GREMLIN Database
ENVY - Porin thermoregulatory protein EnvY
UniProt: P10805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10268
Length: 253 (228)
Sequences: 34907 (29937)
Seq/√Len: 1982.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V236_Y3.3111.00
188_T196_E3.2201.00
156_Q197_C3.0731.00
211_K219_L3.0151.00
154_I158_D2.7211.00
166_R176_P2.6421.00
199_M236_Y2.6141.00
196_E235_F2.5951.00
201_Y204_Q2.5211.00
205_M219_L2.4101.00
232_F243_Y2.3941.00
151_V179_L2.3791.00
158_D161_H2.3261.00
202_A228_F2.3101.00
183_L193_I2.0451.00
205_M220_C2.0341.00
159_I197_C2.0111.00
164_N167_I1.9741.00
154_I171_S1.9591.00
19_E27_T1.9581.00
211_K215_Q1.9121.00
238_L246_K1.9111.00
191_S195_T1.9021.00
231_V234_A1.8251.00
205_M211_K1.8131.00
151_V172_L1.7851.00
19_E29_T1.7831.00
225_T229_I1.7731.00
212_N215_Q1.7591.00
155_I194_V1.7441.00
203_V243_Y1.7421.00
21_S27_T1.7131.00
178_L182_K1.6721.00
176_P180_K1.6691.00
165_L180_K1.6581.00
168_V190_Y1.6491.00
31_P34_Y1.6481.00
199_M235_F1.6361.00
188_T192_Q1.6271.00
197_C201_Y1.6121.00
201_Y205_M1.5911.00
14_T54_L1.5491.00
17_E29_T1.5311.00
159_I201_Y1.5281.00
9_C44_V1.5141.00
121_L124_T1.5101.00
204_Q208_M1.5081.00
214_T225_T1.4971.00
152_C156_Q1.4841.00
179_L190_Y1.4701.00
154_I163_W1.4701.00
120_A124_T1.4631.00
206_L213_I1.4521.00
238_L242_N1.4411.00
145_S186_E1.4331.00
177_S181_K1.4271.00
153_R157_S1.4121.00
215_Q219_L1.4091.00
214_T218_Q1.3961.00
215_Q218_Q1.3901.00
202_A220_C1.3841.00
227_Y231_V1.3831.00
15_E52_H1.3711.00
189_S192_Q1.3691.00
196_E200_R1.3641.00
174_L178_L1.3641.00
180_K190_Y1.3581.00
178_L181_K1.3571.00
216_V220_C1.3561.00
201_Y220_C1.3511.00
156_Q193_I1.3471.00
167_I171_S1.3451.00
241_L245_A1.3381.00
197_C200_R1.3381.00
151_V168_V1.3351.00
124_T128_N1.3331.00
120_A127_S1.3241.00
222_Y231_V1.3141.00
195_T231_V1.3131.00
190_Y194_V1.3071.00
17_E31_P1.2991.00
155_I197_C1.2811.00
226_S229_I1.2441.00
147_V174_L1.2331.00
174_L179_L1.2081.00
23_N42_N1.2061.00
19_E46_E1.2041.00
175_S178_L1.1981.00
182_K186_E1.1921.00
160_Q219_L1.1891.00
119_R123_F1.1831.00
120_A123_F1.1661.00
166_R170_S1.1621.00
203_V207_L1.1501.00
39_A42_N1.1341.00
211_K216_V1.1311.00
14_T52_H1.1191.00
200_R203_V1.1141.00
182_K185_N1.1081.00
98_F104_H1.1061.00
195_T234_A1.1051.00
98_F102_A1.0991.00
154_I172_L1.0921.00
229_I239_T1.0811.00
169_A176_P1.0591.00
165_L190_Y1.0591.00
94_T104_H1.0561.00
230_S234_A1.0511.00
241_L244_L1.0511.00
229_I241_L1.0401.00
224_S230_S1.0361.00
146_S150_S1.0311.00
15_E32_K1.0251.00
