GREMLIN Database
LPXB - Lipid-A-disaccharide synthase
UniProt: P10441 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10546
Length: 382 (370)
Sequences: 2245 (1634)
Seq/√Len: 85.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_G97_I4.9041.00
291_V313_S4.0111.00
321_R357_T3.7411.00
142_L162_R3.6601.00
32_H375_Q3.0561.00
194_L228_I2.9271.00
312_V328_L2.8381.00
8_T37_R2.7841.00
351_S355_H2.6091.00
122_S154_Y2.5251.00
26_I51_C2.4921.00
208_L274_A2.4781.00
145_A161_C2.3761.00
27_R49_E2.3361.00
10_A85_R2.3101.00
333_E336_K2.2661.00
93_V118_I2.2631.00
59_E74_R2.2621.00
232_L241_F2.2611.00
26_I38_F2.2491.00
273_L278_A2.2161.00
219_L226_L2.2131.00
331_E336_K2.1651.00
191_A227_E2.1541.00
30_K49_E2.1401.00
28_A371_E2.1361.00
223_Y342_L2.1301.00
238_R242_E2.1071.00
218_L338_A2.0871.00
196_L216_A2.0811.00
131_K134_F2.0701.00
151_K155_D2.0621.00
270_A341_L2.0601.00
227_E255_H2.0411.00
8_T39_V2.0281.00
118_I144_L2.0221.00
94_F110_L1.9811.00
101_D129_R1.9601.00
42_A51_C1.9551.00
67_E299_T1.9421.00
297_P301_W1.9301.00
72_L76_L1.9231.00
301_W305_R1.9011.00
76_L80_A1.8991.00
319_A323_L1.8441.00
319_A361_L1.8291.00
311_Y322_E1.7861.00
310_D320_G1.7851.00
152_A155_D1.7641.00
343_P350_T1.7471.00
265_M282_C1.7351.00
143_V154_Y1.7311.00
257_L264_A1.7231.00
84_K88_E1.7211.00
194_L226_L1.7191.00
195_A268_S1.7131.00
130_Q308_K1.7031.00
124_S166_H1.6951.00
9_I93_V1.6721.00
222_T342_L1.6681.00
83_T109_N1.6641.00
300_F304_K1.6321.00
118_I377_V1.6311.00
260_M263_E1.6261.00
181_A185_L1.6081.00
211_D332_C1.6061.00
219_L342_L1.6061.00
31_E371_E1.6011.00
286_K362_H1.5911.00
340_A343_P1.5671.00
10_A86_F1.5651.00
327_L340_A1.5631.00
25_L95_V1.5601.00
286_K359_R1.5541.00
336_K339_A1.5421.00
215_T337_L1.5151.00
73_R76_L1.5141.00
212_F292_G1.5040.99
272_L292_G1.5020.99
238_R258_D1.4960.99
87_G113_Q1.4920.99
118_I380_L1.4880.99
170_D368_N1.4810.99
289_M324_V1.4740.99
375_Q379_E1.4640.99
220_R253_S1.4640.99
40_G51_C1.4540.99
218_L335_Q1.4470.99
354_M357_T1.4460.99
177_D180_A1.4400.99
8_T89_L1.4390.99
271_A282_C1.4280.99
216_A228_I1.4270.99
195_A271_A1.4230.99
85_R89_L1.4140.99
223_Y346_A1.3950.99
195_A265_M1.3940.99
28_A31_E1.3930.99
124_S147_L1.3910.99
37_R52_E1.3900.99
188_P191_A1.3840.99
273_L282_C1.3790.99
292_G332_C1.3790.99
26_I46_M1.3780.99
96_G117_T1.3640.99
33_V378_L1.3560.99
100_P128_W1.3550.99
68_V101_D1.3520.99
153_F317_L1.3510.99
265_M271_A1.3350.99
130_Q157_Y1.3250.99
206_E240_Q1.3190.99
144_L373_A1.3100.99
348_G351_S1.3070.99
9_I36_A1.3060.99
271_A287_C1.2990.98
325_K340_A1.2870.98
215_T338_A1.2800.98
121_V146_F1.2790.98
144_L376_A1.2780.98
144_L377_V1.2780.98
39_V89_L1.2670.98
170_D369_A1.2630.98
184_V260_M1.2580.98
279_A313_S1.2500.98
96_G107_E1.2480.98
232_L256_L1.2470.98
209_S244_I1.2470.98
122_S143_V1.2440.98
71_R74_R1.2340.98
79_R105_T1.2330.98
142_L160_P1.2300.98
355_H359_R1.2160.98
153_F157_Y1.2150.98
215_T327_L1.2140.98
29_L36_A1.2060.98
