UGPC - ECOLI - GREMLIN Contacts

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UGPC - sn-glycerol-3-phosphate import ATP-binding protein UgpC

UniProt:	P10907	Sequences: MAGLKLQAVTKSWDGKTQVIKPLTLDVADGEFIVMVGPSGCGKSTLLRMVAGLERVTEGDIWINDQRVTEMEPKDRGIAMVFQNYALYPHMSVEENMAWGLKIRGMGKQQIAERVKEAARILELDGLLKRRPRELSGGQRQRVAMGRAIVRDPAVFLFDEPLSNLDAKLRVQMRLELQQLHRRLKTTSLYVTHDQVEAMTLAQRVMVMNGGVAEQIGTPVEVYEKPASLFVASFIGSPAMNLLTGRVNNEGTHFELDGGIELPLNGGYRQYAGRKMTLGIRPEHIALSSQAEGGVPMVMDTLEILGADNLAHGRWGEQKLVVRLAHQERPTAGSTLWLHLAENQLHLFDGETGQRV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11048
Length:	356 (309)
Sequences:	23996 (17317)
Seq/√Len:	985.1

ECOLI - UGPC YCJV MALK CYSA FBPC POTA POTG PROV METN YDCT MODC DPPD SAPD DPPF YADG YEHX RBSA OPPD MACB OPPF DDPD ARAG DDPF GSIA UUP YHES YECC TAUB MLAF HISP LPTB CYDC FEPC MDLB NIKE MDLA LSRA YTFR SAPF MSBA FHUC SSUB FECE YOJI PHNC CYDD GLNQ YHDZ GLTL THIQ SUFC ETTA FTSE LIVG YPHE ARTP PHNK PSTB XYLG ZNUC MODF LIVF ALSA NIKD LOLD BTUD MGLA FETA YBBA CCMA YDDA PHNL YEJF YNJD YBHF YBIT
BACSU - MSMX YURJ YVRA OPUBA OPUCA OPUAA METN TAGH OPPD DPPD YKFD YHAQ YFIL YXLF APPF APPD YHCH YCBN YDBJ YVFR YFMM OPPF YKPA RBSA YTRB FHUC YDIF ECFA1 YFMF SUNT YFMR SKFE YUSV ECSA YHEH YFIC YTLC YVCR BCEA TCYN YFIB YCLP YKNV YKNU ALBC BMRA MNTB CYDD YXDL YLMA SUFC YHEI YGAD YWJA ECFA2 FTSE NATA YXEO TCYC GLNQ YKOD ARTM CYDC SSUB YTHP PSTB1 ZNUC YVRO YCLH YJKB YKNY PSTB2 YYBJ EXPZ YHCG YUFO YYDI YTRE
HALSA - Q9HHQ5 Q9HR06 Q9HNZ9 Q9HMT3 Q9HMX3 Q9HMW0 BTUDA Q9HMX2 Q9HMU8 Q9HRJ6 PHNC Q9HMG1 Q9HRH8 PSTB2 Q9HHM2 Q9HSQ7 Q9HMG6 Q9HNY3 Q9HRV7 Q9HRZ9 Y2317 Y1631 PSTB1 Q9HR96 Q9HHR7 Q9HS04 Q9HT03 Q9HQA8 Q9HR21 Q9HMC1 Q9HMW1
SULSO - Q97YY4 Q97UF2 Q97UY8 Q97ZC0 Q97VC1 Q7LX64 Q97UH3 Q97VH6 Q97VF5 Q97YP3 Q97VK8 Q97UD4 Q97X18 Q97YK2 Q97VK9 Q97YP7 Q97UJ9 Q97VF4 Q97YP8 Q97YQ7 Q97Z03 Q97U54 Y2030 Y1893 Q980W0 Q97V01 Q97UH4 PSTB Q97W42 Q97V00 Q7LY07 Q97VM2 Q7LXM4 Q97VY4 Q7LX80 Q97Z56 Q97UG5 Q97YP4 Q97Z96 Q97UC2 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
217_G	221_E	3.954	1.00
34_V	202_A	3.840	1.00
60_D	67_R	3.762	1.00
31_E	204_R	3.666	1.00
8_A	22_P	3.523	1.00
5_K	26_D	3.490	1.00
297_M	313_G	3.423	1.00
