GREMLIN Database
FTSY - Signal recognition particle receptor FtsY
UniProt: P10121 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10346
Length: 497 (413)
Sequences: 1956 (1659)
Seq/√Len: 81.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
370_A374_R8.4991.00
344_G351_V7.7841.00
395_E398_K5.3501.00
416_M444_T5.0731.00
325_M376_I3.8981.00
317_F378_V2.7951.00
247_K462_D2.7591.00
193_E201_R2.7181.00
141_A145_A2.6761.00
325_M350_P2.5951.00
432_K463_Q2.5121.00
327_A367_A2.3921.00
88_A94_P2.3811.00
435_H440_L2.3631.00
246_R250_T2.3341.00
172_P176_E2.2841.00
365_F369_Q2.2681.00
175_E179_P2.2281.00
157_T163_A2.2161.00
173_P177_E2.2151.00
272_K490_E2.1471.00
113_P117_D2.1191.00
432_K436_E2.0411.00
110_E114_L2.0331.00
251_N274_E1.9871.00
126_E129_Q1.9811.00
169_M173_P1.9281.00
355_H358_A1.9211.00
88_A92_A1.8991.00
113_P116_E1.8971.00
89_E92_A1.8631.00
155_L161_A1.8421.00
133_E151_T1.8381.00
138_V141_A1.8341.00
92_A95_E1.8321.00
325_M379_L1.7881.00
244_T462_D1.7811.00
245_T249_I1.7671.00
123_V129_Q1.7541.00
98_V104_P1.7541.00
145_A149_E1.7531.00
388_Q401_V1.7521.00
445_L457_I1.7501.00
87_E91_V1.7471.00
90_V94_P1.7161.00
318_E348_N1.7151.00
123_V126_E1.7151.00
352_I370_A1.7141.00
93_Q100_E1.6821.00
94_P101_T1.6671.00
84_A88_A1.6511.00
296_I380_I1.6421.00
132_A144_E1.6371.00
91_V95_E1.6301.00
138_V144_E1.6131.00
168_V171_V1.6011.00
369_Q407_L1.5841.00
150_I156_E1.5831.00
138_V143_E1.5771.00
140_A152_D1.5741.00
210_L213_G1.5701.00
86_P92_A1.5661.00
86_P91_V1.5641.00
108_E111_E1.5631.00
364_I381_A1.5531.00
341_Q353_A1.5511.00
110_E113_P1.5471.00
109_R115_P1.5461.00
315_R477_I1.5310.99
137_I142_E1.5260.99
171_V177_E1.5210.99
372_K407_L1.5030.99
401_V405_K1.4930.99
82_E86_P1.4920.99
129_Q135_V1.4880.99
161_A165_E1.4810.99
154_E158_A1.4670.99
173_P179_P1.4600.99
134_T137_I1.4590.99
298_M388_Q1.4500.99
136_E144_E1.4500.99
476_R484_K1.4490.99
136_E142_E1.4450.99
146_A149_E1.4420.99
431_A464_F1.4360.99
316_Q482_P1.4350.99
128_W131_E1.4300.99
174_A178_Q1.4290.99
443_I460_V1.4280.99
344_G350_P1.4190.99
276_G486_D1.4190.99
132_A135_V1.4160.99
247_K251_N1.4140.99
144_E148_E1.4090.99
165_E173_P1.4080.99
168_V174_A1.3940.99
126_E133_E1.3910.99
97_V150_I1.3870.99
153_E159_L1.3850.99
347_N477_I1.3830.99
94_P98_V1.3770.99
94_P100_E1.3660.99
174_A177_E1.3650.99
160_A164_A1.3630.99
128_W132_A1.3400.99
108_E120_A1.3390.99
141_A144_E1.3370.99
113_P125_P1.3320.99
146_A154_E1.3300.99
121_E130_A1.3260.98
153_E163_A1.3250.98
194_G197_A1.3160.98
100_E172_P1.3040.98
129_Q132_A1.3020.98
93_Q108_E1.2980.98
368_I407_L1.2870.98
123_V128_W1.2780.98
98_V102_P1.2770.98
109_R116_E1.2740.98
