GREMLIN Database
HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
UniProt: P10371 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10444
Length: 245 (232)
Sequences: 5976 (3076)
Seq/√Len: 201.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_V115_W3.3261.00
143_S147_E2.5501.00
113_K163_V2.5371.00
108_S114_G2.4351.00
161_L197_V2.4011.00
128_L157_V2.3601.00
36_Q71_G2.3501.00
126_L160_Y2.3241.00
159_T163_V2.3161.00
84_S87_D2.3161.00
139_Q148_N2.2841.00
36_Q40_A2.2121.00
12_T26_D2.1701.00
234_T237_E2.1371.00
107_K143_S2.1061.00
89_A93_E2.0881.00
209_D212_A2.0521.00
37_D41_Q2.0281.00
139_Q152_S2.0131.00
179_L232_K1.9421.00
209_D213_A1.9281.00
82_V91_L1.9181.00
139_Q150_G1.9011.00
115_W124_L1.8791.00
39_A73_N1.8771.00
88_V124_L1.8391.00
55_K146_Q1.8381.00
62_I90_A1.8241.00
188_E192_A1.7661.00
106_V142_V1.7341.00
170_C186_L1.7301.00
152_S155_Q1.7221.00
89_A118_R1.6981.00
30_D33_P1.6771.00
161_L196_Q1.6751.00
212_A241_C1.6451.00
85_E115_W1.6421.00
158_E193_R1.5851.00
224_V228_L1.5851.00
20_D23_K1.5661.00
184_V213_A1.5651.00
46_L74_V1.5601.00
30_D67_T1.5511.00
208_I233_F1.5451.00
41_Q236_K1.5331.00
224_V227_A1.5271.00
205_I214_L1.5221.00
207_D210_D1.5181.00
21_Y55_K1.4991.00
151_V159_T1.4901.00
10_D52_T1.4901.00
61_Q64_L1.4861.00
101_V104_T1.4861.00
98_R125_V1.4771.00
227_A233_F1.4741.00
9_I24_Q1.4531.00
69_V76_V1.4411.00
127_A169_L1.4381.00
159_T162_P1.4361.00
63_P66_K1.4161.00
28_G34_R1.4151.00
3_I45_V1.4111.00
110_D114_G1.4041.00
67_T70_A1.3811.00
104_T111_M1.3761.00
92_L123_A1.3761.00
191_C199_F1.3641.00
137_N152_S1.3641.00
138_K189_E1.3631.00
141_A148_N1.3551.00
208_I241_C1.3361.00
86_E89_A1.3301.00
233_F238_A1.3271.00
85_E118_R1.3261.00
210_D213_A1.3261.00
4_P43_A1.3221.00
192_A218_G1.3111.00
85_E114_G1.2931.00
48_L68_L1.2761.00
211_V224_V1.2711.00
172_D183_N1.2621.00
45_V98_R1.2601.00
113_K117_E1.2591.00
110_D113_K1.2431.00
211_V227_A1.2431.00
105_A126_L1.2431.00
65_I78_V1.2321.00
88_V99_V1.2221.00
66_K70_A1.2091.00
37_D40_A1.2071.00
157_V190_V1.2021.00
127_A171_T1.1941.00
170_C190_V1.1841.00
41_Q234_T1.1751.00
106_V151_V1.1711.00
236_K240_A1.1691.00
130_V170_C1.1641.00
66_K94_A1.1641.00
103_S107_K1.1451.00
142_V147_E1.1351.00
168_V197_V1.1251.00
27_Y230_E1.1231.00
182_S205_I1.1201.00
166_K198_A1.1111.00
214_L222_V1.1001.00
169_L223_I1.0991.00
125_V169_L1.0941.00
208_I238_A1.0911.00
116_F121_A1.0881.00
126_L165_L1.0821.00
32_L64_L1.0781.00
45_V75_P1.0701.00
158_E162_P1.0641.00
189_E192_A1.0631.00
25_R230_E1.0611.00
