GREMLIN Database
FADL - Long-chain fatty acid transport protein
UniProt: P10384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10280
Length: 446 (395)
Sequences: 3470 (2643)
Seq/√Len: 133.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
412_V436_W5.1401.00
370_I392_F4.8021.00
318_L350_Y4.7801.00
63_T158_A3.7681.00
173_A230_W3.6901.00
406_A442_F3.5861.00
414_Y436_W3.4951.00
246_N306_N3.3701.00
165_W240_Y3.3511.00
298_E322_S3.3451.00
324_S348_D3.2411.00
394_L416_H3.1401.00
360_Y366_F3.0871.00
63_T166_S3.0871.00
117_F157_G2.9501.00
312_W356_T2.8481.00
68_P109_F2.8301.00
164_A240_Y2.8191.00
165_W238_I2.8051.00
73_G106_N2.7141.00
395_S413_S2.6911.00
312_W358_Y2.5731.00
46_G301_E2.4261.00
252_Y298_E2.4101.00
173_A232_F2.3811.00
46_G303_S2.3771.00
47_A305_Y2.3651.00
123_I153_L2.3361.00
167_F238_I2.3331.00
305_Y313_A2.3211.00
320_Y350_Y2.1801.00
250_L302_V2.1161.00
363_N400_Y2.0891.00
399_T409_D2.0841.00
117_F159_Y2.0761.00
64_M241_E2.0531.00
55_V122_S2.0211.00
161_L167_F2.0011.00
311_Q358_Y2.0001.00
407_S443_N1.9831.00
41_A371_A1.9751.00
246_N304_G1.9731.00
61_L239_L1.9661.00
68_P111_A1.9391.00
121_A153_L1.9161.00
67_R112_P1.9131.00
372_F392_F1.9101.00
410_V440_T1.9101.00
174_V258_I1.9031.00
35_S439_G1.8701.00
354_L370_I1.8681.00
62_I156_S1.8651.00
76_Y101_T1.8561.00
250_L300_W1.8541.00
367_R399_T1.8441.00
62_I110_V1.8431.00
300_W320_Y1.8311.00
233_G256_V1.8291.00
234_W254_S1.8221.00
359_Y365_T1.8071.00
318_L352_I1.7861.00
364_W398_T1.7851.00
367_R409_D1.7661.00
406_A444_Y1.7611.00
322_S325_Q1.7541.00
20_S24_W1.7501.00
245_N306_N1.7481.00
255_E295_N1.7481.00
141_S220_T1.7401.00
118_G158_A1.7321.00
316_Y352_I1.7311.00
402_F408_V1.7261.00
161_L165_W1.7171.00
54_N61_L1.6671.00
371_A393_W1.6631.00
40_R357_T1.6421.00
412_V438_F1.5991.00
309_D312_W1.5941.00
349_A374_D1.5931.00
364_W400_Y1.5921.00
170_G235_N1.5701.00
316_Y354_L1.5651.00
314_I356_T1.5531.00
322_S348_D1.5381.00
243_D246_N1.5311.00
238_I250_L1.5201.00
63_T118_G1.5181.00
257_K295_N1.5051.00
360_Y364_W1.5041.00
64_M239_L1.4791.00
162_N165_W1.4681.00
399_T407_S1.4601.00
356_T368_T1.4531.00
27_G31_N1.4441.00
361_D364_W1.4341.00
41_A395_S1.4331.00
242_L248_Y1.4321.00
248_Y304_G1.4291.00
27_G30_L1.4271.00
108_H122_S1.4151.00
251_T301_E1.4121.00
125_S128_G1.4101.00
421_K430_E1.4011.00
241_E247_R1.4001.00
347_K378_P1.3801.00
43_S315_H1.3771.00
248_Y302_V1.3751.00
123_I151_M1.3741.00
235_N253_R1.3721.00
365_T399_T1.3701.00
68_P112_P1.3651.00
169_L236_A1.3651.00