7_Q	60_D	3.373	1.00
120_R	125_D	3.228	1.00
18_Q	21_K	3.217	1.00
300_D	314_R	2.801	1.00
112_A	116_K	2.711	1.00
214_E	228_S	2.613	1.00
33_I	206_M	2.576	1.00
21_K	212_V	2.505	1.00
7_Q	62_W	2.497	1.00
107_G	110_Q	2.487	1.00
218_T	221_E	2.485	1.00
127_L	130_R	2.467	1.00
10_T	58_E	2.427	1.00
5_K	62_W	2.407	1.00
28_A	31_E	2.405	1.00
6_L	9_V	2.403	1.00
10_T	18_Q	2.389	1.00
94_E	98_A	2.372	1.00
11_K	49_M	2.367	1.00
114_R	152_D	2.342	1.00
12_S	18_Q	2.332	1.00
77_G	154_A	2.200	1.00
94_E	129_K	2.199	1.00
10_T	22_P	2.138	1.00
199_M	220_V	2.136	1.00
123_E	172_Q	2.096	1.00
179_Q	183_R	2.091	1.00
94_E	116_K	2.038	1.00
8_A	24_T	2.002	1.00
119_A	128_L	1.992	1.00
64_N	154_A	1.947	1.00
62_W	67_R	1.927	1.00
206_M	213_A	1.922	1.00
94_E	112_A	1.906	1.00
11_K	57_T	1.899	1.00
49_M	56_V	1.896	1.00
9_V	56_V	1.896	1.00
209_N	214_E	1.875	1.00
4_L	155_V	1.869	1.00
229_L	277_T	1.811	1.00
20_I	49_M	1.797	1.00
114_R	117_E	1.788	1.00
110_Q	113_E	1.787	1.00
206_M	216_I	1.771	1.00
47_L	191_V	1.770	1.00
113_E	117_E	1.743	1.00
11_K	54_E	1.690	1.00
98_A	115_V	1.684	1.00
94_E	115_V	1.617	1.00
49_M	61_I	1.559	1.00
298_V	314_R	1.554	1.00
50_V	189_L	1.554	1.00
116_K	128_L	1.526	1.00
12_S	57_T	1.525	1.00
118_A	150_V	1.521	1.00
109_Q	113_E	1.517	1.00
48_R	54_E	1.517	1.00
67_R	70_E	1.516	1.00
158_F	188_S	1.493	1.00
6_L	25_L	1.460	1.00
106_M	110_Q	1.445	1.00
252_T	256_L	1.444	1.00
66_Q	154_A	1.438	1.00
63_I	68_V	1.431	1.00
23_L	46_L	1.409	1.00
47_L	157_L	1.403	1.00
92_S	95_E	1.396	1.00
229_L	233_S	1.394	1.00
116_K	120_R	1.393	1.00
117_E	120_R	1.392	1.00
6_L	50_V	1.366	1.00
66_Q	71_M	1.365	1.00
220_V	224_E	1.365	1.00
33_I	216_I	1.356	1.00
98_A	111_I	1.355	1.00
10_T	21_K	1.348	1.00
27_V	33_I	1.346	1.00
271_Y	274_R	1.344	1.00
110_Q	114_R	1.341	1.00
302_L	311_A	1.321	1.00
106_M	111_I	1.319	1.00
122_L	146_G	1.311	1.00
95_E	98_A	1.307	1.00
25_L	206_M	1.304	1.00
229_L	242_L	1.294	1.00
7_Q	24_T	1.292	1.00
91_M	99_W	1.288	1.00
68_V	71_M	1.286	1.00
204_R	216_I	1.258	1.00
90_H	133_R	1.250	1.00
92_S	131_R	1.246	1.00
6_L	46_L	1.241	1.00
242_L	277_T	1.228	1.00
221_E	225_K	1.227	1.00
252_T	255_E	1.223	1.00
100_G	151_R	1.220	1.00
253_H	256_L	1.216	1.00
95_E	102_K	1.205	1.00
