GREMLIN Database
UGPE - sn-glycerol-3-phosphate transport system permease protein UgpE
UniProt: P10906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11049
Length: 281 (248)
Sequences: 67408 (44223)
Seq/√Len: 2808.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_R190_D4.3541.00
34_A58_I3.2491.00
78_L82_V3.1841.00
163_R167_M3.0261.00
178_R187_F2.8631.00
104_W174_V2.7941.00
174_V192_V2.7291.00
76_M233_G2.6871.00
75_R78_L2.5941.00
56_E59_H2.5661.00
177_A187_F2.5271.00
183_S186_R2.4591.00
88_T204_F2.3921.00
56_E60_N2.3781.00
74_W78_L2.3701.00
162_F200_L2.3631.00
228_G236_G2.3341.00
185_M189_C2.3251.00
165_F199_N2.3191.00
59_H63_V2.3181.00
96_M188_F2.2361.00
184_P187_F2.2231.00
107_F110_R2.1421.00
186_R189_C2.1141.00
166_F196_S2.0821.00
90_G153_M2.0771.00
103_V167_M2.0601.00
182_A186_R2.0581.00
158_A203_L2.0131.00
246_E249_S1.9751.00
173_L195_L1.9291.00
92_I204_F1.8991.00
84_A208_F1.8491.00
95_S158_A1.8241.00
177_A182_A1.8031.00
96_M196_S1.7761.00
178_R184_P1.7451.00
28_Y32_V1.7121.00
102_I159_T1.7011.00
75_R79_N1.6941.00
114_F163_R1.6871.00
174_V187_F1.6841.00
32_V36_L1.6581.00
96_M162_F1.6391.00
82_V86_S1.6381.00
233_G237_M1.6161.00
225_V228_G1.5981.00
98_S159_T1.5931.00
87_I211_G1.5881.00
54_L57_N1.5671.00
86_S149_T1.5651.00
215_Y219_L1.5521.00
106_R110_R1.5331.00
60_N249_S1.5321.00
99_A162_F1.5281.00
31_F255_L1.5221.00
174_V178_R1.5141.00
193_F200_L1.4841.00
25_F29_V1.4721.00
202_A206_I1.4711.00
13_H17_I1.4541.00
103_V163_R1.4521.00
109_L112_L1.4341.00
55_L59_H1.4261.00
158_A207_T1.4151.00
60_N63_V1.3891.00
83_M229_T1.3761.00
171_D174_V1.3721.00
162_F203_L1.3561.00
166_F192_V1.3531.00
217_W221_I1.3421.00
177_A191_I1.3221.00
145_Y227_L1.3161.00
91_K207_T1.3151.00
104_W171_D1.3081.00
215_Y235_K1.3011.00
58_I255_L1.2761.00
93_T97_L1.2741.00
29_V33_A1.2681.00
96_M200_L1.2611.00
171_D175_E1.2551.00
72_P75_R1.2451.00
169_L195_L1.2381.00
82_V145_Y1.2341.00
266_L270_R1.2311.00
222_I227_L1.2271.00
224_D227_L1.1981.00
86_S89_L1.1911.00
100_F166_F1.1831.00
183_S187_F1.1661.00
261_P265_V1.1511.00
161_L203_L1.1461.00
89_L93_T1.1401.00
162_F199_N1.1301.00
172_E175_E1.1261.00
155_S159_T1.1201.00
30_A255_L1.1201.00
228_G233_G1.1161.00
17_I21_A1.1061.00
237_M246_E1.0981.00
40_A52_T1.0971.00
37_D40_A1.0911.00
229_T232_A1.0901.00
195_L198_T1.0871.00
62_W74_W1.0871.00
214_Q218_P1.0831.00
100_F188_F1.0801.00
197_K201_A1.0771.00
112_L115_W1.0661.00
8_L12_S1.0601.00
92_I200_L1.0591.00
86_S90_G1.0581.00
174_V184_P1.0561.00
80_S230_T1.0541.00
112_L116_M1.0531.00
110_R167_M1.0401.00
79_N82_V1.0371.00
97_L101_A1.0221.00
87_I91_K1.0211.00
267_V271_A1.0211.00
100_F184_P1.0161.00
136_I147_G1.0091.00
57_N248_N1.0051.00
