GREMLIN Database
UGPC - sn-glycerol-3-phosphate import ATP-binding protein UgpC
UniProt: P10907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11048
Length: 356 (309)
Sequences: 23996 (17317)
Seq/√Len: 985.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_G221_E3.9541.00
34_V202_A3.8401.00
60_D67_R3.7621.00
31_E204_R3.6661.00
8_A22_P3.5231.00
5_K26_D3.4901.00
297_M313_G3.4231.00
7_Q60_D3.3731.00
120_R125_D3.2281.00
18_Q21_K3.2171.00
300_D314_R2.8011.00
112_A116_K2.7111.00
214_E228_S2.6131.00
33_I206_M2.5761.00
21_K212_V2.5051.00
7_Q62_W2.4971.00
107_G110_Q2.4871.00
218_T221_E2.4851.00
127_L130_R2.4671.00
10_T58_E2.4271.00
5_K62_W2.4071.00
28_A31_E2.4051.00
6_L9_V2.4031.00
10_T18_Q2.3891.00
94_E98_A2.3721.00
11_K49_M2.3671.00
114_R152_D2.3421.00
12_S18_Q2.3321.00
77_G154_A2.2001.00
94_E129_K2.1991.00
10_T22_P2.1381.00
199_M220_V2.1361.00
123_E172_Q2.0961.00
179_Q183_R2.0911.00
94_E116_K2.0381.00
8_A24_T2.0021.00
119_A128_L1.9921.00
64_N154_A1.9471.00
62_W67_R1.9271.00
206_M213_A1.9221.00
94_E112_A1.9061.00
11_K57_T1.8991.00
49_M56_V1.8961.00
9_V56_V1.8961.00
209_N214_E1.8751.00
4_L155_V1.8691.00
229_L277_T1.8111.00
20_I49_M1.7971.00
114_R117_E1.7881.00
110_Q113_E1.7871.00
206_M216_I1.7711.00
47_L191_V1.7701.00
113_E117_E1.7431.00
11_K54_E1.6901.00
98_A115_V1.6841.00
94_E115_V1.6171.00
49_M61_I1.5591.00
298_V314_R1.5541.00
50_V189_L1.5541.00
116_K128_L1.5261.00
12_S57_T1.5251.00
118_A150_V1.5211.00
109_Q113_E1.5171.00
48_R54_E1.5171.00
67_R70_E1.5161.00
158_F188_S1.4931.00
6_L25_L1.4601.00
106_M110_Q1.4451.00
252_T256_L1.4441.00
66_Q154_A1.4381.00
63_I68_V1.4311.00
23_L46_L1.4091.00
47_L157_L1.4031.00
92_S95_E1.3961.00
229_L233_S1.3941.00
116_K120_R1.3931.00
117_E120_R1.3921.00
6_L50_V1.3661.00
66_Q71_M1.3651.00
220_V224_E1.3651.00
33_I216_I1.3561.00
98_A111_I1.3551.00
10_T21_K1.3481.00
27_V33_I1.3461.00
271_Y274_R1.3441.00
110_Q114_R1.3411.00
302_L311_A1.3211.00
106_M111_I1.3191.00
122_L146_G1.3111.00
95_E98_A1.3071.00
25_L206_M1.3041.00
229_L242_L1.2941.00
7_Q24_T1.2921.00
91_M99_W1.2881.00
68_V71_M1.2861.00
204_R216_I1.2581.00
90_H133_R1.2501.00
92_S131_R1.2461.00
6_L46_L1.2411.00
242_L277_T1.2281.00
221_E225_K1.2271.00
252_T255_E1.2231.00
100_G151_R1.2201.00
253_H256_L1.2161.00
95_E102_K1.2051.00
56_V61_I1.1821.00
20_I46_L1.1811.00
33_I204_R1.1731.00
117_E152_D1.1711.00
28_A204_R1.1581.00
60_D69_T1.1541.00
12_S16_K1.1511.00
181_H188_S1.1411.00
93_V135_L1.1391.00
258_G261_E1.1371.00