56_V	61_I	1.182	1.00
20_I	46_L	1.181	1.00
33_I	204_R	1.173	1.00
117_E	152_D	1.171	1.00
28_A	204_R	1.158	1.00
60_D	69_T	1.154	1.00
12_S	16_K	1.151	1.00
181_H	188_S	1.141	1.00
93_V	135_L	1.139	1.00
258_G	261_E	1.137	1.00
270_Q	274_R	1.129	1.00
246_R	275_K	1.126	1.00
79_A	148_A	1.108	1.00
20_I	23_L	1.104	1.00
233_S	242_L	1.096	1.00
254_F	257_D	1.095	1.00
62_W	65_D	1.090	1.00
117_E	121_I	1.090	1.00
240_M	279_G	1.084	1.00
29_D	64_N	1.084	1.00
12_S	58_E	1.081	1.00
71_M	75_D	1.080	1.00
192_T	198_A	1.080	1.00
178_Q	200_T	1.067	1.00
108_K	112_A	1.054	1.00
260_I	263_P	1.052	1.00
181_H	186_T	1.048	1.00
34_V	198_A	1.045	1.00
48_R	53_L	1.043	1.00
13_W	19_V	1.040	1.00
207_V	222_V	1.038	1.00
56_V	69_T	1.036	1.00
178_Q	201_L	1.035	1.00
207_V	231_V	1.034	1.00
111_I	115_V	1.031	1.00
280_I	285_I	1.029	1.00
249_N	252_T	1.024	1.00
241_N	245_G	1.022	1.00
240_M	243_L	1.012	1.00
253_H	257_D	1.011	1.00
244_T	277_T	1.010	1.00
102_K	108_K	1.004	1.00
261_E	264_L	0.996	1.00
261_E	265_N	0.995	1.00
180_L	186_T	0.995	1.00
72_E	75_D	0.994	1.00
12_S	19_V	0.994	1.00
259_G	262_L	0.990	1.00
104_R	151_R	0.985	1.00
121_I	183_R	0.982	1.00
209_N	230_F	0.982	1.00
9_V	49_M	0.977	1.00
41_C	208_M	0.975	1.00
32_F	181_H	0.974	1.00
31_E	203_Q	0.970	1.00
131_R	134_E	0.970	1.00
29_D	154_A	0.970	1.00
94_E	128_L	0.969	1.00
162_L	177_L	0.969	1.00
116_K	125_D	0.968	1.00
291_A	294_G	0.961	1.00
178_Q	182_R	0.960	1.00
32_F	188_S	0.959	1.00
96_N	147_R	0.959	1.00
88_Y	91_M	0.954	1.00
91_M	95_E	0.954	1.00
51_A	157_L	0.948	1.00
256_L	259_G	0.947	1.00
46_L	208_M	0.947	1.00
252_T	257_D	0.943	1.00
8_A	58_E	0.942	1.00
130_R	134_E	0.941	1.00
99_W	103_I	0.934	1.00
118_A	149_I	0.927	1.00
304_I	309_N	0.923	1.00
162_L	190_Y	0.923	1.00
97_M	146_G	0.922	1.00
108_K	111_I	0.920	1.00
152_D	186_T	0.916	1.00
5_K	65_D	0.908	1.00
220_V	304_I	0.907	1.00
117_E	183_R	0.905	1.00
79_A	153_P	0.904	1.00
259_G	264_L	0.895	1.00
224_E	304_I	0.893	1.00
241_N	244_T	0.892	1.00
299_M	311_A	0.885	1.00
27_V	187_T	0.877	1.00
209_N	212_V	0.875	1.00
244_T	275_K	0.873	1.00
88_Y	100_G	0.868	1.00
30_G	187_T	0.868	1.00
87_L	132_P	0.858	1.00
305_L	310_L	0.853	1.00
257_D	260_I	0.852	1.00
190_Y	202_A	0.852	1.00