405_D444_Y1.3541.00
307_R313_A1.3361.00
116_Q159_Y1.3311.00
236_A254_S1.3301.00
176_A258_I1.3171.00
8_T11_A1.3171.00
36_S357_T1.3141.00
65_F110_V1.3091.00
313_A357_T1.2941.00
401_A407_S1.2901.00
119_W157_G1.2851.00
40_R315_H1.2791.00
156_S170_G1.2791.00
62_I118_G1.2781.00
298_E320_Y1.2591.00
247_R305_Y1.2471.00
63_T160_R1.2371.00
307_R359_Y1.2371.00
259_D293_T1.2361.00
368_T396_A1.2311.00
378_P381_N1.2231.00
357_T367_R1.2031.00
112_P118_G1.1920.99
298_E325_Q1.1920.99
14_V17_A1.1870.99
305_Y315_H1.1760.99
258_I296_L1.1750.99
113_I119_W1.1740.99
74_A103_W1.1660.99
411_G439_G1.1590.99
176_A260_F1.1570.99
231_G258_I1.1550.99
398_T410_V1.1540.99
171_F232_F1.1470.99
308_V312_W1.1450.99
175_Y230_W1.1450.99
116_Q160_R1.1210.99
179_K224_H1.1190.99
408_V440_T1.1140.99
39_G411_G1.1130.99
154_N235_N1.1110.99
401_A445_A1.1030.99
229_Q258_I1.1020.99
389_Q417_G1.1010.99
62_I158_A1.0920.99
319_A353_A1.0890.99
255_E298_E1.0880.99
111_A119_W1.0870.99
408_V442_F1.0850.99
15_A18_L1.0830.99
152_N174_V1.0820.99
308_V314_I1.0780.99
38_L413_S1.0760.99
8_T12_L1.0750.99
164_A242_L1.0660.99
13_A16_V1.0650.99
116_Q122_S1.0640.99
350_Y374_D1.0530.99
18_L22_Q1.0500.99
179_K226_N1.0450.99
121_A155_L1.0400.99
123_I129_L1.0330.98
9_K16_V1.0280.98
113_I157_G1.0270.98
125_S129_L1.0250.98
114_N117_F1.0230.98
333_S339_L1.0190.98
9_K12_L1.0190.98
357_T365_T1.0130.98
416_H436_W1.0090.98
122_S154_N1.0000.98
239_L247_R0.9950.98
124_T128_G0.9940.98
147_D179_K0.9920.98
64_M247_R0.9900.98
227_G260_F0.9880.98
321_T351_R0.9860.98
128_G131_T0.9810.98
178_A292_L0.9730.98
12_L16_V0.9710.98
154_N170_G0.9710.98
396_A412_V0.9700.98
370_I394_L0.9650.98
78_D438_F0.9630.98
66_D112_P0.9620.98
10_S14_V0.9620.98
366_F398_T0.9590.98
73_G441_N0.9540.97
49_A64_M0.9540.97
28_F31_N0.9510.97
233_G254_S0.9500.97
261_K291_Y0.9470.97
159_Y167_F0.9470.97
330_K341_Q0.9460.97
149_E177_R0.9430.97
253_R299_M0.9420.97
27_G346_F0.9410.97
326_F344_E0.9410.97
51_D61_L0.9410.97
75_V439_G0.9390.97
231_G256_V0.9380.97
21_T24_W0.9320.97
410_V438_F0.9260.97
338_T341_Q0.9260.97
393_W413_S0.9230.97
27_G32_E0.9160.97
132_E145_T0.9140.97
314_I354_L0.9130.97
75_V437_L0.9130.97
46_G251_T0.9120.97
49_A61_L0.9110.97
40_R45_E0.9110.97
160_R241_E0.9110.97
252_Y300_W0.9060.97
264_Y333_S0.9060.97
127_Y131_T0.9060.97
265_S287_T0.9050.97
152_N172_N0.9030.96
83_I429_F0.9000.96
55_V156_S0.8990.96
120_G128_G0.8960.96
49_A247_R0.8940.96
308_V316_Y0.8940.96
160_R163_N0.8930.96
67_R110_V0.8880.96
227_G262_G0.8850.96
