GREMLIN Database
RLPA - Rare lipoprotein A
UniProt: P10100 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10854
Length: 362 (353)
Sequences: 238 (188)
Seq/√Len: 10.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_I134_I5.9771.00
92_S166_I3.6910.98
87_D147_S3.3780.96
107_T149_S3.3340.96
308_Q312_G3.2940.96
99_E133_R2.9170.92
53_L58_N2.7840.90
113_L119_A2.7770.89
123_N126_N2.6500.87
103_P130_I2.6210.86
179_G187_V2.5600.85
13_G165_R2.5410.85
85_I147_S2.5350.84
249_G252_E2.5200.84
87_D92_S2.4790.83
231_G234_V2.4660.83
110_H133_R2.4520.82
324_N352_A2.4320.82
99_E135_N2.3480.79
90_P153_A2.3380.79
113_L165_R2.3040.78
70_I85_I2.2800.77
31_P101_F2.2720.77
311_L344_L2.1210.72
17_A56_T2.1160.72
121_I147_S2.1030.71
16_A343_T2.0900.71
63_R134_I2.0840.70
57_A134_I2.0480.69
87_D90_P2.0380.69
233_P237_S2.0260.68
99_E110_H1.9720.66
90_P103_P1.9610.66
78_S167_D1.9600.65
20_S145_V1.9470.65
84_A87_D1.9430.65
84_A147_S1.8890.62
80_A165_R1.8700.62
20_S191_T1.7340.56
62_Q67_S1.7120.55
53_L158_T1.6990.54
240_L245_T1.6880.54
251_L255_E1.6700.53
87_D149_S1.6310.51
224_L237_S1.6280.51
307_Y354_L1.6190.50
85_I91_G1.6080.50
233_P247_A1.6000.50
22_D359_T1.5960.49
120_R167_D1.5950.49
28_V56_T1.5900.49
19_T283_V1.5860.49
64_D105_Q1.5840.49
111_P140_Y1.5720.48
29_S152_A1.5640.48
17_A107_T1.5620.48
251_L256_P1.5550.47
342_S358_I1.5420.47
345_Q356_S1.5210.46
168_P172_A1.5090.45
223_T266_A1.5080.45
90_P147_S1.5030.45
313_Q358_I1.4960.45
87_D121_I1.4940.45
176_S182_M1.4930.45
246_L250_V1.4890.44
63_R147_S1.4770.44
315_F352_A1.4720.44
101_F162_T1.4710.44
8_I231_G1.4550.43
229_P272_A1.4520.43
34_A70_I1.4500.43
60_D70_I1.4460.42
185_T188_A1.4410.42
20_S67_S1.4270.42
245_T265_T1.4200.41
86_Y109_A1.4040.41
150_R165_R1.3820.40
84_A153_A1.3810.40
246_L249_G1.3790.40
57_A97_S1.3760.39
39_P45_G1.3730.39
294_Q329_R1.3700.39
242_A250_V1.3690.39
251_L259_A1.3620.39
266_A279_T1.3550.38
34_A58_N1.3510.38
58_N70_I1.3490.38
58_N97_S1.3490.38
58_N168_P1.3380.38
84_A144_R1.3310.37
63_R76_R1.3260.37
84_A90_P1.3200.37
79_Q94_L1.3200.37
299_S307_Y1.3180.37
119_A130_I1.3110.37
43_I131_V1.3090.36
204_A210_S1.2990.36
101_F130_I1.2980.36
133_R146_I1.2980.36
315_F324_N1.2870.36
221_N241_G1.2870.36
233_P241_G1.2840.35
77_F352_A1.2830.35
335_F341_A1.2770.35
309_Q312_G1.2750.35
232_A235_T1.2740.35
227_E233_P1.2680.35
86_Y149_S1.2650.35
233_P302_A1.2580.34
299_S334_P1.2520.34
207_S270_T1.2490.34
14_M270_T1.2430.34
74_P172_A1.2410.34
63_R152_A1.2400.34
342_S345_Q1.2380.34
53_L67_S1.2360.33
294_Q333_G1.2320.33
101_F113_L1.2280.33
49_R52_P1.2260.33
145_V187_V1.2230.33
109_A136_D1.2100.32
128_R188_A1.2050.32
80_A163_K1.1960.32
35_V40_I1.1960.32
329_R344_L1.1890.32
260_P281_Q1.1880.32
220_S258_P1.1830.31
227_E278_V1.1720.31
263_V267_P1.1630.31
299_S354_L1.1630.31
