GREMLIN Database
RNH2 - Ribonuclease HII
UniProt: P10442 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10861
Length: 198 (182)
Sequences: 4914 (3292)
Seq/√Len: 244.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_D160_A4.6831.00
156_Q177_H3.3931.00
104_Y120_M2.8571.00
44_N127_S2.6861.00
58_Y62_K2.5331.00
150_L182_H2.5071.00
68_W138_L2.4001.00
28_V72_R2.3801.00
79_D186_S2.3251.00
44_N48_K2.2501.00
158_G169_F2.2101.00
69_S97_G2.1971.00
55_L145_A2.1231.00
172_E176_E2.1041.00
53_R56_A2.0181.00
29_T90_A2.0031.00
125_G132_I1.9841.00
62_K68_W1.9801.00
60_E64_K1.8741.00
58_Y141_V1.7851.00
58_Y145_A1.7811.00
51_E148_A1.7811.00
159_F162_H1.7251.00
72_R146_E1.7001.00
58_Y142_T1.6871.00
122_V128_R1.6871.00
161_Q169_F1.6701.00
84_L110_N1.6441.00
124_K127_S1.6351.00
81_L89_L1.6191.00
73_A93_R1.5581.00
106_L132_I1.5501.00
51_E163_K1.5491.00
24_V159_F1.5391.00
48_K127_S1.5311.00
77_E89_L1.5161.00
169_F173_K1.4801.00
77_E93_R1.4661.00
85_H88_M1.4601.00
11_L103_E1.4371.00
31_A94_A1.4101.00
89_L93_R1.4061.00
149_A152_I1.3931.00
112_C121_A1.3821.00
72_R142_T1.3701.00
158_G173_K1.3601.00
92_Q96_A1.3461.00
104_Y118_P1.3431.00
51_E55_L1.3421.00
174_L179_A1.3401.00
171_L175_A1.3351.00
23_L171_L1.2771.00
168_A172_E1.2731.00
151_D156_Q1.2711.00
84_L111_R1.2651.00
55_L141_V1.2591.00
67_S99_H1.2561.00
74_E77_E1.2401.00
78_I83_I1.2371.00
43_L133_S1.2371.00
13_A31_A1.2341.00
26_A72_R1.2191.00
105_V117_M1.2051.00
70_L142_T1.2041.00
61_I65_A1.2001.00
43_L137_I1.1961.00
26_A146_E1.1871.00
29_T87_T1.1801.00
28_V142_T1.1761.00
146_E150_L1.1721.00
13_A102_P1.1561.00
13_A33_I1.1401.00
168_A171_L1.1391.00
23_L166_P1.1321.00
162_H173_K1.1311.00
112_C119_A1.1261.00
49_L137_I1.1241.00
158_G161_Q1.1091.00
153_V182_H1.0991.00
179_A185_R1.0971.00
77_E80_E1.0951.00
38_R64_K1.0891.00
73_A90_A1.0821.00
171_L189_P1.0731.00
188_G191_K1.0721.00
71_G94_A1.0561.00
82_N85_H1.0541.00
15_V105_V1.0501.00
56_A60_E1.0481.00
159_F182_H1.0421.00
18_V141_V1.0391.00
15_V87_T1.0331.00
81_L85_H1.0301.00
110_N121_A1.0271.00
122_V129_V1.0241.00
172_E175_A1.0241.00
10_Q103_E1.0221.00
158_G162_H1.0211.00
43_L134_A1.0191.00
50_S53_R1.0151.00
95_V105_V1.0041.00
35_D38_R1.0031.00
42_G53_R0.9971.00
15_V95_V0.9931.00
148_A152_I0.9921.00
59_E145_A0.9911.00
30_A70_L0.9831.00
92_Q114_K0.9721.00
62_K142_T0.9601.00
98_L102_P0.9581.00
49_L53_R0.9531.00
24_V147_M0.9531.00
62_K138_L0.9491.00
49_L57_L0.9491.00
77_E81_L0.9411.00
88_M110_N0.9401.00
59_E62_K0.9361.00
122_V132_I0.9351.00
60_E63_E0.9301.00
73_A77_E0.9301.00
20_R87_T0.9211.00
24_V182_H0.9141.00
124_K128_R0.9131.00
129_V133_S0.9091.00
28_V146_E0.9081.00
27_V83_I0.9051.00
92_Q115_L0.8941.00
43_L130_P0.8931.00
148_A163_K0.8921.00
75_P79_D0.8901.00
106_L129_V0.8901.00
73_A89_L0.8800.99
87_T91_M0.8790.99
88_M111_R0.8660.99
162_H167_T0.8640.99
55_L148_A0.8570.99
59_E63_E0.8480.99
13_A95_V0.8470.99
112_C115_L0.8460.99
71_G90_A0.8460.99
66_L100_I0.8400.99
76_H80_E0.8230.99
142_T146_E0.8230.99
70_L138_L0.8200.99
