GREMLIN Database
UGPQ - Glycerophosphoryl diester phosphodiesterase
UniProt: P10908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11050
Length: 247 (229)
Sequences: 9410 (6974)
Seq/√Len: 460.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_A92_E3.2201.00
204_K230_D2.9421.00
29_V32_K2.5951.00
102_E135_E2.5851.00
98_S131_L2.5521.00
72_N75_D2.4281.00
28_D103_R2.4241.00
17_K236_A2.3841.00
27_I40_F2.3341.00
77_L99_Q2.2931.00
216_N235_D2.2651.00
73_W77_L2.2551.00
73_W96_L2.2461.00
221_A240_I2.1971.00
24_L95_P2.1561.00
112_N146_S2.1341.00
53_L68_A2.0651.00
67_V70_E2.0341.00
18_L238_D1.9821.00
98_S134_R1.9251.00
44_L127_K1.9191.00
49_E73_W1.9171.00
58_L79_V1.9121.00
40_F100_V1.8861.00
166_G187_S1.8611.00
23_T81_A1.8431.00
28_D32_K1.8261.00
46_K72_N1.8031.00
45_S51_F1.7991.00
236_A239_V1.7781.00
98_S135_E1.7731.00
10_V37_M1.7601.00
40_F52_L1.6941.00
52_L100_V1.6901.00
62_S81_A1.6861.00
64_G79_V1.6701.00
31_A109_M1.6461.00
96_L99_Q1.6431.00
53_L61_T1.6391.00
127_K130_A1.6311.00
19_A29_V1.6251.00
58_L71_L1.6091.00
51_F73_W1.5921.00
49_E96_L1.5671.00
37_M110_M1.5661.00
217_K220_R1.5621.00
126_G159_A1.5611.00
29_V33_Y1.5321.00
97_L113_I1.5311.00
145_L156_A1.5121.00
11_A26_S1.5121.00
211_L231_C1.5061.00
16_G26_S1.4931.00
220_R223_E1.4721.00
13_R21_E1.4461.00
131_L135_E1.4451.00
45_S49_E1.4361.00
59_E65_W1.4121.00
66_G71_L1.3871.00
155_A159_A1.3721.00
212_V229_V1.3701.00
44_L50_I1.3701.00
133_A160_A1.3701.00
24_L103_R1.3681.00
126_G130_A1.3651.00
51_F68_A1.3631.00
223_E227_W1.3431.00
27_I100_V1.3381.00
157_Q165_R1.3351.00
21_E60_R1.3201.00
49_E98_S1.3131.00
76_L94_L1.3071.00
130_A134_R1.2871.00
45_S76_L1.2871.00
98_S102_E1.2861.00
125_T152_A1.2801.00
145_L163_L1.2641.00
190_L212_V1.2591.00
71_L75_D1.2441.00
15_G18_L1.2381.00
129_V160_A1.2331.00
48_G127_K1.2111.00
15_G29_V1.2081.00
80_D91_G1.2051.00
50_I128_M1.2031.00
146_S233_C1.2001.00
129_V156_A1.1981.00
197_K201_M1.1911.00
42_A50_I1.1891.00
55_D60_R1.1711.00
200_V210_I1.1631.00
64_G71_L1.1581.00
157_Q186_V1.1551.00
57_N67_V1.1551.00
132_A145_L1.1541.00
192_H220_R1.1511.00
155_A158_Q1.1501.00
86_S90_K1.1471.00
71_L76_L1.1411.00
203_L210_I1.1311.00
59_E66_G1.1201.00
146_S189_H1.1201.00
222_A226_R1.1191.00
27_I38_I1.1121.00
9_I240_I1.1071.00
45_S73_W1.1051.00
53_L94_L1.1031.00
131_L134_R1.1001.00
101_A132_A1.0941.00
62_S66_G1.0931.00
201_M205_D1.0901.00
209_R230_D1.0791.00
101_A111_A1.0711.00
139_G142_P1.0701.00
42_A97_L1.0661.00
10_V231_C1.0651.00