48_P51_E1.1610.30
96_A111_P1.1610.30
95_T136_D1.1610.30
42_E48_P1.1580.30
63_R87_D1.1580.30
18_C116_P1.1520.30
53_L97_S1.1460.30
115_I352_A1.1420.30
97_S166_I1.1400.30
331_Q348_L1.1360.30
85_I98_G1.1340.29
86_Y147_S1.1310.29
132_V136_D1.1240.29
111_P118_Y1.1220.29
227_E231_G1.1210.29
131_V171_V1.1180.29
148_L158_T1.1180.29
51_E178_S1.1140.29
64_D143_D1.1070.28
240_L252_E1.1070.28
97_S100_A1.1050.28
262_P286_S1.1050.28
53_L168_P1.1040.28
13_G130_I1.1030.28
211_G229_P1.1020.28
116_P156_L1.1010.28
204_A212_P1.0930.28
99_E112_T1.0930.28
230_T235_T1.0860.28
130_I150_R1.0850.28
121_I143_D1.0830.28
85_I106_L1.0680.27
13_G32_Q1.0680.27
239_F252_E1.0660.27
85_I119_A1.0660.27
166_I323_Q1.0650.27
92_S147_S1.0600.27
155_R177_L1.0580.27
204_A207_S1.0350.26
61_Y116_P1.0320.26
91_G100_A1.0310.26
160_N300_D1.0310.26
283_V288_S1.0300.26
272_A279_T1.0260.25
116_P122_T1.0260.25
221_N235_T1.0260.25
239_F249_G1.0250.25
189_K198_P1.0220.25
25_Q30_V1.0180.25
90_P129_M1.0130.25
271_P274_S1.0130.25
294_Q341_A1.0100.25
274_S281_Q1.0050.25
57_A63_R1.0030.25
311_L315_F1.0010.25
50_F182_M0.9990.25
70_I112_T0.9960.24
92_S129_M0.9890.24
134_I147_S0.9890.24
11_A82_L0.9880.24
169_I348_L0.9870.24
322_T334_P0.9780.24
207_S258_P0.9710.24
290_N297_A0.9680.24
119_A184_C0.9630.23
241_G248_P0.9610.23
294_Q303_R0.9600.23
39_P172_A0.9580.23
213_Q231_G0.9570.23
319_G328_W0.9520.23
38_G93_N0.9510.23
99_E166_I0.9470.23
227_E244_T0.9450.23
27_T30_V0.9450.23
258_P265_T0.9440.23
287_A290_N0.9430.23
290_N309_Q0.9420.23
130_I176_S0.9400.23
40_I70_I0.9390.23
128_R181_G0.9370.23
101_F155_R0.9360.22
348_L355_Q0.9340.22
46_A69_K0.9310.22
207_S218_P0.9250.22
89_E130_I0.9250.22
17_A220_S0.9240.22
121_I127_G0.9240.22
144_R153_A0.9240.22
6_L151_A0.9230.22
94_L121_I0.9230.22
234_V238_G0.9210.22
117_S120_R0.9210.22
223_T264_V0.9200.22
230_T281_Q0.9190.22
120_R123_N0.9180.22
81_G116_P0.9170.22
39_P173_Q0.9150.22
103_P167_D0.9100.22
31_P298_V0.9080.22
56_T97_S0.9050.22
95_T109_A0.9040.21
245_T251_L0.9020.21
232_A244_T0.9020.21
45_G106_L0.8970.21
144_R147_S0.8970.21
82_L301_Q0.8960.21
248_P251_L0.8940.21
241_G250_V0.8920.21
89_E101_F0.8920.21
33_P96_A0.8910.21
59_Q182_M0.8880.21
252_E257_T0.8870.21
8_I21_D0.8860.21
64_D330_I0.8830.21
17_A248_P0.8820.21
234_V242_A0.8820.21
19_T160_N0.8810.21
53_L57_A0.8800.21
110_H118_Y0.8800.21
223_T267_P0.8770.21
144_R166_I0.8730.21
206_T241_G0.8720.20
10_I13_G0.8720.20
352_A356_S0.8690.20
211_G248_P0.8680.20
133_R166_I0.8680.20
62_Q94_L0.8670.20
228_D262_P0.8660.20
72_Q97_S0.8640.20
340_E343_T0.8540.20
254_S287_A0.8540.20
109_A132_V0.8490.20
11_A279_T0.8440.20
25_Q37_N0.8440.20
230_T264_V0.8410.20
253_G258_P0.8410.20
29_S69_K0.8370.19
260_P263_V0.8320.19
85_I121_I0.8310.19
131_V175_G0.8300.19
345_Q348_L0.8300.19
