IAP - ECOLI - GREMLIN Contacts

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IAP - Alkaline phosphatase isozyme conversion protein

UniProt:	P10423	Sequences: MFSALRHRTAALALGVCFILPVHASSPKPGDFANTQARHIATFFPGRMTGTPAEMLSADYIRQQFQQMGYRSDIRTFNSRYIYTARDNRKSWHNVTGSTVIAAHEGKAPQQIIIMAHLDTYAPLSDADADANLGGLTLQGMDDNAAGLGVMLELAERLKNTPTEYGIRFVATSGEEEGKLGAENLLKRMSDTEKKNTLLVINLDNLIVGDKLYFNSGVKTPEAVRKLTRDRALAIARSHGIAATTNPGLNKNYPKGTGCCNDAEIFDKAGIAVLSVEATNWNLGNKDGYQQRAKTPAFPAGNSWHDVRLDNHQHIDKALPGRIERRCRDVMRIMLPLVKELAKAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10488
Length:	345 (275)
Sequences:	6258 (4800)
Seq/√Len:	289.4

ECOLI - IAP YFBL
BACSU - BSAP
HALSA - Q9HNP7 Q9HRR8
SULSO - Q7LXL7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_Q	67_Q	4.054	1.00
62_R	66_Q	3.798	1.00
65_F	171_A	3.518	1.00
108_A	164_E	3.373	1.00
150_V	206_L	2.961	1.00
111_Q	166_G	2.750	1.00
153_E	156_E	2.621	1.00
54_E	173_S	2.546	1.00
52_P	56_L	2.459	1.00
148_L	171_A	2.435	1.00
107_K	164_E	2.366	1.00
115_M	200_V	2.361	1.00
36_Q	60_Y	2.328	1.00
184_N	188_R	2.299	1.00
106_G	166_G	2.256	1.00
61_I	118_L	2.243	1.00
55_M	59_D	2.233	1.00
58_A	100_V	2.226	1.00
103_A	168_R	2.219	1.00
110_Q	165_Y	2.214	1.00
151_M	171_A	2.211	1.00
115_M	172_T	2.200	1.00
182_A	265_I	2.186	1.00
186_L	269_A	2.183	1.00
34_N	38_R	2.159	1.00
39_H	44_F	2.022	1.00
38_R	293_A	1.998	1.00
285_N	290_Q	1.958	1.00
61_I	171_A	1.928	1.00
77_F	81_Y	1.926	1.00
111_Q	168_R	1.919	1.00
62_R	74_I	1.876	1.00
71_R	105_E	1.859	1.00
58_A	98_S	1.857	1.00
36_Q	64_Q	1.824	1.00
59_D	63_Q	1.806	1.00
37_A	149_G	1.789	1.00
292_R	295_T	1.775	1.00
37_A	145_A	1.754	1.00
48_M	51_T	1.739	1.00
63_Q	67_Q	1.730	1.00
42_T	139_Q	1.719	1.00
54_E	118_L	1.706	1.00
32_F	153_E	1.693	1.00
101_I	170_V	1.679	1.00
103_A	166_G	1.673	1.00
45_P	53_A	1.636	1.00
29_P	32_F	1.599	1.00
172_T	200_V	1.584	1.00
116_A	148_L	1.583	1.00
212_L	215_N	1.548	1.00
303_S	309_L	1.547	1.00
18_F	21_P	1.506	1.00
17_C	21_P	1.503	1.00
114_I	151_M	1.489	1.00
97_G	173_S	1.487	1.00
65_F	155_A	1.485	1.00
59_D	62_R	1.483	1.00
104_H	169_F	1.483	1.00
109_P	196_N	1.482	1.00
58_A	118_L	1.474	1.00
36_Q	68_M	1.469	1.00
32_F	156_E	1.461	1.00
53_A	56_L	1.460	1.00
64_Q	156_E	1.452	1.00
155_A	169_F	1.426	1.00
158_L	167_I	1.419	1.00
110_Q	198_L	1.414	1.00
168_R	185_L	1.400	1.00
64_Q	68_M	1.379	1.00
302_N	306_D	1.370	1.00
41_A	293_A	1.356	1.00
170_V	185_L	1.356	1.00
76_T	96_T	1.354	1.00
144_N	202_N	1.354	1.00
65_F	102_A	1.348	1.00
62_R	100_V	1.323	1.00
194_K	271_I	1.322	1.00
163_T	167_I	1.307	1.00
48_M	177_E	1.301	1.00
63_Q	66_Q	1.283	1.00
143_D	175_E	1.281	1.00
183_E	187_K	1.266	1.00
116_A	151_M	1.265	1.00
