GREMLIN Database
LEUO - HTH-type transcriptional regulator LeuO
UniProt: P10151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10531
Length: 314 (287)
Sequences: 79253 (57508)
Seq/√Len: 3394.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_Q95_L3.6451.00
36_E45_V3.4101.00
179_V309_V2.6571.00
117_C162_T2.4871.00
88_S102_G2.4851.00
32_A45_V2.3921.00
250_V257_A2.2301.00
183_K286_T2.2251.00
180_P183_K2.2251.00
194_H209_E2.2251.00
113_V144_M2.2211.00
180_P286_T2.2181.00
185_E261_R2.1251.00
66_D81_R2.1141.00
29_V56_A2.0911.00
113_V142_H2.0841.00
31_D90_R2.0501.00
41_R44_H2.0371.00
247_L267_F2.0241.00
183_K284_S2.0191.00
88_S95_L2.0121.00
202_L205_D2.0091.00
251_S272_E1.9981.00
31_D35_Q1.9911.00
133_H307_Q1.9851.00
187_V261_R1.9801.00
115_H144_M1.9641.00
32_A36_E1.9621.00
35_Q90_R1.9581.00
31_D86_F1.9281.00
32_A35_Q1.9271.00
34_M78_P1.9061.00
29_V53_V1.8981.00
212_A255_L1.8791.00
190_A276_L1.8671.00
92_A96_V1.8661.00
86_F90_R1.8291.00
187_V275_V1.7671.00
251_S267_F1.7351.00
70_V77_Q1.7181.00
178_S288_Y1.7121.00
210_Q237_A1.7081.00
85_L99_E1.6901.00
39_I57_V1.6881.00
84_Q102_G1.6861.00
34_M86_F1.6691.00
156_Q161_E1.6631.00
153_T165_V1.6401.00
36_E41_R1.6051.00
177_T293_E1.5731.00
31_D89_V1.5601.00
35_Q45_V1.5541.00
26_L56_A1.5311.00
88_S91_Q1.5261.00
134_I304_M1.5251.00
26_L63_M1.5191.00
155_H159_Y1.5191.00
179_V291_W1.5171.00
30_F86_F1.4931.00
38_N41_R1.4891.00
29_V48_M1.4841.00
109_S140_N1.4651.00
220_A224_Q1.4651.00
26_L59_R1.4631.00
49_S52_A1.4501.00
134_I141_I1.4501.00
40_T50_Q1.4341.00
67_E70_V1.4321.00
23_D26_L1.4311.00
124_S244_M1.4261.00
167_S290_S1.4171.00
32_A46_L1.4151.00
88_S98_N1.4081.00
177_T291_W1.3961.00
80_A83_F1.3881.00
169_E288_Y1.3821.00
291_W305_E1.3801.00
305_E309_V1.3721.00
31_D93_L1.3661.00
297_R301_H1.3561.00
92_A99_E1.3501.00
95_L98_N1.3461.00
72_Y77_Q1.3461.00
115_H146_K1.3351.00
156_Q162_T1.3291.00
111_E140_N1.3261.00
184_D262_W1.3141.00
157_L165_V1.3111.00
158_R175_E1.3091.00
137_I307_Q1.3051.00
303_W306_E1.3041.00
289_L305_E1.3011.00
192_K272_E1.2971.00
24_L96_V1.2901.00
85_L100_L1.2841.00
246_V257_A1.2831.00
133_H137_I1.2741.00
87_G91_Q1.2701.00
164_F289_L1.2671.00
135_E237_A1.2661.00
164_F301_H1.2611.00
88_S99_E1.2501.00
190_A256_V1.2481.00
209_E256_V1.2351.00
248_S251_S1.2331.00
267_F272_E1.2241.00
180_P288_Y1.2201.00
261_R275_V1.2141.00
192_K274_Q1.2121.00
135_E210_Q1.2021.00
84_Q87_G1.1981.00
48_M52_A1.1971.00
221_S225_P1.1871.00
30_F69_F1.1861.00
132_N136_Q1.1801.00
227_Y232_K1.1671.00
55_N59_R1.1651.00
261_R265_E1.1581.00
132_N252_Q1.1541.00
148_S152_N1.1501.00
178_S290_S1.1431.00
195_P209_E1.1411.00
30_F34_M1.1401.00
83_F87_G1.1401.00
199_G274_Q1.1321.00
55_N58_A1.1291.00
58_A62_V1.1281.00
84_Q88_S1.1081.00
200_P279_P1.1021.00
265_E269_E1.0991.00
144_M239_Q1.0961.00
63_M100_L1.0951.00
91_Q98_N1.0911.00
210_Q235_S1.0871.00
138_A303_W1.0801.00
129_Q252_Q1.0751.00
275_V278_L1.0751.00
123_D147_S1.0701.00
39_I76_I1.0701.00
212_A246_V1.0671.00
148_S156_Q1.0671.00
27_L89_V1.0641.00
32_A42_A1.0621.00
201_L205_D1.0561.00