98_A	102_K	0.851	1.00
152_D	183_R	0.849	1.00
219_P	223_Y	0.847	1.00
7_Q	26_D	0.846	1.00
61_I	68_V	0.846	1.00
97_M	150_V	0.844	1.00
32_F	201_L	0.843	1.00
278_L	281_R	0.834	1.00
170_R	194_D	0.831	1.00
280_I	283_E	0.829	1.00
30_G	185_K	0.828	1.00
156_F	186_T	0.824	1.00
119_A	124_L	0.824	1.00
253_H	261_E	0.819	1.00
173_M	176_E	0.819	1.00
97_M	119_A	0.817	1.00
171_V	175_L	0.812	1.00
262_L	265_N	0.799	1.00
132_P	143_V	0.797	1.00
255_E	259_G	0.796	1.00
270_Q	273_G	0.795	1.00
36_V	207_V	0.794	1.00
268_Y	272_A	0.789	1.00
38_P	41_C	0.788	1.00
96_N	132_P	0.786	1.00
6_L	61_I	0.785	1.00
269_R	273_G	0.782	1.00
196_V	200_T	0.774	1.00
79_A	151_R	0.769	1.00
179_Q	301_T	0.765	1.00
35_M	46_L	0.764	1.00
176_E	179_Q	0.763	1.00
269_R	272_A	0.763	1.00
232_A	236_G	0.762	1.00
240_M	244_T	0.759	1.00
44_S	48_R	0.755	1.00
11_K	45_T	0.753	1.00
78_I	155_V	0.752	1.00
85_Y	164_N	0.749	1.00
160_E	193_H	0.749	1.00
35_M	206_M	0.749	1.00
71_M	74_K	0.746	1.00
239_A	243_L	0.745	1.00
49_M	57_T	0.745	1.00
279_G	282_P	0.740	1.00
175_L	179_Q	0.736	1.00
154_A	186_T	0.734	1.00
239_A	242_L	0.731	1.00
25_L	216_I	0.731	1.00
217_G	222_V	0.730	1.00
112_A	115_V	0.730	1.00
92_S	129_K	0.728	1.00
245_G	276_M	0.728	1.00
97_M	100_G	0.722	1.00
9_V	61_I	0.722	1.00
118_A	121_I	0.721	1.00
223_Y	283_E	0.719	1.00
248_N	253_H	0.715	1.00
91_M	96_N	0.714	1.00
49_M	54_E	0.713	1.00
174_R	200_T	0.711	1.00
83_Q	137_G	0.710	1.00
258_G	262_L	0.708	1.00
191_V	195_Q	0.706	1.00
13_W	54_E	0.704	1.00
63_I	78_I	0.704	1.00
22_P	58_E	0.703	1.00
33_I	189_L	0.702	1.00
145_M	158_F	0.700	1.00
158_F	190_Y	0.697	1.00
153_P	156_F	0.694	1.00
29_D	185_K	0.691	1.00
255_E	258_G	0.690	1.00
125_D	128_L	0.690	1.00
118_A	146_G	0.690	1.00
106_M	114_R	0.690	1.00
238_P	242_L	0.689	1.00
175_L	301_T	0.686	1.00
301_T	304_I	0.681	1.00
220_V	309_N	0.680	1.00
126_G	139_Q	0.677	1.00
93_V	143_V	0.677	1.00
250_E	253_H	0.676	1.00
196_V	305_L	0.675	1.00
167_A	171_V	0.675	1.00
191_V	194_D	0.674	1.00
248_N	251_G	0.673	1.00
281_R	288_S	0.669	1.00
305_L	308_D	0.669	1.00
259_G	263_P	0.668	1.00
102_K	111_I	0.667	1.00
79_A	188_S	0.667	1.00
168_K	233_S	0.665	1.00
256_L	261_E	0.663	1.00
124_L	127_L	0.657	1.00
299_M	313_G	0.655	1.00