133_V153_F1.2060.98
303_A307_V1.2050.98
8_T92_D1.2020.97
368_N371_E1.2020.97
321_R360_E1.1930.97
172_M285_A1.1840.97
230_V254_V1.1780.97
152_A156_K1.1750.97
125_V133_V1.1740.97
188_P227_E1.1690.97
23_A45_R1.1610.97
86_F94_F1.1510.97
368_N372_Q1.1490.97
32_H371_E1.1470.97
214_K334_P1.1460.97
22_G46_M1.1450.97
342_L346_A1.1370.96
96_G119_H1.1370.96
300_F330_E1.1320.96
211_D294_R1.1300.96
272_L341_L1.1290.96
12_V106_L1.1280.96
54_W85_R1.1200.96
116_K141_D1.1030.96
209_S241_F1.1010.96
309_T317_L1.1000.96
343_P347_N1.0940.96
334_P338_A1.0930.96
145_A151_K1.0890.95
155_D160_P1.0870.95
80_A84_K1.0850.95
39_V85_R1.0840.95
357_T360_E1.0840.95
353_A357_T1.0800.95
130_Q156_K1.0780.95
194_L345_L1.0770.95
24_G370_D1.0720.95
33_V36_A1.0710.95
47_Q53_A1.0700.95
140_T143_V1.0700.95
143_V161_C1.0660.95
208_L332_C1.0650.95
41_V78_I1.0650.95
11_L38_F1.0640.95
193_C229_V1.0620.95
120_Y164_I1.0540.95
151_K161_C1.0530.95
274_A278_A1.0510.95
211_D334_P1.0480.94
25_L373_A1.0400.94
215_T272_L1.0390.94
142_L376_A1.0370.94
178_K287_C1.0310.94
26_I49_E1.0280.94
292_G337_L1.0260.94
136_I154_Y1.0250.94
203_A207_M1.0230.94
146_F163_F1.0210.94
108_G139_A1.0190.94
119_H124_S1.0120.93
214_K217_Q1.0110.93
30_K35_N1.0060.93
108_G135_K1.0010.93
25_L120_Y0.9980.93
211_D214_K0.9950.93
11_L51_C0.9830.92
14_G18_G0.9800.92
57_M61_A0.9790.92
147_L317_L0.9770.92
185_L260_M0.9720.92
372_Q375_Q0.9650.92
73_R77_H0.9610.91
12_V82_L0.9600.91
230_V241_F0.9600.91
350_T354_M0.9560.91
197_L278_A0.9530.91
12_V103_N0.9530.91
86_F110_L0.9510.91
192_H223_Y0.9480.91
107_E140_T0.9460.91
133_V159_V0.9430.91
178_K182_R0.9370.90
261_G273_L0.9360.90
347_N350_T0.9360.90
11_L95_V0.9340.90
218_L221_Q0.9320.90
192_H227_E0.9300.90
70_G73_R0.9240.90
10_A39_V0.9230.90
202_G206_E0.9230.90
352_H356_D0.9230.90
22_G25_L0.9220.90
209_S230_V0.9220.90
55_Y78_I0.9180.89
179_N183_D0.9130.89
41_V82_L0.9110.89
55_Y81_D0.9100.89
16_T233_V0.9080.89
304_K330_E0.9070.89
76_L79_R0.9060.89
67_E296_K0.9060.89
231_P264_A0.9030.89
19_D43_G0.9000.88
136_I140_T0.9000.88
66_V296_K0.8980.88
212_F274_A0.8940.88
327_L336_K0.8930.88
323_L357_T0.8930.88
110_L117_T0.8820.87
212_F341_L0.8810.87
237_R240_Q0.8770.87
66_V70_G0.8750.87
300_F328_L0.8730.87
280_L314_L0.8730.87
195_A264_A0.8710.87
350_T353_A0.8690.87
120_Y370_D0.8670.87
299_T303_A0.8670.87
21_L121_V0.8660.87
93_V377_V0.8650.86
366_R372_Q0.8570.86
218_L334_P0.8540.86
300_F329_Q0.8540.86
62_V71_R0.8540.86
295_M300_F0.8520.86
24_G170_D0.8500.85
32_H378_L0.8490.85
192_H269_D0.8480.85
182_R267_A0.8480.85
59_E71_R0.8470.85
336_K340_A0.8450.85
344_L354_M0.8430.85
371_E375_Q0.8410.85
130_Q153_F0.8400.85
125_V136_I0.8380.85
63_M124_S0.8350.84
13_A46_M0.8340.84
63_M295_M0.8320.84
47_Q56_E0.8310.84
39_V86_F0.8300.84
26_I40_G0.8290.84
357_T361_L0.8260.84
83_T106_L0.8220.84
360_E363_Q0.8210.83
170_D372_Q0.8190.83
300_F307_V0.8160.83
356_D360_E0.8120.83
270_A343_P0.8120.83
117_T140_T0.8120.83