130_V186_L1.0591.00
37_D231_G1.0581.00
215_R218_G1.0471.00
190_V199_F1.0381.00
78_V91_L1.0371.00
185_S188_E1.0361.00
237_E240_A1.0331.00
214_L219_V1.0291.00
184_V188_E1.0281.00
13_V34_R1.0261.00
130_V153_L1.0211.00
89_A119_F1.0141.00
41_Q235_V1.0141.00
107_K147_E1.0131.00
187_Y191_C1.0101.00
108_S111_M1.0051.00
69_V96_V1.0041.00
161_L195_P1.0021.00
154_E193_R1.0021.00
9_I21_Y0.9991.00
213_A216_G0.9921.00
191_C217_T0.9911.00
153_L190_V0.9741.00
107_K142_V0.9701.00
153_L157_V0.9680.99
111_M115_W0.9660.99
167_H198_A0.9640.99
32_L67_T0.9640.99
116_F165_L0.9590.99
78_V96_V0.9550.99
66_K90_A0.9480.99
188_E217_T0.9430.99
109_Q159_T0.9390.99
45_V125_V0.9370.99
125_V167_H0.9360.99
34_R37_D0.9350.99
63_P67_T0.9330.99
86_E90_A0.9320.99
157_V195_P0.9300.99
39_A72_V0.9290.99
208_I237_E0.9290.99
54_A103_S0.9270.99
188_E216_G0.9250.99
189_E193_R0.9210.99
226_R230_E0.9190.99
142_V149_S0.9150.99
191_C219_V0.9090.99
38_Y229_L0.9080.99
65_I96_V0.8930.99
208_I212_A0.8910.99
155_Q159_T0.8910.99
69_V97_A0.8900.99
36_Q39_A0.8900.99
154_E189_E0.8890.99
15_R226_R0.8870.99
59_K90_A0.8860.99
131_R141_A0.8850.99
101_V115_W0.8790.99
90_A94_A0.8740.99
77_Q100_V0.8730.99
112_V126_L0.8650.99
92_L119_F0.8630.99
112_V160_Y0.8620.99
88_V119_F0.8560.99
2_I224_V0.8470.99
44_E75_P0.8420.99
131_R174_S0.8420.99
67_T71_G0.8410.99
72_V75_P0.8380.99
154_E158_E0.8290.98
234_T238_A0.8280.98
49_V169_L0.8250.98
59_K87_D0.8140.98
207_D211_V0.8110.98
75_P97_A0.8090.98
141_A173_I0.8050.98
191_C220_R0.7980.98
87_D90_A0.7940.98
106_V156_L0.7930.98
167_H220_R0.7930.98
205_I222_V0.7880.98
39_A74_V0.7870.98
154_E157_V0.7870.98
184_V217_T0.7840.98
206_G210_D0.7830.98
211_V233_F0.7810.98
20_D178_T0.7710.97
85_E119_F0.7680.97
85_E89_A0.7630.97
175_R180_A0.7600.97
185_S189_E0.7590.97
130_V138_K0.7570.97
113_K159_T0.7550.97
175_R178_T0.7520.97
140_V156_L0.7430.97
153_L186_L0.7400.97
187_Y199_F0.7370.97
192_A217_T0.7370.97
9_I52_T0.7360.97
198_A220_R0.7350.97
155_Q158_E0.7350.97
207_D232_K0.7330.97
49_V171_T0.7320.97
3_I200_Q0.7320.97
32_L71_G0.7310.97
98_R166_K0.7290.96
12_T24_Q0.7260.96
59_K83_R0.7240.96
43_A235_V0.7200.96
3_I125_V0.7130.96
62_I66_K0.7110.96
137_N174_S0.7080.96
2_I222_V0.7080.96
33_P37_D0.6980.95
82_V88_V0.6960.95
161_L168_V0.6930.95
158_E161_L0.6890.95
52_T57_P0.6870.95
169_L200_Q0.6860.95
64_L68_L0.6850.95
200_Q221_G0.6840.95
126_L168_V0.6810.95
62_I91_L0.6810.95
182_S206_G0.6760.95
128_L156_L0.6760.95
104_T108_S0.6740.95
117_E162_P0.6730.95
68_L76_V0.6700.94
90_A93_E0.6680.94
