GREMLIN Database
RCSC - Sensor histidine kinase RcsC
UniProt: P0DMC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10822
Length: 949 (820)
Sequences: 456 (373)
Seq/√Len: 13.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
852_K869_I5.6191.00
856_D880_N5.0391.00
874_S886_L4.5281.00
485_L491_N4.0151.00
530_K642_Q3.7240.99
745_D750_D3.6460.99
831_D837_R3.5600.99
914_C919_M3.5500.99
474_L477_V3.5410.99
483_T490_G3.3640.98
581_G668_M3.2780.98
384_N387_A3.2450.98
831_D856_D3.2260.98
878_M883_G3.1230.97
475_A682_S3.0090.97
460_A463_A2.9620.96
543_F581_G2.8680.96
875_D883_G2.8190.95
532_E563_K2.7920.95
466_A470_K2.6720.93
417_L667_M2.6650.93
887_T919_M2.6550.93
463_A466_A2.5680.92
255_I830_V2.5580.92
500_L504_V2.5410.92
449_R453_E2.5070.91
486_Y901_G2.4550.90
480_E483_T2.4510.90
833_H919_M2.3800.89
617_L688_I2.3170.87
592_N599_K2.3120.87
624_T628_I2.3060.87
836_N904_A2.2910.87
857_G891_R2.2880.87
884_Y905_N2.2840.86
904_A919_M2.2790.86
858_V862_N2.2780.86
875_D878_M2.2610.86
530_K682_S2.2540.86
364_A606_I2.2300.85
585_R588_Q2.2260.85
511_M831_D2.2170.85
843_Q874_S2.1980.84
475_A642_Q2.1930.84
642_Q682_S2.1640.83
644_G649_R2.1200.82
905_N910_E2.1030.81
525_I530_K2.0990.81
473_F478_S2.0810.81
553_T608_L2.0770.81
794_L798_I2.0750.80
588_Q660_I2.0620.80
487_G514_S2.0350.79
508_V833_H2.0290.79
477_V498_K2.0260.79
933_K936_L2.0240.79
769_H773_P2.0020.78
351_R355_H1.9990.78
427_S433_Y1.9980.78
882_D891_R1.9830.77
474_L532_E1.9670.77
438_V441_C1.9650.77
861_L886_L1.9610.76
592_N600_F1.9540.76
837_R855_N1.9380.76
843_Q929_L1.9270.75
479_H526_L1.8980.74
594_L608_L1.8940.74
833_H904_A1.8920.74
359_N365_S1.8900.74
482_R599_K1.8690.73
883_G904_A1.8630.73
601_T624_T1.8590.72
601_T656_L1.8590.72
522_I903_T1.8570.72
637_F658_L1.8570.72
473_F599_K1.8510.72
522_I912_Q1.8490.72
878_M904_A1.8400.72
429_V433_Y1.8350.71
482_R592_N1.8280.71
473_F585_R1.8240.71
447_S536_L1.8180.71
180_K184_A1.8150.70
836_N919_M1.8030.70
149_G153_L1.7950.70
620_R683_Q1.7950.70
585_R664_L1.7930.69
843_Q886_L1.7780.69
427_S430_H1.7720.69
428_F433_Y1.7540.68
475_A479_H1.7480.67
549_M606_I1.7460.67
909_E922_C1.7450.67
498_K504_V1.7320.67
359_N363_V1.7310.67
145_V150_S1.7290.67
704_L731_I1.7280.67
640_F914_C1.7090.66
881_M885_R1.7020.65
831_D904_A1.7010.65
221_A225_V1.7000.65
475_A530_K1.7000.65
596_N657_G1.6990.65
832_D857_G1.6950.65
482_R494_L1.6910.65
473_F592_N1.6890.65
542_E580_N1.6840.64
527_D600_F1.6800.64
837_R853_T1.6670.64
473_F482_R1.6630.63
480_E484_P1.6540.63
438_V442_V1.6500.63
510_A827_I1.6470.63
362_I387_A1.6460.63
664_L668_M1.6380.62
797_R803_M1.6260.62
507_L517_L1.6240.62
833_H914_C1.6140.61
878_M898_P1.6080.61
425_Q433_Y1.6070.61
874_S877_N1.5980.60
116_N120_G1.5940.60
487_G919_M1.5880.60
478_S599_K1.5880.60
626_V901_G1.5880.60
479_H483_T1.5860.60
491_N839_L1.5850.60