240_M	245_G	0.655	1.00
175_L	312_H	0.655	1.00
51_A	80_M	0.655	1.00
281_R	285_I	0.653	1.00
177_L	188_S	0.652	1.00
280_I	287_L	0.650	1.00
41_C	46_L	0.649	1.00
167_A	174_R	0.649	1.00
35_M	208_M	0.648	1.00
260_I	265_N	0.646	1.00
100_G	147_R	0.645	1.00
77_G	104_R	0.645	1.00
256_L	260_I	0.644	1.00
21_K	210_G	0.643	1.00
268_Y	271_Y	0.643	1.00
87_L	96_N	0.642	1.00
32_F	190_Y	0.642	1.00
278_L	282_P	0.641	1.00
94_E	97_M	0.639	1.00
100_G	104_R	0.635	1.00
202_A	205_V	0.633	1.00
178_Q	181_H	0.633	1.00
118_A	122_L	0.631	1.00
282_P	286_A	0.631	1.00
123_E	176_E	0.629	1.00
12_S	21_K	0.627	1.00
282_P	288_S	0.626	1.00
297_M	300_D	0.623	1.00
81_V	145_M	0.621	1.00
100_G	103_I	0.621	1.00
92_S	96_N	0.620	1.00
198_A	202_A	0.620	1.00
230_F	234_F	0.619	1.00
213_A	216_I	0.619	1.00
242_L	245_G	0.619	1.00
260_I	264_L	0.618	1.00
299_M	306_G	0.618	1.00
114_R	118_A	0.616	1.00
275_K	279_G	0.616	1.00
299_M	302_L	0.615	1.00
273_G	276_M	0.615	1.00
157_L	189_L	0.612	1.00
107_G	111_I	0.608	1.00
69_T	73_P	0.608	1.00
243_L	247_V	0.608	1.00
277_T	281_R	0.608	1.00
273_G	280_I	0.607	1.00
286_A	290_Q	0.607	1.00
301_T	312_H	0.605	1.00
231_V	234_F	0.605	1.00
292_E	298_V	0.602	1.00
94_E	111_I	0.601	1.00
233_S	237_S	0.599	1.00
195_Q	234_F	0.599	1.00
116_K	124_L	0.599	1.00
231_V	235_I	0.598	1.00
170_R	197_E	0.598	1.00
276_M	280_I	0.598	1.00
123_E	126_G	0.597	1.00
293_G	296_P	0.596	1.00
109_Q	112_A	0.595	1.00
294_G	297_M	0.594	1.00
262_L	266_G	0.593	1.00
121_I	179_Q	0.593	1.00
251_G	254_F	0.590	1.00
285_I	288_S	0.590	1.00
55_R	70_E	0.589	1.00
172_Q	176_E	0.589	1.00
249_N	253_H	0.587	1.00
271_Y	276_M	0.584	1.00
271_Y	275_K	0.584	1.00
126_G	130_R	0.583	1.00
291_A	295_V	0.583	1.00
238_P	241_N	0.582	1.00
156_F	188_S	0.582	1.00
208_M	213_A	0.582	1.00
309_N	312_H	0.582	1.00
288_S	292_E	0.582	1.00
284_H	287_L	0.579	1.00
67_R	71_M	0.579	1.00
215_Q	231_V	0.578	1.00
135_L	143_V	0.578	1.00
282_P	285_I	0.577	1.00
221_E	224_E	0.577	1.00
81_V	148_A	0.575	1.00
101_L	150_V	0.575	1.00
259_G	266_G	0.575	1.00
250_E	257_D	0.574	1.00
171_V	196_V	0.573	1.00
258_G	264_L	0.572	1.00
83_Q	164_N	0.572	1.00
15_G	18_Q	0.572	1.00
233_S	236_G	0.571	1.00
288_S	291_A	0.570	1.00