19_I23_A0.8830.96
45_E57_R0.8810.96
320_Y348_D0.8790.96
49_A54_N0.8790.96
280_P283_T0.8770.96
46_G249_A0.8740.96
122_S125_S0.8730.96
174_V256_V0.8730.96
65_F69_T0.8690.96
71_S441_N0.8640.95
71_S443_N0.8600.95
389_Q418_Q0.8580.95
255_E325_Q0.8580.95
113_I117_F0.8530.95
50_D54_N0.8520.95
247_R307_R0.8470.95
45_E48_I0.8460.95
112_P115_D0.8450.95
280_P284_G0.8440.95
229_Q260_F0.8430.95
122_S129_L0.8430.95
116_Q162_N0.8410.95
131_T146_T0.8400.95
77_I104_V0.8370.95
303_S317_S0.8370.95
36_S409_D0.8340.95
172_N233_G0.8330.94
374_D390_D0.8320.94
301_E317_S0.8300.94
369_G395_S0.8300.94
370_I395_S0.8280.94
92_S96_D0.8260.94
237_G249_A0.8230.94
175_Y228_N0.8220.94
18_L23_A0.8160.94
8_T18_L0.8150.94
407_S445_A0.8150.94
36_S399_T0.8130.94
299_M319_A0.8110.94
47_A239_L0.8110.94
28_F127_Y0.8080.94
150_T174_V0.8000.93
36_S367_R0.7940.93
311_Q362_D0.7900.93
318_L354_L0.7880.93
283_T286_A0.7810.92
29_Q33_F0.7780.92
10_S13_A0.7750.92
313_A359_Y0.7740.92
300_W322_S0.7740.92
130_A147_D0.7720.92
302_V318_L0.7680.92
169_L396_A0.7640.91
45_E315_H0.7630.91
403_N406_A0.7620.91
48_I315_H0.7620.91
51_D71_S0.7610.91
171_F234_W0.7600.91
306_N309_D0.7600.91
11_A14_V0.7580.91
46_G317_S0.7580.91
10_S22_Q0.7570.91
122_S127_Y0.7560.91
123_I128_G0.7490.91
14_V18_L0.7490.91
235_N240_Y0.7480.91
69_T443_N0.7480.91
388_D391_R0.7480.91
119_W155_L0.7470.91
61_L65_F0.7470.91
134_N137_Y0.7430.90
352_I374_D0.7420.90
43_S353_A0.7390.90
27_G128_G0.7360.90
315_H357_T0.7360.90
94_K99_A0.7360.90
245_N307_R0.7350.90
9_K20_S0.7340.90
251_T299_M0.7330.90
47_A315_H0.7320.90
48_I305_Y0.7320.90
159_Y162_N0.7310.90
50_D357_T0.7290.89
130_A145_T0.7260.89
419_S430_E0.7250.89
181_E224_H0.7250.89
245_N309_D0.7240.89
333_S337_D0.7230.89
155_L173_A0.7220.89
47_A61_L0.7200.89
164_A241_E0.7200.89
125_S150_T0.7200.89
423_N426_P0.7190.89
164_A243_D0.7170.89
245_N308_V0.7170.89
423_N428_Q0.7150.89
20_S23_A0.7110.88
29_Q32_E0.7110.88
145_T181_E0.7100.88
301_E319_A0.7090.88
39_G367_R0.7070.88
45_E54_N0.7040.88
16_V24_W0.7020.88
146_T385_S0.7020.88
37_G45_E0.7020.88
252_Y255_E0.7010.88
302_V350_Y0.6980.87
62_I120_G0.6980.87
123_I127_Y0.6970.87
18_L24_W0.6960.87
17_A23_A0.6960.87
352_I372_F0.6960.87
166_S241_E0.6950.87
169_L234_W0.6930.87
249_A303_S0.6920.87
394_L414_Y0.6910.87
52_A71_S0.6900.87
168_G237_G0.6870.87
402_F406_A0.6830.86
120_G124_T0.6820.86
344_E383_S0.6790.86
62_I170_G0.6760.86
70_F107_M0.6750.86
359_Y401_A0.6740.85
48_I51_D0.6730.85
63_T241_E0.6720.85
317_S353_A0.6710.85