270_Q274_R1.1291.00
246_R275_K1.1261.00
79_A148_A1.1081.00
20_I23_L1.1041.00
233_S242_L1.0961.00
254_F257_D1.0951.00
62_W65_D1.0901.00
117_E121_I1.0901.00
240_M279_G1.0841.00
29_D64_N1.0841.00
12_S58_E1.0811.00
71_M75_D1.0801.00
192_T198_A1.0801.00
178_Q200_T1.0671.00
108_K112_A1.0541.00
260_I263_P1.0521.00
181_H186_T1.0481.00
34_V198_A1.0451.00
48_R53_L1.0431.00
13_W19_V1.0401.00
207_V222_V1.0381.00
56_V69_T1.0361.00
178_Q201_L1.0351.00
207_V231_V1.0341.00
111_I115_V1.0311.00
280_I285_I1.0291.00
249_N252_T1.0241.00
241_N245_G1.0221.00
240_M243_L1.0121.00
253_H257_D1.0111.00
244_T277_T1.0101.00
102_K108_K1.0041.00
261_E264_L0.9961.00
261_E265_N0.9951.00
180_L186_T0.9951.00
72_E75_D0.9941.00
12_S19_V0.9941.00
259_G262_L0.9901.00
104_R151_R0.9851.00
121_I183_R0.9821.00
209_N230_F0.9821.00
9_V49_M0.9771.00
41_C208_M0.9751.00
32_F181_H0.9741.00
31_E203_Q0.9701.00
131_R134_E0.9701.00
29_D154_A0.9701.00
94_E128_L0.9691.00
162_L177_L0.9691.00
116_K125_D0.9681.00
291_A294_G0.9611.00
178_Q182_R0.9601.00
32_F188_S0.9591.00
96_N147_R0.9591.00
88_Y91_M0.9541.00
91_M95_E0.9541.00
51_A157_L0.9481.00
256_L259_G0.9471.00
46_L208_M0.9471.00
252_T257_D0.9431.00
8_A58_E0.9421.00
130_R134_E0.9411.00
99_W103_I0.9341.00
118_A149_I0.9271.00
304_I309_N0.9231.00
162_L190_Y0.9231.00
97_M146_G0.9221.00
108_K111_I0.9201.00
152_D186_T0.9161.00
5_K65_D0.9081.00
220_V304_I0.9071.00
117_E183_R0.9051.00
79_A153_P0.9041.00
259_G264_L0.8951.00
224_E304_I0.8931.00
241_N244_T0.8921.00
299_M311_A0.8851.00
27_V187_T0.8771.00
209_N212_V0.8751.00
244_T275_K0.8731.00
88_Y100_G0.8681.00
30_G187_T0.8681.00
87_L132_P0.8581.00
305_L310_L0.8531.00
257_D260_I0.8521.00
190_Y202_A0.8521.00
98_A102_K0.8511.00
152_D183_R0.8491.00
219_P223_Y0.8471.00
7_Q26_D0.8461.00
61_I68_V0.8461.00
97_M150_V0.8441.00
32_F201_L0.8431.00
278_L281_R0.8341.00
170_R194_D0.8311.00
280_I283_E0.8291.00
30_G185_K0.8281.00
156_F186_T0.8241.00
119_A124_L0.8241.00
253_H261_E0.8191.00
173_M176_E0.8191.00
97_M119_A0.8171.00
171_V175_L0.8121.00
262_L265_N0.7991.00
132_P143_V0.7971.00
255_E259_G0.7961.00
270_Q273_G0.7951.00
36_V207_V0.7941.00
268_Y272_A0.7891.00
38_P41_C0.7881.00
96_N132_P0.7861.00
6_L61_I0.7851.00
269_R273_G0.7821.00
196_V200_T0.7741.00
79_A151_R0.7691.00
179_Q301_T0.7651.00
35_M46_L0.7641.00
176_E179_Q0.7631.00
269_R272_A0.7631.00
232_A236_G0.7621.00
240_M244_T0.7591.00
44_S48_R0.7551.00
11_K45_T0.7531.00
78_I155_V0.7521.00
85_Y164_N0.7491.00
160_E193_H0.7491.00
