NADB - ECOLI - GREMLIN Contacts

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NADB - L-aspartate oxidase

UniProt:	P10902	Sequences: MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLPPWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10631
Length:	540 (507)
Sequences:	5409 (2830)
Seq/√Len:	125.7

ECOLI - NADB SDHA FRDA
BACSU - SDHA NADB
HALSA - Q9HQ66 NADB
SULSO - Q97W79 NADB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
12_L	182_A	3.912	1.00
360_D	364_R	3.785	1.00
162_A	227_M	3.351	1.00
523_L	526_S	3.346	1.00
9_C	34_I	3.261	1.00
84_E	88_S	3.198	1.00
78_C	83_V	3.058	1.00
271_R	275_T	2.991	1.00
275_T	280_D	2.972	1.00
451_V	501_V	2.918	1.00
23_L	201_V	2.825	1.00
107_H	111_N	2.820	1.00
86_V	381_L	2.790	1.00
457_T	508_K	2.775	1.00
471_Q	498_E	2.748	1.00
450_Y	462_R	2.665	1.00
279_P	285_G	2.534	1.00
271_R	300_E	2.526	1.00
258_L	262_L	2.509	1.00
276_R	286_E	2.453	1.00
371_Y	405_D	2.451	1.00
457_T	461_E	2.408	1.00
464_L	501_V	2.396	1.00
456_T	517_L	2.337	1.00
157_L	195_C	2.333	1.00
186_N	189_K	2.292	1.00
147_K	150_N	2.291	1.00
508_K	519_Y	2.286	1.00
14_I	182_A	2.284	1.00
442_E	466_R	2.262	1.00
524_T	527_G	2.251	1.00
32_Q	155_R	2.249	1.00
229_W	499_L	2.249	1.00
18_A	395_C	2.249	1.00
89_N	401_S	2.238	1.00
8_S	196_H	2.184	1.00
27_L	406_I	2.158	1.00
461_E	505_M	2.151	1.00
34_I	157_L	2.134	1.00
468_T	498_E	2.128	1.00
364_R	405_D	2.109	1.00
85_F	401_S	2.090	1.00
65_S	126_H	2.057	1.00
318_A	322_R	2.051	1.00
451_V	463_A	2.041	1.00
23_L	373_I	2.032	1.00
164_D	230_R	2.019	1.00
297_I	309_M	2.013	1.00
456_T	459_R	2.010	1.00
357_V	376_V	2.005	1.00
234_R	366_D	1.998	1.00
18_A	46_T	1.993	1.00
10_D	198_K	1.991	1.00
372_A	376_V	1.989	1.00
270_K	343_P	1.972	1.00
225_I	235_V	1.959	1.00
36_L	184_V	1.956	1.00
247_A	349_A	1.919	1.00
27_L	403_A	1.908	1.00
184_V	195_C	1.882	1.00
86_V	398_Y	1.879	1.00
314_S	343_P	1.860	1.00
139_E	142_T	1.847	1.00
202_L	376_V	1.844	1.00
446_F	463_A	1.835	1.00
467_I	501_V	1.832	1.00
169_D	177_R	1.831	1.00
329_Y	333_L	1.808	1.00
451_V	460_L	1.755	1.00
447_M	451_V	1.740	1.00
34_I	195_C	1.725	1.00
201_V	406_I	1.719	1.00
202_L	357_V	1.712	1.00
204_T	224_G	1.706	1.00
80_R	84_E	1.697	1.00
46_T	141_E	1.695	1.00
207_A	353_T	1.685	1.00
270_K	314_S	1.684	1.00
93_C	96_W	1.679	1.00
442_E	473_E	1.679	1.00