134_I307_Q1.0521.00
179_V305_E1.0511.00
30_F68_L1.0501.00
189_V275_V1.0501.00
133_H136_Q1.0501.00
248_S252_Q1.0481.00
56_A59_R1.0481.00
292_H295_A1.0441.00
114_F304_M1.0421.00
247_L251_S1.0401.00
306_E309_V1.0391.00
54_S58_A1.0371.00
92_A95_L1.0331.00
302_Q306_E1.0281.00
158_R173_R1.0271.00
25_N28_T1.0261.00
33_V42_A1.0211.00
221_S224_Q1.0131.00
240_G246_V1.0081.00
191_S253_T1.0081.00
100_L104_G1.0061.00
266_E270_S1.0041.00
185_E284_S1.0021.00
130_I308_L0.9931.00
28_T97_Q0.9881.00
146_K156_Q0.9841.00
78_P82_A0.9821.00
203_K280_L0.9811.00
94_Q98_N0.9721.00
34_M69_F0.9621.00
85_L89_V0.9581.00
48_M53_V0.9561.00
134_I138_A0.9541.00
189_V264_A0.9541.00
188_L256_V0.9531.00
148_S153_T0.9511.00
97_Q100_L0.9461.00
33_V39_I0.9441.00
190_A194_H0.9401.00
29_V46_L0.9381.00
59_R62_V0.9351.00
42_A53_V0.9251.00
240_G249_V0.9221.00
30_F78_P0.9201.00
22_V63_M0.9171.00
213_A236_I0.9121.00
307_Q310_S0.9101.00
30_F60_L0.9101.00
194_H197_I0.9081.00
156_Q159_Y0.9041.00
97_Q101_P0.9001.00
41_R45_V0.8991.00
137_I310_S0.8971.00
84_Q106_E0.8971.00
298_D301_H0.8911.00
120_S242_A0.8881.00
69_F76_I0.8871.00
130_I307_Q0.8831.00
91_Q94_Q0.8831.00
66_D103_S0.8661.00
37_Q77_Q0.8631.00
211_H234_A0.8591.00
162_T165_V0.8541.00
169_E286_T0.8541.00
25_N56_A0.8511.00
40_T44_H0.8501.00
34_M82_A0.8491.00
267_F270_S0.8451.00
87_G90_R0.8411.00
72_Y75_G0.8391.00
96_V100_L0.8361.00
177_T180_P0.8331.00
117_C153_T0.8311.00
117_C167_S0.8281.00
141_I300_G0.8251.00
264_A267_F0.8251.00
154_E158_R0.8251.00
196_T209_E0.8251.00
132_N254_H0.8201.00
142_H235_S0.8201.00
190_A195_P0.8161.00
81_R84_Q0.8111.00
46_L53_V0.8101.00
176_F290_S0.8101.00
116_L164_F0.8091.00
194_H198_K0.8091.00
194_H210_Q0.8081.00
81_R106_E0.8051.00
195_P199_G0.8021.00
81_R103_S0.8001.00
226_W230_V0.7971.00
146_K162_T0.7971.00
112_R300_G0.7961.00
96_V99_E0.7951.00
30_F85_L0.7941.00
202_L279_P0.7941.00
189_V257_A0.7921.00
117_C165_V0.7901.00
98_N102_G0.7891.00
210_Q236_I0.7881.00
297_R302_Q0.7831.00
35_Q86_F0.7831.00
34_M37_Q0.7821.00
24_L93_L0.7811.00
33_V69_F0.7801.00
204_H207_Y0.7791.00
198_K210_Q0.7781.00
50_Q54_S0.7771.00
135_E254_H0.7771.00
37_Q83_F0.7761.00
37_Q75_G0.7761.00
191_S254_H0.7761.00
299_K303_W0.7671.00
36_E42_A0.7631.00
95_L99_E0.7611.00
251_S270_S0.7601.00
175_E293_E0.7591.00
33_V57_V0.7591.00
222_F226_W0.7591.00
58_A67_E0.7581.00
152_N155_H0.7541.00
28_T32_A0.7521.00
249_V254_H0.7471.00
306_E310_S0.7461.00
223_S226_W0.7441.00
225_P229_T0.7431.00
185_E277_P0.7411.00
39_I53_V0.7391.00
112_R141_I0.7371.00
205_D208_N0.7361.00
268_A271_L0.7361.00
26_L29_V0.7341.00
164_F304_M0.7311.00
134_I303_W0.7241.00
197_I274_Q0.7241.00
189_V268_A0.7221.00
89_V92_A0.7191.00
110_S138_A0.7181.00
189_V259_A0.7181.00
191_S194_H0.7171.00
99_E103_S0.7171.00
90_R94_Q0.7161.00
295_A298_D0.7131.00
190_A196_T0.7131.00
33_V53_V0.7111.00
83_F86_F0.7101.00
158_R176_F0.7081.00
215_S239_Q0.7071.00
104_G107_P0.7041.00
137_I303_W0.7031.00
118_V123_D0.7001.00
242_A245_S0.7001.00
193_N197_I0.6971.00
70_V79_T0.6971.00
268_A275_V0.6971.00
223_S227_Y0.6971.00