483_T527_D1.5790.59
522_I531_I1.5770.59
600_F656_L1.5650.59
699_K827_I1.5610.58
832_D883_G1.5590.58
470_K473_F1.5520.58
488_I554_A1.5440.57
519_L624_T1.5420.57
475_A478_S1.5410.57
833_H837_R1.5390.57
486_Y491_N1.5370.57
518_L524_D1.5340.57
599_K637_F1.5320.57
424_L428_F1.5300.57
788_P797_R1.5280.57
746_V750_D1.5250.57
366_A369_G1.5200.56
511_M522_I1.5180.56
588_Q592_N1.5130.56
882_D885_R1.5060.56
482_R600_F1.5010.55
478_S592_N1.5000.55
467_S470_K1.4980.55
588_Q599_K1.4910.55
146_F157_N1.4830.54
479_H599_K1.4710.54
640_F833_H1.4700.54
477_V481_L1.4690.54
482_R588_Q1.4640.53
548_V631_K1.4610.53
475_A674_V1.4600.53
857_G879_P1.4570.53
359_N367_P1.4480.53
465_Q659_A1.4460.52
296_S636_L1.4460.52
479_H588_Q1.4440.52
877_N901_G1.4440.52
906_A924_S1.4350.52
875_D891_R1.4330.52
618_S687_R1.4250.51
539_E581_G1.4240.51
434_R446_V1.4240.51
487_G490_G1.4180.51
477_V533_S1.4170.51
640_F836_N1.4150.51
124_S130_R1.4090.50
600_F642_Q1.4080.50
478_S482_R1.4070.50
649_R827_I1.4050.50
154_C160_L1.4030.50
224_G295_S1.4010.50
588_Q654_T1.3990.50
362_I628_I1.3980.50
297_L633_V1.3920.50
641_F901_G1.3870.49
684_F914_C1.3870.49
173_A180_K1.3870.49
359_N362_I1.3860.49
556_Y644_G1.3750.49
535_Q660_I1.3710.48
643_V652_Q1.3670.48
508_V899_V1.3660.48
640_F660_I1.3660.48
508_V511_M1.3620.48
844_L879_P1.3600.48
530_K588_Q1.3580.48
786_A789_H1.3570.48
478_S526_L1.3570.48
139_A149_G1.3550.48
660_I904_A1.3550.48
470_K592_N1.3540.48
528_F856_D1.3520.47
791_L794_L1.3520.47
856_D910_E1.3470.47
759_G762_V1.3470.47
473_F588_Q1.3470.47
479_H482_R1.3450.47
567_L873_L1.3450.47
292_L450_V1.3430.47
131_Y158_F1.3360.47
646_G649_R1.3350.47
482_R527_D1.3320.46
832_D878_M1.3300.46
474_L498_K1.3270.46
484_P592_N1.3260.46
475_A482_R1.3230.46
660_I667_M1.3230.46
514_S522_I1.3210.46
433_Y438_V1.3200.46
449_R452_M1.3180.46
152_N160_L1.3160.46
473_F600_F1.3150.46
476_T877_N1.3090.45
608_L633_V1.3090.45
682_S914_C1.3080.45
884_Y907_L1.3060.45
139_A143_N1.3060.45
600_F637_F1.3050.45
470_K599_K1.3000.45
479_H592_N1.2990.45
589_V618_S1.2980.45
130_R137_S1.2960.45
477_V487_G1.2940.44
425_Q446_V1.2930.44
527_D531_I1.2920.44
478_S518_L1.2850.44
884_Y910_E1.2840.44
588_Q642_Q1.2800.44
526_L588_Q1.2800.44
837_R899_V1.2780.44
485_L639_P1.2770.44
830_V854_A1.2770.44
439_A442_V1.2750.43
125_L146_F1.2750.43
134_D138_A1.2740.43
884_Y906_A1.2740.43
366_A373_L1.2720.43
125_L176_E1.2720.43
628_I707_K1.2710.43
478_S484_P1.2700.43
366_A476_T1.2700.43
128_F136_F1.2690.43
573_P840_L1.2680.43
358_F367_P1.2660.43
514_S914_C1.2650.43
507_L558_P1.2640.43
463_A467_S1.2630.43
484_P601_T1.2630.43
875_D925_K1.2620.43
471_S626_V1.2590.43
539_E567_L1.2570.43
483_T487_G1.2560.43
585_R668_M1.2540.42
773_P783_H1.2500.42
646_G652_Q1.2470.42
530_K654_T1.2470.42
599_K836_N1.2470.42
648_Q882_D1.2460.42
647_V660_I1.2460.42