75_D78_R1.0591.00
31_A103_R1.0571.00
15_G33_Y1.0501.00
24_L28_D1.0431.00
153_L165_R1.0281.00
139_G143_P1.0271.00
25_A29_V1.0251.00
39_E54_H1.0241.00
115_I128_M1.0191.00
10_V112_N1.0181.00
203_L208_L1.0091.00
200_V204_K1.0081.00
101_A135_E1.0061.00
43_K56_D0.9991.00
27_I52_L0.9901.00
125_T155_A0.9901.00
58_L64_G0.9881.00
77_L93_P0.9781.00
11_A16_G0.9771.00
104_C111_A0.9761.00
115_I152_A0.9681.00
180_T183_L0.9661.00
80_D93_P0.9651.00
42_A113_I0.9641.00
9_I241_G0.9561.00
16_G235_D0.9531.00
42_A128_M0.9521.00
160_A163_L0.9501.00
215_V221_A0.9481.00
215_V224_L0.9471.00
71_L79_V0.9421.00
221_A232_I0.9401.00
112_N211_L0.9361.00
199_R203_L0.9271.00
50_I131_L0.9261.00
11_A35_H0.9201.00
15_G238_D0.9201.00
50_I127_K0.9191.00
46_K70_E0.9131.00
112_N233_C0.9081.00
218_P222_A0.9031.00
51_F76_L0.9011.00
22_N27_I0.8901.00
59_E63_N0.8871.00
18_L33_Y0.8741.00
129_V133_A0.8711.00
140_M160_A0.8681.00
77_L96_L0.8671.00
146_S166_G0.8661.00
11_A15_G0.8571.00
213_Y233_C0.8541.00
204_K210_I0.8531.00
63_N66_G0.8521.00
97_L101_A0.8521.00
126_G155_A0.8481.00
57_N60_R0.8441.00
202_Q206_A0.8431.00
19_A25_A0.8361.00
127_K131_L0.8351.00
14_G27_I0.8291.00
95_P100_V0.8271.00
105_R139_G0.8261.00
112_N189_H0.8231.00
112_N144_L0.8221.00
105_R135_E0.8211.00
176_W179_L0.8201.00
28_D104_C0.8181.00
189_H211_L0.8131.00
198_A202_Q0.8131.00
22_N95_P0.8121.00
202_Q205_D0.8041.00
181_A206_A0.8021.00
114_E148_F0.7991.00
133_A140_M0.7991.00
132_A140_M0.7921.00
146_S168_L0.7911.00
40_F111_A0.7891.00
82_G85_Y0.7831.00
12_H54_H0.7821.00
234_T240_I0.7791.00
179_L182_R0.7791.00
135_E139_G0.7781.00
148_F168_L0.7771.00
133_A162_E0.7761.00
15_G237_I0.7751.00
44_L48_G0.7721.00
201_M204_K0.7661.00
218_P239_V0.7621.00
200_V227_W0.7621.00
125_T129_V0.7611.00
212_V224_L0.7571.00
128_M132_A0.7561.00
164_P186_V0.7521.00
140_M143_P0.7391.00
225_L240_I0.7391.00
149_E152_A0.7391.00
9_I35_H0.7341.00
187_S209_R0.7331.00
177_R180_T0.7311.00
101_A131_L0.7291.00
221_A239_V0.7281.00
35_H237_I0.7251.00
18_L29_V0.7241.00
114_E147_S0.7201.00
49_E127_K0.7161.00
62_S79_V0.7151.00
80_D84_W0.7151.00
28_D92_E0.7101.00
15_G19_A0.7021.00
80_D83_S0.7011.00
10_V233_C0.6981.00
129_V159_A0.6931.00
150_I154_E0.6901.00
176_W180_T0.6871.00
41_D54_H0.6871.00
220_R224_L0.6861.00
58_L76_L0.6851.00
216_N234_T0.6821.00
74_Q78_R0.6801.00
7_P225_L0.6751.00
57_N65_W0.6721.00
56_D67_V0.6641.00
33_Y238_D0.6631.00
12_H39_E0.6581.00
30_G35_H0.6571.00
175_D178_E0.6561.00
20_P92_E0.6541.00
