GREMLIN Database
UGPA - sn-glycerol-3-phosphate transport system permease protein UgpA
UniProt: P10905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11046
Length: 295 (255)
Sequences: 69641 (45297)
Seq/√Len: 2836.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_R205_K3.9011.00
73_W77_K3.2361.00
193_A202_R3.0931.00
178_Y182_Q3.0231.00
70_D73_W2.6431.00
71_S252_K2.5831.00
180_A214_V2.5181.00
85_S166_V2.5021.00
99_Y189_I2.4991.00
247_T255_R2.4851.00
198_G201_R2.4811.00
81_F162_V2.4741.00
60_V64_H2.4491.00
192_A202_R2.4421.00
40_S59_F2.4091.00
69_L73_W2.3801.00
189_I207_A2.3631.00
199_P202_R2.3081.00
83_T219_L2.2801.00
57_D60_V2.2481.00
177_F215_S2.1671.00
262_D265_S2.1501.00
200_I204_F2.1481.00
101_V104_S2.1191.00
57_D61_T2.1041.00
197_A201_R2.0641.00
201_R204_F1.9931.00
77_K158_M1.9851.00
173_N218_L1.9581.00
91_L203_F1.9221.00
38_W42_Q1.9161.00
188_L210_L1.9001.00
98_E182_Q1.8941.00
192_A197_A1.8601.00
108_Q178_Y1.8591.00
181_L211_I1.8421.00
244_Q247_T1.8101.00
91_L211_I1.8021.00
87_L219_L1.7601.00
34_G38_W1.7391.00
70_D74_T1.7181.00
193_A199_P1.6931.00
82_V226_A1.6791.00
189_I202_R1.6751.00
282_V286_R1.6381.00
90_S173_N1.6251.00
77_K81_F1.6211.00
79_S223_L1.6121.00
91_L177_F1.5911.00
189_I193_A1.5901.00
93_F174_F1.5831.00
61_T265_S1.5671.00
252_K256_E1.5611.00
158_M246_T1.5441.00
97_V174_F1.5301.00
186_R189_I1.5251.00
19_A23_I1.4961.00
67_Y70_D1.4481.00
240_G245_A1.4321.00
61_T64_H1.4221.00
31_W35_E1.4181.00
103_G106_F1.4071.00
56_L60_V1.3991.00
35_E39_Y1.3881.00
173_N222_N1.3801.00
100_I104_S1.3721.00
37_L271_V1.3711.00
256_E260_G1.3711.00
98_E178_Y1.3601.00
86_G222_N1.3291.00
55_G58_N1.3261.00
181_L207_A1.3241.00
94_A177_F1.3191.00
88_L92_F1.3161.00
208_L215_S1.3161.00
247_T252_K1.3141.00
78_F248_T1.3021.00
217_F221_V1.2971.00
177_F218_L1.2861.00
186_R190_E1.2861.00
231_F235_D1.2841.00
187_S190_E1.2591.00
91_L215_S1.2531.00
106_F109_T1.2281.00
95_A181_L1.2241.00
99_Y186_R1.2151.00
231_F254_Y1.2131.00
238_T246_T1.2111.00
156_Q159_F1.2091.00
130_F160_L1.2051.00
233_V237_A1.1981.00
87_L215_S1.1961.00
12_W16_L1.1901.00
84_V88_L1.1881.00
192_A206_I1.1821.00
75_T249_L1.1711.00
256_E262_D1.1711.00
255_R259_T1.1591.00
46_P53_F1.1561.00
13_L17_L1.1551.00
81_F84_V1.1511.00
212_A216_F1.1491.00
74_T77_K1.1461.00
184_I210_L1.1381.00
157_A246_T1.1251.00
23_I27_I1.1251.00
164_A237_A1.1191.00
198_G202_R1.1171.00
161_V234_I1.1101.00
162_V166_V1.1091.00
43_S46_P1.1051.00
35_E38_W1.0971.00
286_R289_E1.0951.00
131_N134_R1.0911.00
14_P18_V1.0911.00
106_F110_L1.0821.00
128_F132_P1.0801.00
85_S162_V1.0611.00
177_F214_V1.0391.00
248_T251_Y1.0381.00
16_L20_P1.0341.00
98_E181_L1.0301.00
36_A271_V1.0221.00
189_I199_P1.0201.00
82_V86_G1.0171.00
170_I174_F1.0131.00