35_M206_M0.7491.00
71_M74_K0.7461.00
239_A243_L0.7451.00
49_M57_T0.7451.00
279_G282_P0.7401.00
175_L179_Q0.7361.00
154_A186_T0.7341.00
239_A242_L0.7311.00
25_L216_I0.7311.00
217_G222_V0.7301.00
112_A115_V0.7301.00
92_S129_K0.7281.00
245_G276_M0.7281.00
97_M100_G0.7221.00
9_V61_I0.7221.00
118_A121_I0.7211.00
223_Y283_E0.7191.00
248_N253_H0.7151.00
91_M96_N0.7141.00
49_M54_E0.7131.00
174_R200_T0.7111.00
83_Q137_G0.7101.00
258_G262_L0.7081.00
191_V195_Q0.7061.00
13_W54_E0.7041.00
63_I78_I0.7041.00
22_P58_E0.7031.00
33_I189_L0.7021.00
145_M158_F0.7001.00
158_F190_Y0.6971.00
153_P156_F0.6941.00
29_D185_K0.6911.00
255_E258_G0.6901.00
125_D128_L0.6901.00
118_A146_G0.6901.00
106_M114_R0.6901.00
238_P242_L0.6891.00
175_L301_T0.6861.00
301_T304_I0.6811.00
220_V309_N0.6801.00
126_G139_Q0.6771.00
93_V143_V0.6771.00
250_E253_H0.6761.00
196_V305_L0.6751.00
167_A171_V0.6751.00
191_V194_D0.6741.00
248_N251_G0.6731.00
281_R288_S0.6691.00
305_L308_D0.6691.00
259_G263_P0.6681.00
102_K111_I0.6671.00
79_A188_S0.6671.00
168_K233_S0.6651.00
256_L261_E0.6631.00
124_L127_L0.6571.00
299_M313_G0.6551.00
240_M245_G0.6551.00
175_L312_H0.6551.00
51_A80_M0.6551.00
281_R285_I0.6531.00
177_L188_S0.6521.00
280_I287_L0.6501.00
41_C46_L0.6491.00
167_A174_R0.6491.00
35_M208_M0.6481.00
260_I265_N0.6461.00
100_G147_R0.6451.00
77_G104_R0.6451.00
256_L260_I0.6441.00
21_K210_G0.6431.00
268_Y271_Y0.6431.00
87_L96_N0.6421.00
32_F190_Y0.6421.00
278_L282_P0.6411.00
94_E97_M0.6391.00
100_G104_R0.6351.00
202_A205_V0.6331.00
178_Q181_H0.6331.00
118_A122_L0.6311.00
282_P286_A0.6311.00
123_E176_E0.6291.00
12_S21_K0.6271.00
282_P288_S0.6261.00
297_M300_D0.6231.00
81_V145_M0.6211.00
100_G103_I0.6211.00
92_S96_N0.6201.00
198_A202_A0.6201.00
230_F234_F0.6191.00
213_A216_I0.6191.00
242_L245_G0.6191.00
260_I264_L0.6181.00
299_M306_G0.6181.00
114_R118_A0.6161.00
275_K279_G0.6161.00
299_M302_L0.6151.00
273_G276_M0.6151.00
157_L189_L0.6121.00
107_G111_I0.6081.00
69_T73_P0.6081.00
243_L247_V0.6081.00
277_T281_R0.6081.00
273_G280_I0.6071.00
286_A290_Q0.6071.00
301_T312_H0.6051.00
231_V234_F0.6051.00
292_E298_V0.6021.00
94_E111_I0.6011.00
233_S237_S0.5991.00
195_Q234_F0.5991.00
116_K124_L0.5991.00
231_V235_I0.5981.00
170_R197_E0.5981.00
276_M280_I0.5981.00
123_E126_G0.5971.00
293_G296_P0.5961.00
109_Q112_A0.5951.00
294_G297_M0.5941.00
262_L266_G0.5931.00
121_I179_Q0.5931.00
251_G254_F0.5901.00
285_I288_S0.5901.00
55_R70_E0.5891.00
172_Q176_E0.5891.00
249_N253_H0.5871.00