298_M416_M1.2620.98
101_T104_P1.2620.98
114_L117_D1.2600.98
91_V94_P1.2590.98
164_A168_V1.2580.98
105_V108_E1.2550.98
88_A93_Q1.2550.98
140_A158_A1.2500.98
158_A166_E1.2480.98
143_E150_I1.2460.98
168_V173_P1.2450.98
181_E185_Q1.2440.98
99_E102_P1.2400.98
129_Q133_E1.2390.98
139_E147_K1.2370.98
147_K150_I1.2280.97
352_I374_R1.2190.97
151_T155_L1.2180.97
215_I219_R1.2160.97
86_P90_V1.2120.97
484_K487_D1.2000.97
141_A149_E1.1990.97
95_E101_T1.1930.97
341_Q345_Q1.1930.97
315_R319_Q1.1890.97
149_E153_E1.1890.97
91_V107_I1.1890.97
156_E166_E1.1880.97
152_D170_V1.1810.97
118_V128_W1.1800.97
170_V173_P1.1800.97
121_E124_S1.1790.97
161_A167_A1.1750.97
168_V177_E1.1710.97
371_A379_L1.1680.97
162_E165_E1.1680.97
419_I489_I1.1600.96
165_E175_E1.1590.96
108_E114_L1.1580.96
141_A147_K1.1520.96
143_E147_K1.1510.96
138_V142_E1.1500.96
354_Q366_D1.1470.96
126_E134_T1.1460.96
138_V148_E1.1430.96
142_E145_A1.1410.96
155_L158_A1.1410.96
100_E104_P1.1390.96
149_E155_L1.1360.96
99_E107_I1.1360.96
152_D156_E1.1350.96
90_V93_Q1.1290.96
89_E93_Q1.1290.96
109_R112_L1.1190.96
109_R114_L1.1170.96
140_A146_A1.1140.96
329_G364_I1.1120.95
96_P99_E1.1080.95
138_V146_A1.1060.95
84_A91_V1.1040.95
225_D253_T1.1030.95
119_N125_P1.1000.95
92_A128_W1.0960.95
88_A102_P1.0950.95
142_E159_L1.0920.95
163_A171_V1.0920.95
147_K151_T1.0900.95
123_V139_E1.0860.95
171_V175_E1.0860.95
125_P133_E1.0850.95
255_G274_E1.0830.95
144_E147_K1.0800.95
109_R113_P1.0750.95
84_A87_E1.0730.95
154_E166_E1.0730.95
87_E90_V1.0720.94
137_I141_A1.0670.94
217_L221_K1.0670.94
139_E150_I1.0670.94
82_E85_Q1.0670.94
81_S91_V1.0620.94
96_P108_E1.0610.94
169_M175_E1.0600.94
152_D160_A1.0580.94
138_V160_A1.0550.94
139_E145_A1.0410.94
117_D154_E1.0400.94
81_S85_Q1.0360.93
387_L425_Q1.0350.93
159_L163_A1.0350.93
84_A110_E1.0340.93
170_V174_A1.0320.93
103_E112_L1.0280.93
316_Q470_Y1.0280.93
137_I161_A1.0230.93
159_L164_A1.0210.93
127_E130_A1.0200.93
133_E139_E1.0140.93
435_H439_G1.0130.93
90_V115_P1.0120.93
84_A89_E1.0090.93
138_V151_T0.9970.92
105_V113_P0.9950.92
88_A97_V0.9810.91
130_A133_E0.9780.91
143_E153_E0.9690.91
91_V102_P0.9680.91
149_E152_D0.9640.91
165_E171_V0.9610.91
123_V127_E0.9600.91
96_P102_P0.9580.90
93_Q96_P0.9560.90
151_T154_E0.9560.90
166_E173_P0.9520.90
156_E161_A0.9520.90
138_V150_I0.9490.90
173_P176_E0.9490.90
116_E162_E0.9440.90
128_W133_E0.9400.90
256_A267_L0.9380.89
203_L206_T0.9360.89
160_A166_E0.9340.89
104_P107_I0.9320.89
83_K96_P0.9300.89
81_S86_P0.9290.89
274_E277_E0.9180.88
81_S93_Q0.9160.88
106_A109_R0.9150.88
440_L443_I0.9130.88
314_A326_L0.9120.88
107_I137_I0.9100.88
164_A169_M0.9080.88