118_Y133_R0.8280.19
241_G252_E0.8280.19
140_Y168_P0.8280.19
231_G241_G0.8270.19
53_L70_I0.8260.19
120_R179_G0.8260.19
19_T253_G0.8230.19
333_G341_A0.8220.19
220_S224_L0.8220.19
66_K222_S0.8200.19
54_N185_T0.8180.19
54_N89_E0.8180.19
258_P270_T0.8170.19
270_T274_S0.8160.19
107_T222_S0.8150.19
251_L346_Q0.8140.19
216_I219_V0.8140.19
307_Y330_I0.8120.19
16_A117_S0.8110.19
99_E118_Y0.8110.19
95_T132_V0.8090.19
251_L262_P0.8080.19
123_N311_L0.8080.19
85_I118_Y0.8070.19
302_A310_Q0.8040.19
54_N58_N0.8020.18
268_S275_P0.8020.18
165_R343_T0.8010.18
108_A136_D0.7990.18
147_S166_I0.7970.18
175_G181_G0.7960.18
129_M166_I0.7950.18
215_D260_P0.7950.18
95_T121_I0.7920.18
61_Y136_D0.7890.18
103_P152_A0.7870.18
92_S191_T0.7860.18
17_A106_L0.7850.18
227_E280_P0.7780.18
16_A19_T0.7750.18
98_G118_Y0.7730.18
244_T248_P0.7690.18
12_A16_A0.7690.18
226_S237_S0.7680.18
57_A115_I0.7650.17
330_I354_L0.7650.17
254_S275_P0.7650.17
153_A310_Q0.7640.17
39_P111_P0.7630.17
118_Y169_I0.7620.17
163_K334_P0.7610.17
301_Q305_Q0.7580.17
225_K230_T0.7580.17
27_T113_L0.7540.17
78_S193_A0.7450.17
148_L171_V0.7440.17
226_S248_P0.7430.17
259_A262_P0.7390.17
240_L249_G0.7380.17
309_Q313_Q0.7380.17
97_S352_A0.7360.17
84_A141_G0.7340.17
163_K313_Q0.7320.17
14_M330_I0.7290.17
122_T303_R0.7270.16
134_I208_S0.7240.16
87_D330_I0.7200.16
237_S255_E0.7200.16
84_A359_T0.7170.16
267_P281_Q0.7170.16
247_A339_A0.7170.16
107_T259_A0.7160.16
230_T234_V0.7150.16
16_A339_A0.7150.16
124_L161_N0.7140.16
43_I347_R0.7130.16
8_I218_P0.7100.16
203_G231_G0.7090.16
308_Q334_P0.7090.16
87_D135_N0.7080.16
51_E151_A0.7080.16
25_Q28_V0.7070.16
109_A147_S0.7070.16
146_I155_R0.7040.16
167_D179_G0.7020.16
238_G251_L0.7000.16
103_P192_Y0.6990.16
233_P236_S0.6980.16
58_N67_S0.6950.16
312_G322_T0.6940.16
163_K312_G0.6930.16
121_I145_V0.6920.16
55_A76_R0.6910.16
212_P234_V0.6900.16
242_A252_E0.6900.16
192_Y195_P0.6850.15
194_L198_P0.6830.15
278_V327_V0.6830.15
107_T283_V0.6800.15
79_Q355_Q0.6780.15
127_G152_A0.6770.15
310_Q322_T0.6770.15
21_D166_I0.6770.15
140_Y301_Q0.6760.15
310_Q314_K0.6730.15
33_P36_C0.6720.15
110_H146_I0.6720.15
45_G101_F0.6690.15
307_Y334_P0.6690.15
215_D225_K0.6680.15
84_A91_G0.6670.15
61_Y81_G0.6630.15
227_E230_T0.6600.15
145_V166_I0.6570.15
42_E174_D0.6570.15
85_I168_P0.6560.15
91_G153_A0.6550.15
8_I234_V0.6550.15
11_A15_L0.6550.15
258_P263_V0.6540.15
162_T174_D0.6530.15
165_R316_G0.6520.15
238_G252_E0.6500.15
84_A121_I0.6490.15
241_G244_T0.6460.15
125_A267_P0.6450.15
169_I195_P0.6440.15
8_I300_D0.6440.15
91_G129_M0.6420.14
229_P233_P0.6390.14
35_V39_P0.6370.14
210_S219_V0.6330.14
34_A40_I0.6330.14
11_A17_A0.6300.14
239_F250_V0.6300.14
223_T286_S0.6290.14
206_T209_V0.6280.14
99_E146_I0.6270.14
141_G147_S0.6270.14
151_A179_G0.6260.14
229_P260_P0.6250.14