182_A187_F0.9921.00
77_L230_T0.9911.00
228_G232_A0.9911.00
143_D224_D0.9811.00
81_F85_F0.9771.00
103_V166_F0.9761.00
10_I14_T0.9711.00
12_S16_L0.9701.00
214_Q217_W0.9651.00
147_G151_P0.9601.00
118_F160_F0.9591.00
108_P111_N0.9561.00
187_F190_D0.9551.00
218_P229_T0.9541.00
35_T53_H0.9451.00
141_M146_A0.9451.00
151_P221_I0.9391.00
129_I220_L0.9371.00
10_I13_H0.9311.00
188_F193_F0.9261.00
165_F196_S0.9241.00
77_L81_F0.9201.00
73_F253_A0.9151.00
36_L40_A0.9111.00
87_I152_L0.9091.00
132_T221_I0.9061.00
33_A251_M0.9051.00
197_K200_L0.8861.00
196_S199_N0.8851.00
85_F89_L0.8831.00
20_I24_L0.8801.00
9_T13_H0.8781.00
70_S74_W0.8751.00
162_F196_S0.8741.00
35_T54_L0.8731.00
134_E138_N0.8731.00
90_G93_T0.8711.00
158_A162_F0.8711.00
222_I228_G0.8661.00
189_C193_F0.8661.00
102_I114_F0.8651.00
99_A103_V0.8631.00
34_A38_K0.8611.00
111_N114_F0.8611.00
148_L152_L0.8601.00
29_V32_V0.8561.00
242_E245_T0.8521.00
162_F166_F0.8521.00
63_V70_S0.8501.00
99_A159_T0.8491.00
91_K95_S0.8441.00
129_I216_L0.8441.00
82_V85_F0.8431.00
89_L204_F0.8431.00
173_L191_I0.8381.00
238_I250_V0.8381.00
233_G236_G0.8331.00
237_M244_T0.8311.00
219_L232_A0.8301.00
233_G253_A0.8281.00
30_A251_M0.8281.00
249_S253_A0.8241.00
95_S159_T0.8201.00
61_I256_L0.8181.00
25_F28_Y0.8161.00
99_A166_F0.8161.00
188_F192_V0.8121.00
60_N70_S0.8111.00
152_L211_G0.8041.00
90_G149_T0.7971.00
37_D51_G0.7941.00
207_T211_G0.7931.00
151_P217_W0.7921.00
148_L218_P0.7891.00
149_T153_M0.7881.00
101_A107_F0.7861.00
60_N246_E0.7841.00
33_A36_L0.7791.00
78_L81_F0.7781.00
84_A88_T0.7711.00
197_K271_A0.7701.00
133_V137_A0.7681.00
118_F121_L0.7651.00
251_M255_L0.7541.00
92_I162_F0.7461.00
102_I113_F0.7451.00
145_Y149_T0.7441.00
171_D178_R0.7441.00
187_F192_V0.7431.00
237_M253_A0.7431.00
14_T17_I0.7411.00
54_L58_I0.7411.00
76_M79_N0.7401.00
59_H62_W0.7351.00
169_L196_S0.7341.00
91_K158_A0.7331.00
40_A51_G0.7281.00
184_P188_F0.7281.00
88_T208_F0.7261.00
200_L203_L0.7241.00
146_A150_L0.7211.00
11_F15_M0.7201.00
257_T261_P0.7201.00
61_I249_S0.7161.00
88_T92_I0.7151.00
263_V267_V0.7121.00
80_S231_V0.7021.00
232_A236_G0.7021.00
102_I163_R0.7001.00
268_M271_A0.6911.00
137_A142_L0.6881.00
192_V195_L0.6871.00
144_S227_L0.6841.00
86_S153_M0.6841.00
125_V216_L0.6831.00
95_S162_F0.6821.00
55_L58_I0.6821.00
33_A37_D0.6761.00
139_L142_L0.6741.00
53_H56_E0.6731.00
98_S155_S0.6671.00
74_W77_L0.6651.00
58_I252_V0.6651.00
265_V269_Q0.6631.00
136_I142_L0.6621.00
15_M19_G0.6611.00
121_L156_A0.6541.00
36_L52_T0.6531.00
57_N60_N0.6521.00
87_I149_T0.6521.00
30_A254_M0.6461.00
37_D52_T0.6451.00
19_G23_I0.6421.00
182_A190_D0.6411.00
176_A180_D0.6391.00
243_G246_E0.6381.00
114_F160_F0.6361.00
20_I23_I0.6361.00