162_E174_A0.9070.88
87_E97_V0.9030.88
155_L162_E0.9010.88
139_E142_E0.9000.87
94_P97_V0.8990.87
92_A96_P0.8930.87
489_I494_A0.8920.87
135_V147_K0.8910.87
88_A91_V0.8900.87
93_Q98_V0.8890.87
155_L160_A0.8890.87
153_E156_E0.8870.87
156_E169_M0.8870.87
223_I228_F0.8860.87
121_E126_E0.8850.87
164_A179_P0.8840.87
117_D166_E0.8820.86
415_V439_G0.8780.86
165_E168_V0.8780.86
255_G270_L0.8780.86
148_E152_D0.8760.86
157_T161_A0.8760.86
157_T165_E0.8750.86
149_E159_L0.8750.86
111_E131_E0.8700.86
127_E136_E0.8700.86
146_A158_A0.8700.86
117_D122_A0.8680.85
143_E148_E0.8680.85
101_T107_I0.8680.85
82_E89_E0.8660.85
112_L151_T0.8660.85
113_P119_N0.8640.85
284_E287_N0.8640.85
146_A151_T0.8600.85
104_P113_P0.8580.85
122_A125_P0.8580.85
102_P106_A0.8570.85
88_A100_E0.8560.85
85_Q101_T0.8540.85
108_E112_L0.8530.84
155_L165_E0.8520.84
100_E103_E0.8490.84
171_V174_A0.8470.84
132_A148_E0.8470.84
145_A151_T0.8440.84
112_L115_P0.8430.84
109_R164_A0.8420.84
163_A167_A0.8410.84
234_Q268_Y0.8370.83
226_D230_E0.8360.83
150_I158_A0.8350.83
137_I140_A0.8320.83
131_E134_T0.8310.83
145_A153_E0.8290.83
86_P102_P0.8270.83
192_K196_F0.8250.82
218_F222_K0.8230.82
89_E94_P0.8230.82
85_Q92_A0.8220.82
260_Q270_L0.8210.82
151_T157_T0.8200.82
96_P100_E0.8190.82
259_K273_E0.8180.82
84_A94_P0.8180.82
176_E180_V0.8140.82
116_E123_V0.8130.82
89_E95_E0.8110.81
123_V137_I0.8100.81
82_E87_E0.8100.81
296_I378_V0.8080.81
82_E88_A0.8080.81
110_E148_E0.8070.81
111_E117_D0.8050.81
173_P178_Q0.8000.80
154_E168_V0.7990.80
97_V124_S0.7990.80
90_V105_V0.7980.80
85_Q93_Q0.7980.80
182_E185_Q0.7950.80
90_V97_V0.7940.80
163_A179_P0.7930.80
103_E107_I0.7930.80
187_Q190_P0.7920.80
128_W135_V0.7900.80
90_V98_V0.7880.79
96_P148_E0.7880.79
298_M444_T0.7830.79
86_P89_E0.7820.79
116_E128_W0.7810.79
97_V107_I0.7790.79
86_P95_E0.7790.79
391_S395_E0.7780.79
156_E174_A0.7760.78
87_E115_P0.7750.78
164_A173_P0.7720.78
114_L176_E0.7710.78
136_E148_E0.7700.78
90_V95_E0.7690.78
109_R119_N0.7690.78
142_E156_E0.7690.78
138_V154_E0.7690.78
390_K445_L0.7670.78
83_K91_V0.7670.78
323_S376_I0.7660.78
163_A169_M0.7650.77
109_R149_E0.7650.77
183_I186_E0.7630.77
170_V175_E0.7600.77
419_I431_A0.7590.77
140_A144_E0.7590.77
166_E169_M0.7580.77
133_E143_E0.7580.77
168_V178_Q0.7560.77
147_K153_E0.7550.77
81_S84_A0.7540.76
127_E139_E0.7520.76
119_N139_E0.7520.76
88_A103_E0.7490.76
84_A96_P0.7490.76
208_E212_S0.7490.76
327_A379_L0.7450.76
87_E93_Q0.7450.76
181_E184_A0.7440.75
172_P179_P0.7420.75
124_S128_W0.7410.75
283_D286_L0.7400.75
90_V99_E0.7400.75
91_V98_V0.7380.75
125_P130_A0.7380.75
341_Q351_V0.7350.75
240_V278_I0.7330.74