260_P263_L0.6951.00
226_W229_T0.6951.00
264_A268_A0.6931.00
160_Q292_H0.6911.00
78_P83_F0.6861.00
202_L280_L0.6831.00
222_F225_P0.6811.00
190_A274_Q0.6801.00
303_W307_Q0.6781.00
115_H162_T0.6761.00
80_A84_Q0.6721.00
81_R85_L0.6711.00
28_T31_D0.6691.00
193_N253_T0.6681.00
22_V100_L0.6651.00
163_E301_H0.6631.00
200_P277_P0.6621.00
52_A56_A0.6611.00
70_V75_G0.6601.00
115_H163_E0.6561.00
77_Q83_F0.6561.00
142_H239_Q0.6521.00
220_A239_Q0.6511.00
88_S92_A0.6501.00
124_S248_S0.6491.00
214_V246_V0.6481.00
85_L103_S0.6471.00
98_N101_P0.6401.00
211_H256_V0.6361.00
219_F223_S0.6321.00
185_E281_K0.6311.00
61_K71_R0.6291.00
238_Y249_V0.6281.00
147_S241_M0.6271.00
44_H47_G0.6261.00
193_N196_T0.6251.00
207_Y232_K0.6231.00
25_N59_R0.6231.00
94_Q97_Q0.6181.00
225_P228_D0.6151.00
133_H310_S0.6141.00
188_L258_I0.6111.00
152_N156_Q0.6091.00
224_Q228_D0.6091.00
266_E269_E0.6081.00
61_K66_D0.6081.00
118_V127_T0.6061.00
129_Q132_N0.6011.00
28_T93_L0.5991.00
299_K302_Q0.5971.00
188_L206_V0.5971.00
33_V38_N0.5961.00
89_V93_L0.5941.00
164_F305_E0.5911.00
215_S241_M0.5911.00
57_V61_K0.5901.00
168_Y285_R0.5881.00
42_A46_L0.5851.00
204_H230_V0.5841.00
114_F300_G0.5841.00
127_T130_I0.5811.00
208_N235_S0.5801.00
193_N274_Q0.5791.00
111_E142_H0.5761.00
192_K271_L0.5731.00
101_P105_F0.5711.00
219_F222_F0.5711.00
30_F82_A0.5711.00
84_Q103_S0.5701.00
157_L290_S0.5671.00
64_F85_L0.5671.00
114_F164_F0.5671.00
184_D285_R0.5651.00
25_N29_V0.5631.00
194_H256_V0.5601.00
166_I308_L0.5601.00
39_I75_G0.5601.00
220_A226_W0.5591.00
291_W302_Q0.5551.00
66_D70_V0.5541.00
147_S242_A0.5531.00
182_F287_C0.5531.00
304_M308_L0.5521.00
93_L97_Q0.5521.00
246_V250_V0.5511.00
240_G245_S0.5501.00
64_F103_S0.5501.00
52_A55_N0.5491.00
138_A141_I0.5461.00
49_S55_N0.5451.00
186_M258_I0.5451.00
69_F78_P0.5421.00
51_P55_N0.5421.00
196_T201_L0.5361.00
34_M83_F0.5351.00
78_P86_F0.5341.00
188_L211_H0.5341.00
129_Q133_H0.5331.00
157_L176_F0.5311.00
64_F67_E0.5301.00
221_S226_W0.5291.00
181_L289_L0.5271.00
117_C146_K0.5251.00
249_V255_L0.5241.00
169_E178_S0.5221.00
105_F110_S0.5221.00
221_S227_Y0.5221.00
177_T294_A0.5211.00
218_R221_S0.5211.00
278_L281_K0.5191.00
126_L130_I0.5191.00
259_A264_A0.5181.00
39_I50_Q0.5181.00
112_R140_N0.5181.00
153_T160_Q0.5171.00
122_L126_L0.5161.00
216_L239_Q0.5151.00
224_Q227_Y0.5141.00
124_S242_A0.5121.00
131_Y143_V0.5111.00
220_A223_S0.5101.00
207_Y233_Q0.5091.00
29_V57_V0.5081.00
48_M56_A0.5061.00
200_P205_D0.5041.00
87_G102_G0.5021.00
190_A197_I0.5011.00
185_E282_Q0.5011.00
37_Q76_I0.5001.00
67_E81_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.949 100 0.129 Contact Map
3fzvA 4 0.9172 100 0.137 Contact Map
1uthA 2 0.707 100 0.139 Contact Map
3fxqA 3 0.9299 100 0.144 Contact Map
2h98A 2 0.6401 100 0.152 Contact Map
1ixcA 4 0.9236 100 0.156 Contact Map
2h9bA 2 0.6401 100 0.157 Contact Map
1al3A 1 0.6592 100 0.159 Contact Map
4x6gA 4 0.9459 100 0.159 Contact Map
3szpA 3 0.9204 100 0.164 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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