154_C159_G1.2440.42
589_V689_P1.2420.42
900_I911_K1.2410.42
358_F372_I1.2400.42
340_R453_E1.2400.42
487_G628_I1.2380.42
910_E914_C1.2380.42
901_G904_A1.2350.41
843_Q847_L1.2330.41
797_R802_E1.2330.41
875_D904_A1.2330.41
526_L529_S1.2320.41
146_F154_C1.2290.41
527_D592_N1.2290.41
526_L599_K1.2240.41
831_D835_I1.2190.41
748_I752_V1.2170.41
479_H484_P1.2160.40
500_L508_V1.2160.40
299_I477_V1.2160.40
857_G904_A1.2130.40
484_P599_K1.2130.40
857_G883_G1.2130.40
209_A595_S1.2070.40
854_A863_V1.2060.40
883_G898_P1.2050.40
431_S442_V1.2040.40
779_G782_V1.2040.40
798_I801_I1.1940.39
905_N914_C1.1930.39
644_G651_F1.1930.39
494_L527_D1.1900.39
583_P589_V1.1870.39
312_I391_L1.1850.39
637_F657_G1.1850.39
422_T446_V1.1840.39
135_N594_L1.1830.39
213_V229_I1.1820.39
145_V148_I1.1800.39
390_Y901_G1.1800.39
746_V752_V1.1780.39
463_A475_A1.1780.39
144_R158_F1.1770.39
847_L929_L1.1760.38
596_N637_F1.1760.38
836_N914_C1.1760.38
891_R918_G1.1730.38
875_D879_P1.1690.38
471_S490_G1.1640.38
599_K658_L1.1640.38
485_L689_P1.1600.38
175_H178_I1.1590.38
875_D882_D1.1580.38
592_N642_Q1.1570.38
585_R599_K1.1560.38
473_F484_P1.1560.38
599_K642_Q1.1550.37
585_R592_N1.1550.37
387_A390_Y1.1530.37
142_L149_G1.1530.37
529_S660_I1.1470.37
423_N433_Y1.1460.37
592_N637_F1.1450.37
243_G250_N1.1440.37
473_F479_H1.1440.37
592_N656_L1.1440.37
874_S904_A1.1440.37
428_F431_S1.1430.37
504_V507_L1.1360.37
331_F334_A1.1260.36
660_I919_M1.1240.36
652_Q901_G1.1220.36
492_L496_Q1.1210.36
642_Q684_F1.1200.36
362_I371_C1.1190.36
527_D599_K1.1170.36
569_C833_H1.1160.36
539_E543_F1.1140.35
606_I696_P1.1140.35
181_Y184_A1.1110.35
476_T874_S1.1110.35
642_Q651_F1.1110.35
485_L886_L1.1070.35
624_T928_T1.1040.35
830_V930_D1.1030.35
478_S600_F1.1030.35
877_N910_E1.1020.35
672_I686_V1.1020.35
539_E919_M1.1010.35
231_M302_S1.1000.35
157_N160_L1.0960.35
331_F335_R1.0960.35
878_M882_D1.0960.35
485_L646_G1.0930.34
920_D934_Q1.0930.34
475_A490_G1.0920.34
152_N159_G1.0860.34
124_S134_D1.0830.34
355_H369_G1.0820.34
483_T593_L1.0820.34
778_P781_W1.0810.34
173_A188_D1.0810.34
926_P932_I1.0810.34
778_P803_M1.0790.34
588_Q600_F1.0790.34
475_A600_F1.0750.34
261_E267_D1.0750.34
445_D527_D1.0740.34
473_F660_I1.0730.34
154_C157_N1.0720.33
885_R899_V1.0720.33
231_M247_L1.0700.33
485_L492_L1.0680.33
469_S482_R1.0670.33
592_N658_L1.0670.33
527_D533_S1.0660.33
857_G878_M1.0650.33
833_H906_A1.0650.33
536_L835_I1.0640.33
339_R672_I1.0640.33
115_S124_S1.0630.33
129_M139_A1.0620.33
352_L384_N1.0620.33
777_A782_V1.0600.33
473_F483_T1.0590.33
424_L432_R1.0560.33
413_F589_V1.0560.33
261_E270_W1.0550.33
358_F486_Y1.0550.33
348_D356_E1.0540.33
481_L524_D1.0520.33
877_N880_N1.0500.32
518_L599_K1.0500.32
833_H836_N1.0490.32
477_V486_Y1.0480.32
783_H809_A1.0430.32
151_D155_M1.0420.32
474_L531_I1.0400.32
265_K269_R1.0380.32