90_V153_E0.7330.74
123_V131_E0.7310.74
131_E138_V0.7300.74
156_E170_V0.7290.74
159_L165_E0.7280.74
159_L181_E0.7280.74
123_V142_E0.7250.74
92_A101_T0.7240.73
159_L167_A0.7230.73
82_E106_A0.7220.73
183_I189_K0.7210.73
317_F400_I0.7200.73
110_E133_E0.7170.73
275_M361_A0.7150.73
216_S219_R0.7140.72
83_K110_E0.7140.72
120_A130_A0.7120.72
102_P117_D0.7100.72
125_P131_E0.7100.72
416_M442_G0.7090.72
120_A124_S0.7090.72
368_I379_L0.7080.72
160_A165_E0.7080.72
83_K97_V0.7060.72
171_V179_P0.7060.72
137_I143_E0.7060.72
369_Q373_A0.7020.71
195_F199_L0.7010.71
143_E160_A0.7000.71
120_A123_V0.6990.71
134_T161_A0.6990.71
124_S135_V0.6990.71
88_A96_P0.6980.71
84_A99_E0.6970.71
130_A145_A0.6960.71
142_E148_E0.6960.71
84_A93_Q0.6950.70
106_A110_E0.6940.70
83_K87_E0.6930.70
226_D229_E0.6930.70
94_P99_E0.6930.70
91_V157_T0.6920.70
261_L266_A0.6890.70
118_V130_A0.6890.70
84_A92_A0.6880.70
280_A486_D0.6880.70
114_L134_T0.6860.69
121_E141_A0.6840.69
106_A135_V0.6840.69
137_I147_K0.6830.69
221_K224_D0.6820.69
98_V101_T0.6810.69
153_E157_T0.6810.69
184_A188_E0.6790.69
132_A138_V0.6780.69
97_V104_P0.6760.68
131_E171_V0.6760.68
92_A102_P0.6750.68
104_P149_E0.6750.68
90_V116_E0.6730.68
155_L159_L0.6730.68
108_E123_V0.6720.68
90_V102_P0.6710.68
153_E167_A0.6680.67
144_E154_E0.6680.67
174_A179_P0.6670.67
85_Q90_V0.6640.67
131_E157_T0.6640.67
125_P129_Q0.6620.67
142_E146_A0.6620.67
326_L344_G0.6610.67
142_E164_A0.6600.66
86_P105_V0.6600.66
256_A418_T0.6600.66
143_E163_A0.6530.66
150_I153_E0.6530.66
164_A172_P0.6480.65
342_V345_Q0.6480.65
324_V377_D0.6480.65
389_N401_V0.6470.65
106_A112_L0.6460.65
104_P134_T0.6460.65
117_D156_E0.6460.65
255_G277_E0.6440.65
461_A468_I0.6440.65
429_S433_L0.6430.64
247_K273_E0.6430.64
154_E162_E0.6410.64
135_V138_V0.6400.64
443_I456_V0.6390.64
247_K255_G0.6390.64
108_E172_P0.6370.64
89_E101_T0.6360.64
82_E105_V0.6340.63
139_E143_E0.6340.63
326_L468_I0.6320.63
292_A436_E0.6320.63
168_V172_P0.6320.63
165_E170_V0.6310.63
83_K107_I0.6310.63
109_R123_V0.6310.63
133_E137_I0.6310.63
138_V149_E0.6300.63
219_R222_K0.6300.63
119_N122_A0.6290.63
143_E149_E0.6290.63
117_D130_A0.6290.63
96_P112_L0.6270.63
82_E94_P0.6230.62
158_A164_A0.6200.62
103_E109_R0.6200.62
99_E105_V0.6190.62
100_E106_A0.6190.62
91_V99_E0.6180.61
123_V130_A0.6180.61
93_Q97_V0.6180.61
103_E118_V0.6170.61
294_F460_V0.6160.61
120_A150_I0.6150.61
108_E157_T0.6150.61
147_K152_D0.6150.61
146_A163_A0.6130.61
139_E144_E0.6110.61
142_E150_I0.6100.60
127_E133_E0.6090.60
392_H422_S0.6060.60
103_E148_E0.6060.60
170_V176_E0.6060.60
171_V183_I0.6050.60
138_V145_A0.6050.60
128_W143_E0.6050.60