83_M152_L0.6351.00
200_L204_F0.6321.00
199_N203_L0.6321.00
106_R111_N0.6311.00
209_I213_N0.6311.00
61_I253_A0.6301.00
121_L157_T0.6301.00
149_T152_L0.6271.00
214_Q229_T0.6261.00
147_G221_I0.6231.00
147_G152_L0.6221.00
49_I52_T0.6221.00
36_L50_P0.6191.00
161_L199_N0.6181.00
107_F113_F0.6151.00
135_V142_L0.6111.00
72_P225_V0.6101.00
183_S189_C0.6091.00
237_M249_S0.6081.00
88_T211_G0.6061.00
91_K211_G0.6051.00
101_A105_F0.6051.00
83_M145_Y0.6041.00
36_L51_G0.6041.00
231_V257_T0.6021.00
234_I253_A0.6011.00
71_A75_R0.6001.00
33_A38_K0.5991.00
91_K155_S0.5961.00
176_A179_I0.5941.00
248_N251_M0.5941.00
109_L113_F0.5941.00
11_F14_T0.5931.00
216_L220_L0.5931.00
230_T257_T0.5921.00
249_S252_V0.5921.00
79_N145_Y0.5911.00
132_T135_V0.5861.00
267_V270_R0.5861.00
245_T249_S0.5821.00
34_A252_V0.5801.00
151_P154_A0.5801.00
99_A163_R0.5771.00
247_W250_V0.5761.00
126_E220_L0.5761.00
71_A74_W0.5751.00
52_T56_E0.5731.00
34_A255_L0.5721.00
251_M254_M0.5721.00
80_S212_W0.5711.00
84_A211_G0.5711.00
224_D228_G0.5691.00
76_M230_T0.5691.00
113_F117_I0.5671.00
13_H16_L0.5651.00
125_V129_I0.5631.00
134_E137_A0.5631.00
236_G243_G0.5631.00
16_L20_I0.5621.00
102_I107_F0.5611.00
98_S117_I0.5611.00
216_L219_L0.5601.00
187_F191_I0.5591.00
232_A235_K0.5581.00
169_L174_V0.5561.00
105_F184_P0.5531.00
70_S249_S0.5521.00
94_V155_S0.5511.00
210_Y213_N0.5511.00
31_F35_T0.5511.00
83_M87_I0.5481.00
62_W256_L0.5481.00
52_T55_L0.5471.00
234_I254_M0.5461.00
106_R171_D0.5451.00
92_I97_L0.5441.00
123_L127_V0.5441.00
38_K50_P0.5411.00
160_F164_Q0.5411.00
207_T210_Y0.5391.00
82_V146_A0.5381.00
120_T156_A0.5341.00
117_I156_A0.5331.00
218_P232_A0.5301.00
247_W251_M0.5301.00
9_T12_S0.5271.00
92_I96_M0.5261.00
201_A204_F0.5251.00
111_N115_W0.5241.00
260_P263_V0.5211.00
96_M193_F0.5181.00
142_L146_A0.5181.00
37_D54_L0.5161.00
196_S200_L0.5151.00
115_W119_I0.5131.00
203_L207_T0.5111.00
129_I217_W0.5101.00
108_P112_L0.5101.00
254_M257_T0.5091.00
227_L238_I0.5071.00
175_E178_R0.5071.00
233_G238_I0.5061.00
204_F207_T0.5061.00
21_A25_F0.5051.00
248_N252_V0.5041.00
192_V196_S0.5031.00
262_V266_L0.5031.00
32_V53_H0.5031.00
63_V71_A0.5011.00
238_I242_E0.5001.00
190_D195_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9431 100 0.285 Contact Map
3rlfG 1 0.9609 100 0.306 Contact Map
2onkC 2 0.8541 100 0.333 Contact Map
3d31C 2 0.8363 100 0.359 Contact Map
4tquM 1 0.8932 100 0.36 Contact Map
3rlfF 1 0.911 100 0.391 Contact Map
4ymuD 2 0.7544 99.9 0.502 Contact Map
3tuiA 2 0.7331 99.9 0.541 Contact Map
4hfiA 3 0.4448 6.2 0.954 Contact Map
3hd7A 1 0.1174 6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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