299_H	303_R	1.657	1.00
464_L	498_E	1.656	1.00
365_T	372_A	1.656	1.00
75_A	522_L	1.651	1.00
322_R	329_Y	1.649	1.00
235_V	238_L	1.639	1.00
234_R	358_M	1.637	1.00
177_R	368_E	1.635	1.00
67_V	84_E	1.621	1.00
107_H	115_S	1.619	1.00
268_Y	276_R	1.616	1.00
362_H	405_D	1.612	1.00
178_R	369_G	1.611	1.00
74_G	78_C	1.599	1.00
228_A	357_V	1.594	1.00
111_N	115_S	1.585	1.00
82_A	361_D	1.575	1.00
446_F	466_R	1.574	1.00
230_R	492_N	1.570	1.00
464_L	502_R	1.566	1.00
43_E	48_Y	1.549	1.00
186_N	193_E	1.547	1.00
56_V	63_I	1.544	1.00
179_V	200_V	1.534	1.00
443_L	467_I	1.521	1.00
434_V	473_E	1.516	1.00
11_V	27_L	1.514	1.00
210_V	500_I	1.513	1.00
363_G	402_A	1.504	1.00
402_A	406_I	1.504	1.00
95_Q	99_D	1.493	1.00
359_V	377_S	1.486	1.00
457_T	516_T	1.485	1.00
228_A	233_C	1.485	1.00
160_S	186_N	1.484	1.00
38_K	223_D	1.465	1.00
9_C	12_L	1.463	1.00
463_A	501_V	1.457	1.00
197_A	200_V	1.456	1.00
262_L	267_A	1.447	1.00
450_Y	459_R	1.443	1.00
148_A	156_V	1.438	1.00
471_Q	495_Q	1.436	1.00
9_C	155_R	1.434	1.00
450_Y	463_A	1.433	1.00
466_R	469_M	1.432	1.00
38_K	221_S	1.429	1.00
26_R	404_E	1.415	1.00
322_R	340_T	1.407	1.00
93_C	400_W	1.404	1.00
63_I	67_V	1.404	1.00
63_I	88_S	1.395	1.00
166_I	194_T	1.391	1.00
82_A	86_V	1.387	1.00
46_T	395_C	1.386	1.00
67_V	71_L	1.384	1.00
295_R	515_F	1.382	1.00
89_N	92_S	1.377	1.00
313_I	316_K	1.370	1.00
318_A	340_T	1.368	1.00
498_E	502_R	1.366	1.00
11_V	31_H	1.365	1.00
157_L	160_S	1.350	1.00
354_C	513_L	1.344	1.00
178_R	368_E	1.343	1.00
298_D	302_K	1.343	1.00
212_Q	445_L	1.341	1.00
201_V	373_I	1.338	1.00
199_A	409_R	1.331	1.00
464_L	505_M	1.324	1.00
259_T	262_L	1.321	1.00
207_A	241_N	1.319	1.00
215_T	247_A	1.318	1.00
526_S	529_S	1.313	1.00
98_I	116_Y	1.308	1.00
457_T	505_M	1.304	1.00
202_L	370_L	1.300	1.00
236_A	358_M	1.293	1.00
445_L	449_D	1.287	1.00
9_C	32_Q	1.287	1.00
329_Y	340_T	1.286	1.00
236_A	378_Y	1.285	1.00
160_S	184_V	1.280	1.00
523_L	527_G	1.278	1.00
54_A	389_S	1.274	1.00
19_A	373_I	1.271	1.00
259_T	328_I	1.266	1.00
162_A	182_A	1.266	1.00
165_L	179_V	1.265	1.00
202_L	228_A	1.263	1.00
53_I	140_V	1.259	1.00
223_D	492_N	1.256	1.00
276_R	279_P	1.256	1.00
28_A	31_H	1.256	1.00
38_K	489_E	1.255	1.00
451_V	500_I	1.253	1.00
21_L	148_A	1.249	1.00
405_D	409_R	1.248	1.00
208_S	350_A	1.247	1.00
9_C	157_L	1.237	1.00
269_L	346_I	1.234	0.99