88_M113_P0.8180.99
67_S100_I0.8170.99
156_Q173_K0.8150.99
13_A98_L0.8110.99
145_A149_A0.8090.99
105_V115_L0.8070.99
82_N87_T0.8060.99
29_T71_G0.7970.99
31_A98_L0.7920.99
154_F182_H0.7900.99
33_I67_S0.7900.99
113_P119_A0.7880.99
142_T145_A0.7840.99
174_L190_V0.7760.99
13_A105_V0.7740.99
141_V145_A0.7690.99
109_G113_P0.7670.99
34_L43_L0.7560.98
146_E149_A0.7510.98
35_D39_P0.7500.98
89_L92_Q0.7500.98
122_V125_G0.7470.98
166_P171_L0.7420.98
18_V163_K0.7380.98
159_F180_T0.7340.98
161_Q167_T0.7270.98
169_F172_E0.7230.98
32_V134_A0.7190.98
26_A74_E0.7120.98
18_V58_Y0.7100.98
88_M92_Q0.7100.98
84_L88_M0.7070.98
130_P133_S0.7020.98
75_P182_H0.7010.98
154_F181_E0.6990.97
10_Q36_P0.6990.97
69_S94_A0.6950.97
76_H185_R0.6940.97
57_L137_I0.6930.97
179_A189_P0.6920.97
109_G123_V0.6870.97
53_R57_L0.6800.97
84_L87_T0.6770.97
76_H181_E0.6690.97
15_V91_M0.6670.97
71_G93_R0.6660.97
56_A59_E0.6600.96
79_D185_R0.6590.96
180_T183_H0.6580.96
15_V107_I0.6460.96
23_L190_V0.6450.96
42_G57_L0.6430.96
33_I98_L0.6390.96
44_N133_S0.6380.96
69_S98_L0.6370.96
105_V119_A0.6360.96
29_T69_S0.6360.96
58_Y138_L0.6350.96
111_R119_A0.6310.95
18_V29_T0.6300.95
23_L189_P0.6290.95
179_A190_V0.6280.95
156_Q160_A0.6280.95
18_V138_L0.6270.95
151_D163_K0.6220.95
162_H169_F0.6210.95
87_T166_P0.6210.95
140_K143_R0.6200.95
174_L189_P0.6160.95
162_H166_P0.6150.95
40_I64_K0.6140.95
94_A98_L0.6100.94
52_K56_A0.6100.94
26_A75_P0.6100.94
82_N91_M0.6100.94
126_D133_S0.6080.94
34_L65_A0.6040.94
145_A148_A0.6040.94
27_V87_T0.6020.94
33_I102_P0.5990.94
12_V129_V0.5980.94
24_V183_H0.5950.94
168_A175_A0.5930.94
123_V132_I0.5910.94
82_N86_A0.5890.93
173_K176_E0.5870.93
147_M159_F0.5870.93
34_L130_P0.5860.93
57_L61_I0.5810.93
96_A115_L0.5760.93
109_G121_A0.5680.92
34_L134_A0.5670.92
106_L131_E0.5670.92
110_N123_V0.5650.92
18_V30_A0.5630.92
109_G112_C0.5580.91
38_R63_E0.5560.91
32_V65_A0.5550.91
24_V180_T0.5530.91
154_F180_T0.5510.91
140_K144_D0.5500.91
159_F183_H0.5450.90
83_I86_A0.5390.90
115_L119_A0.5390.90
30_A68_W0.5350.90
88_M112_C0.5350.90
57_L60_E0.5330.90
153_V181_E0.5330.90
81_L86_A0.5330.90
120_M129_V0.5270.89
167_T187_F0.5260.89
55_L58_Y0.5240.89
37_A41_A0.5230.89
13_A103_E0.5220.89
95_V115_L0.5180.88
39_P64_K0.5140.88
38_R41_A0.5130.88
143_R146_E0.5130.88
71_G97_G0.5120.88
34_L38_R0.5110.87
32_V61_I0.5090.87
88_M121_A0.5090.87
106_L122_V0.5080.87
39_P130_P0.5080.87
91_M107_I0.5060.87
128_R131_E0.5040.87
48_K124_K0.5010.86
111_R121_A0.5010.86
40_I43_L0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2etjA 1 0.9293 100 0.101 Contact Map
1io2A 1 0.9343 100 0.16 Contact Map
1uaxA 1 0.9343 100 0.167 Contact Map
1ekeA 2 0.9293 100 0.17 Contact Map
1i39A 1 0.899 100 0.177 Contact Map
3kioA 1 0.9747 100 0.187 Contact Map
2d0bA 1 0.9798 100 0.219 Contact Map
4py5A 1 0.9192 100 0.227 Contact Map
3vn5A 1 0.9242 100 0.24 Contact Map
2qh9A 2 0.7475 16.9 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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