183_N186_L0.6630.94
211_V238_A0.6630.94
100_V169_L0.6620.94
69_V94_A0.6590.94
33_P36_Q0.6560.94
66_K93_E0.6560.94
88_V101_V0.6530.94
53_G58_A0.6520.94
88_V123_A0.6500.93
120_G167_H0.6480.93
187_Y214_L0.6460.93
211_V222_V0.6460.93
217_T220_R0.6440.93
97_A122_D0.6430.93
97_A123_A0.6410.93
211_V228_L0.6390.93
214_L217_T0.6380.93
15_R176_D0.6370.93
228_L238_A0.6360.93
128_L140_V0.6360.93
157_V168_V0.6350.93
60_R65_I0.6330.93
116_F120_G0.6310.92
88_V92_L0.6290.92
83_R107_K0.6280.92
21_Y146_Q0.6260.92
56_D60_R0.6240.92
138_K186_L0.6210.92
52_T61_Q0.6210.92
212_A215_R0.6160.91
114_G117_E0.6160.91
82_V101_V0.6160.91
101_V112_V0.6160.91
98_R167_H0.6150.91
59_K62_I0.6130.91
225_G229_L0.6100.91
3_I77_Q0.6100.91
57_P61_Q0.5990.90
8_L48_L0.5980.90
177_G204_G0.5980.90
142_V146_Q0.5970.90
44_E239_I0.5950.90
43_A238_A0.5940.90
104_T115_W0.5920.90
205_I224_V0.5920.90
187_Y219_V0.5920.90
48_L76_V0.5920.90
235_V239_I0.5910.90
151_V155_Q0.5870.89
138_K152_S0.5870.89
78_V82_V0.5790.89
191_C218_G0.5790.89
187_Y201_S0.5780.89
86_E93_E0.5770.89
116_F126_L0.5760.89
167_H200_Q0.5750.88
212_A242_W0.5720.88
35_L68_L0.5710.88
177_G181_G0.5670.88
120_G123_A0.5610.87
182_S210_D0.5590.87
58_A87_D0.5580.87
128_L160_Y0.5570.87
190_V195_P0.5560.87
28_G37_D0.5490.86
181_G204_G0.5480.86
3_I98_R0.5470.86
108_S117_E0.5460.86
9_I55_K0.5450.86
8_L64_L0.5430.86
16_L145_W0.5380.85
127_A200_Q0.5370.85
206_G232_K0.5340.85
53_G59_K0.5330.84
201_S214_L0.5310.84
59_K91_L0.5310.84
15_R175_R0.5290.84
2_I242_W0.5280.84
115_W119_F0.5280.84
72_V76_V0.5250.84
37_D236_K0.5240.83
113_K162_P0.5230.83
182_S211_V0.5220.83
234_T240_A0.5220.83
171_T202_S0.5210.83
231_G234_T0.5210.83
211_V242_W0.5210.83
49_V127_A0.5200.83
114_G118_R0.5190.83
19_G178_T0.5190.83
16_L102_G0.5190.83
35_L72_V0.5170.83
5_A171_T0.5150.82
138_K153_L0.5130.82
91_L96_V0.5070.81
45_V97_A0.5070.81
205_I233_F0.5070.81
8_L61_Q0.5060.81
164_G197_V0.5040.81
92_L125_V0.5040.81
62_I87_D0.5030.81
3_I220_R0.5030.81
38_Y228_L0.5000.81
122_D166_K0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2agkA 1 0.8816 100 0.245 Contact Map
1jvnA 1 0.951 100 0.296 Contact Map
1qo2A 1 0.9551 100 0.427 Contact Map
4gj1A 1 0.9306 100 0.446 Contact Map
2y88A 1 0.9714 100 0.481 Contact Map
4u28A 1 0.9306 100 0.499 Contact Map
4x2rA 1 0.9388 100 0.5 Contact Map
1thfD 2 0.9796 100 0.501 Contact Map
4evzA 1 0.9796 100 0.504 Contact Map
4axkA 1 0.9592 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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