271_Y276_M0.5841.00
271_Y275_K0.5841.00
126_G130_R0.5831.00
291_A295_V0.5831.00
238_P241_N0.5821.00
156_F188_S0.5821.00
208_M213_A0.5821.00
309_N312_H0.5821.00
288_S292_E0.5821.00
284_H287_L0.5791.00
67_R71_M0.5791.00
215_Q231_V0.5781.00
135_L143_V0.5781.00
282_P285_I0.5771.00
221_E224_E0.5771.00
81_V148_A0.5751.00
101_L150_V0.5751.00
259_G266_G0.5751.00
250_E257_D0.5741.00
171_V196_V0.5731.00
258_G264_L0.5721.00
83_Q164_N0.5721.00
15_G18_Q0.5721.00
233_S236_G0.5711.00
288_S291_A0.5701.00
77_G151_R0.5681.00
88_Y96_N0.5681.00
119_A125_D0.5681.00
223_Y226_P0.5671.00
228_S231_V0.5641.00
99_W102_K0.5641.00
245_G252_T0.5641.00
275_K281_R0.5641.00
263_P266_G0.5631.00
287_L290_Q0.5621.00
258_G263_P0.5601.00
31_E216_I0.5591.00
68_V78_I0.5591.00
113_E116_K0.5581.00
258_G265_N0.5571.00
274_R281_R0.5541.00
281_R284_H0.5541.00
300_D312_H0.5521.00
60_D70_E0.5501.00
119_A122_L0.5501.00
279_G283_E0.5491.00
272_A276_M0.5471.00
155_V187_T0.5471.00
122_L173_M0.5471.00
11_K19_V0.5451.00
243_L246_R0.5451.00
264_L267_G0.5441.00
84_N140_R0.5391.00
192_T195_Q0.5391.00
178_Q203_Q0.5381.00
293_G297_M0.5381.00
251_G255_E0.5381.00
298_V302_L0.5361.00
53_L82_F0.5361.00
288_S293_G0.5361.00
288_S294_G0.5361.00
13_W45_T0.5341.00
269_R276_M0.5311.00
171_V237_S0.5311.00
10_T20_I0.5301.00
11_K20_I0.5291.00
164_N174_R0.5271.00
298_V301_T0.5271.00
205_V219_P0.5261.00
275_K280_I0.5251.00
291_A296_P0.5251.00
163_S167_A0.5241.00
113_E120_R0.5231.00
250_E256_L0.5231.00
260_I266_G0.5221.00
23_L213_A0.5211.00
110_Q152_D0.5191.00
255_E261_E0.5191.00
302_L309_N0.5181.00
248_N257_D0.5151.00
266_G270_Q0.5141.00
241_N246_R0.5141.00
302_L305_L0.5121.00
18_Q22_P0.5121.00
246_R250_E0.5101.00
48_R80_M0.5101.00
237_S310_L0.5101.00
261_E268_Y0.5081.00
207_V226_P0.5081.00
182_R301_T0.5071.00
4_L63_I0.5061.00
250_E255_E0.5061.00
50_V157_L0.5061.00
269_R275_K0.5061.00
292_E296_P0.5051.00
241_N247_V0.5031.00
101_L104_R0.5001.00
247_V250_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2it1A 1 0.9916 100 0.175 Contact Map
1v43A 2 0.9635 100 0.176 Contact Map
2yyzA 1 0.9888 100 0.182 Contact Map
1g291 4 0.9916 100 0.184 Contact Map
3rlfA 2 0.9944 100 0.197 Contact Map
1oxxK 1 0.9522 100 0.203 Contact Map
3fvqA 2 0.9635 100 0.219 Contact Map
4tquS 2 0.9972 100 0.222 Contact Map
1z47A 2 0.9579 100 0.222 Contact Map
3d31A 2 0.9438 100 0.226 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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