162_A	184_V	1.232	0.99
16_S	37_S	1.228	0.99
211_Y	451_V	1.225	0.99
102_V	140_V	1.225	0.99
14_I	202_L	1.220	0.99
35_V	156_V	1.211	0.99
36_L	182_A	1.210	0.99
148_A	154_I	1.207	0.99
461_E	465_R	1.206	0.99
63_I	87_A	1.200	0.99
82_A	381_L	1.199	0.99
22_S	26_R	1.194	0.99
371_Y	409_R	1.192	0.99
90_A	393_L	1.188	0.99
522_L	527_G	1.185	0.99
318_A	341_Q	1.176	0.99
68_E	72_I	1.173	0.99
504_A	514_H	1.170	0.99
338_D	341_Q	1.168	0.99
450_Y	466_R	1.166	0.99
67_V	87_A	1.164	0.99
405_D	408_R	1.159	0.99
160_S	193_E	1.159	0.99
400_W	404_E	1.158	0.99
89_N	93_C	1.157	0.99
316_K	320_F	1.156	0.99
11_V	201_V	1.154	0.99
166_I	183_W	1.138	0.99
57_F	130_L	1.136	0.99
207_A	500_I	1.134	0.99
457_T	519_Y	1.133	0.99
281_F	296_A	1.130	0.99
399_G	403_A	1.129	0.99
85_F	361_D	1.129	0.99
149_L	158_E	1.125	0.99
105_D	131_H	1.123	0.99
54_A	124_H	1.121	0.99
25_L	148_A	1.116	0.99
96_W	400_W	1.116	0.99
12_L	36_L	1.114	0.99
66_H	390_N	1.108	0.99
230_R	495_Q	1.104	0.99
26_R	400_W	1.102	0.99
268_Y	286_E	1.101	0.99
129_I	389_S	1.099	0.99
403_A	407_T	1.098	0.99
64_D	68_E	1.094	0.99
138_R	142_T	1.090	0.99
239_E	507_R	1.090	0.99
446_F	450_Y	1.084	0.99
23_L	406_I	1.082	0.99
26_R	403_A	1.081	0.99
102_V	139_E	1.076	0.99
225_I	496_V	1.071	0.99
10_D	32_Q	1.071	0.99
64_D	84_E	1.070	0.99
164_D	227_M	1.070	0.99
277_F	297_I	1.070	0.99
321_I	329_Y	1.067	0.99
146_S	150_N	1.065	0.99
272_P	306_A	1.063	0.98
21_L	35_V	1.061	0.98
225_I	353_T	1.061	0.98
461_E	464_L	1.059	0.98
145_V	156_V	1.058	0.98
35_V	148_A	1.052	0.98
233_C	370_L	1.050	0.98
359_V	372_A	1.041	0.98
265_E	324_H	1.039	0.98
67_V	80_R	1.039	0.98
116_Y	130_L	1.037	0.98
53_I	94_V	1.036	0.98
381_L	398_Y	1.030	0.98
11_V	406_I	1.026	0.98
23_L	402_A	1.020	0.98
14_I	162_A	1.018	0.98
337_I	342_E	1.016	0.98
357_V	372_A	1.014	0.98
127_R	265_E	1.009	0.98
85_F	89_N	1.002	0.98
168_S	180_V	1.001	0.98
280_D	300_E	1.001	0.98
440_W	493_L	0.999	0.98
77_I	511_R	0.996	0.98
124_H	389_S	0.995	0.98
322_R	333_L	0.992	0.98
12_L	34_I	0.992	0.98
161_N	488_L	0.990	0.98
440_W	444_R	0.989	0.98
66_H	70_T	0.988	0.98
300_E	303_R	0.986	0.98
462_R	466_R	0.983	0.97
102_V	143_T	0.982	0.97
373_I	402_A	0.981	0.97
319_D	323_Q	0.980	0.97
85_F	398_Y	0.980	0.97
441_H	445_L	0.977	0.97
330_E	334_G	0.975	0.97
279_P	286_E	0.974	0.97
28_A	153_N	0.972	0.97
466_R	470_L	0.971	0.97