43_K69_G0.6541.00
136_L140_M0.6541.00
105_R142_P0.6511.00
86_S91_G0.6501.00
99_Q102_E0.6491.00
38_I104_C0.6491.00
166_G189_H0.6431.00
156_A165_R0.6431.00
154_E158_Q0.6421.00
150_I167_L0.6411.00
100_V111_A0.6391.00
76_L79_V0.6360.99
224_L227_W0.6350.99
80_D85_Y0.6340.99
187_S211_L0.6340.99
178_E182_R0.6310.99
100_V104_C0.6300.99
114_E168_L0.6280.99
81_A95_P0.6260.99
108_G142_P0.6250.99
197_K227_W0.6230.99
97_L128_M0.6210.99
43_K68_A0.6190.99
186_V189_H0.6180.99
232_I240_I0.6180.99
59_E64_G0.6170.99
9_I234_T0.6140.99
40_F113_I0.6130.99
33_Y241_G0.6120.99
97_L131_L0.6120.99
147_S153_L0.6100.99
18_L236_A0.6090.99
166_G211_L0.6080.99
58_L66_G0.6080.99
8_R231_C0.6060.99
46_K75_D0.6060.99
132_A143_P0.6010.99
217_K239_V0.5990.99
150_I179_L0.5980.99
74_Q77_L0.5940.99
53_L62_S0.5930.99
128_M145_L0.5910.99
39_E116_K0.5860.99
61_T64_G0.5860.99
10_V211_L0.5850.99
38_I109_M0.5820.99
101_A139_G0.5720.99
8_R36_K0.5710.99
23_T26_S0.5700.99
59_E62_S0.5690.99
164_P209_R0.5680.99
51_F96_L0.5670.99
151_D154_E0.5670.99
15_G35_H0.5630.99
8_R110_M0.5590.99
212_V215_V0.5580.99
214_T234_T0.5570.99
61_T81_A0.5560.99
43_K117_P0.5540.99
197_K200_V0.5530.99
9_I237_I0.5520.99
132_A139_G0.5520.99
125_T128_M0.5510.99
221_A225_L0.5510.99
67_V71_L0.5510.99
153_L157_Q0.5490.99
148_F213_Y0.5480.99
31_A108_G0.5450.98
170_D191_N0.5440.98
62_S65_W0.5430.98
189_H233_C0.5420.98
125_T159_A0.5410.98
179_L183_L0.5410.98
116_K148_F0.5390.98
33_Y237_I0.5340.98
38_I100_V0.5340.98
195_L212_V0.5320.98
31_A38_I0.5280.98
167_L185_C0.5280.98
25_A28_D0.5280.98
199_R202_Q0.5270.98
16_G237_I0.5210.98
106_E142_P0.5210.98
223_E226_R0.5200.98
117_P122_G0.5200.98
54_H116_K0.5150.98
113_I143_P0.5130.98
37_M146_S0.5130.98
117_P120_G0.5120.98
81_A85_Y0.5100.98
211_L233_C0.5090.98
105_R108_G0.5060.98
200_V229_V0.5050.97
24_L27_I0.5030.97
30_G38_I0.5020.97
180_T188_I0.5020.97
168_L189_H0.5010.97
105_R111_A0.5010.97
39_E55_D0.5010.97
136_L139_G0.5000.97
46_K71_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pz0A 2 0.9717 100 0.082 Contact Map
2otdA 1 0.9879 100 0.083 Contact Map
3qvqA 4 0.9919 100 0.101 Contact Map
4r7oA 4 0.9717 100 0.104 Contact Map
3ks6A 1 0.9555 100 0.114 Contact Map
4oecA 1 0.9352 100 0.119 Contact Map
1zccA 5 0.9433 100 0.12 Contact Map
3l12A 2 0.9879 100 0.122 Contact Map
2o55A 1 0.9555 100 0.123 Contact Map
2oogA 4 0.9798 100 0.129 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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