77_G	151_R	0.568	1.00
88_Y	96_N	0.568	1.00
119_A	125_D	0.568	1.00
223_Y	226_P	0.567	1.00
228_S	231_V	0.564	1.00
99_W	102_K	0.564	1.00
245_G	252_T	0.564	1.00
275_K	281_R	0.564	1.00
263_P	266_G	0.563	1.00
287_L	290_Q	0.562	1.00
258_G	263_P	0.560	1.00
31_E	216_I	0.559	1.00
68_V	78_I	0.559	1.00
113_E	116_K	0.558	1.00
258_G	265_N	0.557	1.00
274_R	281_R	0.554	1.00
281_R	284_H	0.554	1.00
300_D	312_H	0.552	1.00
60_D	70_E	0.550	1.00
119_A	122_L	0.550	1.00
279_G	283_E	0.549	1.00
272_A	276_M	0.547	1.00
155_V	187_T	0.547	1.00
122_L	173_M	0.547	1.00
11_K	19_V	0.545	1.00
243_L	246_R	0.545	1.00
264_L	267_G	0.544	1.00
84_N	140_R	0.539	1.00
192_T	195_Q	0.539	1.00
178_Q	203_Q	0.538	1.00
293_G	297_M	0.538	1.00
251_G	255_E	0.538	1.00
298_V	302_L	0.536	1.00
53_L	82_F	0.536	1.00
288_S	293_G	0.536	1.00
288_S	294_G	0.536	1.00
13_W	45_T	0.534	1.00
269_R	276_M	0.531	1.00
171_V	237_S	0.531	1.00
10_T	20_I	0.530	1.00
11_K	20_I	0.529	1.00
164_N	174_R	0.527	1.00
298_V	301_T	0.527	1.00
205_V	219_P	0.526	1.00
275_K	280_I	0.525	1.00
291_A	296_P	0.525	1.00
163_S	167_A	0.524	1.00
113_E	120_R	0.523	1.00
250_E	256_L	0.523	1.00
260_I	266_G	0.522	1.00
23_L	213_A	0.521	1.00
110_Q	152_D	0.519	1.00
255_E	261_E	0.519	1.00
302_L	309_N	0.518	1.00
248_N	257_D	0.515	1.00
266_G	270_Q	0.514	1.00
241_N	246_R	0.514	1.00
302_L	305_L	0.512	1.00
18_Q	22_P	0.512	1.00
246_R	250_E	0.510	1.00
48_R	80_M	0.510	1.00
237_S	310_L	0.510	1.00
261_E	268_Y	0.508	1.00
207_V	226_P	0.508	1.00
182_R	301_T	0.507	1.00
4_L	63_I	0.506	1.00
250_E	255_E	0.506	1.00
50_V	157_L	0.506	1.00
269_R	275_K	0.506	1.00
292_E	296_P	0.505	1.00
241_N	247_V	0.503	1.00
101_L	104_R	0.500	1.00
247_V	250_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2it1A	1	0.9916	100	0.175	Contact Map
1v43A	2	0.9635	100	0.176	Contact Map
2yyzA	1	0.9888	100	0.182	Contact Map
1g291	4	0.9916	100	0.184	Contact Map
3rlfA	2	0.9944	100	0.197	Contact Map
1oxxK	1	0.9522	100	0.203	Contact Map
3fvqA	2	0.9635	100	0.219	Contact Map
4tquS	2	0.9972	100	0.222	Contact Map
1z47A	2	0.9579	100	0.222	Contact Map
3d31A	2	0.9438	100	0.226	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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