366_A382_L1.0380.32
144_R157_N1.0380.32
518_L588_Q1.0360.32
665_I909_E1.0350.32
484_P490_G1.0340.32
642_Q652_Q1.0340.32
526_L592_N1.0330.32
526_L657_G1.0330.32
355_H360_R1.0320.32
586_L760_R1.0300.32
482_R490_G1.0300.32
484_P656_L1.0300.32
529_S918_G1.0280.31
467_S479_H1.0250.31
526_L596_N1.0250.31
168_D174_L1.0250.31
374_R377_D1.0240.31
479_H585_R1.0210.31
475_A649_R1.0200.31
176_E181_Y1.0190.31
179_N184_A1.0180.31
371_C391_L1.0170.31
842_D909_E1.0160.31
588_Q904_A1.0150.31
473_F480_E1.0150.31
474_L485_L1.0150.31
473_F658_L1.0130.31
479_H637_F1.0120.31
483_T599_K1.0110.31
757_W761_A1.0110.31
511_M648_Q1.0110.31
124_S139_A1.0090.31
166_E172_K1.0070.31
524_D531_I1.0070.31
363_V384_N1.0060.30
133_R149_G1.0060.30
474_L905_N1.0040.30
912_Q916_E1.0030.30
833_H901_G1.0020.30
592_N904_A1.0010.30
522_I914_C1.0000.30
875_D918_G1.0000.30
121_S139_A1.0000.30
470_K480_E0.9990.30
879_P891_R0.9990.30
526_L585_R0.9970.30
486_Y652_Q0.9970.30
124_S150_S0.9960.30
518_L592_N0.9960.30
483_T585_R0.9950.30
613_D696_P0.9950.30
585_R642_Q0.9940.30
131_Y134_D0.9940.30
508_V515_S0.9910.30
874_S890_I0.9890.30
491_N886_L0.9890.30
547_E829_V0.9890.30
623_D627_G0.9880.30
623_D655_G0.9880.30
625_G655_G0.9880.30
627_G655_G0.9880.30
424_L433_Y0.9880.30
203_G340_R0.9880.30
530_K640_F0.9870.30
642_Q836_N0.9870.30
349_A353_E0.9860.30
742_T897_L0.9840.30
119_R131_Y0.9830.29
142_L148_I0.9790.29
273_E276_W0.9790.29
125_L131_Y0.9790.29
680_M683_Q0.9790.29
483_T592_N0.9760.29
781_W785_V0.9750.29
204_V213_V0.9730.29
501_P504_V0.9720.29
789_H892_Q0.9720.29
599_K656_L0.9690.29
479_H600_F0.9680.29
471_S482_R0.9680.29
744_E751_E0.9670.29
875_D903_T0.9670.29
876_V907_L0.9660.29
521_I924_S0.9660.29
483_T600_F0.9660.29
688_I707_K0.9640.29
542_E590_I0.9640.29
475_A480_E0.9620.29
126_A151_D0.9620.29
782_V786_A0.9610.29
121_S136_F0.9610.29
672_I923_L0.9600.28
883_G925_K0.9590.28
637_F684_F0.9570.28
560_V841_A0.9520.28
490_G588_Q0.9520.28
779_G787_A0.9500.28
585_R660_I0.9490.28
656_L904_A0.9480.28
208_Y226_E0.9470.28
131_Y144_R0.9450.28
877_N914_C0.9430.28
401_R406_I0.9430.28
792_P799_Y0.9420.28
839_L933_K0.9400.28
874_S928_T0.9390.28
371_C374_R0.9390.28
470_K478_S0.9390.28
832_D926_P0.9380.28
115_S137_S0.9380.28
530_K684_F0.9360.27
470_K484_P0.9350.27
528_F936_L0.9340.27
132_W136_F0.9330.27
519_L601_T0.9330.27
115_S118_W0.9310.27
522_I907_L0.9290.27
781_W784_S0.9290.27
147_L150_S0.9270.27
801_I814_S0.9270.27
586_L609_H0.9260.27
473_F642_Q0.9230.27
626_V651_F0.9220.27
794_L806_D0.9220.27
828_L832_D0.9220.27
925_K932_I0.9220.27
349_A359_N0.9210.27
873_L881_M0.9210.27
470_K482_R0.9200.27
483_T637_F0.9190.27
679_G756_K0.9190.27
147_L153_L0.9180.27
775_E789_H0.9180.27
713_V722_L0.9170.27
875_D926_P0.9170.27
565_L593_L0.9160.27
646_G651_F0.9150.27
491_N507_L0.9120.26
668_M709_C0.9120.26