36_Q	152_L	1.260	1.00
70_Y	169_F	1.260	1.00
34_N	293_A	1.258	1.00
103_A	111_Q	1.257	1.00
39_H	43_F	1.246	1.00
293_A	298_F	1.230	1.00
34_N	298_F	1.211	1.00
68_M	159_K	1.210	1.00
139_Q	292_R	1.209	1.00
52_P	55_M	1.207	1.00
57_S	118_L	1.193	1.00
212_L	218_V	1.190	1.00
186_L	265_I	1.182	1.00
120_T	138_L	1.173	1.00
20_L	23_H	1.171	1.00
121_Y	138_L	1.169	1.00
113_I	200_V	1.168	1.00
75_R	189_M	1.165	1.00
174_G	180_L	1.161	1.00
49_T	174_G	1.152	1.00
74_I	98_S	1.129	1.00
215_N	218_V	1.125	1.00
55_M	98_S	1.118	1.00
35_T	39_H	1.111	1.00
97_G	174_G	1.108	1.00
143_D	287_D	1.100	1.00
185_L	197_T	1.099	1.00
186_L	266_F	1.095	1.00
231_R	234_A	1.088	1.00
215_N	219_K	1.080	1.00
104_H	163_T	1.080	1.00
142_D	205_N	1.077	1.00
193_E	196_N	1.076	1.00
194_K	269_A	1.074	1.00
17_C	22_V	1.071	1.00
40_I	57_S	1.070	1.00
113_I	197_T	1.068	1.00
113_I	170_V	1.064	1.00
77_F	80_R	1.064	1.00
233_L	237_R	1.054	1.00
70_Y	104_H	1.052	1.00
15_G	18_F	1.052	1.00
151_M	169_F	1.051	1.00
156_E	160_N	1.043	1.00
200_V	266_F	1.032	1.00
189_M	193_E	1.030	1.00
212_L	217_G	1.028	1.00
41_A	141_M	1.024	1.00
19_I	23_H	1.024	1.00
107_K	162_P	1.017	1.00
172_T	182_A	1.017	1.00
116_A	144_N	1.014	1.00
267_D	273_V	1.013	1.00
106_G	165_Y	1.012	1.00
187_K	269_A	1.012	1.00
36_Q	39_H	1.006	1.00
36_Q	153_E	1.005	1.00
115_M	170_V	1.004	1.00
16_V	19_I	1.002	1.00
230_D	233_L	1.000	1.00
216_S	219_K	0.998	1.00
263_A	275_S	0.997	1.00
78_N	81_Y	0.996	1.00
39_H	64_Q	0.994	1.00
106_G	163_T	0.994	1.00
301_G	305_H	0.994	1.00
213_Y	216_S	0.993	1.00
39_H	56_L	0.992	1.00
117_H	262_D	0.989	1.00
75_R	79_S	0.983	1.00
70_Y	102_A	0.982	1.00
78_N	96_T	0.981	1.00
60_Y	64_Q	0.977	1.00
30_G	34_N	0.976	1.00
11_A	14_L	0.963	1.00
207_I	210_D	0.963	1.00
172_T	266_F	0.947	1.00
114_I	167_I	0.947	1.00
158_L	163_T	0.947	1.00
73_D	103_A	0.947	1.00
212_L	216_S	0.939	1.00
175_E	287_D	0.938	1.00
75_R	184_N	0.936	1.00
287_D	291_Q	0.935	1.00
235_I	238_S	0.934	1.00
117_H	143_D	0.931	1.00
153_E	157_R	0.930	1.00
118_L	171_A	0.928	1.00
183_E	265_I	0.926	1.00
28_K	157_R	0.925	1.00
35_T	38_R	0.920	1.00
142_D	208_V	0.917	1.00
10_A	13_A	0.916	1.00
31_D	35_T	0.915	1.00
47_R	145_A	0.907	1.00
75_R	188_R	0.906	1.00
244_T	247_P	0.905	1.00
296_P	301_G	0.905	1.00
229_R	233_L	0.901	1.00
17_C	20_L	0.900	1.00
114_I	169_F	0.895	1.00
36_Q	149_G	0.894	1.00
174_G	177_E	0.890	1.00
175_E	286_K	0.885	1.00
38_R	43_F	0.882	1.00
117_H	175_E	0.879	1.00
104_H	159_K	0.877	1.00
12_L	15_G	0.870	1.00
65_F	152_L	0.869	1.00
33_A	305_H	0.868	1.00
77_F	82_I	0.866	1.00
120_T	140_G	0.865	1.00
75_R	99_T	0.863	1.00
70_Y	155_A	0.862	1.00
62_R	72_S	0.862	1.00
264_E	268_K	0.860	1.00