83_K89_E0.6050.60
323_S350_P0.6050.60
135_V165_E0.6040.60
115_P131_E0.6040.60
338_E440_L0.6030.60
149_E154_E0.6000.59
212_S259_K0.6000.59
110_E118_V0.5990.59
148_E163_A0.5980.59
202_S206_T0.5960.59
180_V183_I0.5940.58
167_A177_E0.5940.58
95_E124_S0.5920.58
175_E181_E0.5920.58
137_I148_E0.5910.58
97_V109_R0.5900.58
162_E172_P0.5900.58
106_A111_E0.5890.58
121_E125_P0.5890.58
95_E104_P0.5890.58
87_E92_A0.5880.58
276_G490_E0.5880.58
106_A159_L0.5850.57
360_S400_I0.5850.57
204_L400_I0.5840.57
161_A166_E0.5840.57
156_E180_V0.5840.57
163_A178_Q0.5830.57
122_A143_E0.5820.57
97_V113_P0.5820.57
94_P165_E0.5810.57
102_P122_A0.5810.57
106_A142_E0.5800.57
121_E145_A0.5800.57
88_A146_A0.5790.56
129_Q145_A0.5790.56
82_E97_V0.5780.56
107_I122_A0.5770.56
89_E97_V0.5740.56
127_E146_A0.5730.56
124_S168_V0.5730.56
128_W134_T0.5710.55
337_V356_T0.5690.55
93_Q106_A0.5690.55
107_I113_P0.5690.55
86_P99_E0.5640.55
136_E147_K0.5640.55
166_E172_P0.5630.54
105_V110_E0.5620.54
316_Q320_Q0.5600.54
207_K210_L0.5580.54
107_I110_E0.5580.54
161_A177_E0.5570.54
159_L171_V0.5540.53
271_L491_A0.5540.53
162_E167_A0.5540.53
97_V102_P0.5530.53
143_E151_T0.5530.53
111_E136_E0.5510.53
175_E178_Q0.5490.53
127_E135_V0.5480.52
241_G425_Q0.5420.52
171_V176_E0.5420.52
176_E182_E0.5410.52
129_Q143_E0.5400.51
131_E135_V0.5390.51
122_A181_E0.5380.51
434_F472_G0.5350.51
207_K214_F0.5340.51
81_S88_A0.5310.50
111_E126_E0.5310.50
244_T418_T0.5300.50
384_A393_L0.5300.50
227_L279_L0.5300.50
215_I218_F0.5300.50
359_D399_K0.5290.50
88_A105_V0.5290.50
141_A153_E0.5290.50
162_E166_E0.5280.50
124_S130_A0.5280.50
126_E152_D0.5280.50
244_T278_I0.5280.50
111_E146_A0.5280.50
98_V161_A0.5270.50
138_V156_E0.5260.50
270_L418_T0.5240.49
93_Q113_P0.5230.49
210_L230_E0.5220.49
108_E138_V0.5220.49
103_E108_E0.5210.49
136_E168_V0.5190.49
299_V438_V0.5190.49
424_G427_A0.5190.49
147_K157_T0.5180.48
101_T111_E0.5170.48
91_V97_V0.5170.48
130_A139_E0.5150.48
428_V464_F0.5100.47
240_V243_E0.5090.47
81_S100_E0.5080.47
84_A102_P0.5080.47
148_E151_T0.5060.47
82_E136_E0.5060.47
115_P130_A0.5060.47
126_E166_E0.5050.47
161_A175_E0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yhsA 1 0.6197 100 0.39 Contact Map
2og2A 1 0.6016 100 0.515 Contact Map
1vmaA 1 0.5915 100 0.516 Contact Map
3b9qA 1 0.5915 100 0.543 Contact Map
4c7oA 1 0.5875 100 0.563 Contact Map
1zu4A 1 0.5976 100 0.567 Contact Map
1rj9A 1 0.5332 100 0.571 Contact Map
1ls1A 1 0.5734 100 0.574 Contact Map
2px0A 4 0.5151 100 0.575 Contact Map
2v3cC 1 0.5775 100 0.583 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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