19_T289_G0.6230.14
109_A164_V0.6230.14
55_A174_D0.6210.14
172_A190_Q0.6190.14
262_P350_T0.6190.14
204_A208_S0.6180.14
27_T101_F0.6140.14
83_A164_V0.6140.14
121_I136_D0.6140.14
251_L254_S0.6140.14
239_F254_S0.6140.14
345_Q355_Q0.6140.14
299_S325_G0.6130.14
195_P200_L0.6100.14
279_T284_S0.6100.14
36_C89_E0.6070.14
172_A176_S0.6070.14
128_R185_T0.6060.14
17_A66_K0.6060.14
235_T249_G0.6040.14
226_S242_A0.6020.14
125_A171_V0.6020.14
248_P272_A0.6000.14
260_P272_A0.5990.14
42_E46_A0.5980.13
90_P158_T0.5980.13
62_Q247_A0.5950.13
85_I134_I0.5940.13
151_A155_R0.5940.13
40_I58_N0.5920.13
51_E155_R0.5920.13
77_F122_T0.5890.13
33_P85_I0.5880.13
71_V77_F0.5870.13
74_P168_P0.5860.13
335_F344_L0.5860.13
229_P265_T0.5840.13
136_D139_P0.5830.13
235_T241_G0.5790.13
216_I221_N0.5770.13
48_P105_Q0.5740.13
288_S305_Q0.5700.13
143_D184_C0.5690.13
275_P283_V0.5690.13
205_G208_S0.5670.13
243_P248_P0.5670.13
5_W8_I0.5660.13
102_D133_R0.5660.13
294_Q297_A0.5640.13
295_V341_A0.5640.13
305_Q313_Q0.5620.13
271_P287_A0.5620.13
243_P250_V0.5610.13
210_S284_S0.5600.13
112_T168_P0.5580.13
249_G256_P0.5570.13
201_S276_A0.5560.13
210_S257_T0.5560.13
273_T283_V0.5550.13
46_A166_I0.5550.13
352_A355_Q0.5550.13
237_S274_S0.5540.13
86_Y136_D0.5530.13
139_P149_S0.5530.13
138_G149_S0.5530.13
266_A273_T0.5520.13
273_T282_A0.5510.13
261_Q289_G0.5500.12
77_F166_I0.5490.12
275_P278_V0.5490.12
306_Q339_A0.5470.12
41_V111_P0.5470.12
253_G267_P0.5450.12
321_V346_Q0.5440.12
10_I16_A0.5440.12
202_G231_G0.5420.12
40_I43_I0.5420.12
149_S153_A0.5410.12
122_T129_M0.5410.12
111_P173_Q0.5390.12
171_V174_D0.5380.12
40_I52_P0.5370.12
219_V274_S0.5340.12
88_A168_P0.5330.12
233_P238_G0.5310.12
27_T205_G0.5290.12
218_P235_T0.5290.12
166_I327_V0.5290.12
124_L163_K0.5250.12
120_R129_M0.5240.12
77_F116_P0.5220.12
174_D179_G0.5220.12
87_D349_Q0.5220.12
273_T284_S0.5200.12
107_T193_A0.5180.12
91_G103_P0.5170.12
61_Y109_A0.5160.12
6_L11_A0.5140.12
89_E155_R0.5130.12
199_D236_S0.5130.12
41_V96_A0.5110.12
34_A53_L0.5090.12
351_E357_F0.5090.12
207_S220_S0.5090.12
21_D24_Q0.5080.12
313_Q325_G0.5070.12
229_P271_P0.5070.12
226_S238_G0.5060.12
217_L239_F0.5060.12
15_L18_C0.5060.12
293_V345_Q0.5040.12
315_F351_E0.5040.12
63_R84_A0.5030.12
133_R341_A0.5020.12
182_M185_T0.5010.12
226_S257_T0.5000.12
265_T273_T0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4avrA 2 0.2541 100 0.743 Contact Map
4pmkA 1 0.3619 99.9 0.801 Contact Map
1utaA 1 0.2099 99.5 0.875 Contact Map
1x60A 1 0.2182 99.4 0.877 Contact Map
4jp6A 1 0.3122 98.6 0.913 Contact Map
4jcwA 2 0.5083 98.5 0.915 Contact Map
3d30A 1 0.4917 98.1 0.924 Contact Map
2lfvA 1 0.268 97.9 0.928 Contact Map
3zbiC 1 0.0773 81.7 0.962 Contact Map
1wc2A 1 0.3315 74 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.