39_H	60_Y	0.859	1.00
76_T	79_S	0.857	1.00
49_T	97_G	0.857	1.00
232_A	236_A	0.854	1.00
21_P	24_A	0.840	1.00
213_Y	218_V	0.837	1.00
19_I	22_V	0.837	1.00
78_N	94_N	0.836	1.00
243_A	247_P	0.833	1.00
120_T	145_A	0.831	1.00
138_L	289_Y	0.828	1.00
49_T	177_E	0.820	1.00
69_G	72_S	0.819	1.00
13_A	17_C	0.815	1.00
36_Q	156_E	0.813	1.00
234_A	237_R	0.813	1.00
281_W	284_G	0.805	0.99
298_F	302_N	0.799	0.99
79_S	83_Y	0.799	0.99
203_L	308_R	0.793	0.99
105_E	108_A	0.793	0.99
56_L	59_D	0.790	0.99
49_T	54_E	0.789	0.99
101_I	168_R	0.789	0.99
13_A	16_V	0.787	0.99
10_A	14_L	0.786	0.99
47_R	57_S	0.783	0.99
301_G	304_W	0.778	0.99
303_S	306_D	0.778	0.99
68_M	152_L	0.773	0.99
55_M	58_A	0.769	0.99
227_L	231_R	0.766	0.99
30_G	299_P	0.761	0.99
232_A	235_I	0.756	0.99
58_A	62_R	0.755	0.99
214_F	217_G	0.754	0.99
45_P	52_P	0.753	0.99
199_L	228_T	0.750	0.99
231_R	235_I	0.747	0.99
310_D	314_H	0.746	0.99
13_A	18_F	0.744	0.99
230_D	234_A	0.743	0.99
58_A	74_I	0.738	0.99
71_R	103_A	0.731	0.99
18_F	22_V	0.731	0.99
142_D	296_P	0.729	0.99
76_T	98_S	0.727	0.99
286_K	291_Q	0.724	0.99
260_C	264_E	0.723	0.99
77_F	173_S	0.722	0.99
241_I	245_T	0.721	0.99
265_I	268_K	0.721	0.99
185_L	266_F	0.718	0.99
30_G	33_A	0.717	0.99
308_R	312_H	0.715	0.99
145_A	149_G	0.713	0.99
17_C	24_A	0.713	0.99
197_T	271_I	0.712	0.99
200_V	273_V	0.712	0.99
146_A	296_P	0.709	0.99
61_I	148_L	0.705	0.99
158_L	161_T	0.703	0.99
309_L	313_Q	0.702	0.99
65_F	169_F	0.701	0.99
242_A	247_P	0.699	0.99
17_C	23_H	0.694	0.98
46_G	137_T	0.693	0.98
142_D	146_A	0.692	0.98
190_S	193_E	0.692	0.98
54_E	97_G	0.690	0.98
117_H	176_E	0.690	0.98
257_T	273_V	0.686	0.98
183_E	268_K	0.685	0.98
104_H	158_L	0.684	0.98
28_K	33_A	0.682	0.98
9_T	15_G	0.676	0.98
40_I	148_L	0.674	0.98
143_D	262_D	0.670	0.98
176_E	287_D	0.670	0.98
165_Y	198_L	0.669	0.98
79_S	82_I	0.668	0.98
74_I	77_F	0.668	0.98
144_N	204_D	0.667	0.98
111_Q	197_T	0.667	0.98
32_F	35_T	0.665	0.98
12_L	19_I	0.664	0.98
75_R	78_N	0.664	0.98
285_N	288_G	0.664	0.98
39_H	63_Q	0.657	0.98
65_F	70_Y	0.655	0.98
111_Q	196_N	0.648	0.98
189_M	194_K	0.646	0.98
184_N	187_K	0.646	0.98
175_E	202_N	0.646	0.98
37_A	40_I	0.646	0.98
15_G	26_S	0.645	0.98
288_G	291_Q	0.643	0.98
154_L	158_L	0.642	0.97
16_V	20_L	0.640	0.97
73_D	101_I	0.639	0.97
14_L	20_L	0.639	0.97
54_E	61_I	0.638	0.97
215_N	275_S	0.638	0.97
188_R	193_E	0.637	0.97
117_H	287_D	0.637	0.97
48_M	53_A	0.636	0.97
41_A	139_Q	0.636	0.97
112_I	198_L	0.635	0.97
40_I	145_A	0.632	0.97
213_Y	219_K	0.629	0.97
30_G	302_N	0.625	0.97
182_A	262_D	0.624	0.97
176_E	179_K	0.623	0.97
80_R	94_N	0.623	0.97
143_D	176_E	0.622	0.97
74_I	79_S	0.621	0.97
190_S	194_K	0.620	0.97
33_A	149_G	0.619	0.97