26_I36_A0.8080.82
196_L292_G0.7970.82
273_L289_M0.7950.81
301_W330_E0.7940.81
289_M358_F0.7820.80
73_R80_A0.7820.80
9_I33_V0.7800.80
315_P318_L0.7790.80
270_A345_L0.7780.80
298_F302_L0.7760.80
360_E364_Q0.7730.80
111_K117_T0.7720.80
147_L314_L0.7680.79
218_L222_T0.7680.79
44_P56_E0.7670.79
311_Y320_G0.7660.79
27_R30_K0.7650.79
118_I142_L0.7630.79
168_M284_L0.7610.79
104_I136_I0.7580.78
219_L341_L0.7570.78
133_V137_G0.7520.78
184_V263_E0.7520.78
339_A343_P0.7520.78
37_R89_L0.7470.77
215_T339_A0.7450.77
124_S163_F0.7440.77
223_Y226_L0.7440.77
56_E59_E0.7440.77
312_V332_C0.7420.77
45_R48_A0.7410.77
11_L25_L0.7400.77
74_R78_I0.7400.77
93_V116_K0.7390.76
77_H80_A0.7370.76
265_M287_C0.7370.76
278_A282_C0.7370.76
196_L212_F0.7300.76
108_G112_K0.7280.75
137_G140_T0.7280.75
328_L332_C0.7270.75
10_A94_F0.7270.75
154_Y161_C0.7260.75
302_L306_L0.7260.75
208_L211_D0.7250.75
295_M299_T0.7240.75
261_G265_M0.7230.75
108_G138_R0.7220.75
28_A32_H0.7220.75
239_E243_R0.7200.75
212_F272_L0.7190.75
335_Q339_A0.7160.74
147_L318_L0.7150.74
215_T334_P0.7130.74
77_H81_D0.7120.74
290_V340_A0.7090.73
208_L212_F0.7090.73
373_A376_A0.7090.73
265_M273_L0.7080.73
319_A364_Q0.7060.73
324_V358_F0.7060.73
142_L380_L0.7040.73
131_K306_L0.7010.73
273_L279_A0.7000.73
84_K112_K0.6980.72
137_G159_V0.6950.72
63_M68_V0.6950.72
240_Q244_I0.6950.72
344_L348_G0.6940.72
261_G282_C0.6920.72
272_L337_L0.6900.71
38_F51_C0.6900.71
359_R363_Q0.6870.71
170_D366_R0.6860.71
95_V377_V0.6860.71
217_Q221_Q0.6860.71
84_K87_G0.6840.71
21_L119_H0.6840.71
16_T57_M0.6830.71
79_R82_L0.6820.71
16_T235_A0.6810.70
210_A214_K0.6800.70
124_S314_L0.6790.70
29_L378_L0.6770.70
19_D23_A0.6760.70
265_M285_A0.6760.70
191_A225_D0.6750.70
20_I23_A0.6730.70
155_D161_C0.6720.69
99_A103_N0.6680.69
242_E246_A0.6670.69
11_L97_I0.6660.69
182_R185_L0.6610.68
211_D215_T0.6590.68
142_L379_E0.6570.68
20_I45_R0.6540.67
332_C337_L0.6520.67
213_L217_Q0.6520.67
217_Q251_D0.6520.67
219_L222_T0.6520.67
100_P149_F0.6520.67
291_V324_V0.6480.67
20_I262_R0.6470.67
301_W304_K0.6460.66
38_F95_V0.6460.66
295_M312_V0.6460.66
96_G103_N0.6450.66
361_L364_Q0.6450.66
237_R242_E0.6450.66
47_Q52_E0.6430.66
110_L114_G0.6420.66
273_L283_M0.6420.66
140_T159_V0.6420.66
279_A289_M0.6410.66
135_K139_A0.6410.66
183_D189_H0.6400.66
21_L53_A0.6400.66
279_A291_V0.6400.66
11_L26_I0.6380.65
243_R246_A0.6370.65
283_M361_L0.6360.65
9_I38_F0.6360.65
303_A328_L0.6360.65
100_P122_S0.6290.64
99_A124_S0.6280.64
347_N352_H0.6270.64
294_R329_Q0.6260.64
78_I81_D0.6260.64
231_P261_G0.6240.64
354_M358_F0.6240.64
367_C372_Q0.6220.63
29_L38_F0.6220.63
79_R96_G0.6210.63
297_P330_E0.6190.63
240_Q243_R0.6190.63
214_K335_Q0.6190.63
163_F365_I0.6180.63
182_R193_C0.6170.63
180_A183_D0.6150.63
67_E70_G0.6150.63
310_D322_E0.6130.62
187_I227_E0.6120.62
340_A350_T0.6110.62
266_V285_A0.6100.62
322_E325_K0.6070.62
162_R376_A0.6060.61
229_V264_A0.6060.61