247_T251_Y1.0121.00
230_T233_V1.0101.00
67_Y244_Q1.0091.00
158_M162_V1.0061.00
81_F85_S1.0021.00
16_L19_A1.0021.00
15_Y19_A0.9991.00
63_F69_L0.9921.00
176_F218_L0.9801.00
13_L16_L0.9761.00
76_I80_T0.9741.00
95_A199_P0.9731.00
92_F96_L0.9721.00
95_A203_F0.9711.00
159_F163_F0.9671.00
210_L213_P0.9651.00
82_V165_S0.9641.00
197_A202_R0.9631.00
84_V219_L0.9611.00
283_V287_Y0.9511.00
61_T65_D0.9501.00
257_G266_S0.9441.00
234_I248_T0.9421.00
202_R205_K0.9341.00
77_K159_F0.9321.00
252_K269_Q0.9191.00
39_Y42_Q0.9191.00
252_K255_R0.9181.00
18_V22_L0.9141.00
77_K80_T0.9101.00
126_W237_A0.9051.00
74_T158_M0.8961.00
240_G246_T0.8951.00
235_D251_Y0.8921.00
136_L159_F0.8861.00
40_S44_V0.8811.00
78_F158_M0.8801.00
104_S182_Q0.8801.00
82_V162_V0.8761.00
94_A98_E0.8741.00
58_N264_A0.8721.00
72_F249_L0.8711.00
80_T84_V0.8611.00
230_T234_I0.8561.00
39_Y267_A0.8521.00
126_W164_A0.8501.00
59_F271_V0.8471.00
86_G90_S0.8461.00
26_V30_I0.8451.00
105_R108_Q0.8431.00
42_Q46_P0.8421.00
112_L175_L0.8371.00
45_D48_G0.8371.00
277_V281_T0.8331.00
197_A205_K0.8321.00
202_R207_A0.8291.00
180_A211_I0.8291.00
212_A215_S0.8231.00
62_L272_V0.8231.00
90_S174_F0.8221.00
165_S226_A0.8211.00
177_F211_I0.8191.00
72_F76_I0.8191.00
50_S53_F0.8171.00
78_F165_S0.8171.00
279_V283_V0.8161.00
164_A233_V0.8151.00
41_L54_V0.8131.00
173_N177_F0.8091.00
119_P168_K0.8051.00
211_I214_V0.8051.00
39_Y43_S0.8041.00
102_R105_R0.8041.00
65_D69_L0.8031.00
256_E265_S0.8031.00
97_V108_Q0.8021.00
204_F208_L0.8011.00
68_Y269_Q0.7991.00
94_A174_F0.7971.00
199_P203_F0.7961.00
256_E269_Q0.7951.00
73_W76_I0.7941.00
203_F208_L0.7921.00
96_L101_V0.7911.00
159_F162_V0.7851.00
283_V286_R0.7791.00
127_I131_N0.7771.00
222_N226_A0.7761.00
85_S88_L0.7731.00
66_S70_D0.7721.00
212_A287_Y0.7661.00
284_Q287_Y0.7621.00
254_Y258_F0.7411.00
81_F166_V0.7371.00
58_N61_T0.7341.00
273_L277_V0.7291.00
71_S74_T0.7281.00
86_G169_Q0.7261.00
90_S177_F0.7221.00
86_G173_N0.7211.00
86_G226_A0.7201.00
54_V57_D0.7201.00
123_A232_P0.7181.00
188_L206_I0.7151.00
44_V48_G0.7151.00
94_A181_L0.7131.00
191_A195_D0.7111.00
156_Q160_L0.7101.00
17_L20_P0.7051.00
267_A270_S0.7051.00
157_A160_L0.7021.00
249_L273_L0.7001.00
87_L177_F0.6981.00
60_V63_F0.6951.00
83_T223_L0.6921.00
55_G59_F0.6921.00
43_S53_F0.6891.00
230_T248_T0.6881.00
123_A236_A0.6881.00
97_V178_Y0.6871.00
36_A267_A0.6871.00
169_Q222_N0.6861.00
42_Q51_S0.6861.00
282_V285_F0.6821.00
112_L115_Y0.6821.00
184_I211_I0.6801.00
25_T29_F0.6761.00
119_P232_P0.6751.00
69_L72_F0.6741.00
26_V29_F0.6741.00
191_A194_I0.6731.00
215_S218_L0.6711.00
203_F207_A0.6711.00
56_L59_F0.6701.00
36_A270_S0.6701.00
169_Q225_Y0.6691.00
161_V238_T0.6671.00
122_A167_W0.6671.00
265_S269_Q0.6671.00
71_S249_L0.6611.00
97_V107_Y0.6611.00