214_F	218_V	0.618	0.97
208_V	283_L	0.616	0.97
147_G	204_D	0.616	0.97
183_E	269_A	0.615	0.97
110_Q	166_G	0.615	0.97
214_F	219_K	0.613	0.97
23_H	27_P	0.613	0.97
76_T	81_Y	0.610	0.97
309_L	312_H	0.609	0.97
175_E	204_D	0.607	0.97
32_F	36_Q	0.607	0.97
14_L	19_I	0.607	0.97
285_N	295_T	0.607	0.97
176_E	262_D	0.600	0.96
229_R	232_A	0.598	0.96
61_I	169_F	0.596	0.96
151_M	203_L	0.596	0.96
236_A	243_A	0.596	0.96
235_I	239_H	0.596	0.96
150_V	305_H	0.594	0.96
170_V	266_F	0.594	0.96
31_D	34_N	0.593	0.96
175_E	261_N	0.593	0.96
116_A	147_G	0.593	0.96
80_R	83_Y	0.592	0.96
238_S	242_A	0.592	0.96
14_L	23_H	0.592	0.96
16_V	24_A	0.591	0.96
185_L	189_M	0.590	0.96
46_G	120_T	0.587	0.96
261_N	286_K	0.587	0.96
15_G	19_I	0.586	0.96
37_A	301_G	0.582	0.96
240_G	245_T	0.580	0.95
107_K	163_T	0.580	0.95
300_A	304_W	0.579	0.95
19_I	24_A	0.576	0.95
142_D	278_A	0.575	0.95
101_I	190_S	0.574	0.95
179_K	182_A	0.574	0.95
46_G	122_A	0.574	0.95
16_V	23_H	0.573	0.95
100_V	171_A	0.569	0.95
232_A	274_L	0.569	0.95
12_L	16_V	0.567	0.95
146_A	205_N	0.566	0.95
143_D	286_K	0.564	0.95
14_L	22_V	0.561	0.95
13_A	21_P	0.560	0.95
185_L	192_T	0.559	0.95
45_P	56_L	0.559	0.95
295_T	298_F	0.553	0.94
14_L	17_C	0.551	0.94
58_A	173_S	0.551	0.94
81_Y	97_G	0.550	0.94
306_D	309_L	0.545	0.94
240_G	243_A	0.543	0.94
28_K	305_H	0.538	0.93
109_P	166_G	0.535	0.93
190_S	197_T	0.535	0.93
68_M	102_A	0.534	0.93
32_F	64_Q	0.533	0.93
62_R	78_N	0.533	0.93
150_V	154_L	0.533	0.93
18_F	24_A	0.531	0.93
16_V	21_P	0.529	0.93
213_Y	217_G	0.529	0.93
110_Q	196_N	0.526	0.93
90_K	93_H	0.524	0.92
22_V	25_S	0.524	0.92
118_L	148_L	0.523	0.92
244_T	291_Q	0.522	0.92
113_I	168_R	0.521	0.92
9_T	12_L	0.521	0.92
33_A	37_A	0.519	0.92
57_S	61_I	0.518	0.92
20_L	24_A	0.518	0.92
19_I	25_S	0.516	0.92
60_Y	152_L	0.513	0.92
108_A	166_G	0.513	0.92
236_A	239_H	0.511	0.91
159_K	162_P	0.511	0.91
207_I	296_P	0.511	0.91
180_L	184_N	0.510	0.91
116_A	171_A	0.507	0.91
262_D	287_D	0.505	0.91
182_A	263_A	0.505	0.91
226_K	230_D	0.505	0.91
243_A	246_N	0.505	0.91
117_H	204_D	0.504	0.91
37_A	41_A	0.502	0.91
113_I	172_T	0.501	0.91
237_R	243_A	0.501	0.91
29_P	157_R	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ek8A	2	0.8174	100	0.432	Contact Map
4tweA	2	0.8841	100	0.47	Contact Map
3iibA	2	0.8116	100	0.474	Contact Map
3kasA	2	0.8928	100	0.475	Contact Map
4mhpA	1	0.8261	100	0.48	Contact Map
1tkjA	1	0.7275	100	0.482	Contact Map
3fedA	2	0.8696	100	0.483	Contact Map
3pb6X	1	0.8203	100	0.485	Contact Map
2afwA	5	0.829	100	0.486	Contact Map
3guxA	1	0.6986	100	0.487	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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