103_N106_L0.6040.61
193_C227_E0.6040.61
154_Y159_V0.6020.61
208_L329_Q0.6020.61
104_I133_V0.6010.61
194_L219_L0.6010.61
86_F90_K0.5990.61
317_L369_A0.5950.60
348_G352_H0.5950.60
125_V154_Y0.5930.60
193_C269_D0.5930.60
27_R31_E0.5920.60
171_A262_R0.5920.60
38_F46_M0.5920.60
42_A53_A0.5900.59
197_L274_A0.5900.59
327_L337_L0.5890.59
242_E256_L0.5860.59
183_D186_G0.5850.59
104_I107_E0.5850.59
66_V69_L0.5850.59
234_N237_R0.5830.59
21_L146_F0.5830.59
44_P58_E0.5820.58
30_K34_P0.5810.58
176_P266_V0.5800.58
208_L292_G0.5790.58
30_K38_F0.5780.58
128_W150_E0.5780.58
327_L333_E0.5760.58
302_L305_R0.5750.58
75_L78_I0.5750.58
96_G104_I0.5730.57
41_V60_L0.5730.57
60_L99_A0.5730.57
282_C287_C0.5720.57
12_V65_I0.5720.57
79_R106_L0.5700.57
313_S324_V0.5690.57
180_A184_V0.5690.57
192_H225_D0.5690.57
172_M266_V0.5680.57
344_L351_S0.5670.56
14_G19_D0.5650.56
105_T108_G0.5650.56
53_A60_L0.5620.56
29_L33_V0.5610.56
29_L374_A0.5610.56
52_E89_L0.5600.56
195_A278_A0.5570.55
10_A91_P0.5550.55
161_C317_L0.5550.55
144_L164_I0.5550.55
164_I373_A0.5550.55
133_V160_P0.5540.55
162_R372_Q0.5520.54
103_N119_H0.5520.54
196_L228_I0.5510.54
214_K218_L0.5510.54
143_V159_V0.5490.54
80_A83_T0.5480.54
197_L231_P0.5480.54
106_L265_M0.5450.54
18_G43_G0.5450.54
100_P136_I0.5440.53
38_F49_E0.5420.53
283_M315_P0.5420.53
202_G240_Q0.5420.53
222_T346_A0.5420.53
187_I229_V0.5410.53
349_K352_H0.5400.53
196_L272_L0.5400.53
127_A149_F0.5390.53
96_G124_S0.5380.53
261_G268_S0.5380.53
179_N189_H0.5380.53
74_R77_H0.5380.53
163_F166_H0.5360.52
14_G315_P0.5340.52
9_I118_I0.5340.52
283_M313_S0.5320.52
343_P348_G0.5300.52
296_K299_T0.5300.52
172_M262_R0.5300.52
295_M307_V0.5290.51
313_S317_L0.5290.51
60_L101_D0.5280.51
36_A378_L0.5270.51
195_A261_G0.5260.51
256_L259_G0.5260.51
284_L337_L0.5240.51
77_H379_E0.5240.51
283_M291_V0.5240.51
100_P129_R0.5220.50
333_E340_A0.5220.50
42_A46_M0.5220.50
25_L377_V0.5220.50
45_R49_E0.5220.50
101_D124_S0.5210.50
25_L46_M0.5200.50
205_V274_A0.5200.50
254_V257_L0.5190.50
10_A82_L0.5180.50
147_L166_H0.5180.50
62_V299_T0.5180.50
42_A47_Q0.5170.50
338_A342_L0.5160.50
305_R330_E0.5150.50
94_F117_T0.5150.50
274_A295_M0.5140.49
172_M176_P0.5140.49
93_V380_L0.5130.49
222_T339_A0.5120.49
102_F199_G0.5110.49
315_P324_V0.5070.48
215_T333_E0.5070.48
148_P163_F0.5050.48
40_G49_E0.5050.48
187_I193_C0.5050.48
279_A282_C0.5040.48
239_E242_E0.5030.48
68_V75_L0.5030.48
107_E119_H0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v4vA 2 0.8953 100 0.724 Contact Map
1vgvA 2 0.9031 100 0.73 Contact Map
3dzcA 2 0.9031 100 0.735 Contact Map
4relA 1 0.9319 100 0.771 Contact Map
4nesA 2 0.877 100 0.781 Contact Map
2gt1A 1 0.8115 100 0.789 Contact Map
1pswA 1 0.8089 100 0.795 Contact Map
3ot5A 2 0.9005 100 0.796 Contact Map
2acvA 1 0.9241 100 0.797 Contact Map
3ia7A 2 0.8874 99.9 0.8 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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