147_L154_C0.9110.26
466_A588_Q0.9110.26
380_N387_A0.9100.26
380_N383_S0.9100.26
473_F682_S0.9100.26
402_L405_I0.9100.26
114_M117_T0.9090.26
358_F362_I0.9090.26
402_L667_M0.9070.26
210_L220_Q0.9050.26
174_L188_D0.9020.26
592_N654_T0.9020.26
484_P600_F0.9020.26
529_S640_F0.8970.26
118_W139_A0.8950.26
470_K654_T0.8940.26
507_L660_I0.8940.26
660_I877_N0.8940.26
592_N640_F0.8940.26
476_T486_Y0.8940.26
195_W198_E0.8930.26
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775_E779_G0.5420.14
361_K371_C0.5420.14
871_I911_K0.5410.14
697_Q850_Q0.5410.14
879_P925_K0.5410.14
559_L686_V0.5400.14
124_S159_G0.5390.14
636_L659_A0.5380.14
856_D886_L0.5370.14
204_V231_M0.5370.14
642_Q656_L0.5360.14
632_E643_V0.5360.14
686_V903_T0.5360.14
643_V651_F0.5360.14
644_G901_G0.5360.14
353_E481_L0.5340.14
522_I532_E0.5340.14
842_D929_L0.5340.14
359_N369_G0.5330.14
399_R404_Q0.5320.14
482_R656_L0.5320.14
654_T904_A0.5320.14
588_Q656_L0.5320.14
223_L250_N0.5310.14
573_P827_I0.5310.14
124_S129_M0.5300.14
527_D626_V0.5300.14
794_L804_E0.5300.14
610_V870_D0.5290.14
344_P514_S0.5290.14
661_C928_T0.5290.14
118_W130_R0.5280.14
596_N653_G0.5280.14
495_L847_L0.5280.14
474_L649_R0.5280.14
448_S871_I0.5280.14
143_N172_K0.5280.14
125_L139_A0.5270.14
778_P784_S0.5270.14
333_L530_K0.5260.14
165_V184_A0.5250.14
582_D832_D0.5240.14
231_M333_L0.5210.14
620_R864_L0.5210.14
787_A791_L0.5210.14
426_I525_I0.5210.14
704_L787_A0.5210.14
139_A150_S0.5190.14
483_T621_V0.5190.14
617_L817_K0.5190.14
333_L338_E0.5180.14
518_L585_R0.5180.14
147_L186_Q0.5160.14
530_K600_F0.5160.14
415_D434_R0.5150.14
626_V647_V0.5150.14
511_M899_V0.5140.14
874_S902_V0.5140.14
839_L919_M0.5140.14
661_C864_L0.5130.13
479_H654_T0.5130.13
519_L902_V0.5130.13
118_W132_W0.5110.13
301_Y344_P0.5110.13
450_V557_L0.5100.13
600_F657_G0.5100.13
657_G925_K0.5100.13
483_T518_L0.5090.13
600_F640_F0.5090.13
500_L527_D0.5090.13
476_T487_G0.5080.13
805_S808_P0.5080.13
653_G657_G0.5080.13
660_I835_I0.5080.13
589_V931_V0.5070.13
116_N124_S0.5070.13
470_K532_E0.5060.13
748_I856_D0.5060.13
175_H185_P0.5060.13
582_D875_D0.5060.13
477_V480_E0.5060.13
125_L157_N0.5050.13
831_D900_I0.5030.13
488_I919_M0.5030.13
339_R887_T0.5030.13
165_V180_K0.5020.13
352_L532_E0.5020.13
118_W122_L0.5020.13
127_W142_L0.5020.13
901_G919_M0.5010.13
361_K365_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.3519 100 0.744 Contact Map
4gczA 2 0.3625 100 0.755 Contact Map
3a0rA 2 0.3309 100 0.763 Contact Map
4mpcA 2 0.3467 100 0.796 Contact Map
4q20A 2 0.2424 100 0.799 Contact Map
2c2aA 2 0.2455 100 0.799 Contact Map
4e01A 3 0.2908 100 0.8 Contact Map
1b3qA 2 0.3383 100 0.8 Contact Map
2q8gA 2 0.3477 100 0.804 Contact Map
4r3aA 1 0.3035 100 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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