12_L	197_A	0.971	0.97
321_I	340_T	0.969	0.97
70_T	390_N	0.969	0.97
100_Q	147_K	0.968	0.97
81_H	361_D	0.962	0.97
41_V	158_E	0.961	0.97
91_R	95_Q	0.960	0.97
364_R	409_R	0.959	0.97
233_C	367_V	0.959	0.97
41_V	145_V	0.950	0.97
454_V	517_L	0.949	0.97
317_P	320_F	0.946	0.97
406_I	410_M	0.946	0.97
468_T	502_R	0.946	0.97
310_F	343_P	0.943	0.97
199_A	410_M	0.943	0.97
403_A	406_I	0.942	0.97
103_L	139_E	0.937	0.97
443_L	490_L	0.936	0.97
27_L	31_H	0.933	0.97
199_A	371_Y	0.930	0.96
25_L	100_Q	0.929	0.96
83_V	87_A	0.928	0.96
124_H	129_I	0.926	0.96
135_A	327_M	0.925	0.96
183_W	192_V	0.924	0.96
120_R	127_R	0.924	0.96
65_S	125_S	0.923	0.96
455_R	504_A	0.922	0.96
446_F	470_L	0.922	0.96
161_N	489_E	0.921	0.96
474_I	494_V	0.918	0.96
13_I	33_V	0.916	0.96
332_L	339_L	0.915	0.96
167_V	179_V	0.914	0.96
26_R	29_D	0.911	0.96
183_W	194_T	0.910	0.96
270_K	312_D	0.910	0.96
47_F	138_R	0.905	0.96
440_W	490_L	0.905	0.96
359_V	379_T	0.901	0.96
71_L	83_V	0.896	0.96
212_Q	448_W	0.896	0.96
71_L	78_C	0.895	0.96
24_A	154_I	0.893	0.96
92_S	95_Q	0.889	0.95
281_F	300_E	0.885	0.95
168_S	177_R	0.882	0.95
96_W	100_Q	0.878	0.95
97_L	140_V	0.878	0.95
331_K	334_G	0.876	0.95
238_L	496_V	0.874	0.95
165_L	182_A	0.871	0.95
222_G	496_V	0.871	0.95
63_I	91_R	0.871	0.95
67_V	83_V	0.871	0.95
226_A	230_R	0.870	0.95
28_A	33_V	0.870	0.95
26_R	96_W	0.869	0.95
288_A	292_I	0.869	0.95
165_L	200_V	0.867	0.95
511_R	520_P	0.864	0.95
168_S	178_R	0.863	0.95
276_R	285_G	0.858	0.94
443_L	494_V	0.856	0.94
511_R	519_Y	0.854	0.94
443_L	470_L	0.853	0.94
268_Y	315_H	0.848	0.94
86_V	393_L	0.848	0.94
233_C	366_D	0.845	0.94
226_A	496_V	0.843	0.94
508_K	526_S	0.843	0.94
238_L	500_I	0.838	0.94
447_M	497_A	0.836	0.94
359_V	398_Y	0.836	0.94
280_D	303_R	0.835	0.94
22_S	93_C	0.835	0.94
53_I	393_L	0.834	0.94
362_H	401_S	0.833	0.94
227_M	230_R	0.833	0.94
123_G	354_C	0.828	0.93
250_H	335_L	0.825	0.93
296_A	299_H	0.822	0.93
302_K	449_D	0.820	0.93
119_T	265_E	0.817	0.93
106_T	116_Y	0.814	0.93
407_T	410_M	0.814	0.93
278_M	285_G	0.812	0.93
471_Q	494_V	0.812	0.93
301_M	308_C	0.808	0.93
332_L	344_V	0.807	0.92
203_A	373_I	0.806	0.92
56_V	87_A	0.805	0.92
270_K	310_F	0.802	0.92
272_P	307_D	0.802	0.92
262_L	313_I	0.797	0.92
460_L	501_V	0.797	0.92
198_K	410_M	0.796	0.92
332_L	337_I	0.795	0.92
68_E	80_R	0.794	0.92