261_K347_K0.6710.85
69_T110_V0.6690.85
143_G384_I0.6690.85
365_T401_A0.6680.85
67_R405_D0.6670.85
108_H124_T0.6650.85
35_S411_G0.6640.85
64_M160_R0.6640.85
373_D391_R0.6620.84
52_A69_T0.6600.84
295_N325_Q0.6530.84
186_D268_L0.6520.84
79_P129_L0.6510.83
375_S390_D0.6490.83
167_F171_F0.6470.83
337_D340_F0.6460.83
406_A410_V0.6460.83
49_A63_T0.6450.83
55_V62_I0.6450.83
116_Q123_I0.6420.83
336_G339_L0.6410.83
160_R166_S0.6410.83
164_A244_K0.6400.82
405_D445_A0.6390.82
323_W373_D0.6390.82
401_A404_K0.6390.82
47_A249_A0.6380.82
247_R313_A0.6370.82
15_A21_T0.6370.82
49_A65_F0.6370.82
158_A166_S0.6360.82
127_Y130_A0.6360.82
86_T188_G0.6350.82
12_L17_A0.6350.82
360_Y368_T0.6330.82
154_N253_R0.6300.81
166_S239_L0.6290.81
395_S399_T0.6270.81
153_L230_W0.6270.81
58_N249_A0.6260.81
124_T152_N0.6250.81
48_I61_L0.6250.81
40_R313_A0.6250.81
154_N172_N0.6240.81
305_Y359_Y0.6230.81
308_V356_T0.6230.81
359_Y362_D0.6230.81
125_S131_T0.6220.81
8_T15_A0.6210.81
43_S49_A0.6190.80
186_D189_Q0.6190.80
133_F364_W0.6190.80
117_F155_L0.6190.80
396_A414_Y0.6180.80
280_P285_G0.6170.80
16_V20_S0.6170.80
54_N247_R0.6160.80
350_Y353_A0.6150.80
257_K293_T0.6150.80
38_L411_G0.6150.80
135_D263_N0.6140.80
392_F418_Q0.6120.80
125_S130_A0.6110.79
250_L289_S0.6090.79
38_L437_L0.6080.79
47_A317_S0.6050.79
33_F56_S0.6040.79
14_V21_T0.6040.79
188_G261_K0.6030.79
347_K374_D0.6030.79
304_G314_I0.6020.78
168_G369_G0.6020.78
235_N251_T0.6020.78
174_V296_L0.6010.78
38_L439_G0.6000.78
372_F390_D0.5990.78
122_S126_N0.5970.78
177_R228_N0.5970.78
19_I314_I0.5960.78
64_M166_S0.5950.78
49_A239_L0.5920.77
320_Y352_I0.5910.77
392_F395_S0.5880.77
120_G168_G0.5860.77
321_T346_F0.5860.77
289_S334_T0.5860.77
233_G252_Y0.5840.76
170_G233_G0.5840.76
9_K21_T0.5820.76
11_A15_A0.5810.76
113_I338_T0.5800.76
54_N64_M0.5790.76
290_G331_A0.5780.76
9_K22_Q0.5770.75
349_A373_D0.5770.75
249_A367_R0.5770.75
61_L64_M0.5760.75
300_W350_Y0.5760.75
390_D418_Q0.5750.75
363_N403_N0.5740.75
155_L254_S0.5740.75
118_G124_T0.5740.75
320_Y324_S0.5730.75
219_N283_T0.5720.75
319_A351_R0.5720.75
394_L398_T0.5710.75
80_D434_K0.5700.75
311_Q360_Y0.5700.75
143_G146_T0.5690.74
347_K380_Q0.5690.74
371_A395_S0.5660.74
402_F442_F0.5660.74
162_N167_F0.5650.74
246_N308_V0.5650.74
146_T346_F0.5650.74
340_F343_H0.5640.74
384_I431_S0.5640.74
426_P429_F0.5630.74
36_S39_G0.5630.74
70_F109_F0.5600.73
391_R415_M0.5600.73
122_S130_A0.5600.73
49_A305_Y0.5590.73
19_I22_Q0.5580.73
425_G429_F0.5570.73
363_N401_A0.5560.73