127_S131_E1.0201.00
155_I190_Y1.0191.00
231_V235_F1.0191.00
96_E99_R1.0181.00
147_V182_K1.0171.00
242_N245_A1.0021.00
213_I216_V0.9961.00
209_D244_L0.9891.00
99_R103_N0.9871.00
192_Q195_T0.9841.00
177_S180_K0.9801.00
103_N107_Q0.9781.00
195_T235_F0.9751.00
165_L176_P0.9661.00
239_T242_N0.9651.00
229_I233_K0.9631.00
147_V172_L0.9621.00
205_M216_V0.9571.00
123_F127_S0.9561.00
152_C193_I0.9541.00
149_D153_R0.9461.00
203_V232_F0.9451.00
192_Q196_E0.9451.00
183_L190_Y0.9451.00
161_H167_I0.9401.00
91_H94_T0.9381.00
162_Y223_S0.9331.00
163_W168_V0.9211.00
160_Q201_Y0.9171.00
18_V51_N0.9101.00
148_R182_K0.9071.00
162_Y167_I0.9071.00
227_Y230_S0.8991.00
154_I168_V0.8981.00
150_S171_S0.8921.00
233_K239_T0.8871.00
152_C183_L0.8841.00
158_D171_S0.8821.00
150_S172_L0.8801.00
198_R220_C0.8801.00
124_T127_S0.8791.00
13_L18_V0.8771.00
167_I170_S0.8761.00
117_L121_L0.8711.00
149_D152_C0.8701.00
99_R102_A0.8691.00
150_S153_R0.8681.00
148_R186_E0.8671.00
9_C57_H0.8651.00
191_S227_Y0.8641.00
242_N246_K0.8621.00
236_Y243_Y0.8621.00
206_L216_V0.8591.00
22_V26_A0.8581.00
172_L179_L0.8561.00
168_V171_S0.8541.00
117_L124_T0.8511.00
18_V30_L0.8511.00
87_V90_C0.8461.00
96_E100_L0.8411.00
206_L244_L0.8381.00
192_Q235_F0.8371.00
21_S24_N0.8351.00
23_N26_A0.8291.00
159_I194_V0.8281.00
148_R151_V0.8271.00
199_M231_V0.8241.00
116_E119_R0.8241.00
93_R96_E0.8221.00
95_P99_R0.8211.00
148_R152_C0.8151.00
104_H107_Q0.8111.00
86_P89_A0.8031.00
105_S108_Q0.8021.00
193_I197_C0.8011.00
191_S194_V0.7991.00
174_L182_K0.7941.00
116_E120_A0.7841.00
180_K184_K0.7841.00
102_A106_K0.7801.00
86_P90_C0.7731.00
207_L243_Y0.7711.00
159_I220_C0.7711.00
60_R64_N0.7661.00
218_Q223_S0.7641.00
147_V150_S0.7621.00
100_L103_N0.7591.00
168_V179_L0.7551.00
238_L243_Y0.7511.00
38_F44_V0.7471.00
181_K185_N0.7451.00
199_M228_F0.7441.00
100_L104_H0.7401.00
225_T228_F0.7391.00
158_D167_I0.7391.00
223_S227_Y0.7351.00
21_S46_E0.7321.00
228_F232_F0.7301.00
94_T100_L0.7301.00
159_I163_W0.7271.00
18_V29_T0.7191.00
20_V36_A0.7171.00
217_A225_T0.7151.00
202_A205_M0.7111.00
163_W167_I0.7101.00
95_P98_F0.7091.00
94_T98_F0.7081.00
180_K191_S0.7011.00
145_S149_D0.6981.00
12_I35_L0.6961.00
144_R147_V0.6951.00
159_I198_R0.6941.00
180_K189_S0.6921.00
155_I193_I0.6921.00
209_D216_V0.6911.00
151_V183_L0.6831.00
151_V190_Y0.6821.00
184_K189_S0.6811.00
96_E103_N0.6811.00
224_S227_Y0.6801.00
188_T193_I0.6791.00
151_V154_I0.6771.00
117_L120_A0.6761.00
11_V55_I0.6731.00
30_L36_A0.6711.00
92_S95_P0.6701.00
51_N55_I0.6671.00