98_I	106_T	0.794	0.92
45_S	48_Y	0.792	0.92
82_A	85_F	0.790	0.92
458_K	462_R	0.788	0.92
12_L	200_V	0.788	0.92
333_L	340_T	0.787	0.92
267_A	313_I	0.787	0.92
241_N	500_I	0.783	0.91
87_A	90_A	0.782	0.91
288_A	293_V	0.781	0.91
107_H	110_P	0.780	0.91
141_E	145_V	0.780	0.91
238_L	503_C	0.779	0.91
464_L	468_T	0.779	0.91
28_A	154_I	0.778	0.91
22_S	96_W	0.778	0.91
439_N	490_L	0.776	0.91
201_V	402_A	0.774	0.91
419_L	422_W	0.773	0.91
132_A	139_E	0.773	0.91
25_L	147_K	0.767	0.90
462_R	465_R	0.767	0.90
467_I	498_E	0.767	0.90
424_E	427_V	0.767	0.90
290_R	294_A	0.765	0.90
23_L	27_L	0.764	0.90
450_Y	501_V	0.763	0.90
198_K	415_D	0.762	0.90
509_E	520_P	0.760	0.90
337_I	344_V	0.760	0.90
502_R	506_M	0.757	0.90
45_S	217_P	0.756	0.90
404_E	408_R	0.756	0.90
260_E	263_R	0.756	0.90
282_D	288_A	0.756	0.90
103_L	143_T	0.755	0.90
209_K	444_R	0.755	0.90
472_Q	476_E	0.754	0.90
71_L	80_R	0.754	0.90
39_G	43_E	0.754	0.90
32_Q	153_N	0.753	0.90
296_A	300_E	0.753	0.90
277_F	286_E	0.753	0.90
13_I	31_H	0.752	0.90
53_I	396_L	0.749	0.89
438_H	442_E	0.749	0.89
8_S	32_Q	0.748	0.89
329_Y	339_L	0.746	0.89
45_S	220_S	0.745	0.89
28_A	407_T	0.745	0.89
409_R	413_A	0.745	0.89
169_D	178_R	0.743	0.89
117_H	131_H	0.742	0.89
164_D	231_A	0.741	0.89
55_A	94_V	0.741	0.89
121_E	389_S	0.740	0.89
211_Y	500_I	0.738	0.89
122_G	284_R	0.738	0.89
119_T	131_H	0.737	0.89
469_M	472_Q	0.737	0.89
210_V	496_V	0.736	0.89
522_L	528_P	0.735	0.88
89_N	400_W	0.734	0.88
249_Y	308_C	0.731	0.88
186_N	191_T	0.729	0.88
277_F	300_E	0.729	0.88
39_G	219_I	0.726	0.88
167_V	177_R	0.724	0.88
257_L	260_E	0.724	0.88
309_M	346_I	0.724	0.88
313_I	321_I	0.723	0.88
207_A	225_I	0.722	0.88
461_E	502_R	0.722	0.88
262_L	321_I	0.721	0.88
79_D	378_Y	0.716	0.87
121_E	129_I	0.716	0.87
65_S	68_E	0.715	0.87
442_E	445_L	0.715	0.87
16_S	35_V	0.714	0.87
373_I	399_G	0.712	0.87
160_S	195_C	0.711	0.87
12_L	195_C	0.711	0.87
373_I	403_A	0.711	0.87
198_K	414_H	0.710	0.87
258_L	328_I	0.708	0.87
258_L	346_I	0.707	0.87
209_K	493_L	0.707	0.87
221_S	489_E	0.707	0.87
298_D	454_V	0.707	0.87
199_A	406_I	0.707	0.87
359_V	363_G	0.706	0.86
36_L	195_C	0.705	0.86
291_D	294_A	0.705	0.86
321_I	339_L	0.704	0.86
199_A	369_G	0.704	0.86
240_F	507_R	0.704	0.86
93_C	396_L	0.703	0.86
299_H	454_V	0.703	0.86
30_Q	407_T	0.702	0.86
159_R	188_N	0.702	0.86
177_R	367_V	0.700	0.86