12_L15_A0.5550.73
321_T371_A0.5540.73
37_G57_R0.5540.73
246_N302_V0.5540.73
333_S340_F0.5540.73
26_A346_F0.5540.73
337_D341_Q0.5540.73
88_P92_S0.5530.72
249_A369_G0.5520.72
35_S441_N0.5510.72
392_F398_T0.5500.72
262_G292_L0.5480.72
335_S338_T0.5470.72
120_G125_S0.5460.71
60_A239_L0.5450.71
84_S430_E0.5450.71
31_N319_A0.5440.71
400_Y410_V0.5430.71
151_M155_L0.5410.71
172_N235_N0.5410.71
399_T443_N0.5400.71
372_F418_Q0.5400.71
40_R43_S0.5390.70
74_A78_D0.5380.70
425_G432_E0.5370.70
237_G251_T0.5360.70
359_Y399_T0.5360.70
69_T445_A0.5360.70
145_T226_N0.5350.70
269_N288_Q0.5350.70
130_A149_E0.5340.70
102_A106_N0.5340.70
69_T250_L0.5340.70
13_A24_W0.5330.70
27_G386_I0.5320.70
17_A25_S0.5310.69
414_Y434_K0.5310.69
433_G442_F0.5310.69
56_S150_T0.5310.69
30_L323_W0.5300.69
368_T394_L0.5300.69
35_S39_G0.5290.69
113_I244_K0.5290.69
153_L175_Y0.5280.69
352_I356_T0.5280.69
43_S47_A0.5270.69
440_T444_Y0.5260.69
187_L265_S0.5260.69
41_A393_W0.5260.69
122_S133_F0.5250.69
140_G220_T0.5250.69
14_V22_Q0.5240.68
234_W252_Y0.5230.68
346_F377_V0.5210.68
186_D221_K0.5210.68
369_G397_G0.5200.68
221_K225_L0.5200.68
118_G123_I0.5200.68
309_D358_Y0.5200.68
117_F120_G0.5190.68
30_L33_F0.5190.68
35_S409_D0.5180.67
43_S355_G0.5180.67
55_V65_F0.5180.67
410_V442_F0.5180.67
153_L162_N0.5170.67
55_V120_G0.5170.67
188_G220_T0.5170.67
264_Y339_L0.5160.67
393_W415_M0.5160.67
54_N110_V0.5160.67
42_Y393_W0.5160.67
34_S42_Y0.5160.67
9_K17_A0.5150.67
26_A351_R0.5140.67
141_S185_G0.5140.67
427_Y430_E0.5130.67
296_L329_L0.5120.67
182_R385_S0.5110.66
87_S93_L0.5110.66
54_N62_I0.5110.66
82_N96_D0.5100.66
427_Y431_S0.5090.66
73_G439_G0.5090.66
345_G378_P0.5080.66
15_A23_A0.5070.66
321_T349_A0.5070.66
234_W238_I0.5060.66
48_I313_A0.5060.66
55_V108_H0.5050.66
116_Q163_N0.5040.65
295_N326_F0.5040.65
9_K19_I0.5040.65
36_S51_D0.5040.65
377_V382_R0.5030.65
222_I225_L0.5030.65
99_A104_V0.5030.65
110_V118_G0.5020.65
40_R48_I0.5010.65
326_F386_I0.5010.65
389_Q420_V0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pguA 1 0.9013 100 0.302 Contact Map
3bryA 1 0.8251 100 0.31 Contact Map
3bs0A 1 0.8767 100 0.326 Contact Map
3dwoX 1 0.9081 100 0.365 Contact Map
1i78A 2 0.491 99.4 0.821 Contact Map
3qraA 1 0.3363 98.8 0.861 Contact Map
1ormA 1 0.3251 98.8 0.864 Contact Map
1qjpA 1 0.3004 98.7 0.869 Contact Map
2x27X 1 0.4126 97.9 0.894 Contact Map
2zfgA 3 0.6614 97.6 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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