195_T227_Y0.6661.00
144_R185_N0.6631.00
94_T108_Q0.6621.00
11_V36_A0.6611.00
84_A87_V0.6571.00
62_I65_D0.6571.00
114_E118_T0.6531.00
233_K242_N0.6511.00
103_N121_L0.6511.00
11_V53_V0.6491.00
15_E50_L0.6471.00
115_A119_R0.6461.00
145_S182_K0.6461.00
11_V38_F0.6431.00
226_S230_S0.6411.00
212_N216_V0.6331.00
199_M222_Y0.6311.00
200_R236_Y0.6301.00
154_I167_I0.6291.00
151_V155_I0.6291.00
85_T89_A0.6281.00
169_A172_L0.6251.00
94_T97_V0.6251.00
103_N106_K0.6251.00
202_A216_V0.6221.00
91_H95_P0.6181.00
11_V20_V0.6111.00
200_R235_F0.6091.00
118_T122_L0.6091.00
101_A104_H0.6061.00
232_F236_Y0.6051.00
144_R186_E0.6031.00
226_S239_T0.6021.00
64_N68_L0.6021.00
13_L53_V0.6011.00
13_L30_L0.5991.00
232_F238_L0.5961.00
98_F101_A0.5961.00
203_V238_L0.5941.00
170_S173_C0.5921.00
149_D186_E0.5911.00
96_E128_N0.5871.00
105_S109_P0.5851.00
216_V244_L0.5791.00
168_V172_L0.5781.00
204_Q207_L0.5771.00
146_S186_E0.5761.00
165_L191_S0.5741.00
24_N27_T0.5731.00
163_W198_R0.5731.00
121_L125_V0.5721.00
224_S234_A0.5681.00
195_T199_M0.5671.00
231_V236_Y0.5671.00
17_E49_T0.5661.00
144_R178_L0.5651.00
163_W194_V0.5611.00
60_R63_I0.5591.00
117_L127_S0.5581.00
156_Q201_Y0.5571.00
192_Q234_A0.5541.00
97_V100_L0.5531.00
210_N216_V0.5511.00
102_A105_S0.5501.00
213_I241_L0.5501.00
222_Y228_F0.5481.00
148_R179_L0.5481.00
20_V44_V0.5451.00
155_I163_W0.5451.00
142_I145_S0.5421.00
128_N131_E0.5411.00
153_R156_Q0.5411.00
112_P115_A0.5401.00
116_E123_F0.5391.00
9_C38_F0.5391.00
148_R172_L0.5371.00
228_F240_P0.5371.00
151_V182_K0.5331.00
10_V37_A0.5331.00
116_E127_S0.5311.00
222_Y227_Y0.5301.00
97_V101_A0.5291.00
52_H55_I0.5281.00
13_L51_N0.5271.00
100_L121_L0.5251.00
99_R106_K0.5251.00
206_L243_Y0.5201.00
117_L131_E0.5181.00
22_V38_F0.5171.00
90_C93_R0.5161.00
201_Y219_L0.5151.00
13_L34_Y0.5121.00
54_L57_H0.5121.00
200_R204_Q0.5091.00
165_L177_S0.5061.00
114_E117_L0.5051.00
65_D69_F0.5031.00
117_L128_N0.5021.00
61_N64_N0.5021.00
121_L128_N0.5011.00
107_Q110_S0.5011.00
23_N43_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.9289 100 0.213 Contact Map
1bl0A 1 0.4348 100 0.445 Contact Map
3oouA 1 0.4111 100 0.447 Contact Map
3mklA 1 0.4387 100 0.447 Contact Map
3oioA 1 0.4387 100 0.451 Contact Map
3mn2A 1 0.415 99.9 0.456 Contact Map
2k9sA 1 0.415 99.9 0.462 Contact Map
3w6vA 1 0.4308 99.9 0.468 Contact Map
3lsgA 2 0.3992 99.9 0.472 Contact Map
1d5yA 1 0.4348 99.9 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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