61_T262_D0.6601.00
79_S83_T0.6591.00
41_L55_G0.6521.00
251_Y255_R0.6521.00
186_R193_A0.6511.00
238_T247_T0.6471.00
46_P52_Q0.6461.00
15_Y18_V0.6461.00
28_F32_P0.6461.00
20_P23_I0.6451.00
93_F170_I0.6441.00
278_I282_V0.6431.00
128_F131_N0.6391.00
83_T87_L0.6381.00
93_F111_M0.6301.00
267_A271_V0.6291.00
101_V107_Y0.6291.00
89_V166_V0.6241.00
214_V218_L0.6231.00
31_W34_G0.6221.00
207_A210_L0.6201.00
126_W129_L0.6181.00
120_A236_A0.6181.00
53_F57_D0.6171.00
264_A267_A0.6171.00
160_L164_A0.6161.00
78_F162_V0.6141.00
253_I269_Q0.6121.00
177_F181_L0.6111.00
17_L21_Q0.6101.00
111_M171_S0.6091.00
22_L26_V0.6071.00
43_S52_Q0.6051.00
281_T285_F0.6051.00
66_S69_L0.6051.00
78_F161_V0.6031.00
75_T250_I0.6001.00
102_R106_F0.5981.00
103_G107_Y0.5941.00
234_I251_Y0.5941.00
263_L266_S0.5941.00
51_S54_V0.5941.00
215_S219_L0.5931.00
202_R206_I0.5921.00
108_Q175_L0.5901.00
250_I273_L0.5901.00
263_L267_A0.5891.00
279_V282_V0.5851.00
62_L269_Q0.5841.00
21_Q25_T0.5781.00
53_F56_L0.5771.00
39_Y44_V0.5751.00
204_F207_A0.5751.00
216_F219_L0.5701.00
67_Y252_K0.5681.00
32_P36_A0.5661.00
224_V229_D0.5651.00
100_I105_R0.5631.00
219_L222_N0.5631.00
240_G244_Q0.5631.00
109_T113_L0.5611.00
276_L279_V0.5601.00
176_F214_V0.5601.00
67_Y247_T0.5591.00
101_V105_R0.5571.00
95_A207_A0.5571.00
87_L91_L0.5531.00
165_S230_T0.5531.00
110_L114_P0.5511.00
86_G166_V0.5501.00
115_Y172_Y0.5501.00
105_R109_T0.5491.00
75_T228_F0.5491.00
42_Q52_Q0.5481.00
62_L265_S0.5471.00
74_T246_T0.5461.00
89_V170_I0.5451.00
30_I34_G0.5421.00
135_G138_T0.5411.00
232_P235_D0.5401.00
79_S226_A0.5391.00
78_F82_V0.5391.00
42_Q53_F0.5381.00
79_S228_F0.5381.00
94_A178_Y0.5341.00
225_Y229_D0.5311.00
251_Y254_Y0.5311.00
138_T240_G0.5311.00
104_S108_Q0.5271.00
19_A22_L0.5261.00
161_V165_S0.5261.00
226_A230_T0.5251.00
12_W15_Y0.5231.00
280_L284_Q0.5231.00
93_F96_L0.5221.00
67_Y71_S0.5221.00
114_P171_S0.5211.00
82_V166_V0.5211.00
40_S271_V0.5211.00
27_I31_W0.5201.00
70_D77_K0.5171.00
265_S268_A0.5161.00
123_A127_I0.5151.00
244_Q255_R0.5151.00
160_L237_A0.5111.00
130_F137_I0.5101.00
184_I189_I0.5081.00
108_Q182_Q0.5061.00
43_S47_F0.5061.00
232_P236_A0.5061.00
36_A39_Y0.5051.00
115_Y171_S0.5041.00
95_A99_Y0.5041.00
190_E193_A0.5021.00
90_S170_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.939 100 0.292 Contact Map
2onkC 2 0.8475 100 0.318 Contact Map
3d31C 2 0.8373 100 0.319 Contact Map
4tquN 1 0.8881 100 0.35 Contact Map
3rlfF 1 0.9356 100 0.355 Contact Map
3rlfG 1 0.8983 100 0.366 Contact Map
4ymuD 2 0.7254 99.9 0.516 Contact Map
3tuiA 2 0.7051 99.9 0.543 Contact Map
2kogA 1 0.1356 17.2 0.945 Contact Map
2m8rA 1 0.1254 14.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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