265_A0.6210.13
123_I375_F0.6200.13
273_E544_Y0.6200.13
273_E337_V0.6200.13
96_F126_S0.6190.13
20_Q523_C0.6190.13
433_Q569_F0.6190.13
275_L525_D0.6170.13
314_E339_K0.6170.13
37_Q565_R0.6150.13
292_H378_F0.6140.13
305_L335_F0.6130.13
253_A372_T0.6130.13
44_Q451_A0.6120.13
127_Q292_H0.6110.13
447_Q484_E0.6110.13
513_V539_L0.6100.13
86_Y560_V0.6090.13
34_R38_A0.6080.13
527_R530_P0.6080.13
375_F544_Y0.6070.13
304_Y331_F0.6070.13
481_Y559_D0.6060.13
23_R255_S0.6020.13
246_A285_M0.6020.13
247_S420_V0.6010.13
28_T342_F0.6010.13
156_V354_R0.6000.13
238_T541_R0.6000.13
200_L496_P0.5990.13
408_I509_S0.5990.13
224_L408_I0.5990.13
313_I553_R0.5980.13
201_F363_H0.5980.13
167_Q508_V0.5980.13
402_T411_R0.5970.13
363_H540_F0.5960.13
27_V296_E0.5950.13
401_I547_A0.5950.13
57_H95_R0.5950.13
204_N369_M0.5950.13
225_P548_L0.5940.13
48_K382_K0.5930.13
551_R556_H0.5930.13
434_L472_V0.5930.13
199_E289_C0.5920.13
39_D140_A0.5910.13
375_F526_P0.5900.13
158_S430_E0.5900.13
316_P361_K0.5890.13
153_L564_R0.5890.13
466_T472_V0.5870.13
152_L194_L0.5870.13
147_H440_E0.5870.13
275_L470_R0.5870.13
86_Y482_M0.5870.13
428_Q447_Q0.5850.13
316_P370_A0.5850.13
78_F296_E0.5840.12
157_I169_K0.5830.12
375_F448_L0.5830.12
495_Y504_P0.5820.12
171_R305_L0.5820.12
43_V223_L0.5820.12
79_L212_K0.5810.12
546_R556_H0.5810.12
337_V541_R0.5790.12
197_A562_A0.5790.12
48_K531_L0.5780.12
194_L382_K0.5780.12
134_T490_I0.5780.12
93_Y260_Y0.5760.12
95_R333_R0.5760.12
228_Q231_D0.5760.12
564_R567_Q0.5760.12
323_M368_R0.5730.12
463_F474_Y0.5730.12
368_R463_F0.5730.12
368_R474_Y0.5730.12
323_M463_F0.5730.12
323_M474_Y0.5730.12
278_K348_M0.5720.12
305_L312_F0.5710.12
8_L15_Q0.5710.12
20_Q379_V0.5710.12
337_V400_K0.5670.12
69_T437_A0.5660.12
416_E466_T0.5650.12
321_M458_M0.5640.12
443_N447_Q0.5640.12
147_H393_L0.5620.12
205_K370_A0.5610.12
121_L290_Q0.5610.12
162_L195_Q0.5600.12
307_G380_L0.5590.12
103_F324_L0.5590.12
75_D530_P0.5580.12
335_F381_E0.5580.12
547_A551_R0.5580.12
229_T554_E0.5570.12
378_F481_Y0.5560.12
89_L497_E0.5560.12
311_Q387_P0.5520.12
337_V395_Q0.5520.12
148_G222_F0.5520.12
496_P499_E0.5510.12
112_D169_K0.5500.12
116_L292_H0.5500.12
101_S107_Y0.5500.12
29_S38_A0.5490.12
231_D492_P0.5490.12
445_I472_V0.5480.12
157_I176_I0.5480.12
247_S353_V0.5460.12
98_I290_Q0.5440.12
160_L199_E0.5440.12
230_D485_V0.5430.12
272_R455_P0.5430.12
258_M439_E0.5430.12
252_F296_E0.5420.12
107_Y551_R0.5410.12
73_S394_L0.5400.12
310_E330_G0.5390.12
225_P450_A0.5390.12
95_R121_L0.5380.12
51_I361_K0.5380.12
16_G108_C0.5380.12
184_L290_Q0.5370.12
345_Q485_V0.5370.12
110_L401_I0.5370.12
435_R531_L0.5360.12
301_Y363_H0.5350.12
208_W227_H0.5350.12
415_I426_L0.5340.12
69_T255_S0.5340.12
99_A105_S0.5310.12
77_A405_G0.5310.12
121_L289_C0.5300.11
23_R51_I0.5300.11
41_H231_D0.5300.11
468_H494_R0.5300.11
292_H404_L0.5290.11
234_L484_E0.5290.11
302_L389_L0.5290.11
51_I507_S0.5280.11
116_L332_D0.5280.11
62_V110_L0.5280.11
278_K345_Q0.5280.11
107_Y447_Q0.5280.11
252_F446_R0.5270.11
234_L366_V0.5260.11
153_L557_V0.5250.11
190_A253_A0.5250.11
238_T344_P0.5250.11
547_A556_H0.5240.11
490_I518_F0.5240.11
74_T350_A0.5240.11
311_Q401_I0.5240.11
102_F295_T0.5230.11
134_T517_E0.5230.11
206_A426_L0.5220.11
178_R387_P0.5210.11
309_N411_R0.5200.11
23_R53_L0.5190.11
304_Y562_A0.5190.11
45_Q162_L0.5180.11
253_A470_R0.5180.11
490_I497_E0.5170.11
341_R353_V0.5160.11
249_V410_I0.5150.11
542_A566_R0.5150.11
248_I342_F0.5140.11
511_G553_R0.5130.11
222_F544_Y0.5130.11
314_E319_R0.5120.11
107_Y380_L0.5120.11
98_I350_A0.5100.11
351_A355_A0.5100.11
519_R533_E0.5100.11
479_I482_M0.5090.11
20_Q200_L0.5090.11
104_N254_R0.5080.11
404_L407_Q0.5070.11
236_I345_Q0.5070.11
66_R283_L0.5060.11
229_T493_P0.5060.11
264_P416_E0.5060.11
530_P534_E0.5060.11
96_F132_F0.5060.11
343_A482_M0.5050.11
493_P506_Y0.5050.11
325_V342_F0.5040.11
532_F540_F0.5040.11
168_N553_R0.5030.11
195_Q480_C0.5030.11
417_R468_H0.5020.11
264_P297_S0.5010.11
99_A264_P0.5010.11
325_V473_F0.5000.11
325_V461_K0.5000.11
325_V456_G0.5000.11
38_A164_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3epsA 1 0.9792 100 0.013 Contact Map
4a6qA 1 0.2145 34.6 0.988 Contact Map
4i93A 1 0.3979 23.7 0.989 Contact Map
4q5eA 1 0.282 21.3 0.989 Contact Map
1uvjA 1 0.1661 20.4 0.989 Contact Map
2gw6A 2 0.1228 18.9 0.989 Contact Map
2r6aC 1 0.237 18.8 0.989 Contact Map
3gxvA 4 0.2128 12 0.99 Contact Map
4kb8A 2 0.3668 11.8 0.99 Contact Map
2kxoA 2 0.1522 11.4 0.99 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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