62_S	65_S	0.699	0.86
235_V	499_L	0.699	0.86
204_T	376_V	0.697	0.86
306_A	309_M	0.697	0.86
272_P	308_C	0.695	0.86
246_T	263_R	0.693	0.85
18_A	396_L	0.693	0.85
180_V	196_H	0.693	0.85
364_R	368_E	0.692	0.85
454_V	515_F	0.691	0.85
436_I	487_L	0.691	0.85
145_V	149_L	0.691	0.85
455_R	514_H	0.690	0.85
469_M	473_E	0.690	0.85
18_A	144_L	0.690	0.85
320_F	323_Q	0.689	0.85
277_F	281_F	0.687	0.85
102_V	396_L	0.687	0.85
441_H	444_R	0.686	0.85
523_L	529_S	0.686	0.85
424_E	428_E	0.685	0.85
430_P	433_R	0.684	0.85
244_H	263_R	0.684	0.85
458_K	461_E	0.684	0.85
92_S	400_W	0.683	0.85
82_A	379_T	0.683	0.85
291_D	295_R	0.683	0.85
96_W	99_D	0.682	0.84
226_A	492_N	0.681	0.84
147_K	152_P	0.679	0.84
275_T	300_E	0.679	0.84
167_V	180_V	0.675	0.84
524_T	528_P	0.674	0.84
281_F	299_H	0.673	0.84
468_T	472_Q	0.672	0.84
244_H	260_E	0.670	0.83
182_A	197_A	0.670	0.83
434_V	438_H	0.669	0.83
48_Y	217_P	0.668	0.83
178_R	409_R	0.668	0.83
13_I	23_L	0.667	0.83
302_K	517_L	0.667	0.83
224_G	376_V	0.666	0.83
54_A	87_A	0.665	0.83
364_R	371_Y	0.664	0.83
34_I	155_R	0.663	0.83
470_L	494_V	0.660	0.83
369_G	409_R	0.660	0.83
184_V	193_E	0.659	0.82
129_I	388_A	0.659	0.82
271_R	276_R	0.658	0.82
446_F	467_I	0.658	0.82
54_A	129_I	0.658	0.82
213_Y	448_W	0.657	0.82
510_S	515_F	0.657	0.82
278_M	282_D	0.655	0.82
208_S	216_N	0.655	0.82
77_I	240_F	0.654	0.82
297_I	346_I	0.654	0.82
241_N	353_T	0.652	0.82
333_L	338_D	0.652	0.82
282_D	289_P	0.652	0.82
60_T	126_H	0.652	0.82
143_T	147_K	0.651	0.82
208_S	214_T	0.651	0.82
434_V	442_E	0.651	0.82
103_L	106_T	0.651	0.82
56_V	66_H	0.650	0.82
28_A	152_P	0.650	0.82
277_F	280_D	0.648	0.81
103_L	142_T	0.646	0.81
495_Q	498_E	0.646	0.81
55_A	130_L	0.645	0.81
9_C	195_C	0.645	0.81
210_V	497_A	0.644	0.81
30_Q	408_R	0.643	0.81
269_L	278_M	0.640	0.81
510_S	520_P	0.640	0.81
449_D	462_R	0.638	0.80
166_I	196_H	0.637	0.80
408_R	412_Y	0.637	0.80
215_T	349_A	0.635	0.80
201_V	410_M	0.635	0.80
36_L	157_L	0.632	0.80
236_A	379_T	0.631	0.80
166_I	180_V	0.628	0.79
77_I	239_E	0.628	0.79
463_A	466_R	0.627	0.79
40_P	158_E	0.624	0.79
63_I	84_E	0.623	0.79
208_S	353_T	0.623	0.79
298_D	453_I	0.622	0.79
198_K	416_I	0.619	0.78
229_W	495_Q	0.619	0.78
522_L	526_S	0.618	0.78
277_F	352_Y	0.618	0.78
84_E	87_A	0.618	0.78
422_W	426_R	0.617	0.78
263_R	266_G	0.617	0.78
459_R	463_A	0.617	0.78
375_E	386_R	0.616	0.78
54_A	66_H	0.616	0.78
41_V	156_V	0.614	0.78
278_M	288_A	0.614	0.78
439_N	442_E	0.613	0.78
30_Q	404_E	0.612	0.78
163_V	192_V	0.609	0.77
226_A	495_Q	0.609	0.77
408_R	413_A	0.607	0.77
22_S	399_G	0.607	0.77
306_A	310_F	0.606	0.77
13_I	406_I	0.606	0.77
163_V	185_W	0.605	0.77
301_M	347_V	0.605	0.77
44_G	141_E	0.604	0.77
449_D	459_R	0.603	0.77
224_G	231_A	0.603	0.77
398_Y	401_S	0.601	0.76
165_L	238_L	0.601	0.76
298_D	347_V	0.600	0.76
25_L	154_I	0.599	0.76
351_H	387_M	0.598	0.76
95_Q	98_I	0.597	0.76
472_Q	475_D	0.596	0.76
119_T	324_H	0.595	0.76
271_R	277_F	0.594	0.75
208_S	241_N	0.594	0.75
278_M	284_R	0.591	0.75
25_L	152_P	0.591	0.75
163_V	183_W	0.591	0.75
246_T	260_E	0.590	0.75
245_P	291_D	0.589	0.75
144_L	148_A	0.589	0.75
23_L	399_G	0.588	0.75
29_D	96_W	0.587	0.75
258_L	344_V	0.587	0.75
142_T	146_S	0.586	0.74
221_S	492_N	0.585	0.74
229_W	235_V	0.585	0.74
71_L	76_G	0.585	0.74
521_E	524_T	0.584	0.74
121_E	388_A	0.584	0.74
165_L	202_L	0.583	0.74
509_E	519_Y	0.583	0.74
389_S	394_E	0.582	0.74
68_E	71_L	0.580	0.74
348_P	351_H	0.578	0.73
460_L	504_A	0.577	0.73
467_I	494_V	0.577	0.73
274_G	343_P	0.576	0.73
118_L	130_L	0.575	0.73
40_P	159_R	0.575	0.73
423_D	427_V	0.574	0.73
262_L	328_I	0.574	0.73
29_D	152_P	0.574	0.73
10_D	34_I	0.573	0.73
22_S	100_Q	0.573	0.73
107_H	117_H	0.572	0.73
371_Y	406_I	0.572	0.73
239_E	503_C	0.570	0.72
319_D	322_R	0.568	0.72
447_M	450_Y	0.567	0.72
352_Y	355_G	0.567	0.72
208_S	211_Y	0.567	0.72
331_K	335_L	0.566	0.72
13_I	201_V	0.566	0.72
243_F	452_G	0.565	0.72
351_H	386_R	0.564	0.72
98_I	130_L	0.563	0.72
489_E	493_L	0.563	0.72
47_F	142_T	0.563	0.72
272_P	304_L	0.563	0.72
440_W	486_N	0.562	0.71
271_R	286_E	0.561	0.71
207_A	210_V	0.561	0.71
52_G	244_H	0.561	0.71
465_R	468_T	0.560	0.71
240_F	384_A	0.558	0.71
179_V	369_G	0.558	0.71
419_L	424_E	0.557	0.71
102_V	142_T	0.555	0.70
256_F	328_I	0.555	0.70
406_I	409_R	0.555	0.70
474_I	491_R	0.553	0.70
333_L	339_L	0.552	0.70
317_P	340_T	0.550	0.70
439_N	494_V	0.550	0.70
523_L	528_P	0.549	0.70
143_T	146_S	0.548	0.70
100_Q	143_T	0.547	0.69
243_F	350_A	0.547	0.69
501_V	505_M	0.546	0.69
119_T	325_F	0.545	0.69
318_A	338_D	0.545	0.69
121_E	124_H	0.544	0.69
37_S	156_V	0.543	0.69
248_L	256_F	0.542	0.69
242_Q	386_R	0.542	0.69
282_D	292_I	0.542	0.69
10_D	197_A	0.540	0.68
301_M	304_L	0.539	0.68
417_S	461_E	0.539	0.68
279_P	283_E	0.537	0.68
256_F	259_T	0.536	0.68
213_Y	255_N	0.534	0.68
403_A	410_M	0.534	0.68
247_A	255_N	0.534	0.68
180_V	200_V	0.534	0.68
435_V	438_H	0.533	0.67
373_I	395_C	0.533	0.67
420_P	424_E	0.533	0.67
182_A	200_V	0.533	0.67
419_L	423_D	0.533	0.67
260_E	264_G	0.533	0.67
316_K	321_I	0.532	0.67
180_V	368_E	0.531	0.67
69_D	128_R	0.531	0.67
504_A	510_S	0.530	0.67
502_R	505_M	0.529	0.67
439_N	477_Y	0.528	0.67
45_S	51_G	0.528	0.67
26_R	399_G	0.527	0.67
70_T	83_V	0.527	0.67
468_T	471_Q	0.527	0.67
443_L	493_L	0.525	0.66
361_D	398_Y	0.524	0.66
56_V	67_V	0.524	0.66
292_I	295_R	0.523	0.66
134_D	264_G	0.523	0.66
437_Q	486_N	0.523	0.66
351_H	355_G	0.523	0.66
440_W	489_E	0.522	0.66
26_R	30_Q	0.521	0.66
442_E	469_M	0.521	0.66
35_V	41_V	0.521	0.66
290_R	385_N	0.520	0.66
298_D	301_M	0.519	0.65
67_V	88_S	0.519	0.65
362_H	404_E	0.518	0.65
80_R	528_P	0.518	0.65
308_C	345_P	0.517	0.65
242_Q	245_P	0.516	0.65
363_G	398_Y	0.515	0.65
438_H	449_D	0.515	0.65
256_F	331_K	0.515	0.65
233_C	365_T	0.515	0.65
425_S	428_E	0.513	0.64
237_N	378_Y	0.513	0.64
52_G	260_E	0.513	0.64
135_A	139_E	0.512	0.64
89_N	397_V	0.512	0.64
498_E	501_V	0.511	0.64
272_P	310_F	0.510	0.64
27_L	33_V	0.510	0.64
397_V	401_S	0.510	0.64
167_V	368_E	0.509	0.64
105_D	133_A	0.509	0.64
139_E	143_T	0.509	0.64
434_V	439_N	0.508	0.64
423_D	426_R	0.507	0.64
257_L	263_R	0.507	0.64
377_S	398_Y	0.507	0.64
185_W	190_E	0.506	0.63
52_G	263_R	0.506	0.63
280_D	286_E	0.506	0.63
161_N	492_N	0.506	0.63
87_A	398_Y	0.506	0.63
314_S	339_L	0.505	0.63
473_E	477_Y	0.503	0.63
179_V	370_L	0.503	0.63
399_G	406_I	0.503	0.63
508_K	516_T	0.501	0.63
215_T	350_A	0.501	0.63
177_R	180_V	0.501	0.63
341_Q	417_S	0.501	0.63
420_P	423_D	0.501	0.63
58_D	126_H	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bs2A	2	0.9648	100	0.25	Contact Map
2h88A	2	0.9704	100	0.254	Contact Map
1kf6A	1	0.9667	100	0.264	Contact Map
2wdqA	1	0.9685	100	0.267	Contact Map
1chuA	2	0.8852	100	0.287	Contact Map
2e5vA	1	0.8722	100	0.341	Contact Map
3gyxA	2	0.9481	100	0.346	Contact Map
1jnrA	2	0.9315	100	0.376	Contact Map
4c3xA	4	0.6981	100	0.56	Contact Map
1y0pA	1	0.6963	100	0.622	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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